control of cellular senescence

... interactions of SR proteins [1–5] Reversible phosphorylation of SR proteins is important for assembly and function of the spliceosome and for proper regulation of alternative splicing, and also controls ... ICP27 modulates the kinase activity and cellular localization of SRPK1, which results in hypophosphorylation of SR proteins and, consequently, downregulation of cellular pre-mRNA splicing [29,30] ... role in the life cycle control of viruses, which involves a series of alternative splicing events for expression of viral genome or proteins However, if the expression of these host factors is...

Ngày tải lên: 23/03/2014, 06:20

... can be considered a marker of replicative history and of the cumulative history of stress inducers of senescence, as well as an indicator of the probability of cell senescence [25] In this study, ... investigated cellular senescence in ageing or degenerate IVDs The accumulation of senescent cells in vivo with age, together with their changed pattern of gene expression [11], implicates cellular senescence ... seen with cells capable of only 20 to 25 population doublings prior to senescence A number of studies have shown increased levels of p16INK4a with increased occurrence of senescence [32,33] p16INK4a...

Ngày tải lên: 09/08/2014, 10:20

... Knock-down of sost phenocopies knock-down of lrp5 Fig 23 Schematic interpretation of proposed function of Lrp5/Sost Fig 24 Mismatch morphant control experiments List of Tables: Table List of primers ... four repetitions of the osx:mCherry control experiment, a total of 31 larvae served as DMSO controls and 48 were exposed to Mtz After days of treatment (dot), 30 (=97%) of the DMSO controls survived, ... volume of 10μl Reaction profile: Initial denaturation of DNA took place at 96°C for minute at the beginning of a cycle There were 10 seconds of denaturation at 96°C followed by annealing of the...

Ngày tải lên: 10/09/2015, 08:43

... mediated cellular senescence 20 1.5.2.3 p53 in Replicative Senescence 21 1.5.2.4 p53 in Premature Senescence 22 1.5.2.5 Regulation of p53 22 1.5.2.6 Regulation of p53 by Mdm2 23 1.5.2.7 Regulation of ... List of Figures Figure 1.1 Schematic diagrams on structures of 13 mammalian bHLH-O factors Figure 1.2 Causes and characteristics of cellular senescence 15 Figure 1.3 Two major pathways of cellular ... identify senescence 1.4 Causes of Cellular Senescence - 11 - Over the past decades, many studies have been carried out to understand the causes and underlying mechanisms of cellular senescence...

Ngày tải lên: 10/09/2015, 09:21

... mode of cytotoxic action and molecular basis of resistance Oncogene 2003;22(47):7265-79 Op De Beeck A, Caillet-Fauquet P The NS1 protein of the autonomous parvovirus minute virus of mice blocks cellular ... conductor of cellular responses to DNA replication stress Trends Biochem Sci 2010; [Epub ahead of print] Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, et al Mediation of poly(ADP-ribose) ... proteins of MVM and H-1 parvovirus attach to the viral genome Covalent attachment of NS1 to cellular DNA was investigated in this study using denaturing SDS-PAGE and autoradiography Attachment of NS1...

Ngày tải lên: 25/10/2012, 11:18

... notion of using SGLT inhibitors as a means to control circulating levels of glucose The selective inhibition of hSGLT2 by thioglycoside I, which is responsible for most of the reabsorption of glucose ... used to determine the amount of ATP in mg of protein measured from the number of cells per well After 24 h, the microtiter plate was taken for scintillation counting of radioactive [14C]AMG using ... adverse complications of glucose toxicity observed in diabetes The results of the present study suggest that some thioglycosides have a therapeutic potential for the control of blood glucose levels...

Ngày tải lên: 26/10/2012, 10:04

... located at the C terminus of Cub will be cleaved off and result in downstream reactions, which is the activation of LacZ and HIS3 reporter genes [7] 3.2 Identification of Cellular Membrane Proteins ... medium (rate of 65.8) was significantly higher than the negative control (normal Int J Med Sci 2005 116 culture medium with a rate of 4.3), but lower than the positive control (rate of 221.4) Our ... first round of screening Half of the colony was streaked on SD/-Trp agar plate and the other half inoculated into 20µl of PCR mix PCR products were sequenced to determine the identity of the interacting...

Ngày tải lên: 02/11/2012, 11:08

... birth In Hungary 25.2% of congenital abnormalities were prevented by these methods Previously the selective abortion, i.e termination of pregnancy after the prenatal diagnosis of severe fetal defects ... Hungary about 20% of major congenital abnormalities (8.7% in the total group) were terminated after the prenatal diagnosis of defects Tertiary prevention: complete recovery of congenital abnormalities ... for their prevention Conflict of interest The author has declared that no conflict of interest exists References Czeizel AE, Intődy Z, Modell B What proportion of congenital abnormalities can...

Ngày tải lên: 02/11/2012, 11:12

... mixing duration (15 minutes) was decided from the results of kinetic batch experiments The pH of all solutions of the batch experiments were controlled to 7.0 using HCl and NaOH solutions during ... the schematic diagram of a typical laboratory-scale MBR experiment Each reactor was made of plexiglass and had a designed working volume of 10 L A flat sheet membrane made of chlorinated polyethylene ... 10 L/day with 1,000 mg/L of biological oxygen demand (BOD), 50 mg/L of nitrogen and 25 mg/L of phosphorus The experiments were conducted at a sludge retention time (SRT) of 33 days and the hydraulic...

