cxcr4 cxcl12 in breast cancer progression and metastasis
European guidelines for quality assurance in breast cancer screening and diagnosis pot
Ngày tải lên :
15/03/2014, 00:20
... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring and ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
Ngày tải lên :
09/08/2014, 10:21
... both in monomeric (active) and dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding ... substrate binding domains, Leucine zipper, ATP-binding domains, FAT domain and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative ... Risk for developing breast cancer The association between any variant in the ATM gene and risk of breast cancer was computed by comparing the 95 cancer free women and the 272 breast cancer patients...
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Epithelial mesenchymal transition in breast cancer progression
Ngày tải lên :
05/10/2015, 21:24
... breast and IDC 97 Figure 23 SPARC immunostaining in DCIS of the breast 98 Figure 24 SPARC immunostaining in IDC of the breast 99 Figure 25 Keratin 14 immunostaining in normal breast and skin 107 ... Protein Acidic and Rich in Cystein Terminal Duct Lobular Unit α-Smooth Muscle Actin xii Introduction INTRODUCTION 1.1 Breast Cancer 1.1.1 Incidence of Breast Cancer Cancer of the breast in women ... of SPARC staining intensities in 30 cases of breast carcinoma 95 Table 10 Observed frequency of SPARC staining intensities in the surrounding stromal cells in 30 cases of breast carcinoma 95 Table...
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Báo cáo khoa học: "Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer" potx
Ngày tải lên :
09/08/2014, 03:21
... survival in invasive breast cancers [24] In conclusion, we found that the incidence of sentinel lymph node metastasis in cases of pure DCIS was 0.39% This incidence was lower than that in IDC-predominant ... Rome Breast Cancer Study Group: Sentinel lymph node biopsy in women with pT1a or “microinvasive” breast cancer Breast 2008, 17:395-400 Zavagno G, Belardinelli V, Marconato R, Carcoforo P, Franchini ... cells and the outcome of breast cancer N Engl J Med 2009, 361:653-663 doi:10.1186/1477-7819-8-6 Cite this article as: Tada et al.: Ductal carcinoma in situ and sentinel lymph node metastasis in breast...
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FUNCTION AND MECHANISM STUDIES OF TRPV4 IN BREAST CANCER METASTASIS
Ngày tải lên :
02/10/2015, 17:15
... TRPV4 in invasive human breast cancer cell lines and tissues 37 37 42 TRPV4 is a positive regulator of breast cancer metastasis 3.2.1 Function of TRPV4 in breast cancer cell movement, invasion and ... carboxyl-terminal tail as illustrated in Figure 1.5C appears to be the docking site for at least two interacting sites including calmodulin (CAM) binding sites and region involved in microfilament-associated ... roles and modes of actions in breast cancer metastasis remain obscure We hypothesize that TRPV4 is a positive regulator in breast cancer metastasis In this project, we focus on understanding the...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
Ngày tải lên :
15/03/2014, 00:20
... their main roles focus on ectodomain shedding and nonproteolytic functions, such as binding to adhesion molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and ... [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed ... such as angiostatin, tumstatin, endostatin and endorepellin MMPs also modulate the cell–cell and cell–ECM interactions by processing E-cadherin and integrins, respectively, affecting both cell phenotype...
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Factors infl uencing the risk of breast cancer – established and emerging ppt
Ngày tải lên :
15/03/2014, 01:20
... briefing will outline: The established risk factors for breast cancer, and The current thinking regarding the involvement of certain chemical exposures in breast cancer, and in particular, the ... smoke and breast cancer is clearly defined In the meantime, not smoking has other clear health benefits BREAST CANCER Factors in uencing the risk of breast cancer – established and emerging Other ... for breast cancer include radiotherapy treatment for Hodgkins lymphoma40,41, having dense breasts42, being taller than average 43 and having certain kinds of noncancerous breast disease44 In addition,...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
Ngày tải lên :
15/03/2014, 23:20
... Accumulating evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by maintaining the structural integrity and self-assembly of ... heparanase in human cancer by focusing on head and neck carcinoma and multiple myeloma as examples of solid and hematological malignancies Heparanase in head and neck carcinoma: signaling in motion ... [23,25,30,31] and are not discussed in detail here Heparanase in tumor progression and metastasis Enzymatic activity capable of cleaving glucuronidic linkages and releasing polysaccharide chains resistant...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
Ngày tải lên :
23/03/2014, 17:20
... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of ... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible ... Close and stable relationship 38 Targeting New Pathways and Cell Death in Breast Cancer between proliferation and a hypoxia metagene in aromatase inhibitor treated ERpositive breast cancer Clin Cancer...
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Breast cancer incidence and case fatality among 4.7 million women in relation to social and ethnic background: a population-based cohort study pdf
Ngày tải lên :
29/03/2014, 01:20
... Jensen and colleagues emphasizing the importance of early breast cancer detection in Sweden on decreasing breast cancer mortality [58] Our findings of higher breast cancer survival by increasing ... as Asia and Latin America This is in agreement with studies on immigrants from Asia and Latin America in the US and immigrants from Ireland in the UK [6,25,26] A significant variation in incidence ... diagnosed after age 50 or in 2001 to 2007 had higher breast cancer case fatality compared with corresponding native Swedes Our findings of increasing incidence [37-39] and improving survival [40] over...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
Ngày tải lên :
30/03/2014, 03:20
... truncated BRCA1 or induce apoptosis in a cell line expressing mutated BRCA1 The data in Figs and suggest that TRAIL can alter BRCA1 localization and induce apoptosis in breast cancer cells Therefore, ... to increase We observed an increase in HIF-1a protein, and thus were confident that the cells were being maintained in a low-oxygen environment and were responsive to low oxygen There is also increasing ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer cells...
