clostridial myonecrosis and other clostridial diseases
Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 1) potx
Ngày tải lên :
07/07/2014, 04:20
... CNL, and CEL, which is usually measured in years, and their high rate of transformation into acute leukemia By contrast, the natural history of PV, IMF, and ET is usually measured in decades, and ... exists Some diseases, such as chronic myelogenous leukemia (CML), chronic neutrophilic leukemia (CNL) and chronic eosinophilic leukemia (CEL) express primarily a myeloid phenotype, while in others, ... chapter, therefore, will focus only on PV, IMF, and ET, because their clinical overlap is substantial and their clinical courses are distinctly different Other chronic myeloproliferative disorders...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 2) doc
Ngày tải lên :
07/07/2014, 04:20
... the erythropoietinindependent erythroid colony formation, and the hypersensitivity of PV erythroid progenitor cells to erythropoietin and other hematopoietic growth factors, their resistance to ... induced in the erythropoietin and thrombopoietin receptors following binding to erythropoietin or thrombopoietin leads to JAK2 autophosphorylation, receptor phosphorylation, and phosphorylation of proteins ... terminal differentiation, and their increase in Bcl-XL expression, all of which are characteristic in PV Importantly, the JAK2 gene is located on the short arm of chromosome 9, and loss of heterozygosity...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 3) pptx
Ngày tải lên :
07/07/2014, 04:20
... previous hemoglobin levels and a family study are important Other laboratory studies that may aid in diagnosis include the red cell count, mean corpuscular volume, and red cell distribution width ... erythropoietin production, in which case assessment of pulmonary function and an abdominal CT scan to evaluate renal and hepatic anatomy are appropriate A normal erythropoietin level does not ... erythrocytosis: β-thalassemia trait, hypoxic erythrocytosis, and PV With β-thalassemia trait the RDW is normal, whereas with hypoxic erythrocytosis and PV, the RDW is usually elevated due to iron deficiency...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 5) pot
Ngày tải lên :
07/07/2014, 04:20
... of myelofibrosis and the extent of extramedullary hematopoiesis are also not related Fibrosis in this disorder is associated with overproduction of transforming growth factor and tissue inhibitors ... IMF are polyclonal and not part of the neoplastic clone Clinical Features No signs or symptoms are specific for chronic IMF Many patients are asymptomatic at presentation, and the disease is ... of splenic enlargement and/ or abnormal blood counts during a routine examination However, in contrast to its companion myeloproliferative disorders, night sweats, fatigue, and weight loss may be...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 6) ppt
Ngày tải lên :
07/07/2014, 04:20
... disorders PV and ET, express the JAK2 V617F mutation, often as homozygotes Such patients had a poorer survival in one retrospective study but not in another, where they were found to be older and to ... extramedullary hematopoiesis, while the presence of leukocytosis, thrombocytosis with large and bizarre platelets, and circulating myelocytes suggests the presence of a myeloproliferative disorder as ... will reveal a hypercellular marrow with trilineage hyperplasia and, in particular, increased numbers of megakaryocytes in clusters and with large, dysplastic nuclei However, there are no characteristic...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 8) potx
Ngày tải lên :
07/07/2014, 04:20
... is, at best, temporarily palliative and associated with a significant risk of neutropenia and infection Allopurinol can control significant hyperuricemia, and hydroxyurea has proved useful for ... undefined and its side effects are more pronounced in the older individuals who are usually afflicted with this disorder Glucocorticoids have been used to control constitutional symptoms and autoimmune ... autoimmune complications and may ameliorate anemia alone or in combination with low dose thalidomide (50–100 mg/d) Allogeneic bone marrow transplantation is the only curative treatment and should be considered...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 9) docx
Ngày tải lên :
07/07/2014, 04:20
... erythropoietin, thrombopoietin is produced in both the liver and the kidneys, and an inverse correlation exists between the platelet count and plasma thrombopoietic activity Like erythropoietin, plasma ... informative women patients, and by the expression in patients of nonrandom, though variable, cytogenetic abnormalities Although thrombocytosis is its principal manifestation, like the other chronic myeloproliferative ... hyperplasia and hypertrophy, as well as an overall increase in marrow cellularity If marrow reticulin is increased, another diagnosis should be considered The absence of stainable iron demands an...
