building a new model binder from scratch

... fibrosis via inhibition of vascular remodeling Am J Respir Crit Care Med 2005, 171:261-268 Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, Nakashima N, Maeyama T, Yoshimi M, Nakanishi ... obliterans organizing pneumonia J Pathol 2002, 196(2):220-227 Nakayama S, Mukae H, Ishii H, Kakugawa T, Sugiyama K, Sakamoto N, Fujii T, Kadota J, Kohno S: Comparison of BALF concentrations of ENA-78 ... suggesting that the hypovascular central area of the sarcoid granuloma can contain the microbe in a dormant sate and at the same time promote its eradication through Th1 mediating factors and the...

Ngày tải lên: 12/08/2014, 16:20

... alpha is required for solid tumor formation and embryonic vascularization EMBO J 17, 3005–3015 18 Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama ... BBB remains unclear The physical barrier resulting from tight, adherens and gap junctions enhances transcellular, rather than paracellular, transport when the brain parenchyma Regulation of angiogenesis ... toward an integrated theory that defines the entire cellular and molecular population, anatomically and functionally, as a single ‘unit’ In particular, the concept of a ‘neurovascular unit’ that...

Ngày tải lên: 18/02/2014, 11:20

... residue1173 in vasculogenesis in mice Proc Natl Acad Sci USA 102, 1076–1081 Sawano A, Iwai S, Sakurai Y, Ito M, Shitara K, Nakahata T & Shibuya M (2001) Vascular endothelial growth factor receptor-1 ... promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation Arterioscler Thromb Vasc Biol 26, 2019–2026 4642 Takahashi H, Hattori S, Iwamatsu A, Takizawa ... growth factor are secreted from neuronal cells, astrocytes and inflammatory cells, including macrophages that have infiltrated the stroke area Zhang et al [15] have shown that the intravenous administration...

Ngày tải lên: 18/02/2014, 11:20

... idea of EPC usage as a clinical application will have to be carefully developed and assessed before EPCs can be safely tested and applied in clinical stroke Taken together, accumulating data now ... human stroke Stroke 36, 1415–1420 24 Alvarez-Sabin J, Delgado P, Abilleira S, Molina CA, Arenillas J, Ribo M, Santamarina E, Quintana M, Monasterio J & Montaner J (2004) Temporal profile of matrix ... Total papers per years K Arai et al 50 Neurovascular responses in stroke facilitates neuronal plasticity and remodeling A systematic understanding of these responses may eventually lead us...

Ngày tải lên: 18/02/2014, 11:20

... GGTCTTGGTCAGCTCTGTGAGTC TRPC3 GACATATTCAAGTTCATGGTCCTC ACATCACTGTCATCCTCAATTTC TRPC4 GCTTTGTTCGTGCAAATTTCC CTGCAAATATCTCTGGGAAGA TRPC5 CAGCATTGCGTTCTGTGAAAC CAGAGCTATCGATGAGCCTAAC TRPC6 GACATCTTCAAGTTCATGGTCATA ... GCTACGAGCTGCCTGACGG GAPDH TATCGTGGAAGGACTCATGACC TACATGGCAACTGTGAGGGG TSP1 CCGGCGTGAAGTGTACTAGCTA TGCACTTGGCGTTCTTGT TRPC1 GATTTTGGAAAATTTCTTGGGATGT TTTGTCTTCATGATTTGCTATCA TRPC2 CATCATCAT-GGTCATTGTGCTGC ... GACATCTTCAAGTTCATGGTCATA ATCAGCGTCATCCTCAATTTC TRPC7 CAGAAGATCGAGGACATCAGC GTGCCGGGCATTCACGTGGTA Actin Annealing Cycle T (°C) number acquired with a Hamamatsu (Bridgewater, NJ) camera (10 s intervals,...

Ngày tải lên: 07/03/2014, 05:20

... primers (GAPDH and APN) were used for RT-PCR GAPDH (forward 5¢-TGAAGGTCGGTGTGAACG GATTTGGC-3¢, reverse 5¢-CATGTAGGCCATGAGGTC CACCAC-3¢); APN (forward 5¢-ATGGGCTATGGGTA GTTGCAGTCA-3¢, reverse 5¢-TAGCTTCATGCTTTGG ... Antibody (raised in rabbit) against FAEES was used to react with pure FAEES protein Lane shows no band (control lane) Rat albumin was used as control protein Lane shows a clear band at 60 kDa activity ... stained with a monoclonal antibody against elastin (Sigma) and a CY3-conjugated secondary antibody (Sigma) and examined using a confocal microscope (Zeiss LSM510, Carl Zeiss AG, Jena, Germany)...

