cellular biology of the androgen receptor in the skeleton
molecular and cellular biology of neuroprotection in the cns - christian alzheimer
... block Third, activation of NMDA receptors requires binding of a coagonist to the so-called glycine-binding site of the NMDA receptor Very recently, the amino acid D-serine has been suggested to ... tests new hypotheses using animal models of acute and chronic brain injury Although many of the new findings hold promise for therapeutic interventions, their translation into clinically relevant ... aspartate in various regions of the central nervous system (CNS) has been recognized since the 1960’s.1,2 Nevertheless, the earlier findings that these amino acids are (1) constituents of intermediary...
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Molecular and cellular functions of the alternatively spliced isoforms of GDNF receptor complex in neuronal differentiation
... cysteine-rich domains with various lengths of C-terminal extensions (2, 61) Domain (D2) is involved in the binding of GFLs (50, 62-64) while Domain (D3) provides a stabilizing effect The Nterminal ... the diverse functions of GFLs (5-7) This thesis further explores the emerging view that the combinatorial interactions of the multi-component ligand receptor system with multiple receptor isoforms, ... This thesis details the discoveries of distinct signaling pathways involved in the activation of specific proteins, mRNAs and miRNAs through combinatorial interactions of GFLs, GFRα and RET receptor...
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Reproductive biology of the marbled goby, Pomatoschistus marmoratus (Pisces, Gobiidae), in a northern Aegean estuarine system (Greece) pptx
... lines within each box show the location of the sample medians; the crosses within each box indicate the location of the sample means; the crosses outside the box indicate outliers length of the most ... time of spawning, fecundity, and size at maturity of the marbled goby at the Strymon estuarine system, in the northern Aegean Sea Study Site The River Strymon springs from Bulgaria and outflows in ... V) appeared in March and their percentage was highest in May (78%) During the remaining period of year, all females were resting (stage II) Each spawning female produces an average of 386 (SE=8)...
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Báo cáo khoa học: Presence of membrane ecdysone receptor in the anterior silk gland of the silkworm Bombyx mori pdf
... protein concentration for the binding assay was determined using 25 nM [3H]PonA and increasing amounts of proteins in individual incubations The percentage of specific binding increased in a protein ... second line of evidence to support the existence of a membrane receptor is that the binding affinity of PonA is less than that of 20E The binding affinity of PonA to the nuclear receptor complex of ... analysis of specific binding at 25 °C was performed by incubating the membrane fractions with increasing concentrations of [3H]PonA, then subjecting the binding data to Scatchard analysis (Fig 4) The...
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Báo cáo sinh học: "Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" pot
... N-terminal and a Cterminal region of CIITA interacting with the viral transactivator, although, as stated above, only the Nterminal region is involved in the inhibition of Tax-2 function Interestingly, ... both in the cytoplasm and the nucleus, and the role of CIITA in redirecting, upon binding, Tax-2 molecules mostly in the cytoplasm These results are discussed within the present knowledge of cell ... included in the 253-410 region, themselves very weakly interacting with Tax2, may participate in generating the correct conformation for the critical binding site of the strongly interacting 253-1130...
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o cáo hóa học:" Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" potx
... N-terminal and a Cterminal region of CIITA interacting with the viral transactivator, although, as stated above, only the Nterminal region is involved in the inhibition of Tax-2 function Interestingly, ... both in the cytoplasm and the nucleus, and the role of CIITA in redirecting, upon binding, Tax-2 molecules mostly in the cytoplasm These results are discussed within the present knowledge of cell ... included in the 253-410 region, themselves very weakly interacting with Tax2, may participate in generating the correct conformation for the critical binding site of the strongly interacting 253-1130...
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ADVANCES IN ORGAN BIOLOGY THE BIOLOGY OF THE EYE docx
... glands in the lower lid can be up to mm long The length of the gland depends on the position of the individual gland in the lid The duct of each gland opens directly onto the inner margin of the ... the back of the eye Although the pressure increase is caused by events in the front of the eye, the damage to vision is due to the effects of this pressure in the back of the eye The increased ... nourishes them from the outside The loss of vision results from the death of these nerve cells The hardness of the eye to touch is not determined by the toughness of the fabric of the eye, but by the...
