carotenoids and the insulin like growth factor system

... WA: Insulin- like growth factor- 1 (IGF-1) and growth hormone (GH) in immunity and inflammation Cytokine Growth Factor Rev 1999, 10:5-14 29 Jansson JO, Eden S, Isaksson O: Sexual dimorphism in the ... drugs, and corticosteroids were equal in the HRT and control groups at all check points R204 Six patients in the HRT group and two in the control group withdrew from the study before completing the ... IGF-1, ESR, and E2 and changes of BMD in the total hip and lumbar spine were sought The results are shown in Table 4, except for OPG, which was not associated with any of the other factors Increase...

Ngày tải lên: 09/08/2014, 01:21

... susceptibility to cleavage by the amniotic fluid protease and suggest that not only the degree, but also the position of the phosphate groups influence the process As for the other IGFBPs, the proteolytic cleavage ... Cellular actions of the insulin growth factor binding proteins Endocr Rev 23, 824–854 Baxter RC (2000) Insulin- like growth factor (IGF-) binding proteins: interactions with IGFs and intrinsic bioactivities ... Siwanowicz I, Huber R & Holak TA (2006) Structural basis for the inhibition of insulin- like growth factors by insulin- like growth factorbinding proteins Proc Natl Acad Sci USA 103, 13028– 13033...

Ngày tải lên: 07/03/2014, 00:20

... Miller, R.E & Cascieri, M.A (1990) The roles of tyrosines 24, 31, and 60 in the high anity binding of insulin- like growth factor- I to the type insulin- like growth factor receptor J Biol Chem 265, ... Cascieri, M.A (1988) Structural analogs of human insulinlike growth factor I with reduced anity for serum binding proteins and the type insulin- like growth factor receptor J Biol Chem 263, 6233±6239 ... N.S., Green, B.G & Bayne, M.L (1988) Mutants of human insulin- like growth factor I with reduced anity for the type insulin- like growth factor receptor Biochemistry 27, 3229±3233 14 Bayne, M.L.,...

Ngày tải lên: 08/03/2014, 22:20

... not support the clinical utility of measuring levels of IGFBP-3 and -4 in sera of melanoma patients Abbreviations (IGF): Insulin- like Growth Factor; (IGF1R): Insulin- like Growth Factor- 1 receptor; ... Perloff M, Malone WF, Formelli F: Relationships between plasma insulin- like growth factor- I and insulin- like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide ... represented by box and whisker plots, with upper and lower limits of the boxes indicating the 75th and 25th percentiles, respectively, and the central, horizontal line representing the median Outliers...

Ngày tải lên: 18/06/2014, 15:20

... receptor PCR measurements of insulin- like growth factor- 1 and the growth hormone receptor Bars represent the mean expression of mRNA of insulin- like growth factor- 1 (IGF-I) and growth hormone receptor ... in the activity of the immune system In this regard, the effect of sepsis and the influence of nutrition on tissue protein metabolism and on the functioning of the growth hormone (GH) insulin- like ... IGF-I and of the growth hormone receptor (GHR) in hepatic tissue from these animals These results are reported in the present manuscript Materials and methods Experimental design The Animal Care and...

Ngày tải lên: 13/08/2014, 08:20

... A (1993) Role of insulin- like growth factors in embryonic and postnatal growth Cell 75, 73–82 26 Holt RIG (2002) Fetal programming of the growth hormone insulin- like growth factor axis Trends ... Zapf J (1985) Insulin- like growth factors and insuln: comparative aspects Diabetologia 28, 485–493 Clemmons DR (1989) Structural and functional analysis of insulin- like growth factors Br Med ... Silkmoth IGF -like peptide N Okamoto et al Members of the insulin- like peptide (ILP) family are present in a wide variety of metazoans In vertebrates, insulin and insulin- like growth factors (IGFs)...

Ngày tải lên: 18/02/2014, 13:20

... (1996) Growth hormone and the insulin- like growth factor system in myogenesis Endocrine Rev 17, 481–517 DeVol DL, Rotwein P, Sadow JL, Novakofski J & Bechtel PJ (1990) Activation of insulin- like growth ... (1995) Insulin- like growth factors and their binding proteins: biological actions Endocr Rev 16, 3–34 Baker J, Liu JP, Robertson EJ & Efstratiadis A (1993) A Role of insulin- like growth factors ... Maturation of the myogenic program is induced by postmitotic expression of insulin- like growth factor I Mol Cell Biol 19, 3115– 3124 James PL, Stewart CE & Rotwein P (1996) Insulin- like growth factor...

