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... facility at McGill University Animals were treated according to guidelines of the Canadian Council for Animal Care and protocols were approved by the Animal Care Committee of McGill University Forty-eight ... be the primary mechanism of cytotoxicity, with the acid production being secondary In a similar study from our laboratory, positive staining for 3-nitrotyrosine residues, a marker of oxidative ... proliferation occurring in the airway Increased levels of PCNA immunoreactivity were detectable by 48 hrs and maximal proliferative activity in the airways occurred d postexposure Compared to other studies...

Ngày tải lên: 12/08/2014, 15:21

... BAL neutrophilia was associated with early and overall mortality, but the effect on overall mortality was lost when disease severity was taken into account [3] The authors concluded that BAL findings ... Erlangen, Germany) were performed to determine forced vital capacity (FVC) and total lung capacity (TLC) The pulmonary diffusing capacity for carbon monoxide (DLCO) was determined with the single-breath ... Visual evaluation included a score of severity and a score of extent (range, to 30) and was performed as described [13] To assess intraoperator reproducibility, one radiologist (S.M.) repeated the...

Ngày tải lên: 09/08/2014, 14:22

... stimuli in adults Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal Official Statement of the European Respiratory Society Eur Respir J Suppl 1993, 16:53-83 ... asthma severity, including a varying amount or organization of elastic fibres [10,12,28-30] Therefore, subsequent studies including larger numbers of subjects with varying asthma severity and FCFM ... European Respiratory Society; EVG: Elastica-van Gieson; FCFM: fibered confocal fluorescence microscopy; FEV1: forced expiratory volume in second; FVC: forced vital capacity; GINA: Global Initiative...

Ngày tải lên: 12/08/2014, 13:22

... 6.3.3 U.S Lung Cancer Mortality Estimates Based on Results of Combined Estimates from 11 U.S Studies 6.3.3.1 U.S Lung Cancer Mortality Estimates for Female Never-Smokers ... 6.3.3.2 U.S Lung Cancer Mortality Estimates for Male Never-Smokers 6.3.3.3 U.S Lung Cancer Mortality Estimates for Long-Term (5+ Years) Former ... 6.3.4 U.S Lung Cancer Mortality Estimates Based on Results of the Fontham et al (1991) Study (FONT) 6.3.5 Sensitivity to Parameter Values ...

Ngày tải lên: 15/03/2014, 01:20

... each facility, blinded to mortality outcomes The estimates were based on measurements from 1998 to 2001 DEMS industrial hygiene surveys at each working mining facility, past Mine Safety and Health ... facility were matched to case subjects on the facility where the control subject worked the longest In facility-specific analyses, workers at multiple facilities were assigned to the facility where ... diesel exposure for each type of mining facility (Table 7) Too few workers were employed in the one salt and the one limestone mining facility to estimate risk for these types separately For workers...

Ngày tải lên: 22/03/2014, 17:20

... immunity), T lymphocytes (cellular immunity), macrophages (phagocytic and one of several types of antigen-presenting cells), and mast cells Immunity and T and B cells There are two types of immunity: ... Department of Anatomy and Cell Biology University of Kansas, School of Medicine Kansas City, Kansas New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore ... that result from the use of or inability to use the work, even if any of them has been advised of the possibility of such damages This limitation of liability shall apply to any claim or cause...

Ngày tải lên: 22/03/2014, 21:20

... (polysomes) It depends on the type of neuron whether groups of free polysomes or rER-bound ribosomes predominate While G.E Palade described ribosomes as particles with high affinity to contrast dyes as ... apparatus is the dictyosome or Golgi field In this section, it consists of a stack of 3–8 smooth (i.e., ribosome-free) slightly arcuate stacked membranes in close proximity to each other The ... 35 Golgi Apparatus The Golgi apparatus often contains several dictyosomes (Golgi fields) In cells with a polar structure, dictyosomes are usually localized in the supranuclear region The basic...

