combinatorial and sequential targeted therapy in metastatic renal cell carcinoma

... Kernion J, Figlin R, Belldegrun A: Induction of G250 -targeted and T -cell- mediated antitumor activity against renal cell carcinoma using a chimeric fusion protein consisting of G250 and granulocyte/monocyte-colony ... tumor-infiltrating lymphocytes for adoptive therapy of renal cell carcinoma (RCC) and metastatic melanoma: sequential proliferation of cytotoxic natural killer and noncytotoxic T cells in RCC ... CM, Figlin RA: Sunitinib versus interferon alfa in metastatic renal- cell carcinoma N Engl J Med 2007, 356:115-124 Hiles JJ, Kolesar JM: Role of sunitinib and sorafenib in the treatment of metastatic...

Ngày tải lên: 18/06/2014, 16:20

... Cancer vaccines: moving beyond current paradigms Clin Cancer Res 2007, 13:3776-3782 Pantuck AJ, Belldegrun AS, Figlin RA: Nephrectomy and interleukin-2 for metastatic renal- cell carcinoma N Engl ... from the cell membrane and thus can mediate antibody-dependent cell- mediated cytotoxicity (ADCC) In addition, 5T4-transduced renal carcinoma cell lines can be recognized by human T cells in vitro, ... Engl J Med 2001, 345:1711-1712 Diner EK, Linehan M, Walther M: Response of papillary renal cell carcinoma in a solitary kidney to high dose interleukin therapy International Journal of Urology...

Ngày tải lên: 18/06/2014, 15:20

... with advanced renal cell carcinoma [3,4] Sunitinib malate is an oral multi-kinase inhibitor targeting several receptor tyrosine kinases (PDGFRalpha and PDGFRbeta; VEGFR1, VEGFR2 and VEGFR3; KIT, ... Baum CM, Figlin RA: Sunitinib versus interferon alfa in metastatic renal- cell carcinoma N Engl J Med 2007, 356:115-124 Gollob JA, Wilhelm S, Carter C, Kelley SL: Role of Raf kinase in cancer: therapeutic ... surveillance Targeted tyrosine kinase inhibitor therapy may thus control cancer cell growth both directly and indirectly by changing the immunologic microenvironment These side-effects of therapy...

Ngày tải lên: 09/08/2014, 03:21

... signaling pathways, including the Ras-Raf-MEK (mitogen-activated and extracellular-signal regulated kinase kinase), ERK1 and ERK2 (extracellular-signal regulated kinase and 2) pathway leading to cell ... or irinotecan/gemcitabine [130] Multitargeted Agents: Sunitinib, Sorafenib, Vandetanib and Axitinib Sunitinib malate is an oral, multitargeted tyrosine kinase inhibitor with antiangiogenic and ... of rapamycin) pathway leading to protein synthesis, and the PI3K-AKT (phosphatidylnositol-2 kinase Akt) pathway sustaining cell survival (Figure 2) In cancer cells, abnormal cell signaling through...

Ngày tải lên: 10/08/2014, 22:20

... of renal cell carcinoma: a pitfall in diagnosis of renal lesions Journal of Clinical Pathology 1998, 51(4):334-337 Lam JS, Shvarts O, Leppert JT, Figlin RA, Belldegrun AS: Renal Cell Carcinoma ... CT showing a left renal carcinoma (white arrow) and CT showing a left renal carcinoma (white arrow) and splenomegaly Bumpus described the first reported case of spontaneous regression of metastatic ... spontaneous regression of metastatic renal cell carcinoma in 1928 [7] Metastatic sites include brain, bone, hilar adenopathy and most commonly pulmonary metastases The clinical pattern of the improvement...

Ngày tải lên: 11/08/2014, 10:22

... recipients using various regimens, including ribavirin alone, combination therapy with ribavirin and amantadine [10], interferon in combination with ribavirin [5,11] and interferon alone [12] Combination ... [5] Intravenous interferon-b therapy given daily for six weeks was reported to induce seroclearance of HCV in a renal transplant recipient with stable renal function [12] Lowdose interferon-a in ... but acute graft failure (in one patient) and sepsis (in two patients) also occurred [11] Taken together, interferon and ribavirin could eradicate HCV infection in selected renal transplant recipients,...

