cardiac remodeling and its relationship to the development of heart failure

... parallel The numbers at the right represent the pI values of the major bands in e and f, while the numbers at the left are the pI values of standard proteins The arrow at the right represents the ... lg) and f (1.5 and 3.0 lg) show the electrophoretic position of CLAP fractions e and f, respectively, after re-chromatography on Mono S (Fig 1B,C) The (0) at the bottom shows the absence of protease ... position of CL and CLAP, the catalytic and noncatalytic subunits, respectively, of the protease are shown on the right, while protein standards are shown on the left (B) Lanes labelled e (1.5 and...

Ngày tải lên: 07/03/2014, 16:20

... function to activate Notch only in the absence of p53, possibly due to the interference of Notch activation by p53 The main aim of this study is to find out the causes for the up-regulation of p53 ... particularly what causes the up-regulation of p53 activity Hence, the aim of this study is to investigate what causes the up-regulation of p53 and to further characterize other developmental defects ... regulatory checkpoints The first regulatory event is the G1/S checkpoint, which defines the entry into the cycle in late G1; the G2/M checkpoint, where entry into mitosis is controlled; and the...

Ngày tải lên: 14/09/2015, 14:03

... specialization” and is commonly referred to as the relocation of parts of the production process from one country to another Most of the attention used to focus on fragmentation in the goods chain, ... Among the factors explaining the growth is the expansion of defence R&D and the fast accumulation of IT skills by university graduates and graduates of the military technological units These countries ... matched to the local environment While education and training policies were supportive of the automobile industry in general, they were never the main factor for attracting automobile investors in the...

Ngày tải lên: 23/04/2013, 11:16

... due to fluctuations of prices and costs, and was represented by additive error of 10% for the purpose of this study Its value can also be reduced by the development of relevant economic and marketing ... climate are the main sources of the final error In addition, the low presence of some tree species in the source data set negatively influenced the accuracy of the results Theoretically, the standard ... pure, even-aged and full stocked forest stands, which is related to the essence of basic models used as a source for the yield index computation There arises a question whether and to what extent...

Ngày tải lên: 07/08/2014, 10:21

... Figure The GSH/GSSG ratio of the prototype and expanded models The GSH/GSSG ratio of the prototype and expanded models The prototype model (A) and the expanded model (B) Page of 11 (page number not ... hexokinase and pyruvate kinase, and the maximum activity of these enzymes was allowed to change according to the ratio of GSH and GSSG The equations and parameters used are derived from the literature ... evidence of the disease until the RBCs are exposed to oxidant stress The compensatory effect of the de novo GSH synthesis and GSSG export pathways may thus help to explain why many varieties of G6PD...

Ngày tải lên: 13/08/2014, 22:22

... they were submerged in the 1950s and 1960s, and the number and diversity of these organisations have grown rapidly since the 1990s The re-emergence of NGOs raises the questions whether, and to ... belt between state and society which communicate government policies from the political elite down to the lower levels of society and to voice the demands of the people to the central power, ... treatment to NGOs depending on their nature and the perception of whether they posed a political threat to the government authority or help to promote public governance and the delivery of social...

Ngày tải lên: 13/10/2015, 16:50

... deposits nonetheless exposed U.S taxpayers to the risk of loss—while the profits made possible by deregulation and forbearance would accrue to the owners and managers of the savings and loans The ... Examination of the Banking Crises of the 1980s and Early 1990s Volume I Reagan administration, the FHLBB and the Office of the Comptroller of the Currency approved any application “as long as the owners ... abandoned For a discussion of these issues, see Chapter 168 History of the Eighties—Lessons for the Future Chapter The Savings and Loan Crisis and Its Relationship to Banking Table 4.2 S&L Failures,...

Ngày tải lên: 06/03/2014, 10:20

... on the vascular endothelium are biologically plausible because this is the site of protein C activation, the endothelium contains the receptor for APC (EPCR), and the endothelium contains the ... protein C and endothelial barrier protection Another direct mechanism of action of APC on the endothelium is modulation of the endothelial monolayer, leading to increased cell-cell contact and decreased ... (inhibitor of apoptosis protein) and BCL-2, were upregulated by APC, whereas there was suppression of the apoptotic Page of (page number not for citation purposes) genes calreticulin and TRMP-2 Furthermore,...

Ngày tải lên: 13/08/2014, 03:20

Ngày tải lên: 27/03/2015, 15:05

... protozoa [44] These results prompted us to investigate the role of PPase enzymes in the development and molting process of A suum larvae and to test whether this could be targeted by inhibitors ... the hypodermis of the body wall, which synthesizes components of the cuticle, may offer a useful target for studies into the mechanism of the development and molting process in the roundworms ... musculature The ecdysis of an old cuticle and deposition of the components of a new cuticle that are synthesized in the hypodermis and are secreted across the hypodermal membrane into the space...

Ngày tải lên: 20/02/2014, 11:20

... which conducts research and analysis for the Office of the Secretary of Defense, the Joint Staff, the Unified Commands, the defense agencies, the Department of the Navy, the U.S Intelligence Community, ... within the RAND National Security Research Division (NSRD) of the RAND Corporation NSRD conducts research and analysis for the Office of the Secretary of Defense, the Joint Staff, the Unified Commands, ... part, by donors and by the independent research and development provisions of RAND’s contracts for the operation of its U.S Department of Defense federally funded research and development centers...

