cancer stem cell markers

Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations

Ngày tải lên : 03/10/2015, 20:57

... Significance of Cancer Stem Cells in Colorectal Cancer Associations of Cancer Stem Cell Markers with KRAS, BRAF and Microsatellite Instability Conclusion 74 76 79 82 85 87 iv SUMMARY Colorectal cancer ... cancer development In particular, we intend to: (i) study the prognostic and predictive effect of cancer stem cell markers in colorectal cancers (ii) examine the associations of cancer stem cell ... Predictive Significance of Cancer Stem- Cell Markers For the study of the prognostic and predictive significance of the cancer stemcell markers, a cohort of 501 consecutive colorectal cancer cases treated...

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Báo cáo sinh học: "Cancer stem cell subsets and their relationship" pot

Ngày tải lên : 18/06/2014, 19:20

... distinguish precancerous stem cells from primary cancer stem cells First is the location Precancerous stem cells mainly exist in precancerous lesions, but primary cancer stem cells exist in primary cancer ... lesions progress to cancer when precancerous stem cells transform into primary cancer stem cells [64] Second, precancerous stem cell is a mutated stem cell that highly express stemness factors such ... Relationships among cancer stem cell subsets Up to now, precancerous stem cells, primary cancer stem cells and migrating cancer stem cells have been proven to exist in the progression of cancer [45,52,61,62],...

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báo cáo hóa học:" Cancer stem cell subsets and their relationships" pot

Ngày tải lên : 20/06/2014, 03:20

... distinguish precancerous stem cells from primary cancer stem cells First is the location Precancerous stem cells mainly exist in precancerous lesions, but primary cancer stem cells exist in primary cancer ... lesions progress to cancer when precancerous stem cells transform into primary cancer stem cells [64] Second, precancerous stem cell is a mutated stem cell that highly express stemness factors such ... Relationships among cancer stem cell subsets Up to now, precancerous stem cells, primary cancer stem cells and migrating cancer stem cells have been proven to exist in the progression of cancer [45,52,61,62],...

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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" pot

Ngày tải lên : 20/06/2014, 04:20

... confirm their stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or ... treatments The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within a heterogeneous tumor there is a small subpopulation of cells called cancer stem cells (CSCs)” ... mesenchymal stem cells Stem Cells 2007, 25:371-379 Kuhn NZ, Tuan RS: Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis J Cell Physiol...

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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" ppt

Ngày tải lên : 20/06/2014, 07:20

... confirm their stem cell nature [13] Cells of Origin for Osteosarcoma Cancer Stem Cells CSCs have been proposed to arise either from the transformation of normal stem cells to cancerous stem cells or ... treatments The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within a heterogeneous tumor there is a small subpopulation of cells called cancer stem cells (CSCs)” ... mesenchymal stem cells Stem Cells 2007, 25:371-379 Kuhn NZ, Tuan RS: Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis J Cell Physiol...

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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt

Ngày tải lên : 20/06/2014, 07:20

... overexpressed ovarian cancer cells induce the aggressiveness of the cancer cells and enrich the cancer stem cell population It also showed that MUC4 is expressed in the ovarian cancer stem cell population ... population of stem/ progenitor cells in the breast cancer (MCF7) cell line [11] The fact that the vast majority of MCF7 stem cell enriched SP cells express MUC1 suggests that epithelial cancer stem cells ... universal markers such as CD133, CD44, CD24, ESA and ALDH1 in different cancers [1] Few of these markers were used for the confirmation of an MUC4 enriched cancer stem cell population Stem cells and cancer...

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báo cáo khoa học: " LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus?" ppsx

Ngày tải lên : 10/08/2014, 10:21

... intestinal stem cell marker LgR5 might also be suited to identify cancer stem cells, these might be the actively cycling Barrett (cancer) stem cells Our findings are in line with current cancer models ... The existence of cancer stem cells would explain why only a small minority of cancer cells is capable of extensive proliferation within the tumor Furthermore, these cancer stem cells may be inherently ... theory If LgR5 marks stem cells, there are many of LgR5 negative non -stem cells, which are nevertheless cycling Therefore a combination of clonal selection and cancer stem cell model, as previously...