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Báo cáo y học: "Immunohistochemical localization of mu opioid receptor in the marginal division with comparison to patches in the neostriatum of the rat brain" docx
... border of the neostriatum The mosaic distribution patterns of MOR staining were observed in patches in the rostrodorsal part of the neostriatum Details of the distribution of MORs in the MrD and the ... the rest of the neostriatum Like the patches, the staining of AChE was weaker in the MrD than in the rest of the neostriatum [9], and a layer of densely packed substance P and leu-enkephalin immunoreactive ... higher in the MrD than in the rest of the rat striatum [11] Most of the neuropeptides and receptors expressed in the MrD were reported to exert influences on learning and memory functions of the...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... reinforce the argument that the basic domain should be exposed at the surface of the Tat-containing recombinant proteins and call other reasons to explain the differences in the mechanism of internalization ... mutations in the basic domain of Tat abolished uptake of these constructions [22] thus indicating that this domain is essential for binding to the receptor The present work aimed at de®ning whether ... receptor- mediated mechanism of cellular internalization of the peptide thus appears unlikely The number of arginine residues within the Tat peptide appeared to be the main determinant for maintaining...
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Reproductive Biology of the Laboratory Mouse docx
... Troubleshooting • • • • • Has anything in the room changed? Has anything in the room changed? Do the animals appear healthy? Are nearby strains having problems? Are nearby strains having problems? ... Estrous Cycle Interruption: Mating Estrous Cycle Interruption: Mating Female in proestrus • • • • • Vaginal plug after mating Best observed early morning Produced by seminal vesicle and coagulating gland ... reproductive tract Interventions: – Artificial Insemination Artificial Insemination – In vitro fertilization (IVF) – Intracytoplasmic sperm injection (ICSI) Intracytoplasmic sperm injection (ICSI)...
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BÁO CÁO " SINH HỌC CỦA TÔM NƯỚC NGỌT MACROBRACHIUM IDAE (HELLER, 1862) Ở ĐẢO PHÚ QUỐC, VIỆT NAM THE BIOLOGY OF THE FRESHWATER PRAWN " doc
... The larval development of the prawns Macrobrachium equidens and Macrobrachium sp (Decapoda : Palaemonidae), reared in the laboratory Journal of Zoology Proceedings of the Zoological Society of ... Decapoda) from the Xishuangbanna region of Yunnan province, southern China Hydrobiologia, 400: – 41 Cai, Y & P K L Ng (2001) The freshwater decapod crustaceans of Halmahera, Indonesia Journal of Crustacean ... TP Hồ Chí Minh 1- 188, 25 hình Serène, R 1937 Inventaire des Invertébrés marins de l’ Indochine, 1ere liste, 30e note Institut Oceanographique Nhatrang Short, J W (2004) A revision of Australian...
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molecular biology of the parathyroid - tally naveh-many
... 3’-UTR Binding Proteins and Their Function 61 Identification of the Minimal cis Acting Protein Binding Element in the PTH mRNA 3’-UTR 62 The Structure of the PTH cis Acting Element ... increase of serum calcium through renal reabsorption and intestinal absorption, the latter is caused by the induction of the synthesis of the active form of vitamin D in the kidney Bone is the main ... addition or loss of a single amino acid at the amino terminus greatly reduces biological activity, and the region is involved in binding of PTH to the receptor In addition there is a region of conservation...
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evolutionary developmental biology of the cerebral cortex - novartis foundation
... found in the early cortical plate of the cerebral cortex Thus, the role of the invader as an organizing in uence on cellular society is a theme that may be worth contemplating in studying the development ... determines the size of cortical surface, whereas the number of cells within the columns determines its thickness Kinetics and mode of cell proliferation The size of the cortex is determined in the ... length of cell cycle in each species determines the number of radial units in the cortex and, indirectly, the size of the cortical surface In contrast, the duration of the second phase regulates the...
