cell based analysis of drug response using moving optical gradient fields
Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
Ngày tải lên :
16/03/2014, 11:20
... Intensity of cytoplasm Ratio of Translocation = Intensity of nucleus Intensity of cytoplasm Intensity of nucleus Scheme This is a simplication of a cell as seen by analysis software, where the software ... cell based but also simulated in silico Combining this method of analysis (in vitro, cell- based and in silico analysis) will facilitate systematic understanding of the underlying properties of ... 350 400 450 Time (min) Fig Immunocytochemical staining of A549 cells and analysis of the dynamics of NF-jB nuclear translocation (A,B) Doseresponse data from A549 stimulated with IL-1a and xed...
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Báo cáo khoa học: Antibody-based proteomics Analysis of signaling networks using reverse protein arrays pdf
Ngày tải lên :
16/03/2014, 00:20
... modulation of regulatory networks [5,6] A direct benefit of such an approach would be the early recognition of ‘off target’ and side effects of drug candidates [7], as well as the identification of putative ... translation of ‘physiology’ because Analysis of signaling networks using protein arrays they allow a sufficient level of granularity while integrating the basic organizing principles of the cellular ... Analysis of signaling networks using protein arrays H Voshol et al a contextual understanding of the molecular mechanisms of disease, but also has the potential to facilitate the validation of...
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báo cáo khoa học: "Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohor" pot
Ngày tải lên :
11/08/2014, 12:21
... this article as: Smith et al.: Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional ... pairs) Inspection of raw reads using FASTQC analysis indicated some problems, in particular overrepresentation of particular sequences These were discovered to correspond to the ends of amplicons, ... association analyses using 819 samples with genotypes for up to 18 SNPs A meta -analysis of allelic test results found that 12 of these SNPs were strongly (p < 0.001) associated with response (Table...
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03 analysis of mechanical systems using interval computations applied to finite element methods o dessombz
Ngày tải lên :
12/01/2014, 21:45
... point of view, and the others often encounter convergence problems Moreover, only the mean value and the moments (often the variance only) are known, and since the density of probability of the ... problematic of solving linear systems of interval equations We will then introduce a new formulation of the problem, based on interval parameters which is adapted for the modeling of mechanical ... convergence of the iterative scheme The smaller the spectral radius of |[G]|, the faster the convergence of the algorithm and the smaller the overestimation of the solution 4.2 TEST OF THE NEW...
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Tài liệu Báo cáo khoa học: Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay docx
Ngày tải lên :
14/02/2014, 19:20
... were selected MALDI-TOF/TOF In addition to LC-MS ⁄ MS analysis, we also completed TOF ⁄ TOF analysis of selected peaks to confirm structure using a MDS Sciex 4800 MALDI-TOF ⁄ TOFÔ instrument (Applied ... patterns Glycan analysis of cRBCs Analysis of cRBC glycans by 1H-NMR To determine the most relevant glycan sequences for each composition, we completed additional MS and NMR -based analysis of the cRBC ... Glycan analysis of cRBCs U Aich et al of RBCs occurs when the addition of a limiting amount of virus results in ‘crosslinking’ of RBCs through binding of multiple RBCs to HAs...
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Tài liệu Báo cáo khoa học: "Sense-based Interpretation of Logical Metonymy Using a Statistical Method" pdf
Ngày tải lên :
20/02/2014, 09:20
... interpretations of a metonymic phrase We propose an alternative representation of metonymy interpretation consisting of a list of senses that map to WordNet synsets However, the sense -based representation ... and covers 80% of their lists (our system does not find some of the lowprobability range verbs of Lapata and Lascarides) We compared the rankings of the two implementations in terms of Pearson correlation ... see(7)) was stored This means that sense of watch, sense of view and sense of see would be correct interpretations of the metonymic expression The obtained number of synsets ranges from 14 (try shampoo)...
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Households as Corporate Firms An Analysis of Household Finance Using Integrated Household Surveys and Corporate Financial Accounting pptx
Ngày tải lên :
07/03/2014, 15:20
... hypothesis testing of neoclassical benchmarks using the entire sample of households, but of course this approach foregoes the details of the behavior of individual households The application of the accounts ... c an analysis of household finance We demonstrate two different, but complementary, approaches to the analysis of household finance First, in chapter 5, we conduct a financial analysis of two ... Professor of Economics in the Department of Economics at the Massachusetts Institute of Technology He previously was the Charles E Merriam Distinguished Service Professor in the Department of...
