cerebral magnetic resonance imaging andultrasonography findings after neonatal hypoglycemia pediatrics 103 1999

mechanisms of type 2 diabetes

mechanisms of type 2 diabetes

... Mechanism of Insulin Sensitization Inzucchi, 1999; Yale University, unpublished Thiazolidinediones: Mechanism of Insulin Sensitization Inzucchi, 1999; Yale University, unpublished Thiazolidinediones: ... 1999; Yale University, unpublished Thiazolidinediones: Mechanism of Insulin Sensitization Inzucchi, 1999; Yale University, unpublished Insulin Secretagogues: Mechanisms of Action Intestine: glucose ... (GlucoNorm) Nateglinide (Starlix) Shorter-acting Low sugars less likely Insulin Secretagogues • Watch for hypoglycemia potential: – Any patient with low-normal sugars – Long-acting agents combined with...

Ngày tải lên: 12/08/2014, 20:58

31 495 0
Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"

Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"

... was well controlled HbA1c dropped from 7.3 to 6.6 after treatment His blood pressure was 202/99 before the treatment, which was dropped to 155/73 after two weeks His blood pressure continued within ... sugar was normalized and HbA1c dropped from 7.2 to 6.3 after the treatment Her HbA1c showed a slight increase to 6.4 within three months after therapy was discontinued Case 11: A 70 year old female ... Christman CW, DeWitt DS Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension Circ Res 1985; 57: 781–787 Rubanyi GM, Vanhoutte PM Superoxide...

Ngày tải lên: 26/10/2012, 09:39

7 813 0
Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf

Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf

... faults The secondary faults played a role of the channel system for the olivine basalt eruption After the basalt eruption, the weathering process and the subsidence process to form the Dien Bien...

Ngày tải lên: 13/02/2014, 12:20

4 393 0
Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... experiment is missing for Asp35, Asn101, Thr103, Glu104, Tyr108, Phe127, Thr132, Val134, Leu137, Leu140, and Phe153 These resonances were not visible even after denaturation and refolding to facilitate ... Sequence-specific resonance assignments and secondary structure of nPS As mentioned above, nPS is a dimeric molecule ( 40 kDa) Under the circumstances, the backbone and side chain resonance assignments ... arrangement Under the conditions of these solution studies, the resonances for Tyr108 could not be identified However, we have been able to identify resonances for Val109, Asp110, and Val111 Prediction of...

Ngày tải lên: 16/02/2014, 09:20

16 791 0
Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt

Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt

... value for Glu measured in the tRNAassisted ATP–PPi exchange reaction decreases significantly by 102 )103- fold in comparison with that in the tRNA-independent ATP–PPi exchange reaction (the Km values ... whereas in the absence of tRNAArg, addition of NH2OH induces no increase in the hydrolysis of ATP [3] After PPi is released, the 2¢-OH group of the ribose moiety of tRNA forms a hydrogen bond with O2 ... the absence of tRNA, the Km value of Glu in the ATP–PPi exchange reaction increases to up to 102 )103- fold that in the presence of tRNA at a pH of 7.7 or 7.6 [7,8,33] In the absence of tRNA, the...

Ngày tải lên: 18/02/2014, 11:20

17 512 0
Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

... cartilage after experimentally induced osteoarthritis (A) Photomicrographs of articular cartilage (B) The evaluation of osteoarthritis in the right and left joints of dogs was graded 12 weeks after ... light anaesthesia After surgery, postoperative treatment was given with butophanol (Butopan InjÒ; Hana Pharm Co Ltd.), 10 mgÆkg)1 intramuscularly, every 12 h for days for pain relief After days, no ... slightly green fluorescence in cells treated with ALLN and TRAIL alone, but a highly green fluorescence after combined treatment Photomicrographs indicated that ALLN and TRAIL alone induced a small change...

