calcium signalling and transport in mitochondria

... community and its people Establishing and understanding gender differences in transport needs, access and planning is important, particularly in that men and women have different economic and socio-cultural ... travelling to and from the river, minutes of travelling for primary production purposes, and 52 minutes of travelling to and from the field In addition to this, 74 minutes are spent travelling to and ... dung, 45 minutes tending to the fire and 114 minutes (1 hour 45 minutes) preparing and cooking food Other household activities take an average of 211 minutes (3 hours 31 minutes), bringing the...

Ngày tải lên: 15/02/2014, 01:20

... reduction in cell death in CAVM1 cells An intriguing mechanism, in this regard, is the presence of scaffolding domain in caveolin1 that binds to and inhibits the activity of several signaling proteins ... increase in cell number in sub-G1 and G0/G1 phase, with a corresponding decrease in other phases Interestingly, concentrations of RES between 10 and 100 μM induced a modest but reproducible increase ... signaling proteins in vitro and in situ, including the EGF and Neu receptors, Src-family kinases (Src/Fyn), PKCs, eNOS and the heterotrimeric G-proteins [32] Thus, it remains to be explained why over-expression...

Ngày tải lên: 18/06/2014, 15:20

... for publication on infrastructure design, signalling, and security in railway, as well as being useful for engineers and scientists interested in learning about or developing any system related ... costs in the harvesting and rail transport of sugarcane These efficiencies can be achieved through extending the time window of harvesting, reducing the number of harvesters, and investing in new ... Train loaded with on the way back to the mill 13 14 Infrastructure Design, Signalling and Security in Railway Light railway wagons loading and unloading 4.1 Loading The cane transport administration...

Ngày tải lên: 28/06/2014, 10:20

... Bratthall D: Increased IgA levels in saliva during pregnancy Scand J Dent Res 1984, 92:33-37 Mandel ID: Sialochemistry in diseases and clinical situations affecting salivary glands Crit Rev Clin Lab ... rates, since both unstimulated and paraffin-stimulated flow rates remained unchanged We did not find any difference in the concentrations of calcium and phosphate between the pregnant and nonpregnant ... resting conditions between 07:30 and 10:30 am, at least h after eating, following standard procedures [11] Subjects were asked to sit passively and expectorate into pre-weighed plastic containers...

Ngày tải lên: 11/08/2014, 23:22

... containing the dense material in an ultrathin consecutive section C) Detail of the region indicated in (B)(*), showing presence of nanoparticles in the electron dense material Bar in A and B ... an increasing number of commercial applications [1] Advances have been made in the field of biomedicine, including the development of tools for pathogen bio-detection, tissue engineering and ... were suspended in gelafundine, a commercial succinated gel (30 g/l gelatine, 0.45% w/v sodium chloride, 0.21 g/l calcium, Braun, Melsungen-Germany), and the solution was kept in water in an ultrasonic...

Ngày tải lên: 12/08/2014, 03:20

Ngày tải lên: 14/11/2014, 09:31

... challenges lingering including efficient spin injection from FM to graphene while 18 Chapter Introduction maintaining a low contact resistance Chapter discusses the fundamental physics of graphene band ... spinorbit coupling in graphene, metal/graphene contacts, the importance of a contact barrier for spin injection, diffusion and detection in graphene spin devices, and other factors influencing ... high-efficient spin-injection techniques for injecting from spin polarized sources into carbon Both theoretical and experimental studies have shown that spin-injection efficiency between magnetic metal and...

Ngày tải lên: 10/09/2015, 09:11

... in the center, which consists of the mosaic of small uninfected cells and large infected cells The infected cells contain O2 binding protein "leghemoglobin (Lb)" that keep an important role in ... First, fixed ammonia is incorporated into amide group of glutamine and then into glutamic acid and allantoin and allantoic acid There are two main pathways of fixed N transport to be distributed ... ground in a vibrating machine (CMT, Tokyo, Japan) into a fine powder Samples were analyzed for total N and 15 N using an automated N and C analyzer by Mass Spectrometry machine (Thermo Finnigan...

Ngày tải lên: 20/05/2016, 16:28

... between mitochondrial and chloroplastic targeting signals in terms of arginine and serine content (i.e not as high as in mitochondrial targeting signals) and may be slightly enriched in hydrophobic ... provided, and the insights that may be gained from a greater understanding of the mechanism of dual targeting for the targeting of location-specific proteins is discussed Targeting signals and mature ... residues In yeast, proteins targeted to mitochondria Fig Overview of dual targeting of proteins to mitochondria and chloroplasts in plant cells A gene encoding a dual-targeted protein may: (1)...

Ngày tải lên: 07/03/2014, 03:20

... within the mitochondrial matrix and was instrumental in gaining new insight into mitochondrial Ca2+ handling, i.e the topic of this review [13] In the chimeric cDNA, an aequorin moiety including an ... proteins that modify their activity upon binding of Ca2+ At first, these included cytosolic proteins, such as the Ca2+-dependent kinases [protein kinase C (PKC), CamK] or phosphatases (calcineurin) ... mitochondrial checkpoint Interestingly, the link between Ca2+ signalling and cell death has been reinforced by the study of an unrelated pro-apoptotic protein, the x-protein of the hepatitis B...

Ngày tải lên: 30/03/2014, 20:20

... one In both cases, the Ca2+ concentration increased gradually from the beginning of leaching, decreased after a peak, and then increased and decreased again This behavior indicates that the initial ... the transport of salts such as cations (Na+, Ca2+, Mg2+ and K+) and Cl- in a column were investigated by using a tensiometer and a four-electrode sensor, and the amounts of these salts in soil and ... of amount of moisture infiltration in column infiltration experiment Changes in precipitation, evapotranspiration, and falling infiltration are shown in Fig 15 In April and May, evapotranspiration...

