... not the b domain The distinguishing feature ofmembersofthe meiotic clade of AAA ATPases is the SRH motif, which differs from that ofother AAA ATPases [24] The pair of Arg residues in the ... sheets and 8, the AAA domain helix andthe C-terminal helix) However, the majority of these proteins are likely to be other meiotic clade AAA ATPases and have the AAA domain helix andthe C-terminal ... important One of these, the TRP sequence, includes the start ofthe C-terminal helix as well as the structured loop between the 1440 ATPase domain andthe C-terminal helix and in the 3D structure...
... i.e., the smallest observation, the lower quartile andthe upper quartile cutting off the lowest and highest 25% ofthe data, respectively, the median which is the middle value ofthe data andthe ... denotes the conversion ofthe Au(III), X the value of any ofthe five parameters of each broth, Cov(X, Y) the covariance value and rxy the correlation coefficient of X and Y with a range of [-1, ... those oftheotherand so was the case ofthe proteins The difference in the pH value (Fig 6b) was slight, which is also in accordance with what discussed in the prior section That is, in the biosynthesis...
... converted by the enzyme 5αreductase to dihydrotestosterone in the gland The periurethral portion ofthe gland increases in size during puberty and after the age of 55 due to the growth of nonmalignant ... and Pathology The prostate is located in the pelvis and is surrounded by the rectum, the bladder, the periprostatic and dorsal vein complexes that are responsible for erectile function, andthe ... produced in the epithelial cells Both prostate epithelial cells and stromal cells express androgen receptors and depend on androgens for growth Testosterone, the major circulating androgen, is...
... which the tempo ofthe illness is altered and symptoms controlled until the patient dies ofother causes These can be equivalent therapeutically from a patient standpoint if the patient has not ... death, the states model allows a distinction between cure the elimination of all cancer cells, the primary therapeutic objective when treating most cancers and cancer control, in which the tempo of ... surgically remains in the state of localized disease as long as the PSA remains undetectable The time within a state becomes a measure ofthe efficacy of an intervention, though the effect may not...
... palpable, andof these, 70% are pathologically organ-confined The downside of widespread PSA screening is the detection and treatment of cancers with such a low malignant potential that they would ... examined for the presence of cancer, andthe amount of cancer is quantified based on the length ofthe tumor within the core andthe percentage ofthe core involved ... course of antibiotics before biopsy Men with an abnormal PSA and negative biopsy are advised to undergo a repeat biopsy Each core ofthe biopsy is examined for the presence of cancer, andthe amount...
... to the extent ofthe disease within the gland, the presence or absence of capsular invasion, involvement of seminal vesicles, and extension of disease to lymph nodes Because ofthe inadequacy of ... identified solely on the basis of an abnormal PSA (T1c), those that are palpable but clinically confined to the gland (T2), and those that have extended outside the gland (T3 and T4) (Table 91-1) ... for staging, the staging system was modified to include the results of imaging studies Unfortunately, no single test has proven to indicate accurately the stage or the presence of organ-confined...
... more advanced the disease, the lower the probability of local control andthe higher the probability of systemic relapse More important is that within the categories of T1, T2, and T3 disease ... radiation therapy, or active surveillance Choice of therapy requires the consideration of several factors: the presence of symptoms, the probability that the untreated tumor will adversely affect the ... independent ofother factors The improvements make treatment decisions a dynamic process The frequency of adverse events for the different treatment modalities varies with the modality used andthe experience...
... radiation therapy (IMRT) to maximize the dose to the prostate and to minimize the exposure ofthe surrounding normal structures The addition of IMRT has permitted further shaping ofthe dose, ... radiation therapy The aim is to decrease the size ofthe prostate and, consequently, to reduce the exposure of normal tissues to full-dose radiation, to increase local control rates, and to decrease the ... pretreatment, the dose administered, andthe time of assessment Postradiation erectile dysfunction is related to a disruption ofthe vascular supply and not the nerve fibers Neoadjuvant hormone therapy...
... surgery and/ or radiation therapy By definition, patients have no evidence of disease on scan For these patients the central issue is whether the rise in PSA results from persistent disease in the ... undergone radiation therapy The decision to recommend radiation therapy after prostatectomy is often made on the basis ofthe pathologic findings at surgery, as imaging studies such as CT and bone scan ... estimated that 10–15% of patients had "insignificant" cancers Given the multifocality ofthe disease, a concern is the limited ability to predict pathologic findings on the basis of a needle biopsy,...
... Outcomes of Androgen Depletion The antiprostate cancer effects ofthe various androgen depletion strategies are similar, andthe clinical course is predictable: an initial response, then a period of ... patients treated with radiation therapy and years of androgen depletion relative to radiation alone, was criticized for the poor outcomes ofthe control group Another showing a survival benefit ... quality of life Combined androgen blockade the administration of an antiandrogen plus a GnRH analogue or surgical orchiectomy—was designed to inhibit both testicular and adrenal androgens at the...
