bridging the gap between basic research and clinical applications

... involvement in clinical trials and/ or clinical research networks We began with an environmental scan of academic and trade journals, the internet, and public- and private sector reports of clinical and ... participate in clinical research The goal of this research is to identify the barriers and Table Benefits to community clinicians associated with their participation in clinical research Type ... or the clinical consequences of war, such as the rapid rise in the number of individuals with prosthetic limbs and post traumatic stress syndrome) Further, given their broad set of skills, the...

Ngày tải lên: 10/08/2014, 10:23

... and the clinical research staff Some clinicians expressed distrust or the belief that their patients distrust clinical research [16,17] Community clinicians often expressed the concern that they ... Consulting and Clinical Psychology 1983, 51(3): 390-395 doi:10.1186/1748-5908-6-35 Cite this article as: Beckett et al.: Bridging the gap between basic science and clinical practice: The role of ... participation in clinical research Building upon the model described above to account for decision making about participation in clinical research and the research team’s synthesis of clinician...

Ngày tải lên: 10/08/2014, 10:23

... read and approved the final manuscript Acknowledgements Research in the authors’ laboratory is funded by the British Heart Foundation and the Biotechnology and Biological Sciences Research Council ... are common and timing- and sex-specific Hum Mol Genet 2009, 18:4046-4053 doi:10.1186/gm201 Cite this article as: Burdge GC, Lillycrop KA: Bridging the gap between epigenetics research and nutritional ... vulnerability in the regulation of this gene, and potentially of others This is supported by the finding that the maternal PR diet induced a persistent change in 311 genes in the liver of the adult...

Ngày tải lên: 11/08/2014, 12:21

... companies from the rest of the pack They are in a position to view their marketing mix in the form of 4+1P and 1R, and thereby customize their offerings to the rural market Further, to ensure ... wells, handpumps and ponds For the first in the history of advertising - these were branded Special stickers were put on the handpumps, the walls of the wells were lined with advertising tiles and ... is the application of the marketing concepts and not the concepts themselves that need to be looked at Often, in the rural marketplace it is the application of these concepts which differs the...

Ngày tải lên: 08/03/2014, 02:21

... binding GST-IjBa in the presence and absence of ATP, and the value of a indicates whether the binding of one substrate (ATP) affects the afnity of the enzyme for the other substrate (GST-IjBa) [59] ... wells and the plates left to incubate for 15 The plates were inverted to remove the detergent after the 15 incubation period and the wells were washed twice with wash buffer by inverting the plates ... vitro and in silico analysis of the data The plot shows nuclear NF-jB oscillation in the original model and in the updated model with newly measured kr1, ka1 and kd1 for IKKIjBa complex (D) In the...

Ngày tải lên: 16/03/2014, 11:20

... good estimate to the real uxes through the system as predicted by Teusink et al The discrepancy between the real and FBA solution is due to FBA disregarding the branches of the pathway not involved ... only the stoichiometry of the network and cellular composition Like mechanistic approaches, our estimated model provides at least an intimation of the kinetic nature and behaviour of the system The ... in the absence of an accurate kinetic model and detailed kinetic rate equations for each reaction The predictions of the proposed model agree well with the Teusink et al model solutions and, therefore,...

Ngày tải lên: 23/03/2014, 07:20

... Physicians, basic scientists, mathematicians, statisticians and computer scientists met at the Third Bertinoro Systems Biology workshop [1], sponsored by the University of Bologna, focused on the theme ... Biology Meets the Clinic’ to address these questions Participants sought to identify key challenges facing the successful translation of systems biology to the clinical arena and discussed and debated ... the types of entities and the specific nature of their relations that determine disease pathophysiologic processes? What challenges might be resolved and opportunities opened for both basic research...

Ngày tải lên: 11/08/2014, 12:20

... Have you ever heard these comments?  Defining language anxiety  What research on language anxiety suggest  Talking about students’ fears: BALLI and FLCAS  Bridging the gap: activities that ... especially in the early stages of learning, to alleviate the frustration that occurs when they have to focus both on meaning and on form Information Gap Activity: Find out where the international ... help them manage their anxiety  Activities that help learners cooperate and depend on their peers foster an environment conducive to the development of community  Learners feel more at ease and...

Ngày tải lên: 01/12/2016, 23:18

... legendary in the film industry have several things in common They know how to draw, they study art and the history of their craft, they hang out with their peers, they are objective, and they make ... LinG of the Inkwell Thinking Animation: Bridging the Gap Between 2D and CG Productions to produce The Flintstones, Scooby-Doo, and other shows.4 The traditional animation skills of drawing and inking ... essential to all the arts, especially the art of animation The structure, design, and composition of a scene, the gesture of a character, the angle of view, the location, the set, and the props are...

Ngày tải lên: 23/03/2014, 22:20

... matrix B for the WN synsets and the R O G E T classes A similarity score B(j, k) is computed for the jth WN synset (taking the synset itself, the hypernyms, and the coordinate terms) and the k th ... matrix for the L D O C E senses and the WN synsets A similarity score 4(i,j) is computed for the i th L D O C E sense and the jth WN synset using a weighted sum of the overlaps between the L D O ... membership, and so on, though we did not deal with them in this study the synsets Also collect the corresponding gloss definitions, Gl(Sn), if any, the hypernym synsets Hyp(Sn), and the coordinate...

