cancer of unknown primary site

... neuroendocrine carcinomas of unknown primary site 17 years after the initial diagnosis of the synchronous described malignancies Neuroendocrine tumors from an unknown primary site are uncommon; they ... clinical evidence of the primary site Our patient is undergoing a palliative chemotherapy based on a combination of cisplatin and etoposide Discussion An association of multiple cancers in a single ... carcinoma from an unknown primary site: A case report and review of the literature Journal of Medical Case Reports 2011 5:462 Authors’ contributions MM was involved in the analysis of the data and...

Ngày tải lên: 10/08/2014, 23:20

... small number of patients; primary tumors were identified in ~21–30% The diagnostic contribution of PET to the evaluation of noncervical CUP is controversial PET or PET-CT helps to detect primary tumor ... 20–35% of patients PET-CT can be helpful for patients who are candidates for surgical intervention for solitary metastatic disease because the presence of disease outside the primary site will ... adenopathy MRI of the breast is a recognized follow-up modality in patients with suspected occult primary breast carcinoma (following negative mammography and sonography findings) The results of these...

Ngày tải lên: 07/07/2014, 04:20

... URO-III, thrombomodulin Bladder cancer Α Fetoprotein Hepatocellular cancer, germ cell cancer β-Human chronic gonadotropin Germ cell cancer Prostate specific antigen Prostate cancer ... Useful in the Diagnosis of CUP Tissue Marker Estrogen and progesterone receptors Breast cancer BRST-1 Breast cancer Gross cystic disease fibrous protein15 Diagnosis Breast cancer Thyroid transcription ... transcription factor Lung and thyroid cancer Thyroglobulin Thyroid cancer Chromogranin, synaptophysin, neuron Neuroendocrine cancer specific enolase CDX-2 Gastrointestinal cancer Calretinin, mesothelin...

Ngày tải lên: 07/07/2014, 04:20

... profiles Typically, a training set of gene profiles from known cancers (preferably from metastatic sites) are used to train the software The program can then be used to predict the origin of ... the role of molecular studies in CUP Carcinoma of Unknown Primary: Treatment General Considerations The treatment of CUP continues to evolve, albeit slowly The median survival duration of most ... positive in lung and thyroid cancers Approximately 68% of adenocarcinomas and 25% of squamous cell lung cancers stain positive for TTF-1, which helps differentiate a lung primary tumor from metastatic...

Ngày tải lên: 07/07/2014, 04:20

... characteristics of ovarian cancer but no ovarian primary tumor identified on transvaginal sonography or laparotomy Studies suggest that ovarian cancer and PPSC, which are both of mullerian origin, ... confirmatory evidence of prostate cancer in these patients Those with elevated levels are candidates for hormonal therapy for prostate cancer, although it is important to rule out other primary tumors ... Treatment of Favorable Subsets of CUP Women with Isolated Axillary Adenopathy Women with isolated axillary adenopathy with adenocarcinoma or carcinoma should be treated for stage II or III breast cancer...

Ngày tải lên: 07/07/2014, 04:20

... of unknown primary site Br J Cancer 89(Suppl 1):S59, 2003 Culine S et al: Cisplatin in combination with either gemcitabine or irinotecan in carcinomas of unknown primary site: Results of a randomized ... biology of unknown primary tumors Semin Oncol 20:238, 1993 [PMID: 8503019] Bugat R et al: Summary of the standards, options and recommendations for the management of patients with carcinoma of unknown ... etoposide in the treatment of carcinoma of unknown primary site Semin Oncol 24(6 Suppl 19):S19, 1997 Kende AI et al: Expression of cytokeratins and 20 in carcinomas of the gastrointestinal tract...

Ngày tải lên: 07/07/2014, 04:20

... imaging techniques and the emergence of targeted therapies that have been shown to be effective in several cancers, oncologists must decide on the extent of workup that is warranted Specifically, ... procedures may affect the choice of therapy and the patient's survival and quality of life The reason tumors present as CUP remains unclear One hypothesis is that the primary tumor either regresses ... so small that it is not detected It is possible that CUP falls on the continuum of cancer presentation where the primary has been contained or eliminated by the natural body defenses Alternatively,...

Ngày tải lên: 07/07/2014, 04:20

... on the discovery of metastases This ‘type’ of cancer is known as a cancer of unknown primary (CUP) and represents a condition requiring specific clinical attention The origin of the metastasis ... their cancer of target tissue more often than the target tissue For thyroid carcinoma, five out of the six samples resembled the target tissue more than the cancer of target tissue However, four of ... ts-scores for that cancer Additional file 2: A summary of the reference data, the name of each cancer type and the number of samples it has Additional file 3: Heatmap of all genes and all cancers used...

Ngày tải lên: 11/08/2014, 12:21

... Lung Page of (page number not for citation purposes) Breast Cancer Research Vol No Satram-Hoang et al Table Risk of second primary cancer among men with first primary breast cancer Cancer site N ... increased risk of second primary breast cancer observed with Page of (page number not for citation purposes) Breast Cancer Research Vol No Satram-Hoang et al Table Risk of second primary cancer by ... use of fractions of years if applicable Person-years of observation were calculated two months from the date of breast cancer diagnosis up to and including age 85, the date of the second primary...

Ngày tải lên: 22/03/2014, 17:20

... the diagnosis of papillary thyroid cancer, SPMs of the breast were observed All these patients had been already operated at the moment of the interview and their diagnosis of breast cancer had been ... mean time interval between the diagnosis of thyroid cancer and the subsequent diagnosis of breast cancer was 5.80 ± 3.24 years Two cases of detected breast cancer occurred within years from the ... incidence only of in situ SPM breast cancer, we observed an increased risk of invasive breast cancer Chen et al (2001) [3] and Brown et al (2008) [11] observed a higher incidence of SPM of the breast...