Ngày tải lên: 18/02/2014, 14:20

11 461 0
Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx

Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx

... The spectral width for the NMR data was 8000 Hz with the carrier frequency at the HDO resonance The solvent resonance was suppressed by presaturation Each FID was composed of 16k data points with ... determination of an octameric 110 kDa protein using TROSY in triple resonance experiments J Am Chem Soc 122, 7543–7548 Wider G & Wuthrich K (1999) NMR spectroscopy of ¨ large molecules and multimolecular ... (2,5-dihydroxy-1,4-dioxane) by FTIR spectroscopy Carbohydr Res 309, 31–38 20 Collins GCS & George WO (1971) Nuclear magnetic resonance spectra of glycolaldehyde J Chem Soc B 1352–1355 21 Kuzmic P (1996) Program DYNAFIT...

Ngày tải lên: 19/02/2014, 00:20

13 479 0
Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf

Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf

... al (1999) Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury Nat Med 5, 1396–1402 Tiffany CW, Lapidus RG, Merion A, Calvin DC & Slusher BS (1999) ... Petsko GA (1999) 1-Butaneboronic acid binding to Aeromonas proteolytica aminopeptidase: a case of arrested development Biochemistry 38, 9048–9053 Harris MN, Bertolucci CM & Ming LJ (2002) Paramagnetic ... metal centers involved in peptide mechanism Coord Chem Rev 232, 5–26 15 Mahadevan D & Saldanha JW (1999) The extracellular regions of PSMA and the transferrin receptor contain an aminopeptidase domain:...

Ngày tải lên: 19/02/2014, 02:20

13 430 0
Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx

Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx

... is the equilibrium value of fluorescence 10 after protein addition, F0 the initial fluorescence of the vesicle suspension, and F100 the fluorescence value after addition of Triton X-100 Light scattering ... Pfuller U, Schiuetzel M & Bus¨ ¨ sing A (1999) Thionins from Viscum album L: influence of the viscotoxins on the activation of granulocytes Anticancer Res 19, 1037 –1042 18 Stein GM, Schaller G, Pfuller ... Chemicals, 6th edn Molecular Probes, Inc, Eugene, OR 28 Chandra S, Leinhos GM, Morrison GH & Hoch HC (1999) Imaging of total calcium in urediospore germlings of Uromyces by ion microscopy Fungal Genet...

Ngày tải lên: 19/02/2014, 07:20

12 530 0
Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc

Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc

... Briefly, after SDS ⁄ PAGE, the gel was incubated in 50 mm Tris ⁄ HCl (pH 7.5) buffer containing 100 mm NaCl and 2.5% Triton X-100 at room temperature for 1.5 h to renature the proteins on the gel After ... Dickson RB (1999) Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity J Biol Chem 274, 18231–18236 Takeuchi T, Shuman MA & Craik CS (1999) Reverse ... AEBSF, on the proteinase activities (Fig 4) The sample was treated with mm AEBSF before and ⁄ or after SDS ⁄ PAGE and subsequent renaturation of separated proteins The pretreatment of the sample...

Ngày tải lên: 19/02/2014, 07:20

13 603 0
Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt

Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt

... potassium fluoride, mm MgCl2, 50 lm [1-14C]IPP, 10 lm E,E-FPP, and 50 lg proteins of membrane fractions After incubation at 30 °C for 30 min, reaction products were extracted with 1-butanol saturated ... synthase Proc Natl Acad Sci USA 98, 4337–4342 Apfel CM, Takacs B, Fountoulakis M, Stieger M & Keck W (1999) Use of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: cloning, expression, ... essential uppS gene J Bacteriol 181, 483–492 Sato M, Sato K, Nishikawa S, Hirata A, Kato J & Nakano A (1999) The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes...

Ngày tải lên: 19/02/2014, 07:20

11 406 0
Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc

Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc

... glucose + 100 mM acetate harvest after 27 h; 10 mM glucose + 100 mM propionate harvest after 29 h; 10 mM glucose + 100 mM acetate + 100 mM propionate harvest after 29 h Determination of the residual ... during growth on 100 mM propionate, we added 10 mM glucose to the medium to support initial growth After total consumption of glucose cells were grown further for at least 12 h Therefore, the wild-type ... of the residual glucose concentration confirmed that the strains were incubated for at least 12 h after total consumption of glucose In addition, we proved that acetate was still present under all...