Ngày tải lên: 19/02/2014, 06:20

... function to either activate or inhibit protein synthesis and cell growth [2] The most well defined signaling mechanism regulating mTOR activity in skeletal muscle is the insulin like growth factor- 1 ... from the membrane to the cytosolic fraction On the basis of these findings, we examined whether or not IGF-1 stimulation caused a redistribution of TSC1 and ⁄ or TSC2 from the membrane to the cytosol ... distributions of TSC1 and TSC2 proteins were also detected on the same time scale as the Akt and S6K1 phosphorylations The relative amounts of both TSC1 and TSC2 proteins in the membrane fraction...

Ngày tải lên: 15/03/2014, 11:20

... and PDGFRA receptors and may overcome KIT and PDGFRA-dependent imatinib resistance [55] Glycemic derangements related to insulin- like growth factors such as the pro-IGF-IIE and insulin- like growth ... growth factor receptor- and insulin- like growth factor- 1 receptor signaling: implications for cancer therapy Curr Cancer Drug Targets 2009, 9:748-60 Zha J, Lackner MR: Targeting the Insulin- like ... Hankinson SE: Insulin- like growth factors and neoplasia Nat Rev Cancer 2004, 4:505-18 20 21 Tao Y, Pinzi V, Bourhis J, Deutsch E: Mechanisms of diseases: signalling of the insulin- like Growth Factor...

Ngày tải lên: 18/06/2014, 16:20

... Correlation between IGF-I zSDS (a and b) and IGFBP-1 (c and d), with HS score at ultrasound (US), and FM% IGF-I zSDS, standard deviation score (SDS) of insulin- like growth factor- I levels according to ... IGF-I The values for the molecular mass of IGF-I and IGFBP-3 used for the calculation were 7.649 kDa and 28.5 kDa, respectively [17] and then averaged A cut off for LSD was set at 103 mm [7] The ... analyze the relationships between IGFI levels and the other variables, we calculated the standard deviation score (SDS) of IGF-I levels according to age (zSDS) To this aim, we calculated the mean and...

Ngày tải lên: 18/06/2014, 22:20

... Correlation between IGF-I zSDS (a and b) and IGFBP-1 (c and d), with HS score at ultrasound (US), and FM% IGF-I zSDS, standard deviation score (SDS) of insulin- like growth factor- I levels according to ... IGF-I The values for the molecular mass of IGF-I and IGFBP-3 used for the calculation were 7.649 kDa and 28.5 kDa, respectively [17] and then averaged A cut off for LSD was set at 103 mm [7] The ... analyze the relationships between IGFI levels and the other variables, we calculated the standard deviation score (SDS) of IGF-I levels according to age (zSDS) To this aim, we calculated the mean and...

Ngày tải lên: 20/06/2014, 04:20

... establish the similarities and differences between the mammalian IGF-IGFBP system and the Drosophila Dilp-Imp-L2 system Characterization of the Dilps at the protein level, and of whether and how they ... important regulator of growth, and overexpression of the Drosophila insulin receptor in the eye during development results in hyperplasia (overgrowth) of the eye Honegger and coworkers [2] used ... conserved function of the Drosophila insulin receptor and insulin- like peptides in growth control Curr Biol 2001, 11:213-221 Mohan S, Baylink DJ: IGF-binding proteins are multifunctional and act via IGF-dependent...

Ngày tải lên: 06/08/2014, 18:21

... VA, Davidson B: Diagnostic and prognostic role of the insulin growth factor pathway members insulin- like growth factor- II and insulin- like growth factor binding protein-3 in serous effusions Hum ... Chillar R: Plasma insulin- like growth factor- I and serum IGF-binding protein can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of ... throughout the measurements of the electrical signal and the pulse width was sec The reference electrode is the back (bottom) side of the grounded wafer A schematic of the experimental setup of the...

Ngày tải lên: 11/08/2014, 00:23

... HAI-1 Based on these facts, the 95- and 110-kDa bands in zymography (Figs 3A and 4) and immunoblotting (Fig 3B) are most likely to correspond to the matriptase ⁄ HAI-1 complexes The 95- and 110-kDa ... C band of the single-chain, latent enzyme and a minor 50 kDa band of the two-chain, active enzyme (Fig 7C) [10] Based on the relative band intensity, the percentage of the active enzyme to the ... Culture, Sports, Science and Technology and from the Ministry of Welfare and Labor of Japan References Jones JI & Clemmons DR (1995) Insulin- like growth factors and their binding proteins: biological...