Ngày tải lên: 08/04/2014, 12:35

... medication was recorded Clinical measures of severity and response to therapy included improvement in percent predicted PEF after 60 and a four-point severity score, similar to the Acute Asthma Index ... were undertaken with Statview 5.0.1 (SAS Institute Australia Pty Ltd., NSW, Australia) and SPSS 15.0 for Windows (SPSS Australasia Pty Ltd., Chatswood, NSW, Australia) Results Acute asthma Fifteen ... relationships between plasma albuterol enantiomer levels and severity or response to treatment, measured both by the four-point severity score (Table 3) and percent improvement in predicted PEF at...

Ngày tải lên: 21/06/2014, 03:20

... for anti HIV drug development However, these show an insufficient bioavailability due to their limited water solubility This situation demands intensive efforts for development and characterization ... lysosomes could alter the pharmacological property, which could lead to a loss of function by degradation with intra-lysosomal enzymes To exclude this possibility, we used here the LysoTracker red staining ... motifs of the CAI-Inhibitor is monitored here by UV-CD polarity titration The ordinate reveals the relative percentage of structure type The abscissa shows the concentration of TFE in water To...

Ngày tải lên: 08/08/2014, 17:20

... only govern disease susceptibility in PM and DM, but also to govern the expression of certain phenotypic features common to both myositis subtypes The PM/DM subtype differences detected may be ... FS carried out the genotyping NF carried out the serological typing NS assisted with the statistical analysis BT assisted with the genotyping WT assisted with the genotyping and contributed to ... myositis serology p DQB1 p P, global probability for disease versus controls (using genotype data) n (%), number/percentage of patients with individual phenotypes and the presence of ILD As strong...

Ngày tải lên: 09/08/2014, 07:20

... immunophenotypic and genetic findings support the diagnosis of primary lung adenocarcinoma (papillary subtype) coexisting with a non-Hodgkin, B-cell lineage, mantle cell lymphoma involving both, visceral ... mitotic activity was low (< mitoses per 10 HPF) There were also foci of necrosis, hyalinosis and ossification Immunohistochemical stains showed the following tumor-cell immunophenotype: TTF-1(+) ... coexistence of different types of lung carcinomas and malignant lymphomas Chanel et al described a synchronous pulmonary adenocarcinoma and extranodal marginal zone lymphoma of MALT type [8] Rothenburger...

Ngày tải lên: 09/08/2014, 07:22

... expiratory volume in second to forced vital capacity (FEV 1.0%) was less than 70%, as constrictive dysfunction when the percent vital capacity (%VC) was less than 80%, and as mixed dysfunction ... respectively Toxicity was evaluated using the Common Terminology Criteria for Adverse Events Version Grade radiation pneumonitis (symptomatic but not interfering with activity of daily life) was ... not significantly influence SpO2 levels in the majority of patients Clinical outcome of our patients in terms of antitumor effect and toxicity compares favorably with that published recently [3,23],...

Ngày tải lên: 09/08/2014, 09:22

... Eligibility Eligible patients had no more than two targets and sufficient pulmonary function (FEV ≥ 1.0 l/s) Further criteria had to be fulfilled: Karnofsky performance status ≥ 60%, no proximity to ... initial remission was assessed months after single-dose radiation treatment had occurred Fifty-eight of sixty-four (90.6%) tumors responded to therapy (Fig 3a,b,c,d) The extent of tumor response ... follow-up period > 12 months Thirty-one of 33 NSCLC (94%) and 27 of 31 metastases (87%) manifested local control Relative to the number of lesions irradiated, the probability of Page of (page number...

Ngày tải lên: 09/08/2014, 10:21

... properties of candidate material including toxicity, toxigenicity, biocompatibility, biodegradability, durability, cell adhesion characteristics, and ability to mimic the function of a native organ ... fibromodulin, and types IX and XI collagen all interact with type II collagen and regulate collagen fiber assembly and structure Types II and VI collagen bind matrix receptors (integrins) Type II collagen ... of a variety of infectious and inflammatory respiratory diseases such as chronic bronchitis, asthma, chronic obstructive pulmonary disease, and cystic fibrosis These pathologies are typically...