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Báo cáo y học: "Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential" pot

Ngày tải lên : 13/08/2014, 15:21

... G, Medema JP: Cancer stem cells - old concepts, new insights Cell Death Differ 2008, 15:947-958 Bomken S, Fiser K, Heidenreich O, Vormoor J: Understanding the cancer stem cell Br J Cancer 103:439-445 ... than markers: biological significance of cancer stem cell- defining molecules Mol Cancer Ther 9:2450-2457 43 Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, et al: Colon cancer stem cells ... combination with other stem cell markers improves the enrichment of CSCs [8,13,42] A likely cell of origin for the sarcoma-CSC is an MSC-like stem or progenitor cell However, since no markers are known...

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Báo cáo y học: ":Identification of novel stem cell markers using gap analysis of gene expression data" ppsx

Ngày tải lên : 14/08/2014, 08:20

... method produces a set of 4,449 cell and tissue markers, including 45 out of 71 known stem cell markers (69%) Analysis of the markers that segregate six types of stem cells (hematopoietic, mast, ... differentiated sets of stem cells We chose six pairs of stem cell samples and their differentiated derivatives from our dataset (two embryonic stem cell lines, hematopoietic stem cells [HSCs], osteoblasts, ... appears to be no single stemness gene for all stem cells [60] This set of 426 markers of stem cell differentiation allowed us to make some general observations regarding stem cell function and evolution...

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Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx

Ngày tải lên : 10/08/2014, 09:22

... profiling of cancer stem cell in human lung adenocarcinoma A549 cells Mol Cancer 2007, 6:75 19 Pfeiffer MJ, Smit FP, Sedelaar JP, Schalken JA: Steroidogenic enzymes and stem cell markers are up-regulated ... tumor cells In particular, AK1C1, and AK1C3 are reported in human non-small cell lung carcinoma (A549) cells [21], and a high expression of AL1A1 in lung cancer cell lines, especially in AC cell ... inhibitor in the MAP kinase pathway, is effective to malignant tumor cells with AL1A [29] AL1A1 would be not only cancer stem cell markers, but also an attractive target of treatment of LCNEC In addition...

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Báo cáo y học: "A simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studies" pptx

Ngày tải lên : 13/08/2014, 13:21

... labelled the samples into two groups - Low (< 30 CD45 sidescatter low/CD34+ stem cells/μL blood) and High (~100 cells/μL) stem content This collection of plasma produced 158 samples, each associated ... 70 samples were categorised as containing a “High” number of stem cells and the remaining 88 samples with a “Low” number of stem cells Methods 4.1 Data preprocessing The proposed data preprocessing ... simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studies Clinical Proteomics 2011 8:14 Submit your next manuscript to BioMed Central...

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Báo cáo y học: "Population genetics of cancer cell clones: possible implications of cancer stem cells" pptx

Ngày tải lên : 13/08/2014, 16:20

... Clark MF, Weisman IL: Stem cells, cancer and cancer stem cells Nature 2001, 414:105-111 15 Shipitsin M, Polyak K: The cancer stem cell hypothesis: in search of definitions, markers, and relevance ... J: Understanding the cancer stem cell Br J Cancer 2010, 103:439-445 11 Lindeman GJ, Visrader JE: Insights into the cell of origin in breast cancer and breast cancer stem cells Asia Pac J Clin ... of cancer stem cells into models of clonal evolution leads to the prediction that in cancers which contain stem cells, clonal evolution of stem cells may be considerably faster than somatic cell...

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Stem cell and cancer 2014

Ngày tải lên : 27/08/2014, 19:00

... bào, tự đổi mới, biệt hóa nhiều dòng tế bào, tế bào gốc tạo tế bào gốc TẾ BÀO GỐC UNG THƯ (CANCER STEM CELL - CSC) Tế bào ung thư tạo bướu (bướu đặc bướu huyết học), đặc biệt khả làm phát sinh...

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Human pluripotent stem cell derived cellular vehicles for cancer gene therapy

Ngày tải lên : 09/09/2015, 10:08

... Stem cells- unique candidates for therapeutic platform 1.2.1 What are stem cells 1.2.1.1 Pluripotent stem cells 19 20 20 1.2.1.1.1 Embryonic stem cells 20 1.2.1.1.2 Induced pluripotent stem cells ... pluripotent stem cells 21 1.2.1.2 Adult stem cells 23 1.2.1.2.1 Mesenchymal stem cells 23 1.2.1.2.2 Neural stem cells 23 1.2.2 Clinical relevance of stem cell vectors for cancer gene therapy 24 1.2.3 New ... cultivation 1.2.1.2 Adult stem cells - Multipotent stem cells that can form some specific types of cells in their family 1.2.1.2.1 Mesenchymal stem cells Mesenchymal stem cells (MSCs) were first...

