... integration of biomarker development from the preclinical through the clinical trial process T cell therapy clinical trials The concept of enhancing cellular immunity through the transfer of ex-vivo ... robust in vivo expansion of CAR-modified cells and dramatic but transient increases in systemic levels for a number of pro-inflammatory cytokines and chemokines and a rapid and robust clinical ... evaluated and confirmed in primate models [64], and a number of clinical trials are being planned at multiple institutions that involve the specific transfer of memory cell populations into patients A...
Ngày tải lên: 18/06/2014, 22:20
... integration of biomarker development from the preclinical through the clinical trial process T cell therapy clinical trials The concept of enhancing cellular immunity through the transfer of ex-vivo ... robust in vivo expansion of CAR-modified cells and dramatic but transient increases in systemic levels for a number of pro-inflammatory cytokines and chemokines and a rapid and robust clinical ... evaluated and confirmed in primate models [64], and a number of clinical trials are being planned at multiple institutions that involve the specific transfer of memory cell populations into patients A...
Ngày tải lên: 20/06/2014, 04:20
Báo cáo khoa học: "The script concordance test in radiation oncology: validation study of a new tool to assess clinical reasoning" potx
... encountered in their practice Discussion With SCT, examinees are probed on a specific component of clinical reasoning: data interpretation, i.e a crucial step within the clinical reasoning process ... therefore provides an indication of clinical reasoning quality Clinicians find the test appealing because it contains cognitive tasks similar to those they encounter during their daily practice ... are made in the clinical reasoning process Scoring reflects the degree of concordance of these judgments to those of a panel of reference A series of studies, held in domains such as intra-operative...
Ngày tải lên: 09/08/2014, 09:22
báo cáo khoa học: "New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer" doc
... was overall disappointing in early clinical trials [22,37,40,41] New HDAC inhibitors HDAC inhibitors generally consist of three parts in the chemical structure: (1) a zinc-chelating group; (2) a ... of clinical development HDAC inhibitors may have more potential in the combination therapy of a wide range of malignancies Combination of novel epigenetic agents, including hypomethylating agents ... Keshet I, Bustin M, Cedar H: The role of DNA methylation in setting up chromatin structure during development Nature Genet 2003, 34:187-192 Cang S, Liu DL: Clinical advances in hypomethylating agents...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: " Clinical response to Auron Misheil Therapy in a man with advanced multifocal hepatocellular carcinoma: A case report" ppsx
... IGFR in hepatocarcinogenesis [13,14,16,17] In particular, the Ras/Raf-protein family seems to play a major role in HCC development This intracellular signaling pathway involves ligands binding ... margin of segment The two defined lesions TL1 and TL2 that had been in complete remission remained in remission TL3 that had been in partial remission had increased in size to 16 mm Adrenal involvement ... consequence of infection and chronic inflammation But even cancers not induced in association with chronic inflammation show extensive inflammatory infiltrates, with high cytokine expression levels in the...
Ngày tải lên: 10/08/2014, 23:20
Báo cáo y học: "Possible adverse events in children treated by manual therapy: a review" pptx
... insufficient in terms of validity, reliability and clinical responsiveness It is clear that more high quality clinical studies are needed specifically designed to investigate adverse events in ... consensus study Manual Therapy 2010, 15(1):2-6 Carnes D, Mars TS, Mullinger B, Froud R, Underwood M: Adverse events and manual therapy: A systematic review Manual Therapy 2010 in press Evans DW, ... al [15] comprehensive literature search covering a 58 year period, involving eight major databases and including all language reports, resulted in nine serious adverse events (SAE) related to...
Ngày tải lên: 13/08/2014, 14:20
Báo cáo y học: "Effect of erythropoietin therapy on clinical outcome in patients after acute ischemic stroke: a debatable issue" doc
... Stroke Trial Group: Recombinant human erythropoietin in the treatment of acute ischemic stroke Stroke 2009, 40:e647-656 Minnerup J, Wersching H, Schäbitz W: Erythropoietin for stroke treatment: ... doi:10.1186/cc10145 Cite this article as: Yuen C-M, et al.: Effect of erythropoietin therapy on clinical outcome in patients after acute ischemic stroke: a debatable issue Critical Care 2011, 15:425 ... Tsai TH, Lin HS, Chen SF, Sun CK, Leu S, Yuen CM, Tan TY, Lan MY, Liou CW, Lu CH, Chang WN: Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients...