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Molecular biology of the lung and kidney of the african lungfish, protopterus annectens, during three phases of aestivation cystic fibrosis transmembrane conductance regulator, gulonolactone oxidase and p53
... studied the differential gene expression in the liver of P annectens at the end of the induction phase and the beginning of the maintenance phase Their results confirmed the importance of reconstruction ... the mRNA expression of these cftr isoforms in the lungs of P annectens during the induction, maintenance and arousal phases of aestivation The hypothesis tested was that the mRNA expression of ... expressed in the lung of P annectens, suggesting that noncoding DNA may not be the only reason to explain the huge genome of P annectens The predominant isoform of Cftr from the lungs of P annectens...
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Molecular analysis of the breeding biology of the asian arowana (scleropages formosus)
... and long fins of the RG1 and the intense colouration of the MG One of the shortfalls of the hybrid is the large variation of phenotypes produced in their offsprings which is common in hybridisation ... possibility of kinselection occurring in the pond where kins are helping each other in parental care The grey bar indicates the k value of the thief with the genetic father where the white 18 ... Figure 12: The breeding cycle of the Asian arowana in the farm The graph shows the total production in terms of number of batches（dotted line）and number of offspring (solid line) for the three...
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Báo cáo khoa học: Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system pot
... determined by RT-PCR The results of the RT-PCR are shown in Fig The SacMC4 Discussion We describe here the cloning of the first MC receptor in spiny dogfish The phylogenetic analysis indicates that the ... polymorphism The putative importance of the unique amino acid exchange in the SacMC4 receptor was investigated by mutating the Ala ÔbackÕ to Glu We investigated the mutant receptor both regarding binding ... agreement with the mammalian MC4 receptors that have only been found in brain tissue [8,41] The DreMC4 receptor was also found in the brain but rather surprisingly also in the eye, gastrointestinal tract...
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báo cáo khoa học: " Cellular localization of ROS and NO in olive reproductive tissues during flower development" doc
... detected in the anthers in this stage The stigmas of the newly opened flowers (stage 3) started to be coloured soon after the initiation of the histochemical staining In this case, the presence of the ... breakdown of the anther cells at the stomium, a specialized structure situated at the side of the anthers Dehiscence of the anther involves a number of PCD mechanisms involving degeneration of the ... grouped in clusters in the pollen cytoplasm (Figure 6D) Pollen tubes on the surface of the stigma also showed a weak labelling in their cytoplasm, which increased in intensity in the area of the...
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Biology of microorganisms on grapes, in must and wine
... new wealth of information is being presented in the Biology of Microorganisms on Grapes, in Must, and in Wine The editors were lucky in obtaining the cooperation of many specialists in the various ... inhibitory cell-cell interactions during winemaking In the last part of the book, a compilation of some modern methods round off the chapters This broad range of topics about the biology of the ... microbes involved in the vinification process could be provided in one book only because of the input of many experts from different wine-growing countries We thank all the authors for offering their...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
... absence of R1881 (C) Western analysis of indicated GalAD-AR.NTD proteins in the yeast protein interaction system (left panel) and of indicated AR.NTD proteins in the mammalian protein interaction ... and the role of individual amino acid residues in and flanking the 23 FQNLF27motif in AR16)36 in N/C interaction Yeast protein interaction assays indicated that AR3)13 contributed to the ligand-induced ... LBD Amino acids 3–36 in the NTD (AR3)36), including the 23 FxxLF27 motif, play a pivotal role in N/C interaction [15,20] Here we studied the function of the AR3)36 subdomain AR3)13 in N/C interaction...
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báo cáo hóa học:" Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival" doc
... carcinomas arise within the fimbrial tubal epithelium [10,17,18] Our findings indicate that malignant transformation could involve a downregulation of AR in certain EOC cases AR expression in ... stratification in this subgroup Our findings also highlight the need for further studies investigating the influence of both lifestyle-related and genetic factors in relation to ovarian cancer risk in general ... prognostic value within the entire cohort, reduced AR expression was an independent predictor of decreased OCSS in serous tumors The main limitation of this study is the absence of data on residual...
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