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Chapter 103. Polycythemia Vera and Other Myeloproliferative Diseases (Part 10) potx
Ngày tải lên :
07/07/2014, 04:20
... without a reduction in platelet number Still others may represent an interaction between an atherosclerotic vascular system and a high platelet count, and others may have no relationship to the platelet ... effects Hydroxyurea and aspirin are more effective than anagrelide and aspirin for prevention of TIAs but not more effective for the prevention of other types of arterial thrombosis and actually less ... of high-molecular-weight von Willebrand multimers are removed from the circulation and destroyed by the platelets, resulting in an acquired form of von Willebrand disease This can be identified...
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Báo cáo y học: "Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases" pps
Ngày tải lên :
09/08/2014, 08:22
... lanes Ki and rP/Ki/his) and U1snRNP-A (U1-A, lanes nRNP and Ku/nRNP), RPA70 co-migrates with Ku p70 (lanes Ku/nRNP and Ku), and RPA14 co-migrates with histone H4 (lanes rP/Ki/his, Histones, and BM6.5) ... six, and 1:312,500 in two, indicating that the titers of anti-RPA were as high as those of other high-affinity IgG autoantibodies in SLE Sera from patients with SLE and other systemic rheumatic diseases ... AR40391, AR050661, and M01R00082, and State of Florida funds to the Center for Autoimmune Diseases References Tan EM: Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for...
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báo cáo khoa học: "Brachypodium distachyon: a new pathosystem to study Fusarium head blight and other Fusarium diseases of wheat" pdf
Ngày tải lên :
11/08/2014, 11:20
... became bleached and, between 96 and 144 hpi, necrotic symptoms spread down the rachis and into neighbouring spikelets above and below (Figure 1d) Disease continued to develop and between and 14 days ... Infection on other Bd tissues Additional assays were used to investigate the ability of Fg and Fc to infect other tissues and assess the potential of Bd as a model for other cereal diseases caused ... spray and point inoculations, disease assessments and detached leaf assays and normal light and SEM microscopy analysis GB carried out Bd root inoculations and CLSM analysis of root tissues and...
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Báo cáo y học: "Integrative analysis for finding genes and networks involved in diabetes and other complex diseases" ppt
Ngày tải lên :
14/08/2014, 08:20
... function and biological processes relate to each other in a simple manner and the current study supports that regulation of transcription and translation, signal transduction, ATP binding, and DNA and ... contributions Basic idea and protocol formation: RB and FP Data mining and decision tree analyses: MA, RB and FP Analysis and interpretation of gene-gene interaction data: RB, MA and FP Development ... specific positional candidates and cellular systems that may underlie disease susceptibility We believe the genetic interactions produced here and the specific candidates and molecular systems...
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Chapter 135. Gas Gangrene and Other Clostridial Infections (Part 1) pps
Ngày tải lên :
08/07/2014, 02:20
... produce abundant gas in artificial media and form subterminal endospores C perfringens, one of the most clinically important species, is encapsulated and nonmotile and rarely sporulates in artificial ... great care C perfringens is the most common of the clostridial species isolated from tissue infections and bacteremias; next in frequency are C novyi and C septicum In the category of enteric infections, ... antibioticassociated colitis, and C perfringens is associated with food poisoning (type A) and enteritis necroticans (type C) Pathogenesis Despite the isolation of clostridial species from many...
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Chapter 135. Gas Gangrene and Other Clostridial Infections (Part 2) doc
Ngày tải lên :
08/07/2014, 02:20
... symptoms include epigastric pain, nausea, and watery diarrhea usually lasting 12–24 h Fever and vomiting are uncommon Molecular methods including ribotyping and pulsed-field gel electrophoresis have ... and adults in New Guinea A similar disease, darmbrand, was epidemic in Germany after World War II Clinical features of pigbel include acute abdominal pain, bloody diarrhea, vomiting, shock, and ... (Typhlitis) See Chaps 82 and 157 Suppurative Deep-Tissue Infections Clostridia are frequently recovered from various suppurative conditions in conjunction with other anaerobic and aerobic bacteria...