Ngày tải lên: 14/08/2014, 08:21
Tài liệu Clinical trials in gynecological cancer ppt
... are being designed In addition to possible benefits for relapsed disease, these trials could provide valuable information for first-line therapy Infrastructure for clinical trials In the remainder ... utilizing erythropoietin in head and neck squamous cell carcinoma showed a decrease in local-regional 2007 IGCS and ESGO, International Journal of Gynecological Cancer 17, 547–556 Clinical trials in ... clinical trials, and all the physicians and patients must be encouraged to participate in the trials increase into clinical trial recruitment, already exceeding the government set targets Gaining...
Ngày tải lên: 13/02/2014, 07:20
Clinical Cases in Restorative & Reconstructive Dentistry_1 potx
... Gregory J Clinical cases in restorative & reconstructive dentistry / Gregory J Tarantola p ; cm – (Clinical cases) Other title: Clinical cases in restorative and reconstructive dentistry Includes ... condyle in centric hinging Future lateral pole changes may result in more excursive interferences, whereas medial pole changes result in centric occlusion changes Bear that in mind when designing ... to involve the patient in the overall process Just identifying the interferences and noting it in the patient record does nothing to elevate the patient’s awareness and understanding As these interferences...
Ngày tải lên: 06/03/2014, 12:20
Clinical Cases in Restorative & Reconstructive Dentistry_2 potx
... testing Occlusion Denture occlusion is not coincident to the arc of closure Aesthetics Insufficient maxillary incisor display Lower denture interferes with neutral zone 240 Clinical Cases in Restorative ... anterior teeth Retruded mandible and chin 250 Clinical Cases in Restorative & Reconstructive Dentistry THE 10 DECISIONS TMJ Diagnosis Begin bite splint therapy in a treatment position with the goal ... impaction (keeping incisal edge where it is and impacting by elevating posteriorly around the incisal edge) and mandibular autorotation Lower Incisal Edge Idealize with orthodontics Upper Incisal Edge...
Ngày tải lên: 06/03/2014, 12:21
FAST FACTS FOR THE CLINICAL NURSING INSTRUCTOR Clinical Teaching in a Nutshell pot
... prepare for clinical teaching, including organizing the clinical experience, developing relationships with the staff in the clinical facilities, making clinical assignments, planning orientation ... effective clinical nursing instructor are daunting It can be a prodigious undertaking even for individuals with training or degrees in clinical instruction They are continually faced with the changing ... new clinical faculty with the following: Essential Clinical Materials A Clinical Packet Clinical course syllabus Clinical Practicum or Academic Calendar Schedule Clinical Assignment Sheet Clinical...
Ngày tải lên: 06/03/2014, 12:21
Clinical Genetics in Nursing Practice Third Edition pptx
... disorder; participating in public education about genetics; developing an individualized plan of care; reinforcing and interpreting genetic counseling and testing information; supporting families when ... disorder; coordinating care and services; managing home care and therapy; following up on positive newborn screening tests; interviewing clients; assessing needs and interactions in clients and ... to clinical applications including testing, screening, counseling, prenatal diagnosis, assisted reproduction, intrauterine and postnatal treatment, transplantation of tissues and organs, gene therapy, ...
Ngày tải lên: 06/03/2014, 12:21
Essentials of Clinical Genetics in Nursing Practice potx
... genetics Developing an individualized plan of care Reinforcing and interpreting genetic counseling and testing information Supporting families when they are receiving counseling and making decisions ... appropriately in practice Becoming competent in the use of genetic content begins in nursing education programs It was with this in mind that this book, The Essentials of Clinical Genetics in Nursing Practice, ... entire reading frame and can cause (1) changes in the amino acids inserted in the polypeptide chain after the shift, (2) premature chain termination, or (3) chain elongation, resulting in a defective...
Ngày tải lên: 06/03/2014, 12:21
Access to unapproved therapeutic goods Clinical trials in Australia pdf
... 67 67 67 Reporting of adverse reactions during a clinical trial of medicines 69 Definitions Reporting of adverse reactions occurring in clinical trials Clinical trial event reporting algorithm ... training of the clinician using the device These are important points for consideration in assessing a clinical trial application Regulation of Medicine and Medical Device Clinical Trials in ... goods Clinical trials - an overview Classification of clinical trials Clinical trials of medicines Medical device trials Regulation of medicine and medical device clinical trials in Australia An Introduction...
Ngày tải lên: 07/03/2014, 08:20
Báo cáo khoa học: "TEMPORAL REASONING IN NATURAL LANGUAGE UNDERSTANDING: THE TEMPORAL STRUCTURE OF THE NARRATIVE" docx
... discourse In Dowry, 1988:37-61 Perhaps the biggest task involved in narrative understanding is to infer, using knowledge about causality and the internal constituency of events, the missing links ... with a distinct beginning and end; packaged in between the beginning and end of an event is the %tuif the event is made of, = which is a process or state This intuitlon is dlscussed in a considerable ... Tense in texts In R Bauerle, C Schwarze, Arnim yon Stechow (eds.), Meaning, Use and Interpretation in Language Berlin: De Gruyter Lyons, John 1982 Deixis and subjectivity In R Jarvelia and W Klein...
