costs of residues in the livestock industry
Essential Elements of Sanitation in the Beverage Industry
... ARE THERE SANITATION NEEDS? The word sanitation is derived from the Latin “sanitas,” which means health Sanitation in the food industry has been applied to the process of creating and maintaining ... against contamination of food The methods for maintaining cleanliness include, but are not limited to: (1) Wearing outer garments suitable to the operation in a manner that protects against the ... that resembled the surface of the moon — or worse, a mushroom farm — because of the amount of yeast growth on it The intensity of the yeast and dirt substrate growing in the duct had, in some places,...
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The Role of Probiotics in the Poultry Industry doc
... hurdles, such as the low pH of the stomach, the presence of bile acids in the intestines, and the competition against other micro-organisms in the gastro-intestinal tract [91,92] The tentative ways ... selection of probiotics in the poultry industry (modified from [93-97]) Isolation of microbial strains Screening of poultry In vitro assays for pre-selection of probiotic strains In vivo evaluations of ... supplementation of probiotic to the diet The manipulation of gut microbiota via the administration of probiotics influences the development of the immune response [75] The exact mechanisms that mediate the...
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Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
... and the estrogen receptor [31,32] In the case of RXR a mutation of Phe318 into an alanine in helix causes a destabilization in a network of hydrophobic interactions in the apo-receptor core In the ... built a homology model of human PXR in order to identify residues that were likely to be involved in ligand binding Since the initiation of this study the crystal structure of the human receptor ... this region of PXR The two receptor sequences are furthermore most dissimilar in this part of the structure In addition there are four deletions of one or two amino acids in the LBD of the PXR sequence...
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Báo cáo y học: "Health and economic impact of combining metformin with nateglinide to achieve glycemic control: Comparison of the lifetime costs of complications in the U.K" pps
... regarding the lifetime cost of managing complications These arise mainly from a reduction in the costs of treating end stage renal disease (72%) and neuropathy (19%) The increase in the treatment costs ... nateglinide-metformin combination on the cost of managing complications, the difference in mean cost between metformin alone and the combination group was determined (Table 3) Thus, savings of £464 ... level Costs For each complication, the direct medical costs were estimated for the immediate impact of the event (costs arising in the year the event occurs) and the subsequent impact of the complication...
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Tài liệu Báo cáo khoa học: The role in the substrate specificity and catalysis of residues forming the substrate aglycone-binding site of a b-glycosidase docx
... was further investigated by determining the in uence on the glycone binding of the Sfbgly interactions with the aglycone Thus, the effect of the alteration of the glycone structure in the stability ... positioning within subsite )1 [13] Nevertheless, details about the role of different residues of the aglycone-binding site in the stabilization of ESà and the interdependence between the binding of ... Moreover, F179 is part of the aglycone-binding site of Cpbgly [22] In order to compare the aglycone-binding sites of these b-glycosidases, the effect of the aglycone size on the binding of several alkyl...
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Tài liệu Báo cáo khoa học: A novel type of highly negatively charged lipooligosaccharide from Pseudomonas stutzeri OX1 possessing two 4,6-O-(1-carboxy)-ethylidene residues in the outer core region ppt
... found either in wild-type strains and in mutant strains harboring mutations in the genes encoding enzymes of the biosynthesis and/or the transfer of the O-specific polysaccharide [12,13] The core ... particular, the linkage to O-6 of G was inferred by taking into account the downfield shift of the carbon signal C-6 (63.7 p.p.m., Table 1) indicating its involvement in a glycosydic linkage The HMBC ... Elucidation of the structure of the ¨ lipopolysaccharide core and the linkage between the core and the O-antigen in Pseudomonas aeruginosa immunotype using strong alkaline degradation of the lipopolysaccharide...
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Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
... ubiquitinated in the presence of the inhibitor of proteasome function Furthermore, the extent of ubiquitination of TNSALP (1559delT) was further augmented in the cells expressing ubiquitin, strongly ... eliminate the original translational stop codon and instead causes the extension consisting of 80 amino acid residues at the C-terminus of TNSALP Goseki et al detected a larger form of TNSALP in ... N-linked high-mannosetype oligosaccharide chains of glycoproteins [31] The involvement of EDEM and ⁄ or SCFFbs2 in the degradation of TNSALP mutant proteins is currently being investigated The...
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Tài liệu Instrumentation in the brewing industry Automation of the brewing process pot
... grains However, with the rapidly rising value of these commodities it is becoming more and more important to have a current status of inventory levels to allow for planning and advanced purchasing ... applications Infrastructure - In Plant Monitoring or Remote Sites Ethernet/Land line/GSM/GPRS for connection of remote location Intranet/ERP Integration Data visibility for our CUSTOMER Ethernet Installation ... FTI55 View of levelflex cable Inventory and supply chain management Rising commodities drives the need for real-time information Accounting of bulk inventory kept in tanks and silos has traditionally...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... demonstrates the importance of each of the negatively charged residues in the C-terminal extension in maintaining the solubility of the Hsp25 oligomer Similarly, the introduction of hydrophobicity into the ... Frequency of amino acid residues in the flexible region of the C-terminal extensions of human and murine sHsps Residues present in the flexible region of the C-terminal extension of each of the eight ... that the structure of the N-terminal domain is maintained, at least in the vicinity of the tryptophan residues The increase in exposed clustered hydrophobicity observed for the mutants is therefore...
