cancer stem cell or stochastic model

... progress to cancer when precancerous stem cells transform into primary cancer stem cells [64] Second, precancerous stem cell is a mutated stem cell that highly express stemness factors such as ... are able to transform into primary cancer stem cells or benign tumor stem cells depending on the microenvironment While benign tumor stem cells may be originated from normal stem cells and become ... primary cancer stem cells can evolve into chemoradioresistant cancer stem cells is not well known but recent studies provided indirect evidence for the existence of chemoradioresistant cancer stem cells...

Ngày tải lên: 18/06/2014, 19:20

... progress to cancer when precancerous stem cells transform into primary cancer stem cells [64] Second, precancerous stem cell is a mutated stem cell that highly express stemness factors such as ... are able to transform into primary cancer stem cells or benign tumor stem cells depending on the microenvironment While benign tumor stem cells may be originated from normal stem cells and become ... primary cancer stem cells can evolve into chemoradioresistant cancer stem cells is not well known but recent studies provided indirect evidence for the existence of chemoradioresistant cancer stem cells...

Ngày tải lên: 20/06/2014, 03:20

... their stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or from ... markers for MSCs will aid in identifying the osteosarcoma CSC Possible Niche for Osteosarcoma Cancer Stem Cells Normal stem cells are found within niches (microenvironments) that support the stem cell ... maintain their stem cell characteristics [20] Like normal stem cells, CSCs also require a microenvironmental niche to maintain stemness CSCs may form their own niche or take over normal stem cell niches...

Ngày tải lên: 20/06/2014, 04:20

... their stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or from ... markers for MSCs will aid in identifying the osteosarcoma CSC Possible Niche for Osteosarcoma Cancer Stem Cells Normal stem cells are found within niches (microenvironments) that support the stem cell ... maintain their stem cell characteristics [20] Like normal stem cells, CSCs also require a microenvironmental niche to maintain stemness CSCs may form their own niche or take over normal stem cell niches...

Ngày tải lên: 20/06/2014, 07:20

... population of stem/ progenitor cells in the breast cancer (MCF7) cell line [11] The fact that the vast majority of MCF7 stem cell enriched SP cells express MUC1 suggests that epithelial cancer stem cells ... HER2-overexpression in breast cancer cells enriched the cancer stem cell population, evidenced by an increased number of tumor sphere formation and cancer stem cell marker aldehyde dehydrogenase ... overexpressed ovarian cancer cells induce the aggressiveness of the cancer cells and enrich the cancer stem cell population It also showed that MUC4 is expressed in the ovarian cancer stem cell population...

Ngày tải lên: 20/06/2014, 07:20

... a cancer stem cell compartment [8] The existence of cancer stem cells would explain why only a small minority of cancer cells is capable of extensive proliferation within the tumor Furthermore, ... explanation - that tumors are initiated and driven by a single, abnormal type of cancer stem cell, resulting in a population of genetically identical tumor cells This is the cancer stem cell hypothesis’ ... selection theory If LgR5 marks stem cells, there are many of LgR5 negative non -stem cells, which are nevertheless cycling Therefore a combination of clonal selection and cancer stem cell model, as...

Ngày tải lên: 10/08/2014, 10:21

... of abbreviations CSC: cancer stem cell; bFGF: basic fibroblast growth factor; FGFR: fibroblast growth factor receptor; HSC: hematopoietic stem cell; MSC: mesenchymal stem cell; ALDH: aldehyde ... stem cells - old concepts, new insights Cell Death Differ 2008, 15:947-958 Bomken S, Fiser K, Heidenreich O, Vormoor J: Understanding the cancer stem cell Br J Cancer 103:439-445 Kondo T: Stem cell- like ... Aldefluorhigh CD133high cells were able to differentiate into mature adipocytes more efficiently than the other sorted cell populations (Figure 4) Aldefluorhigh CD133high cells form tumors more efficiently...

Ngày tải lên: 13/08/2014, 15:21

... monoclonal expansions of transformed cells - but rather as complex tissues where abnormal growth is driven by a minority of cancer stem cells These cancer stem cells possess tumour-related features ... accountable for the majority of colorectal cancers (Figure 2) The other major pathway to sporadic colorectal cancers is the CpG island methylator phenotype (CIMP), which includes the sporadic microsatellite ... pancreatic cancer (Li et al., 2007) 14 Figure A simplified model of malignant transformation based on the cancer stem cell concept This model describes the transformation of a tumour cell from a normal...

Ngày tải lên: 03/10/2015, 20:57

... administration or neural stem cell transplant A: reddish brown coloration of caspase III immunoreactivity along the ventricular lining of cells of ischemic rat having undergone neural stem cell transplant ... transplant for four weeks, B: caspase III+ cells took the glial morphology Scale bar: 75 μm Data from our present and previous studies demonstrate that a minority of implanted donor stem cells can ... spinal cord contusion injury model Biomed Environ Sci 2007, 20:242-249 Lindvall O, Kokaia Z, Martinez-Serrano A: Stem cell therapy for human neurodegenerative disorders–how to make it work Nat...

Ngày tải lên: 18/06/2014, 16:20

... at 37°C, 5% CO2 for 18 h The tumor targets included the tumor cell line used for vaccination (mGC8) and a related gastric tumor cell line (424GC) An unrelated, syngeneic tumor cell line (MCA 310) ... the tumor cells in the LRAST treatment In order to determine whether the protected (tumorfree) mice had developed a systemic, long-term antitumor immunity, we injected live mGC8 tumor cells into ... tumors GM-CSF significantly reinforced the tumor-specific immune response induced by the tumor vaccine Furthermore, we observed a transient reduction of Tregs, supporting the priming of a tumor-specific...