Ngày tải lên: 10/08/2014, 05:21

... pleural space [15] We have tested the application of a lung synthetic sealant to evaluate the safety and efficacy of this surgical sealant for the treatment of parenchymal air leaks occurring after ... prospective randomized blinded study was carried out between January 2008 and December 2008 Forty-six consecutive adult patients with pleural empyema that received pleural decortication for empyema ... ventilated under positive-end expiratory pressure and warm saline was installed into the chest cavity to test air leaks The operating surgeon corrected any leaks surgically, until satisfied The patients...

Ngày tải lên: 10/08/2014, 09:22

... positivity ratio Staining positivity was defined if the ratio ≥ 10% (+), and negative if ration < 10% (-) As EGFR and COX-2 were not expressed in normal tissues, any observed positivity of EGFR ... negative 40.50% Ages 0.448 Sex 0.445 Female 11 42.10% Pathologic type Squamous carcinoma 13 40% Adencarcinoma 13 13 50% Mixed type 66.70% ≤3 cm 43.80% >3 cm 18 16 47.10% 21 19 40% 47.50% I-II ... gender, histopathologic type, cell differentiation, tumor size and TNM stages (P > 0.05) However, EGFR over-expression was correlated with lymph node metastasis, the probability of lymph node metastasis...

Ngày tải lên: 10/08/2014, 10:21

... local lymph node metastases EGFR mutations were detected in twenty-one primary tumors and twenty-six lymph node metastases The types and locations of the mutations in paired tumors were shown ... each patient DNA extraction Thirty mg of frozen tissue was shredded by scissors The E.Z.N.ATM Tissue DNA Kit (purchased by OMEGA) was used to extract genomic DNA Quality and concentration of the ... KRAS 73 6 case * E746-A750/L747-T751; L747-P753insS/R748-P752 Abbreviation: WT, wild type; MUT, mutational type Discussion NSCLC represents a major global health problem, but the introduction...

Ngày tải lên: 10/08/2014, 10:21

... 0.445 Pathologic type 0.543 Adencarcinoma 13 Mixed type P value 0.599 ≤60 43.80% 13 Positive expression rate negative positive Ages Squamous carcinoma COX-2 0.362 Pathologic type 0.022* 38.10% ... Oncology, Tumor Center, West China Hospital, Sichuan University, PR China 2Department of Pathology, West China Hospital, Sichuan University, PR China Table (corrected table five) COX-2 expression ... *P < 0.05 Table (corrected table four) COX-2 expression in neoplastic and normal tissue Tissue type 0.476 9.10% N1-3 TNM Stage 24 21 45 Total 27 23 50 There was no significant relationship between...

Ngày tải lên: 10/08/2014, 10:21

... decreased perfusion in the subsegment of the left lung, indicating a low probability of pulmonary emboli Lower extremity venous ultrasound showed no evidence of thrombosis Culture of bronchoalveolar ... spontaneous improvement Although hemoptysis following ESWL usually starts during or shortly after the procedure [4,6], our patient Page of first showed evidence of hemoptysis one week after ESWL Chest ... cooperation Author details Nephrology Department, Sadoughi Medical University, Yazd, Iran Pulmonary Department, Sadoughi Medical University, Yazd, Iran Received: 30 October 2009 Accepted: 31 August 2010...

Ngày tải lên: 11/08/2014, 03:21

... decreased perfusion in the subsegment of the left lung, indicating a low probability of pulmonary emboli Lower extremity venous ultrasound showed no evidence of thrombosis Culture of bronchoalveolar ... spontaneous improvement Although hemoptysis following ESWL usually starts during or shortly after the procedure [4,6], our patient Page of first showed evidence of hemoptysis one week after ESWL Chest ... cooperation Author details Nephrology Department, Sadoughi Medical University, Yazd, Iran Pulmonary Department, Sadoughi Medical University, Yazd, Iran Received: 30 October 2009 Accepted: 31 August 2010...

Ngày tải lên: 11/08/2014, 07:20