cimetidine—a rational approach to drug design

... crystallographic software The traditional approach is to create a list of atom–atom contacts (which immediately identifies the connectivity) together with symmetry operations used to define the contact The extensive ... search is then undertaken from this atom in order to identify atoms that are connected to it and this procedure continues from each atom until no new bonded atoms are found In the simple case of ... the multi-purpose crystallographic tool, PLATON [12] is used throughout this study PLATON terms and notations Historically, the 555 terminology used in PLATON arose from the Oak Ridge program...

Ngày tải lên: 29/05/2020, 15:16

... Control: a partnership approach to curriculum design and delivery Project lead institution University of Edinburgh Project title Sharing Control: a partnership approach to curriculum design and delivery ... Napier University Prior to the summer break of 2011 the second author approached students on a third year module that he took to ask if they would like to participate in redesigning this fourth ... for students to understand institutional and contextual factors (policies, regulations etc) if they are to actively engage with individual course design and delivery? Our approach to this sharing...

Ngày tải lên: 20/10/2022, 06:14

... also been possible to computationally design a membrane protein8 Here we introduce an easy to use protein design method that is not computationally heavy, yet can be a powerful approach for the ... from 7.1 to 9.5 ppm, indicating well-formed secondary structure NADPH was added to the 15N-rDHFR-1 sample to a final ratio of 10:1 NADPH to 15N-rDHFR-1 The overlay of this spectrum onto the spectrum ... www.nature.com/scientificreports OPEN Protein rethreading: A novel approach to protein design Sayeh Agah*, Sandra Poulos*, Austin Yu, Iga Kucharska & Salem Faham received: 08 October 2015 accepted: 04 May 2016 Published:...

Ngày tải lên: 04/12/2022, 16:06

... Chromatography A 1658 (2021) 462604 Contents lists available at ScienceDirect Journal of Chromatography A journal homepage: www.elsevier.com/locate/chroma A regressive approach to the design ... process development of continuous chromatography, the common approach to optimize a multi-column continuous capture chromatography (periodic counter-current chromatography, PCCC) process heavily relies ... schematic design and loading strategy [2,6–8] Generally, the design of the model-based PCCC approaches includes the adsorption isotherm of mAb for protein A chromatography columns related to the...

Ngày tải lên: 25/12/2022, 02:48

... Situational Approach to Syllabus Design Introduction: The Development of the Situational Approach Few language teachers today are familiar with the term Situational Language Teaching, which refers to ... defective items to stores Situation: Mrs Lopez bought a pair of shoes on sale She wore them one week and noticed the sewing was starting to come out She took them back to the shoe store and this ... (1999) How to design a functional-notional syllabus Retrieved October 30, 2005, from www.sil.org/lingualinks/LANGUAGELEARNING/MangngYrLnggLrnng Prgrm/HowToDesignAFunctionalNotional.htm Paulston, C...

Ngày tải lên: 19/10/2022, 12:01

... dedicated to evaluating the programme Discussion The goal of this study was to develop a practical support for a programmatic design approach to assessment and to determine the steps that need to be ... (Dijkstra 2014) In formulating a stepwise approach to programmatic assessment design, we aim to contribute to fulfil the stated promises of a programmatic approach to assessment (see Table 1) These promises ... in a programmatic design approach Early identification of key stakeholder groups (e.g teachers, students, programme directors) allows designers to (1) take multiple interests into account, (2)...

Ngày tải lên: 19/11/2022, 11:43

... vulnerable to operational risks, including computer breakdown, loss of data, virus attacks and operator errors. These operational risks may be very significant, and correct procedures will need to be designed and ... and protocols 7 A structured approach to Enterprise Risk Management Recognition and ranking of risks together form the risk assessment activity. ISO 31000 uses the phrase ‘risk treatment’ to include ... strategic and operational objectives. This will include knowledge of the factors critical to success and the threats and opportunities related to the achievement of objectives. It should be approached...

Ngày tải lên: 21/02/2014, 12:20

... such ques- tions implicitly by proceding to answer the ques- tion or to seek information relevant to formulat- ing an answer. However IS may refuse to accept the question posed by IP because ... pushed onto the discourse stack. [SP2]When IS poses a question to IP, Expand- Question is pushed onto the discourse stack. Once IP begins answering the question, the stack is popped up to and ... goal rule DG-Obtaln-Info to deter- mine if the elliptical fragment is being used to accomplish the discourse goal of seeking information in order to construct an answer to the posed question....

Ngày tải lên: 21/02/2014, 20:20

... the representational capacity to make such definitions, we have chosen as part of our design no_._tt to use it. For to use it, would mean stepping outside of NIKL to specify constants, and therefore, ... SThe ruJels may need to be used tecureively to get to a constanL aEvery expression in WML has a type. 4.1.¢ Knowledge Acquisition We have developed two complementary tools to greatly increase ... has a role from A to B (or from B to A) can be referred to by a definite NP. This has not yet been integrated into the Janus model of reference processing [4]. 4.3.2. Metonymy Unstated relations...

Ngày tải lên: 21/02/2014, 20:20

... services can better respond to them; the need to go beyond a health- needs and fertility-based approach, and to include legislation, advocacy and education to change cultures that ... and reproductive behaviour, and to effectively use methods to prevent... Statistics confirm that men  iii Partnering: A New Approach To Sexual And Reproductive Health ... directives, has been to translate them into comprehensive strategies and measurable changes in policies and programmes while maintaining a gender perspective In addition to noting that ...