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TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER pot
Ngày tải lên :
27/06/2014, 11:20
... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of ... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible ... Close and stable relationship 38 Targeting New Pathways and Cell Death in Breast Cancer between proliferation and a hypoxia metagene in aromatase inhibitor treated ERpositive breast cancer Clin Cancer...
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Báo cáo y học: "Physical Exercise and Quality of Life in Breast Cancer Survivors" potx
Ngày tải lên :
08/08/2014, 16:23
... exercise training and natural killer cell cytotoxic activity in breast cancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma prognosis Cancer ... other diseases, and extending survival in cancer survivors Preliminary research suggests that exercise may be an effective intervention for enhancing QOL in cancer survivors and that this effect ... few in number, however, and of limited quality Further research using rigorous methodology is needed to definitively answer questions concerning the role of exercise in enhancing QOL in cancer...
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báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot
Ngày tải lên :
09/08/2014, 01:24
... cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal objective of this study was to determine the relationship between serum IL-6 and CRP levels and staging and prognosis ... prognosis in breast cancer patients Page of immunoassay The sandwich principle was used and the total duration of assay took 18 minutes The measuring range of IL-6 is 1.5-5000 pg/ml(defined by ... TNM staging system of breast cancer thus indirectly correlating with the prognosis of the patient CRP estimation does not seem to be very useful in evaluating the patient with breast cancer, ...
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báo cáo khoa học: "CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion" pptx
Ngày tải lên :
09/08/2014, 01:24
... tumors originating from the interstitial cells of Cajal, which are pacemaker cells regulating autonomic motor activity in the gastrointestinal tract The majority of the GISTs arise in the stomach ... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ... design and coordination and helped to draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received:...
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Báo cáo khoa học: "Postmastectomy locoregional recurrence and recurrence-free survival in breast cancer patients" pdf
Ngày tải lên :
09/08/2014, 03:21
... Stefanick ML: Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized ... contraceptives and prognosis in breast cancer: effects of duration, latency, recency, age at first use and relation to parity and body mass Page of 39 40 41 42 index in young women with breast cancer ... new era in breast cancer Invasion, size, and nodal involvement dramatically decreasing as a result of mammographic screening Arch Surg 1996, 131(3):301-308 Fisher B, Slack NH, Bross ID: Cancer...
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Báo cáo khoa học: "Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer" ppsx
Ngày tải lên :
09/08/2014, 04:21
... carcinoma of breast treated between July, 2008 and March, 2009 at The 181 Hospital and Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in ... results, including variability in tissue fixation and processing, variable sensitivity and specificity of commercially available antibodies, and differences in scoring criteria with considerable interobserver ... variability in interpretation of results [23] Our study is trying to answer a simpler question about the concordance between IHC and FISH in our local setting in Guilin city of China, using some...
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Báo cáo khoa học: "Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer" docx
Ngày tải lên :
09/08/2014, 07:21
... of lymph vessels leading to Sentinel nodes and the number of Sentinel nodes Single rout and Single node Multi routs and single node Single rout and multi nodes Multi routs and multi nodes 151(68%) ... detailed investigation Our results showed that there was a single route leading to a single SN in 68% of the patients, multiple routes leading to a single SN in 4%, a single route leading to multiple ... H, Inaji H: Sentinel node biopsy for breast cancer: technical aspects and controversies Breast Cancer 2007, 14:25-30 Giuliano AE, Jones RC, Brennan M, Statman R: Sentinel lymphadenectomy in breast...
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Báo cáo khoa học: "A biologically competitive 21 days hypofractionation scheme with weekly concomitant boost in breast cancer radiotherapy feasibility acute sub-acute and short term late effects" pot
Ngày tải lên :
09/08/2014, 09:20
... recurrence and cosmetic outcome [6-8] In order to intensify treatment, a simultaneous boost dose, concomitant or integrated, has been introduced in clinics by using 3-D conformal radiotherapy or intensity-modulated ... had stage I-II breast carcinoma as defined by the international Union Against Cancer (fifth edition) and had gone through macroscopic total resection of the primary tumor and sentinel node biopsy ... Freedman GM, Andersson PR, Goldstein LJ, Ma CM, Li J, Swaby RF, Litwin S, Watkins-Bruner D, Sigurdson ER, Morrow M: Four-week course of radiation for breast cancer using hypofractionated intensity...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
Ngày tải lên :
09/08/2014, 09:20
... bMedial, cInvasive ductal carcinoma, dInvasive Paget’s disease, eDistance metastasis patients had lung metastasis and two had liver metastasis One patient had mediastinal involvement On the other hand, ... clavicular fossa and above the seventh rib Any relapse involving the axillary lymph nodes, and/ or other nodes in the infra or supraclavicular fossa or in the internal mammary chain was considered ... supraclavicular and internal mammary lymph nodes alone) Local recurrence was defined as any relapse in the area of surgery between the sternum and the anterior axillary line, and below the inferior...
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