cognitive models of human information interaction

... Developing computational models is of scientific importance in so far as models are implemented theories: models of language processing allow us to test scientific hypothesis about the cognitive processes ... enhances our understanding of a key aspect of human cognition, language processing There is also an applied side to the proposed challenge Once computational models of human language processing ... models of human language processing discussed so far rely on supervised training data This raises another aspect of the modeling challenge: the human language processor is the product of an acquisition...

Ngày tải lên: 30/03/2014, 21:20

... Handbook of Human- Machine Interaction The Handbook of Human- Machine Interaction A Human- Centered Design Approach Edited by Guy A Boy Florida Institute of Technology, USA, Florida Institute for Human ... Socio -Cognitive Issues in Human- Centered Design for the Real World Saadi Lahlou 75 153 165 The Handbook of Human- Machine Interaction vi Cognitive Function Analysis in the Design of Human and ... operator’s cognitive functions The fundamental postulate of the Theory of Activity is well summarized by Smirnov (1966): human becomes aware of the surrounding 28 The Handbook of Human- Machine Interaction...

Ngày tải lên: 31/05/2014, 01:47

... regression of IL13Ra2-positive human tumors derived from variety of human cancers including pancreatic cancer [15,16] However, for efficacy, these tumors must express high levels of IL-13Ra2 ... immunotoxin in murine models of human pancreatic cancer Journal of Translational Medicine 2011 9:37 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online ... anticancer effect of IL-13-PE in IL-13Ra2-negative Fujisawa et al Journal of Translational Medicine 2011, 9:37 http://www.translational-medicine.com/content/9/1/37 Page of 13 Figure Regulation of IL-13Ra2...

Ngày tải lên: 18/06/2014, 19:20

... regression of IL13Ra2-positive human tumors derived from variety of human cancers including pancreatic cancer [15,16] However, for efficacy, these tumors must express high levels of IL-13Ra2 ... immunotoxin in murine models of human pancreatic cancer Journal of Translational Medicine 2011 9:37 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online ... anticancer effect of IL-13-PE in IL-13Ra2-negative Fujisawa et al Journal of Translational Medicine 2011, 9:37 http://www.translational-medicine.com/content/9/1/37 Page of 13 Figure Regulation of IL-13Ra2...

Ngày tải lên: 20/06/2014, 03:20

... The Cognitive Neuroscience of Human Communication The Cognitive Neuroscience of Human Communication Vesna Mildner Lawrence Erlbaum Associates ... for integration and processing of input information before transmitting the output signal to other parts of the brain On the basis of continuous inflow of sensory information from the periphery, ... possible separate transmission of groups of frequencies containing different bits of information, but at the same time preserves the possibility of integration of complementary features in the...

Ngày tải lên: 06/07/2014, 15:30

... interologous prediction of human interactions from model organisms [10-12], some of which integrated predicted, curated, and experimentally derived interactions [10,13] Analyses of these large datasets ... presence of transient interactions within this network refereed research Figure Properties of PPI networks Properties of PPI networks (a) Co-expression of yeast 'high confidence' protein interactions ... entire range of protein degrees, an average of 81% of the human proteins are conserved in mice - a number that increases with increasing degree Similarly, on average, 59% of the human proteins...

Ngày tải lên: 14/08/2014, 07:21

... if N is the number of proteins, then n + m = ily of solutions (a one-dimensional set of solutions in a space of three variables; Figure 6) To gain insight into the prevalence of FP and FN stochastic ... on the remaining filtered set of data, typically with lower estimates for PFP and PFN interactions ⎛N⎞ ⎜ ⎟ , which is the number of all pairs of proteins Any two of ⎝ ⎠ these three equations imply ... equations By the method of moments[42], we replace the left hand side of Equations1 to with the observed values for the number of reciprocated interactions (x1), for the number of reciprocally non-interacting...

Ngày tải lên: 14/08/2014, 08:20

... aggregation of several channels of information sources into one state has not considered the contribution variation of individual channels of information to that state The remainder of this paper ... kinds of signals of information about persons’ contexts, situations, goals, and preferences [12] Along this line of thinking, a few studies have been reported considering the contextual information ... From the above analysis, a conclusion is perhaps made that the inferring of human cognitive states based on the fusion of multiple features is an effective way, especially for getting reliable...

Ngày tải lên: 22/06/2014, 19:20

... repeat unit of MIT domains of human calpain directly interacts with the C-terminal region of IST1 (Fig 5) We previously reported an interaction between calpain and CHMP1B [28], but this interaction ... further Estimation of cleavage sites in mGFP–calpain Direct interaction between recombinant calpain 7MIT and GST–IST1 proteins The use of cleared lysates of HEK293T cells for all of the experiments ... investigated the effect of this interaction on the autolysis of calpain Results Glutathione-S-transferase (GST) pulldown assay of FLAG–IST1 To investigate whether MIT domains of calpain (calpain...

Ngày tải lên: 18/02/2014, 04:20

... pseudoatomic models of capsid-like particles [30,39]; (b) analyses of the effect of CA mutations on the assembly of mature capsidlike particles (Fig 2E,F) and ⁄ or the formation of viral cores; ... analysis of the precise residues and interactions involved in the NTD–CTD interface [46] Most of these involve side chains from helix of the CTD which pack against the N-terminal end of helix of the ... Functional domains of the capsid ¨ protein of human immunodeficiency virus type J Virol 68, 8180–8187 ˚ ¨ Reicin AS, Ohagen A, Yin L, Hoglund S & Goff SP ¨ (1996) The role of Gag in human immunodeficiency...

