... underscoring the importance ofthe interactions between the Tyr OH and the side chains of Asn174 and Asp148 in TEV protease (Fig 4A) The importance of these interactions is further supported by the results ... effects ofthe mutations Hence, the results are consistent with the predicted role for these residues (based on crystal structure) in the interaction with substrate The loss of activity ofthe mutants ... Mutational analysis of TEV protease cleavage sites established that the specificity ofthe enzyme is restricted to the P6–P1¢ positions ofthe substrate [7,13] The crystal structure of catalytically...
... hand, and on the other by the attitude ofthe speaker towards the message and the addressee "Thus into the domain ofthe organization of utterance pertains all that is connected with the processual ... basic hypotheses, the second of which can conveniently be elaborated in terms of Ong's list ofthe characteristics of an orally-based language The two hypotheses and their respective sub-hypotheses ... aspect of utterance (in contrast to the abstract and static character ofthe other two levels), that is to say, the dynamism ofthe relations between the meanings of individual lexical items in the...
... Senior Lecturer of Anesthesia and Director ofthe Obstetric Anesthesia Unit at Shaarei Zedek Medical Center He is the current Chair ofthe Israel Association of Obstetric Anesthesia His main ... experience of personnel Accordingly, the OAAI is not a measure ofthe total activity ofthe obstetric anesthesia services Based on these limitations, it is important to appreciate that although the ... for the data presented in this study and will attempt to identify an ideal obstetric anesthesia staffing number based on the OAAI In summary, the use ofthe OAAI may facilitate a comparisonof the...
... measure ofthe rate of oxidation of oxyHb RESULTS The effect of pH on the auto-oxidation of cross-linked Hb was studied The rate of decrease ofthe concentration of oxyHb increased as the pH was ... in the absence and presence of EDTA, on the oxidation of Hb A0 The mean ± SD of three independent experiments is shown Other conditions as in Fig Our studies ofthe effect ofthe structure ofthe ... the LPS of rough E coli (Fig 1) The effect ofthe LPSs of smooth and rough S minnesota on the oxidation rate of Hb A0 was compared (Fig 5) In Fig Comparisonofthe effects ofthe LPSs of rough...
... due to the proximity ofthe negative charge ofthe side chain of Glu706 from the neighboring subunit The mutation of these residues might interfere with the oligomerization required for the proteolytic ... Successful determination ofthe crystal structure ofthe proteolytic domain of E coli Lon [30] allowed us to explain the loss of proteolytic activity ofthe mutants at these sites [25] These three residues ... analysis ofthe amino acid sequences ofthe majority ofthe currently known Lon proteases The results of site-directed mutagenesis of E coli Lon protease and insights from the crystal structure of...
... above the capitals At the uppermost section ofthe entablature there is another cornice that outlines the roof ofthe entire building (picture 16) The main component ofthe façade is flanked by the ... the end ofthe exhibition, find himself on the ground floor, near the exit By doing this, the viewer is made to experience the entire building, from the top ramp, to the bottom and perceive the ... staircase is a set of parallel columns (picture 21) Just above the start ofthe staircase is a grand statue of Perseus with the Head of Medusa Unlike the Guggenheim museum, the Met offers a more conventional...
... into the active site ofthe human DPP-IV; 3, docked into the active site ofthe crystalline structure of PepX from L lactis; and 4, docked into the active site ofthe modeled structure of PepX ... group ofthe ligand and the NH2 of Asn470 (equivalent to Asn710 in DPP-IV) Another potential bond can be proposed between the OH atom of Tyr380 and the carbonyl group ofthe ligand Finally, the ... us to model the docking ofthe inhibitor into the PepX active site using the Lamarckian genetic algorithm of autodock 3.0 [26] We started from the reference ofthe crystal structure of DPP-IV complexed...
... expenditures would have the effect of breaching the 60% rule and would have to be financed either on the revenue or the expenditure side ofthe budget Since the bulk ofthe increase in government ... in the share ofthe over 65s in the populations ofthe EU15, US and Japan will inevitably occur due to the fact that the post-war baby-boom generations in the latter areas will be reaching the ... on the basis of an examination ofthe consequences of World War I and the subsequent low birth rates ofthe 1920s, that the French population would only be 35 million in 1980 when in fact the...
... Overview 1.2 Statement ofthe results 1.2.1 Almost-harmonic map results 1.2.2 Heat flow results 1.3 Heuristics ofthe proof of Theorem 1.2 Almost-harmonic maps — the proof of Theorem 1.2 2.1 Basic ... Control of e∂ ¯ 2.5.2 Analysis of neighbourhoods of antiholomorphic bubbles 2.5.3 Neck surgery and energy quantization 2.5.4 Assembly ofthe proof of Theorem 1.2 Heat flow — the proof of Theorem ... smooth maps S → S of degree k onto the space of rational maps of degree k, which is known to be impossible Indeed, we can think ofthe bubbling ofthe flow as measuring the discrepancy between the...