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Human embryonic stem cell derivatives as cancer therapeutics

Ngày tải lên : 09/09/2015, 18:52

... Human embryonic stem cell Human embryonic stem cell derived dendritic cell Human embryonic stem cell derived mesenchymal stem cell Human embryonic stem cell derived neural stem cell Hematopoietic ... observed 1.2 Adult stem cells and cancer therapy Stem cells, by definition, possess two main characteristics Stem cells are able to produce daughter cells that retain their stem cell potential (selfrenewal), ... dendritic cell Myeloid progenitor cells Mesenchymal stem cell Natural killer T cell Neural stem cell Poly(2-hydroxyethylmethacrylate) Protein phosphatase 1, regulatory subunit 12C Pluripotent stem cell...

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Tế bào gốc (Stem cell)

Ngày tải lên : 18/08/2012, 20:56

... loại tế bào gốc trưởng thành giai đoạn biệt hóa thấp c/ Tế bào gốc trưởng thành (Adult stem cells/Somatic stem cells): Còn gọi tế bào gốc thân Là tế bào chưa biệt hóa tìm thấy với số lượng mô người ... tế bào gốc thai, tế bào gốc trưởng thành a/ Tế bào gốc phôi (Embryonic stem cells-ESCs) tế bào mầm phôi (Embryonic germ cells) Tế bào gốc phôi tế bào gốc vạn lấy từ phôi giai đoạn sớm (4-7 ngày ... tế bào, mô định Các tế bào gốc phôi lấy từ khối tế bào bên (inner cell mass) tế bào gốc vạn c/ Tế bào gốc đa (multipotent stem cells): Là tế bào có khả biệt hóa thành nhiều loại tế bào thể từ...

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Tài liệu Review of Chronic Graft- Versus-Host Disease in Children After Allogeneic Stem Cell Transplantation: Nursing Perspective pptx

Ngày tải lên : 12/02/2014, 19:20

... common after peripheral blood stem cell transplantation than BMT because it is generally accepted that peripheral blood stem cells con tain greater numbers of infused T-cells (Bishop, 2009; Schmitz ... graft-versus-host disease; PBSCT, peripheral blood stem cell transplantation; BMT, bone marrow transplantation; UBMT, unrelated bone marrow transplantation; T-UBMT, T -cell- depleted bone marrow transplantation; ... double-positive cells expressing CD4+CD8+ antigens These double-positive cells undergo a process referred to as negative selection or apoptosis (Kansu, 2004) Only a few CD4 or CD8 single-positive cells...

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Tài liệu INNOVATIONS IN STEM CELL TRANSPLANTATION doc

Ngày tải lên : 18/02/2014, 04:20

... any cell type A stem cell does not differentiate directly to a specialized cell, however There are often multiple intermediate stages A stem cell will first differentiate to a progenitor cell ... investigating the role of stem cells in cell transplantation or regenerative medicine increased remarkably across all sections of the stem cell related journals The largest number of stem cell articles was ... aspects of stem cells and cell transplantation Although we are close to finding pathways for stem cell therapies in many medical conditions, scientists need to be careful how they use stem cells ethically...

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Tài liệu New Advances in Stem Cell Transplantation Edited by Taner Demirer ppt

Ngày tải lên : 20/02/2014, 08:20

... remain a stem cell, or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell Because of the unique abilities of stem cells, as ... Keratinocytes ND ND Neural stem cells

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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot

Ngày tải lên : 06/03/2014, 09:22

... endothelial cells, pancreas, liver astrocytes Acts on activated T cells Acts on lymphocytes, dendritic cells, haematopoetic cells LD78b (CCL3 ⁄ L1) Eotaxin (CCL11) Expressed by T cells, B cells and ... melanoma cells and in ovarian carcinoma cells [94,95] In vivo, nude mice injected with DPIV-overexpressing cancer cells showed inhibition of tumour progression compared with control cancer cells ... invasiveness of cells [89] Overexpression of DPIV in cell lines results in interesting cell- behavioural effects Our studies have found that 293T epithelial cells transfected with DPIV exhibited less cell...

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