creactive protein kidney function

Ngày tải lên: 18/06/2014, 22:20

Ngày tải lên: 20/06/2014, 04:20

Ngày tải lên: 20/06/2014, 08:20

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Ngày tải lên: 13/08/2014, 08:21

Ngày tải lên: 31/12/2013, 10:33

... (KIND) is a putative protein protein interaction module. Four KIND-containing proteins, Spir-2 (actin-nuclear factor), PTPN13 (protein tyrosine phosphatase), FRMPD2 (scaffold protein) and very-KIND ... compilation ª 2011 FEBS 1655 Introduction Protein protein interactions play important roles in the molecular recognition and functional modulation between proteins in many signal transduction path- ways ... for 1 h, followed by rotation with protein A-sepharose or protein G-sepharose (GE Healthcare UK Ltd) at 4 °C. Proteins immunoprecipi- tated with the antibody protein A- or G-sepharose com- plexes...

Ngày tải lên: 14/02/2014, 19:20

... study, we report the structural and functional characterization of the human HPRT homolog PRTFDC1. To shed light on the potential function of PRTFDC1, the protein was screened against a nucleotide ... was annotated as a protein with unknown function, the use of a DSLS thermal-melt assay proved to be a good initial step for elucidating which compounds could stabilize the protein. The increased ... mm Hepes (pH 7.5), 300 mm NaCl, 10% glycerol, 2 mm TCEP]. The purity of the protein was estimated on SDS ⁄ PAGE. The protein concentration was measured using Bradford reagent [27]. A similar protocol...

Ngày tải lên: 15/02/2014, 01:20

... regulation of which can have distinct functional consequences. MLL1 contains a number of conserved functional domains that work together for the assembly of multiprotein complexes that influence the ... full-length protein is proteolytically processed into two fragments, MLL-N and MLL-C, which associate to form a complex in vivo (Fig. 1A) [14,15]. The mature protein assembles with numerous regulatory proteins ... & Cheng X (2005) The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol 6, 227. M. S. Cosgrove and A. Patel MLL1: a structure function perspective FEBS Journal 277...

Ngày tải lên: 16/02/2014, 14:20

... cysteine dioxygenase (CDO) (Protein Data Bank identifier: 2ATF) [20], ARD (Protein Data Bank identifier: 1VR3) [21], QDO (Protein Data Bank identifiers: 1Y3T and 1JUH) [11,12], gentisate 1,2-dioxygenase (Protein Data ... characterized cupin protein from Rubrivivax gelatinosus PM1 (Protein Data Bank identifier: 2O1Q) that has been functionally annotated as acetyl ⁄ propionyl-CoA carboxylase (RgCarb). The three proteins share ... Bakker FT & Dunwell JM (2001) Phylogeny, function, and evolution of the cupins, a structurally conserved, functionally diverse superfamily of proteins. Mol Biol Evol 18, 593–605. 2 Dunwell...

Ngày tải lên: 18/02/2014, 06:20

... bound proteins were washed from the col- umn using 50 mL of lysis buffer containing 20 mm imidazole. The recombinant protein was eluted with 5 mL of lysis buffer containing 200 mm imidazole. The protein ... the linear relationship. This difference is small (< 10%) for well folded and stable proteins, whereas for mis- folded proteins it is usually larger than 10% [12]. The large difference in SFEs for St ... 2008 The Authors Journal compilation ª 2008 FEBS 5859 Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium A. Pappachan 1 , H. S....

Ngày tải lên: 18/02/2014, 14:20

... analyses to identify putative proteins interacting with MCPIP (data not shown). Of the identified proteins, 73% are proteins involved in mRNA stability, but there are also proteins involved in other ... Henics et al. [13], who showed that cytoskeleton proteins have binding capacity for proteins involved in mRNA metabolism. Moreover, cytoskeleton proteins, such as actin or tubulin, are thought ... of MCPIP with red fluorescent protein (RFP). Using various concentrations of the plasmid vector overexpressing the fusion protein MCPIP–RFP, we observed that the protein was localized in the cyto- plasm,...