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Báo cáo khoa học: Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding pdf
... unfolding of some protein substrates is initiated through productive binding to the substrate via two elements in ClpA, one in the N-domain and the other in the pore of the ClpA hexamer In the ... controls binding of ClpA to ClpP [14] Interestingly, there is also considerable debate regarding the role of the ClpB N-domain (which shares a common fold with the N-domain of ClpA) in substrate ... N-domain and two ATP-binding domains referred to as the D1 and D2 domains Interestingly, deletion of the N-domain from ClpA not only abolishes binding of the adaptor protein, ClpS, but additionally...
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Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
... simulation of DK9 thrombin in explicit water solvent supports the role of the A-chain in affecting the conformation and catalytic properties of the B-chain, particularly in some insertion loops of the ... side-chains to the solvent the smaller the intrinsic fluorescence of the enzyme The smaller gain in the intrinsic fluorescence of DK9 upon Na+ concentration (9 vs 18% in WT) may reflect not only the ... thrombin show that the A-chain closely follows the contour of the catalytic B-chain, hinging the two interacting six-stranded barrel-like domains of the B-chain [17] A well-structured network of...
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Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues in the same enzyme To obtain an insight into ... be the major determinant of the acidity of Asp140 Thus, it would seem that the acidity of Asp140 is in uenced by additional residues in ChiB, i.e by the many positive residues further down in the ... positioned in the ÔupÕ position rows and shows that in the presence of the substrate, rotation of Asp142 towards Glu144 lowers the pKa of the latter by 0.8 pH units The calculated effects of the D140N...
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Báo cáo khoa học: Leishmania donovani methionine adenosyltransferase Role of cysteine residues in the recombinant enzyme pptx
... are located in the central domain of each subunit, in the interface between the two dimers comprising the tetrameric structure [29] This domain contains five cysteine residues, two of them (Cys35 ... forming a disulfide bond which may be necessary for the tetrameric state of the enzyme In addition, Cys69 is involved in the correct folding of the monomer, supporting the establishment of the ... whereas the slope of the slow semi-inactivation process was rather similar to the slope of the curve found when the medium did not contain AdoMet, with an estimated halflife of 10.5 The role of the...
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Báo cáo khoa học: Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase potx
... containing the regulatory and catalytic domains [15] hPAH), expressed in E coli, it has been concluded that at least two of the labile Asn residues are located in the catalytic domain of the protomer ... of the protomer [13] Furthermore, on the basis of a nearest neighbour amino acid analysis of all the Asn residues in wt-hPAH and taking into account the contribution of the 3D structure (PDB accession ... 3106.455); note, however, the lower S/N ratio of the spectra in Fig 4E than in 4B that has an effect on the accuracy of the deconvoluted spectrum Lability of the Asn residues in the autoregulatory sequence...
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the impacts of incorporating total quality management (tqm) principles towards the cost effectiveness in the steel industry
... level of involvement of employees in decision making process and productivity improvement during the 1930s These changes remarked a huge change in the management accounting Following the inventions ... equipments in the factory need time to buy, install and operate Expanding the business or making new products mean installing new equipments and training new personnel Normally, installing new machines ... to the organizations Since they work harder, the quality of products, time of producing and number of products also increased In other words, employees are a key point to identify survives of the...
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Báo cáo khoa học: Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S-transferases pdf
... quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 40 Laemmli UK (1970) Cleavage of structural proteins during the assembly of head of ... sensitive to the nature of the leaving group, as the substitution of the chlorine atom with the more electronegative fluorine in the CDNB molecule did not affect the kcat values Altogether, these results ... secondary structure elements The topological arrangement of these elements is usually bababba, similar to the thioredoxin fold of other GSH-binding or cysteine-binding proteins The H-site is entirely...
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Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf
... Stereo figures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars and the side-chains of three acidic residues in the conserved ... almost identical, but the D524A mutation resulted in a remarkable change in the conformation of the Glu526 side-chain The 2Fobs ) Fcalc electron density of the Glu526 side-chain in the D524A–substrate ... orientations of the Glu526 side-chain in the A-form were almost identical, and the maximum coordinate shift ˚ after superimposition of the two structures was 0.78 A In the B-form, in contrast, the Glu526...
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Báo cáo khoa học: Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1 ppt
... residue in the initial binding and correct positioning of CA during catalysis A role of N302 in anchoring the side-chain carboxylate of CA is further supported by the enhanced binding of amine substituted ... 2-aminoquinoline (Ks ¼ 17 lM) and indole3-carboxylic acid (the natural auxin, Ks ¼ 18 lM) These compounds are ordered from gain to loss of binding to the mutant proteins in Table As shown in Table ... on the regiospecificity of I2C ringhydroxylation support the hypothesis that the side chain of I371 is an essential element ensuring correct positioning and orientation of the aromatic ring in the...
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Báo cáo khoa học: "The Costs of Inheritance in Semantic Networks" pot
... nonmatching C with the question term B by discovering that B is either in the abstractive closure or the complex product closure of C The abstractive closure of an element is the set of all triples ... e2, or in the case that el and e2 are lists of the same length, each of the elements of el matches a corresponding element of e2 Since semantic relations (SRs) are unordered lists of binary relations ... match If these fail, then complex product arcs, *OF, HAS, LOC, AND, and OR may lead to a matching value The graph below outlines the essence of the procedure The primitive elements of SRs include...
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx
... catalytic residues, indicating a role in binding the nucleotide into the active site [15,16] The crystal structure of CNS from Neisseria meningitidis crystallized in the presence of the substrate ... stereo-view of the residues of interest (blue) in the active site of the CNS from Neisseria meningitidis containing CDP (yellow) (PDB 1EYR) [12] superimposed with their equivalent residues (green) of the ... concentrations in the presence or absence of 0.2 mm dithiothreitol Effect of Mg2+ concentration The effect of an increase in the concentration of Mg2+ was determined by measuring the rate of the reaction in...
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