... at bedtime) act by relaxing the smooth muscle ofthe bladder neck and increasing peak urinary flow rates No data show that these agents influence the progression ofthe disease Surgical approaches ... Over 5 how often past month, the have you found it difficult to postpone urination? Over the past month, how often have you had a weak urinary stream? Over the (No (1 (2 (3 (4 (5 how often past ... regardless ofthe size ofthe gland, while those with an inability to urinate, gross hematuria, recurrent infection, or bladder stones may require surgery In patients with symptoms, uroflowmetry...
... Hainanese communityand its identity, from both within thecommunityand from outside ofthecommunity In the process of exploring the various views ofthe Hainanese community, this thesis will also ... contributions of their members either towards the associations, the Hainanese community or to society in general in the pages of their books and magazines In addition to celebrating the success ofthe ... 20 from other dialect groups and as the chapter will demonstrate, even within some membersofthe Hainanese community themselves The Hainanese, a Small Communityand Late Migrants One ofthe key...
... are candidates for measurement of their radiation One of them corresponds to the frequency 22.23 GHz (λ = 1.35 cm) andtheother one to the frequency 118.31 GHz (λ = 0.16 cm) The center ofthe ... unknown parameters ofthe atmosphere (e.g., air humidity, W, andthe liquid content of clouds, Q) andofthe surface ofthe Earth, such as the surface temperature ofthe ocean (Ts) and near-surface ... to the case of clouds To begin, the theoretical description must include consideration ofthe velocity of drop fall, which depends on the radius ofthe drop The sizes of rain drops are larger then...
... removal ofthe CUB domains and thereby activation ofthe growth factor domains PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and proteolytic cleavage is therefore ... perivascular lymphoid cell infiltrates ofthe lung and fibrosis in the liver [110] Conclusions The novel members, PDGF-C and -D, ofthe PDGF subfamily ofthe cystine knot family of growth factors are potent ... interplay with othermembersofthe cystine knot family and in particular the PDGF-A, -B, and VEGF growth factors, must be the focus of future investigations PDGF-C and -D, structure and function...
... SLEEP ANDTHE AWAKENING VII THE COUNTRY OF CRATERS, THE PATH OF SKULLS, ANDTHE SNAKE VIII - THE CATACLYSM THE PRIESTESS "LOOK AND FORGET" IX FORTY YEARS! THE AWAKENING THE SALTING OFTHE GREAT ... respite, for the bushes were few, and I could find no sign of others or of t'samma And so for days I wandered, finding a few ofthe berries here and there, often half maddened and stupefied by them, ... front of us, and another and another and a tiger- wolf (hyena) lurched its gorged and ungainly carcass down the farther slope The fire was alive, but those that had built and lit it were dead of...
... “delivery” to the “target organ” (the decision-maker) This fate and transport terminology is adopted because it is part ofthe vernacular of many of those providing the information andof many ofthe ultimate ... dozen There was an effort to ensure balance in the group of respondents for any particular case study, but because ofthe relatively small number of respondents andthe non-random nature ofthe ... pedestrian As a group, the cases tend toward the “high-profile” end ofthe distribution of EPA decisions Nevertheless, among the case studies, there is some variability in the political and economic stakes...
... nutrient content may then be further increased during the storage, transportation and preparation ofthe foodstuffs prior to reaching the plate ofthe consumer An understanding ofthe various factors ... methods ofthe crop or livestock product analysed (including the name of any certifying body) - specification ofthe cultivar of crop, or breed of livestock - a statement of which nutrient(s) andother ... cannot improve the quality of published data, but can provide details ofthe characteristics and quality of studies All natural products vary in their composition of nutrients andother nutritionally...
... part ofthe “Land of Israel” and that it is their religious duty to settle in the West Bank They are the pioneers ofthe settlement movement and typically live in settlements in the northern and ... on the claim that they serve the “natural growth” needs of a settlement.24 The creation of an outpost close to a settlement expands the amount of land under the mother settlement's control The ... dispossession of their land in the areas west ofthe Barrier if their access continues to be denied.39 Through the application and reinterpretation ofthe Ottoman Land Code to the West Bank,...
... population of France MSY was the main investigator and analysed the data and wrote the first draft AI and CR contributed to the study design andthe analysis AM contributed to the analysis and wrote the ... available, including the GHQ-30, the GHQ-28, the GHQ-20 andthe GHQ-12 The shortest version ofthe questionnaire (GHQ-12) has been extensively validated and used in a number of countries and in different ... coefficient and was found to be 0.83, well above the threshold for a satisfactory value Relationship between the GHQ-12 andthe VS The correlation between the GHQ-12 andthe VS scores was investigated and...