Ngày tải lên: 18/02/2014, 14:20

... large number of membrane proteins with an as yet undeter- mined function [11–13]. A previous study has shown the importance of the melA gene (encoding an Rv2560 homologous protein) in Mycobacterium ... Mycobacterium tuberculosis Rv2536 protein implicated in specific binding to human cell lines. Protein Sci 14, 2236–2245. D. F. Plaza et al. M. tuberculosis Rv2560 protein characterization FEBS Journal ... known function in other microorganisms, no functional counterparts have been found for many of these mycobacterial genes. Pro- teome studies have led to the determination of some of the proteins...

Ngày tải lên: 18/02/2014, 16:20

... is shown here that the ESSS protein is another essential protein for the formation of a functional complex I in mammals. The null mutants can be complemented with ESSS proteins epitope-tagged (HA ... homologous protein in the prokaryotic com plex, it had previously been grouped among the ÔancilliaryÕ proteins, also referred to as ÔaccessoryÕ proteins. Our present studies estab lish that the ESSS protein ... subunit, wh ile functional, does not function as well as the native ESSS protein. It is the only subunit present in the complemented null mutants. In transfected wild-type cells the ESSS-HA protein competes with...

Ngày tải lên: 19/02/2014, 16:20

... HEK, human embryonic kidney; HRP, horseradish peroxidase; MAP, mitogen-activated protein; MEK, mitogen-activated protein ⁄ extracellular signal-regulated kinase kinase; PKA, protein kinase A; Sos1, son ... Ras family of small G proteins. The activity of Ras proteins is under tight control of several classes of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins. Mammalian Son ... Plowman GD, Rudy B & Schlessinger J (1995) Protein tyrosine kinase Pyk2 involved in Ca 2+ - induced regulation of ion channel and MAP kinase functions. Nature 376, 737–745. 5 Dikic I, Tokiwa...

Ngày tải lên: 19/02/2014, 18:20

... nucleolin, Bop1, p120 and p19 Arf . Each of these proteins was found to function at least partially through RNA protein or protein protein interactions [12,14,38–42]. Among the 18 RNA helicases which ... not accurately reflect the exact functional states of protein inter- actions since the possibility exists that the shortened proteins may be unfolded and thus nonfunctional. Gua–RPL4 interaction ... undiscovered mechanisms. RNA helicases are believed to function through regulation of RNA structure rearrangement and RNA- RNA, RNA -protein or protein protein interactions [23,24]. To date, at least...

Ngày tải lên: 20/02/2014, 01:20

... middle of the protein. Additionally, the C terminus of the protein is important for this activity. Experimental methods Production of recombinant protein Production of recombinant mouse prion protein ... for prion protein function and proteinase resistance. EMBO J. 19, 1180–1186. 46. Miele, G., Jeffrey, M., Turnbull, D., Manson, J. & Clinton, M. (2002) Ablation of cellular prion protein expression ... antioxidant function are early changes in prion disease. Biochem. J. 362, 253–258. 32. Brown, D.R. (2000) PrP Sc -like prion protein peptide inhibits the function of cellular prion protein. Biochem....

Ngày tải lên: 21/02/2014, 00:20

... contrast to the antimyotoxic proteins described so far, DM64 is structurally related to DM43 [24] and to a 1 B- glycoprotein, a single chain human serum protein with unknown function, and a member ... physiological functions is to afford circulating protection against foreign toxins, there- fore indicating that DM64 performs functions of the innate immune system. It is remarkable that two proteins ... J.J. & Kress, L.F. (1992) Isolation from opossum serum of a metalloproteinase inhibitor homologous to human alpha 1B- glycoprotein. Biochemistry 31, 410–418. 41. Ishioka, N., Takahashi, N. &...

Ngày tải lên: 21/02/2014, 01:21

... free e xtract protein from Artemia cysts; 2, p26-full; 3, p26-ND36; 4, p26-CD40; 5, p26-CD10. Ó FEBS 2002 Small heat shock/a-crystallin protein from Artemia (Eur. J. Biochem. 269) 937 Functional ... when oligomer size and protein concentration are low. The findings have important impli- cations for understanding the functional mechanisms of small h eat s hock/a-crystallin proteins. Keywords: ... transport and multimerization of nascent proteins, as well as preventing the irreversible aggregation of denaturing proteins. The small heat shock/a-crystallin proteins consti- tute a structurally...

Ngày tải lên: 22/02/2014, 04:20