Ngày tải lên: 30/03/2014, 11:20

... 3-node graph (9 from Fig 7) as its FTC 3u2: graphs each having a particular 3-node graph (10 from Fig 7) as its FTC 3b: 11 graphs each of which has a balanced 3-node graph as its FTC (in a balanced ... within a directed graph We say that A B if there exists at least one directed path from A to B There always exists a trivial directed path from any node to itself so that A The relation, A A is ... parameters depends on the choice of timescale for the model; a parameter at a shorter timescale may be considered a dynamical variable at a longer one However, there are other candidate mechanisms...

Ngày tải lên: 20/06/2014, 20:20

... 3-node graph (9 from Fig 7) as its FTC 3u2: graphs each having a particular 3-node graph (10 from Fig 7) as its FTC 3b: 11 graphs each of which has a balanced 3-node graph as its FTC (in a balanced ... within a directed graph We say that A B if there exists at least one directed path from A to B There always exists a trivial directed path from any node to itself so that A The relation, A A is ... parameters depends on the choice of timescale for the model; a parameter at a shorter timescale may be considered a dynamical variable at a longer one However, there are other candidate mechanisms...

Ngày tải lên: 21/06/2014, 17:20

... Gottlieb AB, Masud S, Ramamurthi R, Abdulghari A, Romano P, Chaudhari U, Dooley LT, Fasanmade AA, Wagner CL: Pharmacodynamic and pharmacokinetic response to anti-tumor necrosis factor-α monoclonal antibody ... (ICAM-1) J Immunol 1986, 137:245-254 Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, Murray JS, Siahaan TJ: Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation ... (Fig 1) At week 16 the mean PASI was 1.8 Table Demographic and clinical data of study patients at baseline Data Age (years) 49 (26–70) Male:female ratio 6:5 Duration of joint disease (years) (1–22)...

Ngày tải lên: 09/08/2014, 01:23

... mammary carcinoma and in a syngenic heterotopic allograft tumor model Tumor growth delay of syngenic mammary carcinoma allografts (A) and orthotopic spontaneous mammary carcinomas (B) in response ... radiation Obtaining preclinical data with spontaneous tumor models is highly laborious and cost-effective Our comparative study furthermore demonstrates that an allograft tumor model is adequate ... Broggini-Tenzer A, Caravatti G, Vuong V, Pruschy M: Hypoxia modulation and radiosensitization by the novel dual EGFR and VEGFR inhibitor AEE788 in spontaneous and related allograft tumor models Mol Cancer...

Ngày tải lên: 09/08/2014, 09:20

... data in public databases such as dbGaP [13] for use in (disease sub-type-specific) meta-analyses ITGAV is the latest example of a candidate gene that may be relevant to RA Increased significance ... Migliorini P, Balsa A, Westhovens R, Barrera P, Alves H, et al.: The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study Arthritis ... between PADI4 and CTLA4, but not with other associations [12] With OR in the range 1.1 to 1.2, variants of PADI4 and CTLA4 confer a similar risk to that of the new ITGAV variant Because confirmed associations...

Ngày tải lên: 09/08/2014, 10:21

... G, Nakazawa T, Morinobu A, Kumagai S: Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies Ann Rheum Dis 2009 in press Sakalihasan N, ... The association between case/control status and cardiovascular risk factors was examined by means of logistic regression models Each cardiovascular risk factor was examined individually and after ... surgical specimens as the standard for evaluating inflammation was chosen to increase the internal validity of the study Cases were selected from a large tertiary care referral center, perhaps...

Ngày tải lên: 09/08/2014, 13:22

... suggestions Author Details 1Instituto "Reina Sof a" de Investigación Nefrológica, Departamento de Fisiolog a y Farmacolog a, Universidad de Salamanca, Salamanca, Spain and 2Red Cooperativa de Investigación ... kidney of rats with unilateral ureteral obstruction Jpn J Pharmacol 2002, 90:361-364 51 Satoh M, Kashihara N, Yamasaki Y, Maruyama K, Okamoto K, Maeshima Y, Sugiyama H, Sugaya T, Murakami K, Makino ... Klahr S: Enalapril decreases nuclear factor kappa B activation in the kidney with ureteral obstruction Kidney Int 1997, 52:926-933 23 Miyajima A, Kosaka T, Seta K, Asano T, Umezawa K, Hayakawa...