Ngày tải lên: 19/02/2014, 16:20

15 678 0
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

... performed with these two amplified fragments as the templates and primers, M13 forward and M13 reverse After sequence confirmation, the EcoRI–BamHI fragment was inserted into the expression vector for ... optical rotations were measured at 1-min intervals at 589 nm using a JASCO DIP-360 polarimeter After 10 (IPU) or 20 (R niveus glucoamylase and Bacillus a-glucosidase), 20 lL of 15 M ammonium ... expression of the gene in Bacillus subtilis J Bacteriol 170, 1554–1559 Kuriki, T & Imanaka, T (1999) The concept of the a-amylase family: Structural similarity and common catalytic mechanism...

Ngày tải lên: 19/02/2014, 16:20

8 551 0
Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc

Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc

... of the solution measured with glass electrode was adjusted to 8.6 by adding KOH solution in D2O After incubation for 68 h the mixture was analyzed by PMR The degree of a-proton exchange was shown ... mM pyridoxal-P, and 1.27 unitsÆmL)1 TPL Aliquots (1 mL) of the reaction mixture were withdrawn after 71, 125, 265, 381 and 490 and heated at 90° for to inactivate the enzyme The content of the ... and TPL being 95.23 mM and 2.64 unitsÆmL)1, respectively One-milliliter aliquots were withdrawn after 108, 250, 360, 568, and 754 and treated as above The theoretical values of isotopic exchange...

Ngày tải lên: 19/02/2014, 16:20

7 533 0
Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx

Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx

... radical intermediate is short-lived and can be detected by EPR only after stabilization with a spin-trap at room temperature or after rapid freezing at liquid helium temperature The radical, as ... Biol Chem 270, 18413–18419 12 Rutter, R & Haber, L.P (1982) The detection of two electron paramagnetic resonance radical signals associated with chloroperoxidase compound I J Biol Chem 257, 7958–7961 ... & Ortiz de Montellano, P.R (1999) Spin-trapping and protein cross-linking of the lactoperoxidase protein radical J Biol Chem 274, 35441–35448 52 Goff, H.M & Chen, K (1999) Protein radicals and...

Ngày tải lên: 20/02/2014, 02:21

10 529 0
Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx

Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx

... presence of mM iodoacetamide (lane 5), MSSAE as in lane after electrophoresis under reducing conditions (lane 6) and BS-RNase as in lane after electrophoresis under reducing conditions (lane 7) ... Scribner, A.W & Loscalzo, J (1999) Cellsurface protein disulde isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide J Clin Invest 103, 393399 23 Shin, B.K., ... electrophoretic mobilities of BS-RNase and monomeric BS-RNase, respectively almost totally dimeric after a 24-h contact with growing cells When 125I-labelled MSSAE was incubated in binding buffer...

Ngày tải lên: 20/02/2014, 11:20

8 605 0
Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx

Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx

... at time 750 s (solid line) after the start of the experiment in (A) (D) Spectra at time zero (dashed line), at time 544 s (solid line), and at time 558 s (dotted line) after the start of the experiment ... (2000) Imaging sustained dissipative patterns in the metabolism of individual living cells Phys Rev Lett 84, 27542757 Amit, A., Kindzelskii, A.L., Zanoni, J., Jarvis, J.N & Petty, H.R (1999) Complement ... random perturbation switches to an oscillatory state, the degradation of the enzyme slows down after the transition from the nonoscillatory to the oscillatory state [12] Thus, oscillatory kinetics...

Ngày tải lên: 20/02/2014, 11:20

9 435 0
Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt

Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt

... and the two connecting amino acids at the beginning and the end, were mutated to glycines and, after remodelling back to their side chains in agmatinase, the whole hydrogen bond network was optimized ... catalytic activity of wild-type and D153N agmatinase The enzymes were assayed before (Control) and after dialysis against 10 mM EDTA in mM Tris/HCl (pH 7.5) for h at °C Enzyme activities were measured ... arginase Nature 382, 554–557 ´ Carvajal, N., Lopez, V., Salas, M., Uribe, E., Herrera, P & Cerpa, J (1999) Manganese is essential for catalytic activity of Escherichia coli agmatinase Biochem Biophys...

Ngày tải lên: 21/02/2014, 01:21

5 475 0
w