Ngày tải lên: 10/08/2014, 23:21

... autoantibodies against C-reactive protein and other acute phase proteins Clin Chim Acta 2007, 378:13-23 Marnell L, Mold C, Du Clos TW: C-reactive protein: ligands, receptors and role in inflammation Clin Immunol ... proteins, which are expressed during infection, systemic inflammation or tissue damage and participate in the acute phase response in many species [7] The pentraxin family includes long pentraxins ... animals - indicating a preventive and disease-modifying role for CRP in SLE [8,13] Very recently, however, this finding was contradicted by others [15] The presence of autoantibodies against CRP in...

Ngày tải lên: 12/08/2014, 11:22

... acetylcholinesterase and butyrylcholinesterase seem to play noncatalytic roles, which would explain their wide distribution in tissues and cells [16], including stem cells [17] Increasing evidence links ... al ˜ Cholinesterases in renal carcinomas Results Cholinesterase activity in human kidney and renal tumours Butyrylcholinesterase activity predominated over acetylcholinesterase activity in healthy ... with the lectins concanavalin A, Lens culinaris agglutinin 4522 (LCA), and Ricinus communis agglutinin (RCA) (Fig 3), ruled out the blood origin and supported the renal cells themselves as the most...

Ngày tải lên: 06/03/2014, 22:21

... Thrombospondin-1 loss in renal cancer A B Fig Role of TSP1 in angiogenesis, and localization in renal cells and tissue (A) Sections of RCC tumors and adjacent normal tissue (HNK) were stained for TSP1 and ... CM and cell lysates (CM and L, respectively) were collected and TSP1 was detected by western blotting Note the low TSP1 secretion and higher intracellular levels in RCC cells (F) HNK and P769 cells ... peptide-containing proteins in renal cell carcinoma tissues is associated with a decrease in tumor growth and angiogenesis Clin Cancer Res 9, 1734–1740 19 Lawler J (2002) Thrombospondin-1 as an...

Ngày tải lên: 07/03/2014, 05:20

... verified independently by reamplifying the corresponding fragment and repeating the sequencing procedure using both forward and reverse primers in the samples fixed in Bouin's solution Regarding the ... paraffin-embedded tissue fixed in Bouin's and 23 in formalin solution The majority of the tumours were of the clear cell RCC subtype: 46 were solid clear cell RCC and were cystic clear cell RCC ... VHL transversions in sporadic Renal Cell Carcinoma Pharmacogenetics 2001, 11:521-535 La Vecchia C, Negri E, D'Avanzo B, Franceschi S: Smoking and renal cell carcinoma Cancer Res 1990, 50:5231-5233...

Ngày tải lên: 20/06/2014, 00:20

... gelatin matrix remained as a fine particulate suspension in both normal and sanguineous urine so that the implications of these findings with regard to sealing the renal parenchyma or the collecting ... Patard JJ, Sinescu IC: European Association of Urology Guideline Group for renal cell carcinoma Renal cell carcinoma guideline Eur Urol 2007, 51:1502-10 12 Kulkarni R: Alternative and topical ... bleeding and nephrotoxicity, suggests a possible employ for FloSeal in the treatment of devastating renal injuries [14,15] Furthermore, a porcine model investigating on the use of FloSeal and...

Ngày tải lên: 09/08/2014, 03:21

... Breslow index was 2.5 mm (0.15 to 33 mm) The Clark level was known in 66 patients and was: level I in patient, level II in patient, level III in 16 patients, level IV in 44 patients and level V in ... Kefford RF: The spectrum of in vitro radiosensitivity in four human melanoma cell lines is not accounted for by differential induction or rejoining of DNA double strand breaks Int J Radiat Oncol Biol ... classification consisted in grade toxicity for an asymptomatic finding noted at the time of the follow-up physical examination; grade for a symptomatic finding requiring any form of medical therapy (e.g.,...

Ngày tải lên: 09/08/2014, 09:20

... performed both in Europe and in the United States to explore ways to refine the use of RT in that setting: a Danish study found equivalence between 27 Gy in fractions and 40 Gy in fractions, and an RTOG ... of cell kill in vivo via an anti-angiogenic pathway involving endothelial cell apoptosis [24] Coincidentally, apropos of the present clinical series, the preclinical studies initially suggesting ... metastatic renal cell carcinoma Int J Radiat Oncol Biol Phys 1985, 11:2007-2009 Halperin EC, Harisiadis L: The role of radiation therapy in the management of metastatic renal cell carcinoma Cancer 1983,...