Ngày tải lên: 11/08/2014, 03:20

... suggestions Author Details 1Instituto "Reina Sof a" de Investigación Nefrológica, Departamento de Fisiolog a y Farmacolog a, Universidad de Salamanca, Salamanca, Spain and 2Red Cooperativa de Investigación ... kidney of rats with unilateral ureteral obstruction Jpn J Pharmacol 2002, 90:361-364 51 Satoh M, Kashihara N, Yamasaki Y, Maruyama K, Okamoto K, Maeshima Y, Sugiyama H, Sugaya T, Murakami K, Makino ... Klahr S: Enalapril decreases nuclear factor kappa B activation in the kidney with ureteral obstruction Kidney Int 1997, 52:926-933 23 Miyajima A, Kosaka T, Seta K, Asano T, Umezawa K, Hayakawa...

Ngày tải lên: 11/08/2014, 06:22

... Kadota J, Matsukura S, Kohno S: Raised plasma concentrations of α-defensins in idiopathic pulmonary fibrosis Thorax 2002, 57:623-628 Nagata N, Takayama K, Nikaido Y, Yokosaki Y, Kido M: Comparison ... collagen and to release oxidants such as superoxide and hydrogen peroxide that damage tissue cells [30] As far as BAL is concerned, its role in evaluating diffuse parenchymal lung disease remains ... manuscript and critical interpretation of all data CS performed part of the statistical analysis JME has made substantial contributions to conception and design of the Page of (page number not for citation...

Ngày tải lên: 11/08/2014, 08:21

... between two and more than two variables was assessed with Mann-Whitney U and Kruskal Wallis test, respectively Data was calculated as mean from at least two concurrent samples of several tissue ... disturbed Page 11 of 13 Additional material Additional file 1: Table S1 Detailed data of the morphometrical analysis of Hba and Hbb positive area (sum of the bronchial/alveolar epithelium and interstitium; ... and participated in its design and coordination and helped to draft the manuscript All authors have read and approved the final manuscript Acknowledgements The authors thank Tiina Marjomaa for...

Ngày tải lên: 12/08/2014, 11:22

... 5’-CTA GTG AGA GCC TCA AGA CTG G-3’, PDE 6A FP: 5’-TGG CAA AGA GGA CAT CAA AGT-3’; RP: 5’-TAA TCA TCC ATC CAG ACT CAT CC-3’, PDE6B FP: 5’-GCA GAA CAA TAG GAA AGA GTG GA-3’; RP: 5’-CAG GAT ACA GCA ... GGA CAT CAA AGT-3’; RP 5’TAA TCA TCC ATC CAG ACT CAT CC-3’, PDE6B FP: 5’-GCA GAA CAA TAG GAA AGA GTG GA-3’; 5’-CAG GAT ACA GCA GGT TGA AGA CT-3’, PDE6C FP: 5’-AAG AAT GTT TTG TCC CTG CCT A- 3’; RF: ... 5’-AAG AGT GGC TTT GGT TTG GTT-3’, PDE6D FP: 5’-GGA TGC TGA GAC AGG GAA GAT A- 3’; RP: 5’-GCC AGG TAT TTG TGG AGT TAG G3’, PDE6G FP: 5’-GAC AGA CCA GGC AGT TCA AGA G-3’; RP: 5’-TGA GCA GGG TTT AGA...

Ngày tải lên: 12/08/2014, 11:22

... of CCR4 was analyzed Statistical Analysis All data are presented as mean ± SEM A one-way analysis of variance (ANOVA) followed by Fisher's least significant difference (LSD) test was applied to ... Waki Y, Urano T, Sayama K, Sakamaki F, Terashima T, Soejima K, Tasaka S, Ishizaka A, et al.: Priming of alveolar macrophages for interleukin-8 production in patients with idiopathic pulmonary fibrosis ... Soejima K, Waki Y, Nakamura M, Ishizaka A, Kanazawa M: Flow cytometric detection of cell-associated cytokines in alveolar macrophages Eur Respir J 1996, 9(6):1181-1187 Nakamura H, Fujishima S, Waki...

Ngày tải lên: 12/08/2014, 14:20

... Yanagisawa K, Osada H, Masuda A, Kondo M, Saito T, Yatabe Y, Takagi K, Takahashi T, Takahashi T: Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta ... human normal lung epithelial cells Oncogene 1998, 17:1743-1747 44 Kuwano K, Hagimoto N, Kawasaki M, Yatomi T, Nakamura N, Nagata S, Suda T, Kunitake R, Maeyama T, Miyazaki H, Hara N: Essential ... 152:2084-2089 Yoshida M, Sakuma J, Hayashi S, Kinya A, Saito I, Harada S, Sakatani M, Yamamoto S, Matsumoto N, Kaneda Y, Kishimoto T: A histologially distinctive interstitial pneumonia induced by overexpression...

Ngày tải lên: 12/08/2014, 18:20