Ngày tải lên: 18/03/2014, 02:20
Good Clinical Treatment in Assisted Reproduction ‐ An ESHRE position paper potx
... Women with hyperprolactinaemia should be offered treatment with dopamine agonists such as bromocriptine or carbegoline after checking for thyroid function and correcting any anomalies. INTRAUTERINE INSEMINATION (IUI) Although IUI represents a “mild” ART procedure, it must be performed with care, according to strict criteria. ... pregnancy in each individual case. Couples who have not conceived after one year of regular unprotected sexual intercourse should be offered further clinical investigation, including semen analysis and assessment of ... any centre carrying out ovulation induction with gonadotrophins should have facilities for regular monitoring with ultrasound, and expertise in monitoring such cycles. 4. Women with hyperprolactinaemia should be offered treatment with dopamine agonists such as ...
Ngày tải lên: 22/03/2014, 12:20
Accuracy of Clinical Signs in the Diagnosis of Pulmonary Tuberculosis: Comparison of Three Reference Standards Using Data from a Tertiary Care Centre in Rwanda doc
... take into account the existing uncertainty surrounding the performance of the so-called reference standard Clinical decisions regarding TB status should be made taking into account the final ... Diagnostics, Singapore) in case of a discordant result; chest x-ray read by a radiologist and an internist or by three internists on a consensus base, all blinded to previously obtained clinical information ... results in this study including clinical, bacteriological and Julie et al radiological findings not permit the measurement of disease status directly, because they are all (imperfect) indicators...
Ngày tải lên: 22/03/2014, 18:20
Clinical Judgement in the Health and Welfare Professions Extending the evidence base pot
... underlying causal processes that can be known in principle Because much clinical reasoning involves diagnosis or backward inference (i.e making inferences from effects to prior causes), the clinician, ... judgement-making Again, the field is dominated by analyses of clinical reasoning in biomedicine and professions allied to medicine Tackling error: the clinician and cognitive (in) competence The ... Bayes is more widely used in routine clinical contact include clinical genetics and epidemiology, as Angus Clarke (pers comm 2000), a clinical geneticist, notes: We, in clinical genetics, use [Bayes]...
Ngày tải lên: 22/03/2014, 20:20
PLANNING THE PROJECT MANAGEMENT WAY: EFFICIENT PLANNING BY EFFECTIVE INTEGRATION OF CAUSAL AND RESOURCE REASONING IN REALPLAN pdf
... 3.0 5.0 7.0 2.0 time (in secs) 4.0 6.0 8.0 GP-G GP-S GP-TOT PS-G PS-S PS-TOT 10.0 in 8-Block Inversion Problem in Blocks World Performance of Graphplan v/s Planning+Scheduling ¤Þ¤øx¨È¾Í¼É"wC¼Ỵìr§Ỵ©©ỴF4 ... Ù ÏỴ ÌÛ ÌỉÉ Ç Ë Ù Ê Ï êÞ Þ HARD UNSOLV [1] INCRLEN [2] SAMELEN [3 4] FIX EASY INH-UNSOLV[5 10] INFRES FINRES Classes of Resource Allocation Scheduling ĐÇ u s u sq o m ³ ª q i ... SOLVING RESOURCE SCHEDULING PROBLEM C O N V E N T I O N A L P L A N N E R DECLARATIVE PROCEDURAL SAT (BLACKBOX) GRAPHPLAN GP-CSP SAT MANY CHOICE OF TECHNIQUES FOR SOLVING ABSTRACT PLANNING...
Ngày tải lên: 23/03/2014, 05:22
Recent Advances in the Biology, Therapy and Management of Melanoma Edited by Lester M. Davids ppt
... tyrosinase, the rate-limiting enzyme involved in melanin production Tyrosinase is a glycoprotein found in the melano‐ somal membrane The protein has an inner melanosomal domain, which contains ... manifestations of XP Estimated incidences vary from in 20,000 in Japan to in 250,000 in the US (Robbins et al., 1974) Beginning in the first or second year of life, UVexposed skin (e.g on the face and ... participated in indoor tanning With more than 25,000 facilities in the US alone, indoor tanning represents a multi-billion dollar industry Employing over 160,000 people, the tanning industry has...
Ngày tải lên: 23/03/2014, 14:20