Ngày tải lên: 31/03/2014, 04:20

... Macular Degeneration – The Recent Advances in Basic Research and Clinical Care presents  the most  recent  advances  in  basic research and clinical care  of  AMD.  Different  from  other  AMD  books,  ... to  cover  the new  findings  from  basic and translational research on the biological and genetic mechanism of AMD, and the new  interventions to prevent and treat this disease.  The book has a total of 15 chapters, grouped into two sections. Section one includes six  ... debris between the retinal layer and the Bruch’s membrane leading to retinal degeneration (Nandrot et al., 2004) 6 Age Related Macular Degeneration – The Recent Advances in Basic Research and Clinical...

Ngày tải lên: 27/06/2014, 15:20

... in the context of pregnancy and wherever possible be discontinued, in some instances the wellbeing of the mother has to be weighed against the Brain Damage – Bridging Between Basic Research and ... birth, and before discharge) and clinical, imaging and electrophysiological predictors, and neurological examination criteria The purpose is to rationalize hypothermia and other intervention therapies, ... Damage – Bridging Between Basic Research and Clinics situations, and with fetal hypoxia in particular, the physiological effects on the fetus generate detectable changes in the fetal heart rate The...

Ngày tải lên: 28/06/2014, 12:20

... Germany, about the above mentioned gap between research and practice The conference was founded by the Landesstiftung foundation Baden-Württemberg, and was supported by the prime minister of the state ... translating science and research findings into practice, or, on the other hand, defining research problems out of practical relevance The articles in this special issue are the result of a conference ... security In Handbook of attachment Theory, research, and clinical applications 2nd edition Edited by: Cassidy J, Shaver PR New York Guilford; 2008:745-761 Sigel IE: Practice and research A problem...

Ngày tải lên: 13/08/2014, 18:21

... every and some) Pairs Qx are further function symbols (the variable binders of x in the object language) The symbol ≤ for the outscopes relation Formulas of MRS have three kinds of literals, the ... call of the solver, where L1 dominates L3 and L4 The solved form of the restricted graph is then put below the left hole of L2, since it is connected to this hole As a result, we obtain the solved ... Let M be a set of literals The label set lab(M) contains those handles of M that occur in label but not in argument position The argument handle set arg(M) contains the handles of M that occur in...

Ngày tải lên: 20/02/2014, 16:20

... variables how they will be situated in a solution of the solved form They can either dominate each other in either direction, or they can be disjoint But if they are disjoint, we also know the lowest ... holes X1 ,1 and are different is called the set of upper fragments of the chain, and QI is the set of lower fragments We call all the Xj ,1 and Xi r connecting holes of C, and all other holes ... < n, either (a) Fi E and Ft+ i E U, and there is a hole Xj,,,:i*R(Fi+i); or of Fi s.t (b) F, E U and Fi+ E 0, and there is a hole Xi+ 1,1 of Ji s.t X,+1,/

Ngày tải lên: 22/02/2014, 02:20

... VNU-HCM brand identity and brand image? - Is there any possible gap between the VNU-HCM brand identity and brand image? - How much is the gap between the VNU-HCM brand identity and brand image? ... Tesco brand identity and brand image (Ross and Harradine, 2011) - 18- Adapted from the empirical studies about brand identity and brand image, the study The Gap Between Brand Identity And Perceived ... determined between the two constructs, brand identity and brand image Figure 6: Conceptual framework of the gap between brand identity and brand image - 22- 3.1.2 Research hypotheses From the conceptual...

Ngày tải lên: 23/10/2015, 15:38

... muscle on the back of the arm (measured and marked beforehand) The anthropometrist lifts the skinfold with the thumb and index finger, approximately cm above the marked midpoint, and places the calipers ... stores and can provide information on fat patterning.13 The measurement is taken at the midpoint of the upper arm, located halfway between the lateral tip of the acromion and the olecranon when the ... plane.7 The Frankfort plane is the anatomic position when the lower margin of the orbit and the upper margin of the auditory meatus are in line The second person holds the infant’s knees flat to the...

Ngày tải lên: 16/02/2014, 07:20

... monitor the changes in prevalence of these and other microorganisms in the environment as the vaccines alter these dynamic relations The success of the research on viruses and cancer, and in particular, ... 1981, and others) and laboratory studies HCC is the third most common cause of death from cancer in males and the seventh in females There are probably about million deaths a year from HCC and other ... early and late for their timed expression during the viral life cycle (Fig 1.3) The E6 and E7 genes (designated E for early) are expressed from the early promoter (p97), and the E1, E2, E4, and...

Ngày tải lên: 06/03/2014, 09:21

... the Wakefield (later called the Yorkshire) Tissue Bank in the UK by Frank Dexter; the Poland Tissue Bank in Warsaw by Dr Janus Komender and Dr K Ostrowski; and the Democritus Tissue Bank in Athens, ... chamber The lid is closed and the chamber is filled with sterile water The 35% peracetic acid is then aspirated into the chamber All these take place at a low temperature of 50◦ C–55◦ C The exposure ... first removed and the H2 O2 vial is punctured, upon which the H2 O2 vaporizes and diffuses Radiofrequency is then applied and the plasma is activated This process occurs at 40◦ C The exposure...

Ngày tải lên: 22/03/2014, 20:21

... coupled and sites of binding on a protein have a role in determining the fate of the conjugate in the body and the rate of excretion (see also the Pasut chapter in this book) Therefore, understanding ... carbonylimidazole with the terminal hydroxyl group on mPEG, and these have much lower reactivity than either the SC-PEG or BTC-PEG Generally, the slower the reaction the more specific the reagent is ... the last 3–5 years While this is important, and defines the state of the art, it is also wise to remember the historical evolution of any field, acknowledge its roots, the advances made and the...

Ngày tải lên: 29/03/2014, 08:20