Ngày tải lên: 18/02/2014, 06:20

... binding of the a-carboxylate and a-amino groups of BEC were also ascribed to the larger volume of the active site cleft of arginase II, which allows more water-mediated enzyme–inhibitor interactions ... between the active sites of this enzyme and arginase I In spite of the relatively low agmatinase activity of the Asn149Asp variant, it is clear that the interactions of arginase II with l-arginine ... 4540–4548 ª 2005 FEBS Interaction of arginase II with substrate and manganese ions ˚ separation of 2.6 A was considered to be somewhat long for an inner-sphere coordination interaction, as that...

Ngày tải lên: 20/02/2014, 02:21

... synthesis of viral DNA using host cell tRNALys as a primer for initiation Synthesis of cDNA initiates from a primer binding site of 18 bases near the 5¢ end of viral genomic RNA The 3¢ terminal end of ... localized sites of interaction in Gag and LysRS to residues 308–362 at the C-terminal end of CA and 208–259 of the LysRS motif [17] Interestingly, both regions are critical for formation of the homodimer ... support a direct interaction between helix of LysRS and helix (C4) of CA-CTD (Fig 1C) [23] Screening of small molecules, synthetic peptides and nucleic acids, which block the Gag–LysRS interaction...

Ngày tải lên: 07/03/2014, 00:20

... lower Kd The Kd calculation is independent of the amount of Ó FEBS 2004 Interaction of human TCR with superantigen SSA (Eur J Biochem 271) 4081 Fig Vb1–SSA interaction analysis Association curves ... studies of the interaction of SAgs with their specifics ligands will not only advance understanding of the physiological mechanisms of these molecules, but may lead to the development of therapeutic ... immobilized TCR Vb5.2 of wtSSA of 153 lM, which is near the lower limits of the known SAg–TCR interactions [26] To avoid any altered Kd determination due to the immobilization process of the TCR, we...

Ngày tải lên: 07/03/2014, 16:20

... microscopy [15] In this study, we measured the interaction of stefin B with various combinations of phospholipid monolayers and bilayers Interaction of stefin B in the prefibrillar aggregated state ... amyloid fibril formation, interaction with phospholipids, and cellular toxicity, using a model amyloidogenic protein, human stefin B Stefin B is a member of the I25 family of cystatins (MEROPS classification), ... surface of the monolayer The increase in pressure was measured as a function of p0 (Fig 5B,C) Extrapolation to Dp ¼ gives the Fig Permeabilization of SUV by prefibrillar stefin B (A) Kinetics of SUV...

Ngày tải lên: 07/03/2014, 17:20

... not considered in the category of animal models of disease, one can view the field of human genetics as probing a vast natural mutagenesis screen involving billions of individual organisms As in ... orthologue of CCM2) Zebrafish with loss -of- function mutations in san or vtn share a common phenotype with fish lacking heart of glass (heg) Although mutations in the human orthologue of heart of glass ... developing animal models of CCM disease Classically, a CCM consists of a cluster of dilated blood vessels [12,13] Each vessel in the cluster is grossly dilated, earning the name of a cavern; each...

Ngày tải lên: 15/03/2014, 10:20

... activation, subunitsubunit interaction and substrate cooperativity of human m-NAD-ME Results Kinetic parameters of the human wild-type and E59 mutant m-NAD-MEs The kinetic parameters of the wild-type and ... K0.5,Malate values of E59D were 2-fold and 4.4-fold higher, respectively, than that of the wild-type Furthermore, the kcat value of E59 mutant enzymes was only one-third to one-quarter of that of the wild-type, ... Multiple sequence alignments of three clusters of ME isoforms around the fumarate-binding region are shown Amino acid sequences of MEs were obtained by a similarity search of BLAST [44], and alignments...

Ngày tải lên: 23/03/2014, 06:20

... of open and closed models of human P-gp Table Amino acids involved in the binding cavity of the inward (‘in’) and outward (‘out’)-facing conformations of human P-gp; the numbers and letters of ... 2009 FEBS 7019 Comparison of open and closed models of human P-gp I K Pajeva et al A A B B Fig Binding cavity in the inward-facing conformation of the homology model of human P-gp: (A) general ... outward-facing conformations of the human P-gp models In Table 1, the residues involved in the binding cavity in the inward- and outward-facing conformations of the homology model of human P-gp are shown...

Ngày tải lên: 29/03/2014, 22:21

... may often be used with determiners in the general domain Hosaka, Junko and Umetsu, Ryo 2002 Toward the extraction of protein-protein interaction information from immunology literature Proc of ... reliability of the annotators' judgment and the difficulty of the task, we calculated the KAPPA coefficient of their responses, and found it to be 0.54 (Hosaka and Umetsu, 2002) This degree of agreement ... network of human genes for high-throughput analysis of gene expression Nature Genetics, 28: 21-28 Yakushiji, Akane, et al 2001 Event extraction from biomedical papers using a full parser Proc of PSB,...

Ngày tải lên: 31/03/2014, 20:20

... Department of Sciences of Life and Reproduction, Section of Biochemistry, University of Verona, Italy 2Department of Medicine, Section of Hematology, University of Verona, Italy 3Department of Biochemistry ... preclinical models of primary human acute leukemia cells Journal of Translational Medicine 2011 9:45 Page 13 of 13 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... potentiated the effect of the other drug (B) Analysis of synergism between imatinib and a-bisabolol in the imatinib-sensitive BCR/ABL+ human cell line CML-T1 Left side Effects of 40 μM a-bisabolol...

Ngày tải lên: 18/06/2014, 19:20