Ngày tải lên: 05/09/2013, 09:38

... determined at least in duplicate for each sample by placing 100 lL cell suspension in preweighed aluminium foil and dried for 24 h at 80 °C L-Arabinose transport and catabolism in yeast Initial ... share a common transport system It was not possible though to infer anything about the type of inhibition It can transport and catabolism in yeast be seen in Fig that, in C arabinofermentans PYCC ... of l-arabinose catabolism in two yeast strains belonging to distinct species allowed us to gain a more general insight into pentose metabolism in this group of eukaryotic microorganisms and to...

Ngày tải lên: 19/02/2014, 00:20

... plates lacking leucine and tryptophan Diploid cells were resuspended and dropped in equal amounts on to plates lacking histidine and adenine with increasing methionine concentrations (A) Interactions ... data in yeast suggest that the Alr1 protein acts as a Mg2+-permeable ion channel [14] Using in vitro chemical cross-linking and in vivo split-ubiquitin assays to analyze protein–protein interactions, ... are printed in italic Single amino-acid exchanges in alr1–1 and alr1–31 at position 750 and 795, respectively, are indicated by grey boxes The R768E substitution introduced into Alr2p is indicated...

Ngày tải lên: 19/02/2014, 06:20

... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible From ... N-terminus are predicted to form a domain on the matrix side, and 36 form a domain extending into the intermembrane space In the third mutant (V79-G35) one might expect a protein to be inserted into ... mammalian ESSS proteins reveals a high degree of conservation in the C-terminal domain (including the transmembrane region), but a significant number of differences in the N-terminal domain (located on...

Ngày tải lên: 19/02/2014, 16:20

... found to linearly depend on the addition of protein (2.6 ± 0.04 lmolÆmin)1Æmg protein)1, with lg valinomycin), as well as of K+ (6.25 ± 0.16 unitsÆmEq)1 K+, with lg valinomycin) and valinomycin (0.51 ... human ligandins: characterization of a binding-site peptide Biochim Biophys Acta 955, 296–300 52 Gregus Z & Klaassen CD (1982) Role of ligandin as a binding protein and as an enzyme in the biliary ... containing 29 lM BSP and increasing concentrations of sucrose After attainment of the steady state, lL (¼ lg) valinomycin was added Data (n ¼ 3) are means ± SEM and were fitted to a straight line...

Ngày tải lên: 20/02/2014, 01:20

... missing links in insulin signal transduction? FEBS Lett 410, 3–10 Dedhar, S., Benjamin, W & Gregory, H (1999) Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling ... that of PKB protein and activity in the insulin treated and S-PKB cells, indicating that SLex might be regulated by other insulin-induced factor(s) in addition to PKB signalling pathways It is ... alteration in PKB protein was similar to that in PKB activity (Fig 7), suggesting that the insulininduced PKB protein was almost fully phosphorylated and activated Whether insulin was internalized...

Ngày tải lên: 21/02/2014, 00:20

... new elements of insulin signaling Insulin receptor substrate-1 and proteins with SH2 domains Diabetes 42, 643–650 White, M.F (1997) The insulin signalling system and the IRS proteins Diabetologia ... Chen, D., Fucini, R.V., Olson, A.L., Hemmings, B.A & Pessin, J.E (1999) Osmotic shock inhibits insulin signaling by maintaining akt protein kinase B in an inactive dephosphorylated state Mol Cellular ... events in insulin-induced signalling A normal level of phosphorylation of IRS-1,2 and PKB was observed by insulininduction after incubation with arsenite (data not shown) Whereas PI-3¢ kinase...

Ngày tải lên: 21/02/2014, 00:20

... long chain fatty acids (Elovl3), type iodothyronine deiondinase (Dio2), homeobox C9 (Hoxc9), insulin-like growth factor binding protein (Igfbp3), dermatopontin (Dpt), and b-actin are showed in Table ... standard deviation inflammatory response and IR development, were examined in mice As shown in Figure 3, PM 2.5 exposure induced a marked increase in macrophage (F4/80+ cells) infiltration in ... reduced in both eWAT and iBAT in response to PM2.5 exposure Recent studies have implicated PM2.5 in increased adipose inflammation and insulin resistance [11,12], and epidemiological studies indicate...

Ngày tải lên: 06/03/2014, 19:20

... fast membrane binding and integration into the Tic complex Reducing conditions on the other hand lead to solubilization into the stroma and increased interaction with its other known interaction ... N-terminal half of the protein, including the dehydrogenase domain Specific binding of the FNR is mediated by a unique series of proline/serine-rich repeat motifs located in the C-terminus For the integration ... involved in protein–protein interaction are blue and the dehydrogenase domains of Tic32 and Tic62 are shown in green Tic110 contains two transmembrane domains at the proximal N-terminus The topology...

Ngày tải lên: 07/03/2014, 03:20

... proteinaceous insertion machinery Other singlespanning proteins have also been suggested to use this membrane integration route, including the photosystem II subunits, PsbW and PsbX In describing ... N-terminal basic region, a hydrophobic central core and a polar C-terminal region ending in an Ala-X-Ala terminal processing site Proteins destined to be transported by the Tat pathway contain a ... immediate vicinity of the twin arginine motif, whereas Hcf106 cross-links less strongly to residues in the hydrophobic core and the early mature protein [32] Binding of the precursor can occur in the...

Ngày tải lên: 07/03/2014, 03:20