Ngày tải lên: 05/03/2014, 16:20

... Approach. .. 3.6 Eigenvalues of the Nine Factors Retained in the Factor Analysis Procedure 42 3.7 Rotated Factors and Variable Loadings 43 3.8 Means and Standard Deviations of Rotated Factor ... is increasingly recognized that the current approach to joint matters needs to evolve from its current static format to a more dynamic approach that broadens the definitions of ... Framing a Strategic Approach for Joint Officer Management. 10 That work indicated that the next step in the approach to joint officer management was to implement the strategic...

Ngày tải lên: 06/03/2014, 21:20

... these cytochromes have been proposed to be terminal Fe(III) and Mn(IV) reductases, although their role in the reduction of other metals is less well understood To obtain more insight into this, ... were applied to the gels, which were then heme stained according to Thomas et al [29] The outer membrane cytochromes c OmcA and OmcB, the periplasmic FR, and the cytoplasmic tetraheme cytochrome ... kinetics; and (d) OmcB is required to obtain functional OmcA These possibilities are discussed below A heme-staining approach was used to reveal the decaheme cytochrome c pools present in Fe(III)-respiring...

Ngày tải lên: 07/03/2014, 09:20

... op- eration. 3 http://www.extractor.com/ 928 Today, graph-based text representations are be- coming increasingly popular, due to their abil- ity to enrich the document model with syntactic and semantic relations. Salton ... weighted average of two “parent” vectors according to (Vignaux and Michalewicz, 1991). Formally, a new vector v will be created from two vectors v 1 and v 2 according to the formula v = λ ∗ v 1 + (1 ... parame- ters for a keyword extractor embedded in the Ex- tractor tool. 3 Or ˘ asan et al. (2000) enhanced the preference-based anaphora resolution algorithms by using a GA to find an optimal set of values...

Ngày tải lên: 07/03/2014, 22:20

... BIODFVERSITY: AN ILLUSTRATIVE APPROACH TO THE DEVELOPMENT OF COMPOSITE INDICATORS 27 VIII. HUMAN IMPACT/EXPOSURE INDICATORS 29 IX. APPROACHES TO SUSTAINABLE DEVELOPMENT INDICATORS 31 X. IMPLICATIONS ... Climate Change Indicator 18 Figure 7. Ozone Depletion Indicator 18 Figure 8. Acidification Indicator 19 Figure 9. Eutrophication Indicator 19 Figure 10. Toxics Dispersion Indicator 20 Figure 11. ... term "indicator" traces back to the Latin verb indicare, meaning to disclose or point out, to announce or make publicly known, or to estimate or put a price on. Indicators communicate...

Ngày tải lên: 15/03/2014, 16:20

... function To this end, the AFB (or SFB) FIR prototype filter is designed subject to the stopband magnitude constraints, as given by [7], while the SFB (or AFB) prototype filter is fixed to the design ... Prototype Filter To complete the FBP design we present an example for the narrow-band FIR low-pass SFB prototype filter designed by the procedure in Section This SFB prototype filter is matched to ... factor is M = 16, resulting in an oversampling factor of O = 5.1 AFB Prototype Filter First we start with the design of a narrow-band FIR low-pass AFB prototype filter with low group delay designed...

Ngày tải lên: 21/06/2014, 19:20

... PART IV DESIGN AND IMPLEMENTATION 207 Chapter CONCEPTUAL DESIGN Introduction Context-Sensitive Design Design Determinants Creativity and Conceptual Design The Conceptual Design Process Anatomy of ... good design is a frill, or that it simply costs too much to justify the expense There are many reasons, however, to justify the expense of investing in competent site planning and design In Designing ... photograph actually varies over the photo’s surface At the edges of the photograph, the distance depicted is greater than the same distance depicted closer to the photo’s center Horizontal distortion...

Ngày tải lên: 12/06/2014, 08:53

... problems related to each design step and to evolve gradually towards a final, energy efficient implementation Additionally, such design approach shortens the design time: it favors design reuse and ... structured verification and fast prototyping The proposed design flow (Figure 1) uses different models of computation (MoC), adapted to the particular design step, to help the designer reasoning about the ... for an automatic synchronization between the actors: an actor cannot be executed prior to the arrival of its input tokens When a graph can run without a continuous increase or decrease of tokens...

Ngày tải lên: 22/06/2014, 19:20

... application being the analysis of drugs being applied to the stratum corneum (SC) In our approach, the SC is considered to be composed of a periodic structure of cellular skeletons, separated by intercellular ... pressure difference corresponds to 10 × 103 m and 10.002 × 103 m applied to the top and bottom boundaries, respectively These two simulations were done in order to examine Page 12 of 25 Marquez-Lago ... direction As drugs are normally applied to the outer skin surface, source concentrations were placed at the top surface of the model (i.e., the skin surface) Therefore, in order for the drug to enter...

Ngày tải lên: 13/08/2014, 16:20

... that need to be considered for an effective gene therapy: gene delivery systems (vectors), regulatory elements and therapeutic genes The vectors refer to the carriers of transgene into target ... compared to other non-viral vectors Gene delivery using PEI involves condensation of DNA into compact particles, uptake into the cells, release from the endosomal compartment into the cytoplasm, ... increased toxicity To overcome this problem, PEG, a nonionic water-soluble polymer, was grafted to PEI to improve the solubility of complexes, reduce aggregation in vivo, and thus reduce cytotoxicity...

Ngày tải lên: 12/09/2015, 10:15

... for mandatory systematic data collection This agreement gives the farmer a more liberal access to antibiotics The intention behind this legislation probably was to motivate the farmer to enhance ... and between herds At the farm level, the veterinarians seemed to integrate farm-related information into the decision as to how to treat an individual cow for metritis When taking decisions on ... possibilities to perform epidemiological analyses or base advice on systematically collected data This motivation could potentially lead to 'justifying,' i.e., adjusting of the score to fit to the treatment...

Ngày tải lên: 25/10/2012, 10:45