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Báo cáo khoa học: "Tree-based Analysis of Simple Recurrent Network Learning" docx
Ngày tải lên :
31/03/2014, 04:20
... mean of these local proximities measures how close the network responses are to the desired responses Tree -based corpus representation There are diverse methods to represent a given set of words ... information, for example the frequency of a word, if this node is the end of a word Another useful piece of information is the frequency of each node C, that is, the frequency of each left context It is ... recursively as a sum of the frequencies of all successors and the frequency of the word ending at this node, provided that such a word exists These frequencies give us an instant evaluation of the empirical...
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Báo cáo hóa học: " Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer" pot
Ngày tải lên :
18/06/2014, 16:20
... Statistical Analysis The preprocessing of spectral data that included removing outliers by using Dixon test based on areas of the raw spectra, averaging of technical repeats, binning of neighboring ... treatment reflect responses of patients to therapy but not restoration of the "normal healthy" pattern of the serum profile Conclusions Here we established the high potential of MALDI-ToFbased analyses ... potential of mass spectrometry -based analyses of the blood proteome pattern in diagnostics of breast cancer A few previous studies have also used a mass spectrometry -based analysis of the blood...
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Aircraft Flight Dynamics Robert F. Stengel Lecture13 Analysis of Time Response
Ngày tải lên :
04/07/2014, 19:26
... climb rate" • Corresponding dynamic response to thrust step, with LδT = 0" Steady-State Response of " Approximate Short-Period Model " Equilibrium Response of " Approximate Short-Period Model ... angle of attack response to elevator are not zero" Steady vertical wind affects steady-state angle of attack but not pitch rate" Dynamic response to elevator step with LδE = 0! Speed Control of ... n Angle Response to a Sinusoidal Angle Command " Step Response of Angle Controller, with Angle and Rate Feedback " • Single natural frequency, three damping ratios! % Step Response of Damped...
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Báo cáo vật lý: "The Potentiometric Analysis of Chloride Ion Using Modified Heterogeneous Chitosan Membranes" pdf
Ngày tải lên :
07/08/2014, 14:20
... determination of Cl– by chitosan–Fe3+ membrane gave higher response than the chitosan–Cl– in the analysis of Cl– in terms of stability during measurements, near Nernstian slope and degree of correlation ... probably because of The Potentiometric Analysis of Chloride Ion 48 thin membrane used and also elimination of swelling step during the permeation by hydrated chloride ions The response times were ... potential response was taken using the following cell scheme: Pt⏐KCl, 0.1 M⏐Membrane⏐Sample⏐KCl, 3.0 M⏐AgCl, Ag (1) The observed potentials (emf) were measured in 20 ml of chloride solution of concentration...
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Báo cáo lâm nghiệp: "An approach for the analysis of vegetation spectra using non-linear mixed modeling of truncated power spectra" pdf
Ngày tải lên :
08/08/2014, 01:22
... reflectance in the NIR and SWIR regions of the spectrum Analysis of vegetation spectra 519 Figure Summary of F-ratio tests of significance of the variance of the reflectance associated with a specific ... variance of a spectra The choice of r – degrees of freedom in the numerator of the F-ratio test instead of was adopted to keep the experiment-wide error rate at 0.05 or better [38] The number of retained ... the challenge of deciding on an acceptable loss of information and interpretation of the results Our approach provides a transparent and intuitive method of dimension reduction based on fit to...
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Báo cáo khoa học: "Validity of leaf areas and angles estimated in a beech forest from analysis of gap frequencies, using hemispherical photographs and a plant canopy analyzer" pot
Ngày tải lên :
08/08/2014, 14:21
... determination of the structural parameters of the canopy, requiring a single transect performed in overcast conditions [9] [9] observed an underestimation of about 30 % when using all rings and11% when using ... to the base of the live crown and the diameter and age of all branches The total leaf area of these 26 trees was determined using a three-step procedure: 1) At shoot level, a sample of 582 leafy ... estimation of a low limit for the value of the gap fraction: in the case of completely black sectors (with zero white pixel), the logarithm of the gap fraction is undefined Considering the size of these...