Ngày tải lên: 18/06/2014, 22:20

... invertebrate models for stem- cell research They present a number of advantages, including the fact that a large pool of stem cells is available throughout the lifetime of each individual; the stem- cell ... of these remarkable stem cells However, current research in stem- cell biology is providing increasing evidence that the behaviors and fates of stem cells are not inherent, cell- autonomous properties, ... planarian Schmidtea mediterranea Cell Stem Cell 2008, 3:327-339 Pfister D, De Mulder K, Hartenstein V, Kuales G, G B, Marx F, Morris J, Ladurner P: Flatworm stem cells and the germ line: Developmental...

Ngày tải lên: 06/08/2014, 19:21

... prostate formation by the transformed P63+ basal /stem cells in the metastatic loci The data evidently demonstrated both cancer cell and stem cell characteristics of the transformed P63+ basal /stem cells, ... cancer cells Conventional human prostate cancer cells include malignant cells of luminal, basal or neuroendocrine origin at various proportions and unlike the ChgA- luminal cancer cells, tumor ... P63+ basal /stem cells and to examine whether these cancer cells can maintain stem cell characteristics after metastasis More importantly, we intended to elucidate whether P63 + basal /stem cells can...

Ngày tải lên: 10/08/2014, 05:21

... proposed to be the markers of cancer stem cells Their expression in tumor cells could correlate with their aggressive biological behavior, drug resistance and poor prognosis, which are common ... tumor cells In particular, AK1C1, and AK1C3 are reported in human non-small cell lung carcinoma (A549) cells [21], and a high expression of AL1A1 in lung cancer cell lines, especially in AC cell ... ages for each group (p = 0.076 by ANOVA, mean age + SD: 68.4 + 6.3 for LCNEC, 69.8 + 6.8 for SCLC, and 62.8 + 7.7 for LCC) and the number of male accounts for over 80% for all groups The majority...

Ngày tải lên: 10/08/2014, 09:22

... previously reported [17,18] C18 ZipTips (Millipore) were conditioned on a robotic liquid handling system (FluidX XPS-96 for the cord blood plasma samples or Proteome Systems Xcise for the melanoma ... the data is used for training the network, 20% for testing (i.e early stopping criteria based on mean squared error (MSE) for ANN) and the remaining 20% for validating the model We re-sampled ... genetic-algorithm-neural network (GANN) Genetic algorithm-neural network (GANN) is the bespoke hybrid genetic algorithm (GA) and artificial neural network (ANN) program that was developed for microarray...

Ngày tải lên: 13/08/2014, 13:21

... Heidenreich O, Vormoor J: Understanding the cancer stem cell Br J Cancer 2010, 103:439-445 11 Lindeman GJ, Visrader JE: Insights into the cell of origin in breast cancer and breast cancer stem cells Asia ... of cancer stem cells into models of clonal evolution leads to the prediction that in cancers which contain stem cells, clonal evolution of stem cells may be considerably faster than somatic cell ... number of stem cells is calculated by assuming one stem cell per 57 000 non -stem cells [28] A greater proportion of stem cells would result in a less dramatic difference Naugler Theoretical Biology...

Ngày tải lên: 13/08/2014, 16:20

... with the cell' s normal counterpart More practically, transformed cells are also defined by the set of oncogene/suppressor genes that are active within the cell and the number of different cellular ... CML progenitor cells that exhibited the chromosome translocation [32] Figure notypic entropy A normal cell, N, is transformed thereby increasing its pheA normal cell, N, is transformed thereby ... inhibitor, the greater the effect the inhibitor has on reducing cellular growth and /or inducing apoptosis Furthermore, if the inhibitor contributes to the differentiation of the transformed cell, ...

Ngày tải lên: 13/08/2014, 23:20

... astrocyte progenitor cells and their transformation into terminally differentiated oligodendrocytes This model is widely applicable to other in vitro cell systems The precursor cell that gives ... progenitor for the two cell types it could generate in vitro This cell is also known as an oligodendrocyte precursor cell (OPC), and will be referred to henceforth as an O-2A/OPC Such cells appear ... not for citation purposes) Theoretical Biology and Medical Modelling 2006, 3:21 0.045 Correlations We computed correlation coefficients between the times to division for all sister cells and for...

Ngày tải lên: 13/08/2014, 23:20

... each cell type in the models of stem cell differentiation Model Descriptions Definitions Pluripotent stem cell C57Bl/6 cell line A Adult neural stem cell *Neurosphere LVB A Adult mature neural cell ... MF, Fuller M: Stem cells and cancer: two faces of eve Cell 2006, 124:1111-1115 Huntly BJ, Gilliland DG: Leukaemia stem cells and the evolution of cancer- stem- cell research Nat Rev Cancer 2005, ... hematopoietic stem cells †CD45+ c-Kit+ Sca-1+ reports A NSC reviews ESC comment Abbreviation Stem cells and progenitor cells are defined in terms of their surface markers (†by FACS sorting) and /or growth...

Ngày tải lên: 14/08/2014, 20:22

... bào, tự đổi mới, biệt hóa nhiều dòng tế bào, tế bào gốc tạo tế bào gốc TẾ BÀO GỐC UNG THƯ (CANCER STEM CELL - CSC) Tế bào ung thư tạo bướu (bướu đặc bướu huyết học), đặc biệt khả làm phát sinh...

Ngày tải lên: 27/08/2014, 19:00