Ngày tải lên: 19/02/2014, 07:20

... of a single nucleotide polymorphism of the insulin- like growth factor binding protein gene and its association with growth and body composition traits in the chicken J Anim Sci 84: 2902-2906 Nie, ... cuối AA quần thể nghiên cứu 39 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di truyền gen Insulin- like growth factor binding protein gà Bảng Tần số kiểu gen alen ... trình chạy điện di thể bảng 37 Đa dạng di truyền gen Insulin- like growth factor binding protein gà đa dạng di truyền gen Insulin- like growth factor binding protein gà Bảng Các cặp primer sử dụng...

Ngày tải lên: 24/03/2014, 23:21

... increases growth and circulating insulin- like growth factor I (IGF-I) in Vietnamese growth- retarded children Am J Clin Nutr 63: 514-519 Ninh NX, Thissen JP, Maiter D, Adam E, Mulumba N and Ketelslegers ... children The study was carried out in 642 pre-school children in order to determine the reference values of serum IGF-I, one very important hormone regulating growth, and their relationship factors The ... JM (1995) Reduced liver insulin- like growth factor- I gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone (GH) receptors and serum GH-binding protein...

Ngày tải lên: 25/03/2014, 03:22

... MG-F, JEP and IS performed the research; LG analyzed the data; and IC-C designed the research, carried out the in vivo protocol and wrote the paper All authors have read and approved the final ... Role of serum insulinlike growth factor I in mammalian brain aging Growth Horm IGF Res 2004, 14(Suppl A):S39-43 30 Tong M, Dong M, de la Monte SM: Brain insulin- like growth factor and neurotrophin ... myelination Glia 2007, 55:632-641 33 Fernandez S, Fernandez AM, Lopez-Lopez C, Torres-Aleman I: Emerging roles of insulin- like growth factor- I in the adult brain Growth Horm IGF Res 2007, 17(2):89-95...

Ngày tải lên: 18/06/2014, 22:20

... to the brain via the vagus nerves and other immune-tobrain communication pathways [46] The acute peripheral immune response, subsequent delivery of cytokines to the brain via the humoral and ... changes in depression -like behavior when assessed using the TST and FST The anti-depressant activities of IGF-I and GPE in the current experiments assessed with the TST and FST does not appear ... 70:289-297 Bibollet-Bahena O, Cui QL, Almazan G: The insulin- like growth factor- 1 axis and its potential as a therapeutic target in central nervous system (CNS) disorders Cent Nerv Syst Agents Med...

Ngày tải lên: 19/06/2014, 22:20

... MG-F, JEP and IS performed the research; LG analyzed the data; and IC-C designed the research, carried out the in vivo protocol and wrote the paper All authors have read and approved the final ... Role of serum insulinlike growth factor I in mammalian brain aging Growth Horm IGF Res 2004, 14(Suppl A):S39-43 30 Tong M, Dong M, de la Monte SM: Brain insulin- like growth factor and neurotrophin ... myelination Glia 2007, 55:632-641 33 Fernandez S, Fernandez AM, Lopez-Lopez C, Torres-Aleman I: Emerging roles of insulin- like growth factor- I in the adult brain Growth Horm IGF Res 2007, 17(2):89-95...

Ngày tải lên: 20/06/2014, 04:20

... Food and Drug Administration FPLC Fast Performance Liquid Chromatography GH Growth Hormone HRP HorseRadish Peroxidase IPTG IsoPropyl-β-D-Thio-Galactoside hIGF-1 human Insulin- like Growth Factor ... tăng trưởng quan trọng nhóm hormone tăng trưởng insulin- like growth factors (IGFs) IGFs họ protein hormone có trình tự amino acid tương đồng với proinsulin khoảng 50% bao gồm IGF-1 IGF-2 (hay gọi ... carbohydrate nhiều loại hormone hợp chất sinh học khác Sự thiếu hụt hIGF-1 trẻ gây bệnh IGFD (Insulin- like growth factor deficiency) Trẻ bị mắc bệnh IGFD bị lùn so với trẻ bình thường phát triển không...

Ngày tải lên: 25/07/2014, 08:29