cac ung dung cua vi he thong ade 775x

... deemed hemorrhagic, the history was not included The body-mass index (BMI) was calculated as weight in kilograms divided by the square of the height in meters Blood pressure was measured at the time ... JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324 ... patients with rheumatoid arthritis with an onset in the 1980's and 1990's Ann Rheum Dis 2005, 64:1595-1601 28 Wang L, Feng G: Rheumatoid arthritis increases the risk of coronary heart disease via vascular...

Ngày tải lên: 09/08/2014, 10:20

... against Rheumatism, the Göteborg Association against Rheumatism, the King Gustaf V foundation, the Swedish Medical Research Council, the Nanna Svartz Foundation, Stiftelsen Goljes Minne, the Lundberg ... JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324 ... showing the median and the mean ± standard error of the mean Patients' age and disease duration are reported as the mean ± standard deviation P < 0.05 is considered significant Results The levels...

Ngày tải lên: 09/08/2014, 06:23

... their risk factors Materials and methods Subjects The cohort of RA patients met the American College of Rheumatology (ACR) 1987 revised criteria for the classification of RA, and has been previously ... levels were found at the time of the evaluation The percentage risk of coronary heart disease over the next 10 years was estimated using the 'CVD Risk Calculator' based on the Framingham Study ... a stroke was deemed hemorrhagic Body mass index (BMI) was calculated as weight in kilograms divided by the square of the height in meters Blood pressure was measured at the time of evaluation...

Ngày tải lên: 09/08/2014, 13:22

... purchased from Calbiochem (Schwalbach, Germany) Immunohistochemistry of RA synovium and FLS Immunohistochemical staining was performed on sections of synovium Briefly, the synovial samples were obtained ... in OA synovial tissues (Figure 1a) Strong RAGE expression was detected in the synovial lining and sublining layers and the perivascular area in RA synovial tissues The severity of synovial inflammation ... the stimulatory effect of IL-17 on RAGE expression, in rheumatoid synovium, the expression of RAGE was increased as the final outcome as we observed in immunohistochemical staining of RA synovial...

Ngày tải lên: 12/08/2014, 17:22

... transfected HEK 293 T cells To ensure that the observed reduction of the luciferase activity was not a result of cytotoxic activity of the CEdG-modified plasmid DNA, the viability of transfected HEK 293 ... each sample to the mean ratio of the unmodified pGL3 Control vector The results of the luciferase reporter gene assay with the CEdG-modified vector showed that the plasmid with the highest CEdG level ... sufficient sensitivity of the mass analysis, the analytes should elute with a maximal proportion of organic solvent into the ion source On the other hand, the LC should lead to the separation of...

Ngày tải lên: 30/03/2014, 04:20

... chest radiographs were obtained in all the subjects at the time of enrollment in the study, and were examined by two chest physicians for the presence of heart and pulmonary abnormalities The ... and testing the null hypothesis that the intercept is equal to zero and the slope is equal to one, jointly We utilized the data from the 200 COPD patients and the 201 age and sex-matched controls ... (table 3) With regard to lung function, there was a significant relationship between sRAGE and the degree of airflow obstruction, the lower the level of sRAGE the greater the airflow obstruction...

Ngày tải lên: 12/08/2014, 13:22

... of the paper JWK performed the animal experiments and contributed to the writing of the paper CDS supervised the animal experiments and contributed to the writing of the paper AS supervised the ... 1:500) Thereafter, the slides were again washed in PBS, followed by 30 minute incubation with anti-rabbit and anti-mouse EnVision-HRP (DakoCytomation, Heverlee, Belgium) The slides were then washed ... multiplied by the number of vessels positive for this score The multiplication scores were then added and the sum was divided by the area of the slide, resulting in a immunohistochemical score...

Ngày tải lên: 13/08/2014, 16:21

... cytokines ⁄ chemokines [11–13] Previous studies have revealed that endothelial cells are also a major target for LPS; with the help of soluble CD14 in the circulation, LPS directly activates endothelial ... permeability of endothelium, thus exaggerating the inflammatory response [20]; the chemoattractants IL-8 and MCP-1 induce leukocyte–endothelial cell adhesion and promote the migration and infiltration ... to the inflammatory loci, which is a key step in inflammation [21,22] Therefore, the cooperation of AGE-HSA and LPS on the induction of cytokines ⁄ chemokines in endothelial cells observed in the...

Ngày tải lên: 30/03/2014, 01:20

... hours The conditioned media were harvested and stored at -80°C until the measurements were performed Then, cells were detached and counted The results were corrected by the numbers of FLS in the ... in rheumatoid arthritis Rheumatology 2001, 40:302-309 Müller-Ladner U, Ospelt C, Gay S, Distler O, Pap T: Cells of the synovium in rheumatoid arthritis Synovial fibroblasts Arthritis Res Ther ... For preparation of the Master Mix, the FastStart DNA Masterplus SYBR Green I-Kit was used Together with the specific primers, the Master Mix was added to cDNA solutions The cDNA samples were...

Ngày tải lên: 09/08/2014, 14:22

... Briefly, the grade of lung fibrosis was scored on a scale of to using the following criteria: grade 0, normal lung; grade to 2, minimal fibrous thickening of alveolar or bronchiolar wall; grade to ... dose-dependent manner To confirm the effect of AG on the histopathological change of bleomycininduced pulmonary fibrosis, the overall grades of the fibrotic changes of the lungs were performed by Ashcroft ... the first time that AGEs may participate in the process of BLM-induced pulmonary fibrosis, at least partly implicated in TGFb/Smads-HSP47 pathway The further study should focus on whether the...