Ngày tải lên: 29/03/2014, 18:20

... determine the contribution of daily PA to the HRQL of individuals with chronic stroke living in the community and 2) to assess the relationship between the functional ability (motor impairments of lower ... extremity, balance and walking distance) of these individuals to the amount of daily PA they undertake This will enhance our understanding and identify the level of functional ability of individuals ... stroke motor severity and found to account for 13% (p = 0.02) of the total variance of the Physical Composite Score of the SF-36 Adding PA as assessed by the PASIPD resulted in an R2 change of 12%...

Ngày tải lên: 20/06/2014, 16:20

... operator P and give the e relation between T0 -periodic P C-mild solution and the fixed point of P After showing the compactness of the Poincar´ operator P and obtaining the boundedness of the fixed ... sometimes and the conditions for Banach fixed point theorem are too strong Our method is much different from others’, and we give a new way to show the existence of periodic solutions In addition, the ... number; and δ ∈ N τk δ denoted the number of impulsive points between and T0 The operator A is the infinitesimal generator of a C0 -semigroup {T t , t ≥ 0} on X; f is a T0 -periodic, with respect to...

Ngày tải lên: 22/06/2014, 03:20

... order to carry out the maximum photosynthesis, and this tends to be during the spring and part of the autumn During and after the appearance of shoots, the plant discards the old leaves, once the ... anterior to and posterior to the mast year We may suppose that the internal cycle of acorn production at the corkoak forest of Polell takes at least five years 4.4 The relationship of litterfall and ... limiting factor and the density of the crown is found to be balanced with the level of rainfall and soil reserves [14] This is clearly reflected in the positive correlation between rainfall and the production...

Ngày tải lên: 07/08/2014, 16:20

... contributions JB and ET had full access to all of the study data and takes responsibility for the integrity of the data and the accuracy of the data analysis Both authors contributed equally to the study ... related to the development of surgical site infections after major cardiac surgery Journal of Cardiothoracic Surgery 2011 6:4 Submit your next manuscript to BioMed Central and take full advantage of: ... inspired oxygen fraction to cardiac surgery patients in order to prevent SSIs In summary, the PaO2 in adult cardiac surgery patients is not related to SSI rate The strategy of administering supplemental...

Ngày tải lên: 10/08/2014, 09:23

... and B7 had all distorted markers skewed towards the heterozygote These groupings of distorted markers suggest that some regions of the chromosome are more prone to segregation distortion, rather ... example of synteny between A- and B- genomes of Arachis and Medicago An example of synteny between A- and B- genomes of Arachis and Medicago Alignment of linkage group B3 of the developed map with the ... accession of A ipaënsis However, regardless the taxonomic status of the species, it is clear that both genomes used to construct the map are similar to the B-genome of A hypogaea and that the linkage...

Ngày tải lên: 12/08/2014, 03:20

... Description of the use of a web application in the consensus process for the development of the Control of Allergic Rhinitis and Asthma Test (CARAT) The data provide more details on the development and ... reassembled and discussed all the questions, focusing on different aspects related to the items and their importance, the wording of the questions, the response options and the timeframe to be assessed ... CARAT – Control of Allergic Rhinitis and Asthma Test This is a translation to English of the of the preliminary version of Control of Allergic Rhinitis and Asthma Test, the development of which is...

Ngày tải lên: 12/08/2014, 14:20

... proven to be the most accurate and can ensure the accuracy and stability of the hybrid method After explaining the combination scheme of the TDFEM and PSTD, some numerical examples are given The ... The hybrid methods TDFEM-PSTD, PSTD-FDTD and FMM-PSTD developed in this thesis improve the accuracy of the traditional PSTD method and preserve the efficiency of the PSTD algorithm They help to ... Although the PML absorber employed in PSTD and hybrid methods helped to reduce the wraparound effect, it cannot be eliminated and influences the accuracy of the PSTD method The other limitation of PSTD...

Ngày tải lên: 11/09/2015, 09:00

... cultures and the expression is influenced by a number of factors including transfection efficiency of the given cell type, the quality and quantity of DNA taken up by the cells, the cytotoxicity of the ... sequesters NF-κB in the cytoplasm Activation of IKK leads to the phosphorylation and degradation of IκB, resulting in the release and translocation of NF-κB from cytoplasm into the nucleus (Mercurio ... domains (EC) of IL-4Rα, γC or CD14 and the TM/Cyt domains of TLR1 or TLR2 2.4.2 Expression vectors for the expression of fusion receptors between the EC domain of IL-4Rα or γC and the FcγRIIA...

Ngày tải lên: 12/09/2015, 08:20

... transfer its momentum hq and energy ∆Eo to the v v electrons of the solid The projection of q upon the surface kx determines the plasmon wave vector and, together with the dispersion relation, the ... schematic sketch of the cavity system considered in this chapter The distance of the center of the cavity to the surface is h The major and minor axis of the cavity are denoted ˆ as a and b respectively ... specifically, the Maxwell equation for the considered cavity system was solved The solution shows the effect of the aspect ratio of the cavity on the field structure and spectral response of the system...

Ngày tải lên: 14/09/2015, 14:01