Ngày tải lên: 09/08/2014, 02:20

... amplification of this integration site (EU981810) from patient tissue [7] Discussion Current knowledge based on the analysis of several thousand retroviral integration sites suggests that target site ... sequencing studies of thousands of retroviral integration sites have to our knowledge never identified exactly the same site twice It therefore appears very unlikely that the sites illustrated ... reports of patient-derived XMRV integration sites nor have there been any descriptions of polytropic or modified polytropic MLV integration sites in human samples despite the apparent detection of...

Ngày tải lên: 13/08/2014, 01:20

... http://thomsonlifestylecentre.com/breast -cancer- screening-package The American Cancer Society recently launched new cancer of the breast screening recommendations The brand new recommendations stand to find the best ideas in cancer ... report any switch to their healthcare provider - Women having a lifetime chance of 20 % or greater for cancer of the breast ought to obtain an MRI and mammogram each year Women at moderate risk ... healthcare provider concerning the benefits and drawbacks of adding a yearly MRI There's no proof that MRI is an efficient screening tool for ladies of average risk - For ladies at high-risk, MRI screening...

Ngày tải lên: 27/01/2014, 08:52

Ngày tải lên: 16/02/2014, 15:20

... Fig Schematic view of the active site of ACE2 and tACE Binding interactions of the inhibitor (A) MLN-4760 at the active site of ACE2 and (B) lisinopril at the active site of tACE Hydrogen bonds ... inhibitor This study provides the first investigation of the importance of key active -site residues of ACE2 through site- directed mutagenesis, with the aim of providing practical evidence for their role ... result of replacing this single residue could not have 3517 Critical active -site residues of ACE2 been predicted simply by analysis of the active -site structure Further to this, the role of His505...

Ngày tải lên: 20/02/2014, 01:20

... potential PKA sites are present within the primary structure of munc18 according to the Ó FEBS 2002 Phosphorylation of syntaxin-1A by CKI and CKII (Eur J Biochem 269) 911 Fig Phosphorylation of syntaxin-1A ... The mass spectrometry of radioactive peptides showed the presence of a doubly charged phosphopeptide of mass 974.0 and a singly charged phosphopeptide of mass 1946.3 both of which correspond only ... on phosphopeptides from each of the constructs Because the site of phosphorylation by CKII was close to the N-terminus of syntaxin-1A, automated Edman degradation of the syntaxin (1–265) which...

Ngày tải lên: 22/02/2014, 04:20

... DNA-binding activity of Mhr1 in the absence of Mg2+, because the DNAbinding activities of other HP proteins are often increased by the addition of Mg2+ in vitro [31,32] In the presence of 10 mm EDTA, ... changes of Mhr1 after ssDNA binding (A) Schematic representation of the positions of the Trp residues in Mhr1 (B) Emission spectra of wild-type Mhr1 (0.5 lM) with varying concentrations of the ... ssDNA (µM) 1441 DNA-binding sites of Mhr1 T Masuda et al protein; Fig 1C) These results imply that the environment of some of the Trp residues changed after the binding of Mhr1 to the 74-mer ssDNA...

Ngày tải lên: 06/03/2014, 09:22

... NlaIII (CATG) sites were found between the site of the no tag D tag and a poly(dA) among the cDNA of the gene (Hs 436980) The blast results of another 11 sequences in the GenBank sequences of the products ... course of our research on the SAGE data of the human spermatozoa, we became aware that other methods [rapid reverse transcription–PCR analysis of unknown SAGE tags (RAST-PCR) [15], generation of ... serve as a primary library of spermatozoa cDNAs to be used for further studies Amplification of primary library The full-length cDNAs in spermatozoa were amplified by PCR with the use of Takara...

Ngày tải lên: 07/03/2014, 04:20

... comparison of tyrosine-phosphorylated proteins Table Phosphorylation sites of mouse and of human emerin Phosphorylation site Number of phosphorylated residues Peptide sequence Residues S-72 or Y-75 ... FEBS A Schlosser et al Tyrosine-phosphorylation of emerin Fig Identification of emerin and of tyrosine-phosphorylation sites (A) MS ⁄ MS spectrum of the mouse-emerin peptide DYNDD-pY-YEESYLTTK ... in-gel digestion to identify human emerin phosphorylation sites in HeLa cells This led to the identification of tyrosine phosphorylation sites of mouse and human emerin Results To identify tyrosine-phosphorylated...

Ngày tải lên: 07/03/2014, 12:20

... determination of the Km of GlcNAc, different concentrations of GlcNAc were used in the presence of 10 mM ATP For determination of the Km of ATP, different concentrations of ATP were used in the presence of ... ATP-binding subdomains, indicating a common structure of the ATPbinding sites of the two enzymes Interestingly, five of the six cysteines of GlcNAc kinase had an equivalent cysteine in glucokinase, ... feature of the active site of enzymes with phosphate binding sites [27] In GlcNAc kinase these cysteines seem to be C131 and C143 Their counterparts in glucokinase are C233 and C252 Mutations of these...

Ngày tải lên: 08/03/2014, 10:20

... and often produce a large number of possible analyses Out of the test set of 200 words, based on a lexicon consisting of around 3500 morphemes (including the ** entries), the average number of ... would be offset by a speed penalty T h e rules m a k e use of sets of characters Anything is a set consisting of all surface characters, BCDFGKPSTW and HJLMNqRVXYZ are sets consisting of those ... morphological analysis of words into morphemes based on user-defined rules The basic system does not offer analysis of words containing unknown morphemes, nor does it provide a rank ordering of the output...

Ngày tải lên: 09/03/2014, 01:20