Ngày tải lên: 05/09/2013, 10:15

... to control the temperature of a building and have obtained impressive results The fuzzy control method of Zadeh [17] has also been widely used for control of many nonlinear systems; a fuzzy control ... self-adapting controller which changes as the input changes There are two disadvantages of the DMC controller First, the DMC controller is a local controller which can only guarantee the stability of the ... DMC controller to control the displacement ventilation HVAC system The control results using the DMC controller are analyzed and compared with those obtained from another controller The DMC controller...

Ngày tải lên: 05/09/2013, 16:11

... Microsoft host controller driver uses the SOF MODIFY register When the Microsoft host controller driver takes control of the host controller from the BIOS, it always reads the value of the SOF MODIFY ... Microsoft host controller driver uses the SOF MODIFY register When the Microsoft host controller driver takes control of the host controller from the BIOS, it always reads the value of the SOF MODIFY ... An example sequence of events that involves handoff of the host controller in both directions is shown in Figure Figure Example sequence of events in handoff of the host controller The time line...

Ngày tải lên: 07/10/2013, 00:20

... of all oils tested The main component of one of the oils is pulegone The other is not yet identified and it is called SEM76 (Shaaya and Kostyukovsky, 2006) In our study of the mode of action of ... quick and effective tool for the control of stored-product insect pests In view of the scheduled phaseout of methyl bromide under the Montreal protocol, the role of phosphine in grain protection ... because of the pesticidal properties of these chemicals (Fenwick at al., 1983) and because of the potential use of methyl ITC as fumigant for wheat (Ducom, 1994) In our study on the rates of sorption...

Ngày tải lên: 25/10/2013, 05:20

... 2001.6,7 CONTROL OF MICROBIAL CONTAMINATION Microbial contamination of fruit can occur at all stages of growth, harvesting, storage, and processing The surfaces of fresh fruits are often contaminated ... involves the use of mercury lamps, which generate 90% of their energy at a wavelength of 253.7 nanometers Exposure of bacteria to UV results in cross-linking of the thymine dimers of the DNA in ... control of postharvest fungal spoilage of fruits have been studied Ionizing irradiation has been examined, and it was found that doses of 3.5 kGy did not completely control postharvest decay of apple,...

Ngày tải lên: 25/10/2013, 21:20

... the balance of expression of members of the Myc/Max/Mad network of proteins (see Fig 1) may dictate the response to loss of Myc (Walker et al 2005) In mice, the effects of deletion of the c-myc ... arrest upon cre-mediated excision of c-myc (de Alboran et al 2001) Importantly, deletion of the mnt gene, which encodes a member of the Mad family of antagonists of Myc, restores proliferation to ... dramatic loss of proliferative capacity of such cells (Knoepfler et al 2002) As long as questions of redundancy between different members of the myc gene family and compensation by loss of antagonists...

Ngày tải lên: 25/10/2013, 21:20

... also reduces the size of the power supply by containing the complexity of control system within the software Therefore, since digital control is much flexible than analog control, is becoming ... PFC control is the current industry choice but this type of control is not flexible Therefore, digital based control has many advantages with higher performance since the cost of digital controller ... waveforms of control system parameters IV Controller Implementation The proposed control system is implemented by using either ST-Fuzzy Studio (ST52x420) or TI DSP, TMS320LF2407 The features of two...

Ngày tải lên: 27/10/2013, 16:15

... baclofen, like orally administered baclofen, is not metabolized but is mainly excreted unchanged in the urine Pharmacokinetics of intrathecal baclofen Baclofen in cerebrospinal fluid (CSF) Baclofen ... risk of low-pressure headache An initial intrathecal trial dose of 25 or 50 μg of baclofen is used The smaller initial trial dose should be used if the patient is not on oral baclofen, in case of ... baclofen for treatment of children with spasticity of cerebral origin J Neurosurg, 87: 409–14 Azouvy, P., Mane, M., Thiebaut, J B et al (1996) Intrathecal baclofen administration for control of...

Ngày tải lên: 01/11/2013, 10:20

... thành loại: (1) điều khiển thích nghi tối u (Adaptive Control With Optimization - ACO) (2) điều khiển thích nghi theo điều kiện giới hạn (Adaptive Control With Constraints - ACC) Hệ ACO điều khiển ... On-line giá trị lực cắt, chuyển thành tín hiệu điện áp để cung cấp cho điều khiển (AC Controller) - Chức AC Controller đợc thực nhờ PC, có cắm card thu nhận xử lý tín hiệu PCL-812 PG hãng Advantech ... Production Systems, and Computer Integrated Manufacturing Printice-Hall, 1987 Yoram Koren: Computer Control of Manufacturing Systems McGraw-Hill, 1983 Japanese National Research Institute: Mechanical...

Ngày tải lên: 10/12/2013, 13:16

... Control, pp 38053810, USA, Dec 1995 [17] N Sarkar, X Yun and V Kumar, Control of Mechanical Systems With Rolling Constrains: Application to Dynamic Control of Mobile Robots, The Int Journal of ... Target, Proc of the 34th Conf on Decision & Control, pp 3831-3836, 1995 [16] R Fierro and F.L Lewis, Control of a Non-holonomic Mobile Robot: Backstepping Kinematics into Dynamics, Proc of the 34th ... Modeling and Motion Control of Mobile Robot for Lattice Type of Welding Line, KSME International Journal, Vol 16, No 1, pp 83-93, 2002 [5] B.O Kam, Y.B Jeon and S.B Kim, Motion Control of Two-Wheeled...

Ngày tải lên: 10/12/2013, 13:16

Ngày tải lên: 17/12/2013, 14:15