Ngày tải lên: 09/08/2014, 09:20

... when using a BPNN, care should also be taken when training the network, in order not to under- or overtrain it [25] Since our RMSE function (Figure 4A) from training, testing and validating the ... study Androgen-sensitive prostate carcinoma xenografts received combinations of androgendeprivation therapy (ADT) and/ or radiotherapy (RT) and were subjected functional magnetic resonance imaging ... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination...

Ngày tải lên: 09/08/2014, 09:20

... staining intensity and the percentage of positive tumor cells as follows [23,24]: no staining scored 0; faint or moderate staining in ≤ 25% of tumor cells scored 1; moderate or strong staining in ... staining of PKCε in tissue specimens PKCε is overexpressed in both cytoplasm and nuclei of clear cell renal cell carcinoma (RCC) cells (A) Primary antibody isotype control (B) and normal renal cells ... Merajver SD: Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma Cancer Res...

Ngày tải lên: 10/08/2014, 10:21

... L-arginine to synthesize NOHA from arginase, then increasing its inhibitory effect In contrast, it is also possible the growth of renal cell carcinoma cells is arginase II independent resulting in ... whether arginase II was able to deplete L-arginine from the tissue culture supernatants of murine renal cell carcinoma cell lines and determine their effect on cell proliferation In adult mammals, ... and Renca cells (data not shown) Figure L-arginine, L-ornithine and L-glutamine levels L-arginine, L-ornithine and L-glutamine levels Tissue culture supernatants from CL-2, CL-19, and Renca cells...

Ngày tải lên: 10/08/2014, 22:20

... malignancies, including some forms of NHL and HL [8-10] The mTOR inhibitors everolimus (Afinitor®) and temsirolimus (Torisel®) are currently under clinical investigation for the treatment of NHL and HL, and ... structural proteins involved in the expression of genes that regulate tumor cell differentiation and apoptosis [14,18] Vorinostat (Zolinza®), romidepsin (FK228), valproic acid, and panobinostat (LBH589) ... mTOR Inhibitors The rapamycin analogs everolimus and temsirolimus are mTOR inhibitors that have been approved for treatment of resistant renal cell carcinoma Everolimus is administered orally, and...

Ngày tải lên: 10/08/2014, 22:21

... chain of metastatic spread of renal tumors For that reason we excluded all sites of common metastases from renal tumors, including the lungs, adrenals, intestines and brain and most intra-abdominal ... Acta Otorrinolaringol Esp 2006, 57(1):47-50 Andreadis D, Nomikos A, Barbatis C: Metastatic renal clear cell carcinoma in the parotid gland: a study of immunohistochemical profile and cell adhesion ... Maxillary sinus metastasis of renal cell carcinoma Actas Urol Esp 2006, 30(9):954-957 29 Lee HM, Kang HJ, Lee SH: Metastatic renal cell carcinoma presenting as epistaxis Eur Arch Otorhinolaryngol...

Ngày tải lên: 10/08/2014, 23:20

... species, sensitive to doxycycline and imipenem, resistant to penicillin, erythromycin, trimethoprim, levofloxacin, clindamycin, rifampicin, teicoplanin and vancomycin based on British Society for ... bilirubin 18 μmol/ L, alanine aminotransferase 60i u/L, alkaline phosphatase 92i u/L, total protein 60 g/L, albumin 25 g/L, and C-reactive protein (CRP) 315 mg/L A clotted blood sample and ethylene-diamine-tetra-acetic ... prolonged incubation beyond the usual five days and with frequent and terminal subculturing [5] In the present case, blood cultures incubated in a Bactec blood culture system yielded growth in four...

Ngày tải lên: 10/08/2014, 23:21

... left renal vein to the left ovarian vein, followed by filling of the ovarian and vaginal plexus has been demonstrated in patients with renal cell carcinoma [7] Our case had a right-sided renal ... renal cell carcinoma in both the germline and somatic settings [4], whereas the underlying pathways that drive papillary RCC, particularly in the somatic setting, are less established Reports indicating ... common cellular origin for clear cell RCC and papillary RCC, there are distinct underlying genetic differences Inactivation of the von Hippel-Lindau (VHL) gene occurs in patients with clear cell renal...

Ngày tải lên: 11/08/2014, 00:23