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Chapter 135. Gas Gangrene and Other Clostridial Infections (Part 3) docx
Ngày tải lên :
08/07/2014, 02:20
... black tar heroin Spreading Cellulitis and Fasciitis with Systemic Toxicity This condition involves diffuse spreading cellulitis and fasciitis, without myonecrosis and with only mild inflammation in ... as anaerobic cellulitis, is a localized infection involving the skin and soft tissue and is due to clostridia alone or with other bacteria There are no systemic signs of toxicity, although the ... addicts These patients develop local pain and tenderness in discrete areas (particularly the thigh and forearm), with the subsequent appearance of fluctuance and crepitance that require surgical drainage...
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Chapter 135. Gas Gangrene and Other Clostridial Infections (Part 4) pptx
Ngày tải lên :
08/07/2014, 02:20
... contrast to uterine infections) and, when it does appear, is almost invariably associated with hemoglobinuria, hemoglobinemia, and septicemia Cases of clostridial myonecrosis without a history ... patients have bullous lesions and crepitation of the skin; they present with a rapidly worsening course that includes myonecrosis, especially of the extremities Bacteremia and Clostridial Sepsis The ... failure, and (often) body crepitation, patients with myonecrosis frequently have a heightened awareness of their surroundings until just before death, when they lapse into toxic delirium and coma...
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Chapter 135. Gas Gangrene and Other Clostridial Infections (Part 5) docx
Ngày tải lên :
08/07/2014, 02:20
... misoprostol—United States and Canada, 2001–2005 MMWR 54:724, 2005 Lorber B: Gas gangrene and other Clostridium-associated diseases, in Principles and Practice of Infectious Diseases, 6th ed, GL Mandell et al ... antibiotics Hysterectomy is required for uterine myonecrosis Abdominal wall myonecrosis usually continues despite initial aggressive surgery and antibiotic therapy and requires repeated surgical debridement ... Epidemiological findings and medical, legal, and public health challenges of an investigation of severe soft tissue infections and deaths among injecting drug users—Ireland, 2000 Epidemiol Infect...
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Tài liệu An Account of the Foxglove and some of its Medical Uses With Practical Remarks on Dropsy and Other Diseases doc
Ngày tải lên :
19/02/2014, 11:20
... in caries, and obstinate sore legs DYSPNOEA Pituitosa Sauvages i 657. "Boiled in water, or wine, and drunken doth cut and consume the thicke toughnesse of grosse, and slimie flegme, and naughtie ... water or sugar, doth scoure and clense the brest, ripeneth and bringeth foorth tough and clammie flegme It openeth also the stoppage of the liver spleene and milt, and of the inwarde parts." GERARDE ... Ascites and anasarca, but not much otherwise diseased, and well enough to walk about the house, and see after her family affairs I thought this a fair case for a trial of the Digitalis, and therefore...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
Ngày tải lên :
16/03/2014, 21:20
... Autoimmune Diseases, and Stem Cell and Other Therapies thereby lowering the pH of the blood The combination of hyperglycemia and acidosis is called diabetic ketoacidosis and leads to hyperventilation and ... distribution, and reproduction in any medium, provided the original work is properly cited Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other ... 2010) This Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies disease initiation method, with a single and defined myelin peptide...
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Báo cáo sinh học: " Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases" pot
Ngày tải lên :
19/06/2014, 08:20
... Valley, Japanese, and other encephalitis viruses, Dengue and yellow fever, and seasonal influenza, hepatitis A (HAV) and E (HEV) cause enormous further morbidity and mortality, while pandemic outbreaks ... mortality in man, and other animals, and greater economic loss, than any other molecule 1.2 RNA viruses and immune control Despite a depressing global epidemiology that strongly suggests otherwise, ... this work and not stand to gain financially or otherwise from it Acknowledgements I thank my wife Sophie J Coleman, and sons Matt and Tim, for everything important, my parents Dick and Janet...
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