cutaneous drug reactions ppt
R INTE S OF MEDIC REPORTING ADVERSE DRUG REACTIONS DEFINITIONS OF TERMS AND CRITERIA FOR THEIR USE ppt
... of skin lesions and therefore encompassing virtually all cutaneous adverse reactions. As a general rule, in reporting cutaneous drug reactions specific terms should be used, but only when the ... of the skin. Photosensitivity reactions may be pleomorphic and include dermatitis-like reactions. Phototoxic reactions, which are non-immunological events caused by drugs or chemicals, are far ... for Reporting Adverse Drug Reactions 9 Skin and Appendages Disorders (SOC 0100) 9 Introduction 9 Terms 10 Dermatitis (Eczema) 10 Dermatitis exfoliative 10 Fixed drug eruption. 11 Lichenoid drug eruption...
Ngày tải lên: 07/03/2014, 10:20
Tài liệu Color Atlas of Pharmacology (Part 6): Quantification of Drug Action ppt
... elicit their effect, drug mole- cules must be bound to the cells of the effector organ. Binding commonly oc- curs at specific cell structures, namely, the receptors. The analysis of drug bind- ing ... in the medium in which membrane fragments are suspended, drug concentration at the “site of action” would equal that in the medium. The drug under study is ra- diolabeled (enabling low concentra- tions ... antagonist (p. 60). Use of radiolabeled drugs bound to their re- ceptors may be of help in purifying and analyzing further the receptor protein. 56 Quantification of Drug Action Lüllmann, Color Atlas...
Ngày tải lên: 26/01/2014, 19:20
Tài liệu Color Atlas of Pharmacology (Part 8): Adverse Drug Effects pptx
... in mother Unwanted effect in child Drug ? Extent of transfer of drug into milk Infant dose Rate of elimination of drug from infant Distribution of drug in infant Drug concentration in infant´s blood Effect Ovum 1 ... maturation Age of fetus (weeks) B. Lactation: maternal intake of drug A. Pregnancy: fetal damage due to drugs Sequelae of damage by drug MalformationFetal death Functional disturbances 382 1 2 1 ... reserved. Usage subject to terms and conditions of license. Adverse Drug Effects 71 A. Adverse drug effect: overdosing B. Adverse drug effect: increased sensitivity Effect Dose Decrease in pain perception (nociception) Respiratory...
Ngày tải lên: 26/01/2014, 19:20
Tài liệu Lipases and Phospholipases in Drug Development pptx
... A 2 (sPLA 2 ) in Liposomal Drug Delivery 43 3.3 Lateral Microstructure of Lipid Bilayers and its Influence on sPLA 2 43 3.4 sPLA 2 Degradation of Drug- delivery Liposomes: A New Drug- delivery Principle 46 3.4.1 ... Biophysical Model Drug- delivery System to Study sPLA 2 Activity 47 3.4.3 Effect of Lipid Composition on sPLA 2 -triggered Drug Release and Absorption 48 3.4.4 Effect of Temperature on Liposomal Drug Release ... 121 7.2 Lipases Show Unique Differences in Comparison to Other Drug Targets 122 7.3 Lipase Assays 123 7.4 Hormone-sensitive Lipase (HSL) as a Drug Target in Diabetes 125 7.4.1 Biological Role of HSL...
Ngày tải lên: 17/02/2014, 05:20
Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt
... Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target Louise Egeblad-Welin 1 , Martin Welin 2, *, Liya Wang 1 and Staffan Eriksson 1 1 Department ... sequence or structural homology to the human enzyme CMP–UMPK, which makes them potential targets for drug development, but, in the case of UpUMPK, a search for non-nucleo- side ⁄ nucleotide inhibitors ... and St. pneumo- niae have also been shown to be essential [12–14]. Therefore, UMPK is a potential drug target for the development of antimicrobial agents, and it is of great importance to study...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Plant physiology - Chapter 7 Photosynthesis: The Light Reactions pptx
... carbon reduction. The chemical reactions in which water is oxidized to oxygen, NADP is reduced, and ATP is formed are known as the thylakoid reactions because almost all the reactions up to NADP reduction ... place within the thylakoids. The carbon fixation and reduction reactions are called the stroma reactions because the carbon reduction reactions take place in the aqueous region of the chloroplast, ... is photochemistry, in which the energy of the excited state causes chemical reactions to occur. The photochemical reactions of photosyn- thesis are among the fastest known chemical reac- tions....
Ngày tải lên: 20/02/2014, 01:20
RNA Interference Technology FROM BASIC SCIENCE TO DRUG DEVELOPMENT ppt
... addition, RNAi could facilitate drug screening and development by iden- tifying genes that can confer drug resistance, or genes whose mutant phenotypes are ameliorated by drug treatment. This approach ... therapeutically relevant targets. Section 6: Therapeutic and drug development Selection and validation of molecular targets is of great importance for drug de- velopment in the post-genomic era. Although ... Edbrooke Section six. Therapeutic and drug development 26 RNAi-mediated silencing of viral gene expression and replication 363 Derek M. Dykxhoorn 27 RNAi in drug development: Practical considerations...
Ngày tải lên: 06/03/2014, 09:21
Women and Adverse Drug Reactions Reporting in the Canadian Context pot
... voluntary reporting of adverse drug reactions was inadequate, the jury’s key recommendation called for a national system for the mandatory reporting of adverse drug reactions. Mandatory reporting, ... adverse drug reactions. But as , Dr Joel Lexchin - a Toronto physician who has extensively researched the drug industry - has said, Canada’s regulatory system is “good at not letting drugs on ... adverse drug reactions in Canada, using a 1:10 ratio of the population of Canada to that of the US, would total 7,600 annually – 10% of the estimated 76,000 deaths due to adverse drug reactions...
Ngày tải lên: 22/03/2014, 11:20
A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... mechanical force on the kinetics of chemical reactions. A recent review by Beyer and Clausen-Schaumann describes the role of mechanical forces in catalyzing chemical reactions. [48] The authors noted that ... folding, [46,47] unfold- ing [37,39,64,65] and of chemical reactions. [43,44,49] From the force- dependence, we extract features of the transition state of these reactions that reveal details of the underlying ... protein based chemical reactions. 3. Conclusions Using a combination of force protocols we have demonstrated that protein unfolding, protein collapse, protein folding and chemical reactions are affected...
Ngày tải lên: 22/03/2014, 18:20
Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration pptx
... term "new drug& quot; to mean: (1) Any drug (except a new animal drug or an animal feed bearing or containing a new animal drug) the composition of which is such that the drug is not generally ... Nutrition, Food And Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740- 3835. 301-436-1200 For human drugs, the Division of Drug Information (HFD-240), Center for Drug Evaluation ... conditions of use; or (2) Any drug (except a new animal drug or an animal feed bearing or containing a new animal drug) the composition of which is such that such drug, as a result of investigations...
Ngày tải lên: 23/03/2014, 10:20
Phản ứng có hại của thuốc (Adverse Drug Reactions; ADR) pdf
... 1báo cáo về bệnh thận nhiễm độc. (theo Reactions Weekly; Số 1018; 11/9/2004) TCNCYH 36 (3) - 2005 91 Phản ứng có hại của thuốc (Adverse Drug Reactions; ADR) G.S. Hoàng Tích Huyền Bộ...
Ngày tải lên: 25/03/2014, 05:20