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Báo cáo khoa học: " Fractionated stereotactic radiotherapy for skull base tumors: analysis of treatment accuracy using a stereotactic mask fixation system" pps
Ngày tải lên :
09/08/2014, 10:20
... the square root of the sum of squares of the displacements seen in the directions was calculated The amount of isocenter shift of serial CT scans was assessed using analysis of variance (ANOVA) ... square root of the sum of squares of the SD of systematic and random error Quality control procedures at the CT scanner, simulation room and linear accelerator were performed The accuracy of coincidence ... box consisted of a skeletal aluminium box attached onto the mask system The position of the treatment isocenter and the shapes of the beam projections were generated on four pieces of transparency...
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Báo cáo y học: " Major biological obstacles for persistent cell-based regeneration of articular cartilage" pps
Ngày tải lên :
09/08/2014, 10:20
... cartilage and/or bone compartment (green arrows) of the defect cells is mediated by both cell- cell (neural cadherin and neural cell adhesion molecule) and cell- matrix (hyaluronan and CD44, fibronectin, ... the dense extracellular matrix, there is no compensatory mechanism for loss of native and transplanted chondrogenic cells In cartilage defects, cells can be lost due to leakage of cell suspension, ... kinetics of resorption, selection of bioactive factor, cellular target(s) and mechanism of stimulation [142,146-148] Given these imponderables, a guided biomaterial development focusing on cell and...
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báo cáo khoa học: " Microarray-based analysis of microRNA expression in breast cancer stem cells" doc
Ngày tải lên :
10/08/2014, 10:20
... microarrays for BCSC cells Table S1-MiRNAs microarray- based miRNAs expression profile of MCF-7 cells (signal value ≥800) The table shows the miRNAs expression profile of MCF-7 cells obtained through ... Bioinformatic analysis and preliminary functional analysis of BCSC-related miRNAs Chromosome localisation, sequence analysis and target prediction of the miRNAs were carried out using online software ... S2- MiRNAs microarray- based miRNAs expression profile of ESA+CD44+CD24-/low cells (signal value ≥800) The table shows the miRNAs expression profile of ESA +CD44+CD24-/low cells obtained through...
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Báo cáo y học: " Model-based analysis of two-color arrays (MA2C)" ppsx
Ngày tải lên :
14/08/2014, 08:20
... value) = no of true positive peaks/no of total peaks Sensitivity = no of detected true positive regions/96 Unique = number of unique regions found Correlation = correlation coefficient of the spike-in ... removed from the list We ran MA2C using a window-size of 600 bp at p value cutoffs of 10-5 and 10-4; all other parameters were set to default settings MPeak was run using default parameters As seen ... the performance of different scoring functions, the triplicate H3 acetylation data at 38 bp spacing from [25] were analyzed using a window size of 1,000 bp and a p value cutoff of 10-3 Median...
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Báo cáo y học: "Analysis of genetic systems using experimental evolution and whole-genome sequencing" docx
Ngày tải lên :
14/08/2014, 17:22
... JM, Paunovic M, et al.: Analysis of one million base pairs of Neanderthal DNA Nature 2006, 444:330-336 51 Kellis M, Birren BW, Lander ES: Proof and evolutionary analysis of ancient genome duplication ... complicated regulatory networks of the higher forms of life Evolution acts on biological function, and in viruses functions are often mapped to single genes In complex cellular life forms such as ... provides perhaps the best example of a large cellular network (comprising hundreds of genes) that is relatively amenable to quantitative phenotypic predictions at the whole -cell level [30-33] Although...
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Báo cáo y học: "A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection" doc
Ngày tải lên :
14/08/2014, 21:20
... to responses to distinct types of telomere damage Secondly, in a population of cells lacking telomerase, erosion of telomeres and cell cycle arrest occur heterogeneously and over a period of ... be a common feature in response to telomere damage Induction of a stress response may be a conserved feature of the response to telomere damage A major feature of the response to telomere damage ... with over 80% of cells within a population exhibiting the G2-M cell cycle arrest indicative of telomere uncapping within a single cell cycle [18] We hypothesized that, while the response to telomere...
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