... color, the more exposed the residue) ofthe disks drawn behind some ofthe residues to denote the difference in their solvent exposure as a result ofthe presence ofthe ligand; the ligand solvent ... molecule B The receptor exposure is shown by the size and intensity (the darker the color, the more exposed the residue) ofthe disks drawn behind some ofthe residues to denote the difference in their ... Closer view (from the bottom) ofthe protein–ligand interactions and the surface ofthe binding site in the upper binding site The Gaussian contact surface is presented with the following color...
... pre-MBA income will be one ofthe determinants of his/her incremental income The other, the post-MBA income, is a function ofthe school, the candidate, and the state ofthe economy (GDP growth ... rate of return by comparing the costs ofthe degree (the initial investment) with the subsequent income (cash-flows) over the individual’s work life (the life ofthe project) Literature Review The ... degree is the additional salary that results from the degree, while the cost ofthe investment is the foregone income and associated tuition and fees The internal rate of return (IRR) on the MBA...
... increases the slope in the transition region ofthe unfolding curve for apo¯avodoxin but it has no effect on the slope ofthe curve for ¯avodoxin Furthermore, the slope ofthe curve for the holoprotein ... plots ofthe logarithm ofthe equilibrium constant (Kapp) for the unfolding of apo¯avodoxin calculated at 2.94 M (j) and 3.43 M (d) urea vs the logarithm ofthe mean activity of NaCl (ln a) the ... on the ionic composition ofthe solution The change in protein ¯uorescence as a function ofthe concentration of urea is consistent with a two-state model of unfolding, as are the kinetics of the...
... the back ofthe animals The split human keratome biopsies were then grafted onto the back ofthe animals The grafts were protected by a bandage during the following two weeks All the transplantation ... day 22 and the biomarkers were therefore only scored at the end ofthe study Considering the marked vehicle effect ofthe ointment vehicle observed on clinical score, it is likely that the biomarkers ... [15-17] However, these studies compared the biomarker profiles before and after treatment with the calcipotriol ointment and they did not assess the effects ofthe vehicle on the biomarker responses...
... information about wider effects of oral health on daily living The main advantage of generic measures is that they allow comparisonof various domains of quality of life for the condition being studied, ... treatment These findings differed according to the indicator used to assess the impacts of oral conditions on participants' quality of life (the overall score or the prevalence of oral impacts) or the ... adolescent reported an impact on any ofthe performances, the frequency ofthe impact (scale from to 3) and the severity of its effect on daily life (scale from Page of (page number not for citation...
... asked whether they had experienced any of them within the last months Then, the single interviewer asked about difficulties in daily life caused by the problems that they marked on the list The impacts ... than the current face- to -face interview and would further facilitate the applicability ofthe instrument in both clinical practice and population epidemiological survey settings Therefore, the ... reliability of each mode of administration, inter-item correlations among the performances scores were calculated as correlation matrices Then, thecomparisonofthe 28 inter-item correlations between the...
... acute version ofthe SF-36) for the SF-6D The third difference is that the scoring range ofthe EQ-5D is twice that ofthe SF-6D The location ofthe baseline median scores in the scoring range ... Figure Comparisonof maximal theoretical contribution to the utility score Comparisonof maxim al theoretical contribution to the utility score Domains measuring the same area of health have similar ... between the median values and the limits of agreement in the BlandAltman plot exceed the minimal clinically important difference of both SF-6D and EQ-5D [20,21] The lack of agreement is further...
... 1: The percentage of UK and US respondents endorsing some impact of their muscle disease on each ofthe life domains Figure The percentage ofthe UK and the US samples endorsing the direction of ... (extent of impact, importance of impact and overall impact) for each ofthe life domains and the results ofthe significance tests between the UK and US samples The overall importance score of all the ... weakness ofthe skeletal muscle such as to cause varying degrees of disability The individual muscle diseases differ in their age of onset, their rate of progression and their pattern of weakness...
... that is, the study of derivatives ofthe perturbation function On the other hand, by stability we mean the qualitative analysis, that is, the study of various continuity properties ofthe perturbation ... as the feasible set map In the vector optimization problem corresponding to each parameter valued x, our aim is to find the set of C-minimal point ofthe feasible set map G x The set-valued map ... results concerning the behavior ofthe perturbation map, and Shi studied some quantitative results concerning the behavior ofthe perturbation map Li 10 discussed the continuity of contingent derivatives...