Ngày tải lên: 12/08/2014, 14:20

... prepared the tracers, performed the experiments, and revised the manuscript JL helped in the acquisition of data DW provided the highresolution gamma imaging device AMS and SFY developed the RAGE-/animal ... significantly higher than the WT diabetic group (P < 0.001) Figure 2B shows values as %ID/g for the four groups for the left and right hindlimbs The counts in the left (ischemic) hindlimbs showed the same ... incision was made on the upper thigh of both the left and right legs of each mouse The inguinal ligament and the upper half of the femoral artery were exposed On the left side, the vascular bundle...

Ngày tải lên: 21/06/2014, 02:20

... maintain their chondrogenic phenotype We determined whether primary human OA chondrocytes and chondrocytes passaged once used in these studies maintained their phenotype – by analyzing the expression ... that still-healthy cartilage of patients with a focal degenerative cartilage lesion elsewhere in the joint has higher AGE levels than healthy cartilage from control individuals in which there are ... proteins, while many others present protein–protein crosslinks Once AGEs are formed, they cannot be removed from the protein; they only leave a tissue when the protein involved is degraded Articular...

Ngày tải lên: 09/08/2014, 14:20

... Response: Winding the Way to the Pathogenesis of Endothelial Dysfunction and Atherosclerosis Ann NY Acad Sci 2008, 1126:7-13 189 Chen Y, Akirav EM, Chen W, Henegariu O, Moser B, Desai D, Shen JM, Webster ... bind other substrates [67,69] It remains to be determined if the action of the A-box is the result of competitive inhibition by binding to other substrates or interfering with the ability of the ... dose-dependent manner when both are added Is HMGB1 the lone RAGE activator of the HMG family? For all the reasons noted above, HMGB1 is the sole known HMG-box ligand of RAGE None of the other nuclear HMG...

Ngày tải lên: 18/06/2014, 15:20

... 3, the IgG-AGE levels were higher in the RA patient group at the initial visit as compared with the other groups studied, whereas the levels were similar in all groups at the year follow-up visit ... pathogenic process or whether they are merely the consequence of damage in the past The amount of AGEdamaged proteins present in an individual reflects not only the synthesis of the AGE, which can ... RF, rheumatoid factor follow up, whereas those positive for anti-IgG-AGE antibodies in the other groups had lower frequencies of such antibodies at the year follow up When the change in the anti-IgG-AGE...

Ngày tải lên: 09/08/2014, 01:21

... (-13.8%) induce a T-helper type isotypic switch in B lymphocytes, which may be involved in the pathogenesis of RA Further evidence of the role for TLR9 comes from the efficacy in RA of chloroquine ... media campaign followed by selection of individuals who fulfilled the 1987 American College of Rheumatology revised criteria for RA A rheumatologist reviewed all clinical data In each of 100 French ... association analysis The Hardy–Weinberg equilibrium was checked in control individuals, using a chi-square test with one degree of freedom The linkage analysis relied on the TDT, in which the observed...

Ngày tải lên: 09/08/2014, 01:22

... To our knowledge, the association between the VDR gene polymorphisms and OA has not been studied in the Finnish population The aim of the present study was to examine whether the VDR polymorphisms, ... examine the association between the VDR genotypes and hand OA To evaluate whether the association between the genotypes and OA is modified by daily calcium intake, the odds ratio (OR) of having OA ... odds and those with the AATT genotype the highest odds of hand osteophytes as compared with the AAtt genotype The direction of these associations contrast the findings in the studies of osteophytes...

Ngày tải lên: 09/08/2014, 07:20

... (-13.8%) induce a T-helper type isotypic switch in B lymphocytes, which may be involved in the pathogenesis of RA Further evidence of the role for TLR9 comes from the efficacy in RA of chloroquine ... media campaign followed by selection of individuals who fulfilled the 1987 American College of Rheumatology revised criteria for RA A rheumatologist reviewed all clinical data In each of 100 French ... association analysis The Hardy–Weinberg equilibrium was checked in control individuals, using a chi-square test with one degree of freedom The linkage analysis relied on the TDT, in which the observed...

Ngày tải lên: 09/08/2014, 13:22

... carrying the BclI GG genotype These observations are consistent with the effect of GR polymorphism on gene products and the role of GR in the control of the inflammatory response of the lung in ... of the studied polymorphisms with nutritional status and glucose metabolism Several reasons can be put forward to explain these results They include the types and the sensitivity of the phenotypic ... In the present study, we did not find association of the other studied GR polymorphisms with lung disease progression evaluated from the slopes of decline in lung function parameters Neither...

Ngày tải lên: 12/08/2014, 15:21

... which regulates the flow of the Gibbs free energy inherent in C–C bonds in fatty acids into the production of either chemical energy or heat by directing the flow of iPLA2c into either the peroxisomal ... indicated on the left AUG most proximal to the polyhedrin baculoviral promoter [38,39] Accordingly, the virtual absence of the 88 kDa protein product was unanticipated To begin identifying the reasons ... scale (kb) The 13 exons of the iPLA2c gene are indicated as boxes Spaces between the exons represent the relative sizes of the 12 introns contained within the iPLA2c gene Regions of the gene that...

Ngày tải lên: 19/02/2014, 16:20