breast cancer cellular origins and tumorigenesis

... year for which breast cancer incidence is available (2005 for Republic of Ireland; 2004 for England & Wales, Scotland, Northern Ireland, and Sweden; 2003 for Czech Republic and Finland; 2001 for ... 2003 Figure 11 Breast Cancer in Women within Ages 45-49 in England & Wales, Scotland, Northern Ireland, Republic of Ireland, Sweden, Czech Republic, Finland, and Denmark; 1943-2005 Cancer registrations ... 1998 2003 Year Figure 12 Breast Cancer in Women within Ages 50-54 in England & Wales, Scotland, Northern Ireland, Republic of Ireland, Sweden, Czech Republic, Finland, and Denmark; 1943-2005 Journal...

Ngày tải lên: 06/03/2014, 02:21

... women to breast cancer – BRCA1, BRCA2 and TP53 The objective of this guideline is to decrease breast cancer morbidity and mortality by assessing hereditary risk in people before breast cancer develops ... bilateral breast cancer and one first-degree or second-degree relative diagnosed with breast cancer at younger than an average age of 60 years or • Families containing male breast cancer at any age and ... classification and care of women at risk of familial breast cancer Treatment and care should take into account patients’ needs and preferences People at raised or high risk of breast cancer should...

Ngày tải lên: 15/03/2014, 00:20

... potential drug candidates or therapeutic targets [10] Breast cancer is one of the most common and prevalent cancers in women and a leading cause of cancerrelated death [11] As in other common cancers, ... five breast cancer cell lines that are either ERa positive (MCF-7, T-47D and BT-474) or ERa negative (MDA-MB-231 and SK-BR-3), and 23 breast tumor specimens, of which 10 are ERa positive and 13 ... have been identified in breast cancer, such as miR-21, miR-205 and miR-17-5p, which were shown to be involved in the formation of breast cancer by targeting the TPM1, HER3 and AIB1 genes, respectively...

Ngày tải lên: 22/03/2014, 21:20

... between control and 22.2-MBq-treated animals on the one hand and between 14.8- and 22.2MBq-treated animals on the other hand (p < 0.0001) A significant difference between control and 14.8-MBqtreated ... aggressive breast cancer phenotype CD138 is expressed by about 75% of ER-negative forms of breast cancer [39], and it is associated with a high histological grade, Ki 67 index, tumor size, and lymph ... of triple-negative breast cancer that has a poor prognosis As such, it is often used as xenografts in nude mice to test new drugs and therapeutic strategies against breast cancer Recent studies...

Ngày tải lên: 21/06/2014, 01:20

... years and every months thereafter, with a physical examination, chest X-ray, and blood tests Mammography and ultrasound examinations of the breast and abdomen were performed at months after APBI and ... follow-up of a randomized study comparing breast- conserving surgery with radical mastectomy for early breast cancer N Engl J Med 2002, 347:1227-1232 Morrow M: Rational local therapy for breast cancer ... microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast- conserving surgery and radiation therapy Cancer 1994, 74:1746-1751 18 Polgar...

Ngày tải lên: 09/08/2014, 09:20

... semi-structured interviews with 34 breast cancer patients and 14 health professionals to further determine the information needs that breast cancer patients had before, during and after their radiation ... questionnaires that measured general information needs and specific breast cancer information needs were not appropriate if we wanted to gain an understanding of patient's information needs at different ... Information Satisfaction Questionnaire [14] and the Toronto Informational Needs Questionnaire -Breast Cancer [15] Although these questionnaires provide an understanding of general information needs,...

Ngày tải lên: 09/08/2014, 10:21

... Literature Review Breast cancer in South East Asia 4 Screening for breast cancer 11 Clinical investigations of breast cancer 16 Treatment of breast cancer 20 Prognostic indicators of breast cancer Lymph ... Comparison of presentation and outcome of Singaporean breast cancer patients with Malaysian and SEER breast cancer patients Comparison of presentation and outcome of breast cancer patients between ... of breast cancer each year, breast cancer is the most common type of cancer and the most common cause of cancer deaths among women worldwide [2, 3] In contrast to Europe and the US, where breast...

Ngày tải lên: 09/09/2015, 17:55

... INTRODUCTION 1.1 Breast cancer: epidemiology and risk factors 1.2 Breast cancer: chemoprevention and treatment 1.3 Breast cancer: limitations of current cancer treatment 10 1.4 ... end labeling xv INTRODUCTION 1.1 Breast cancer: epidemiology and risk factors Breast cancer is a type of cancer occurring at breast tissue, and this type of cancer is more common in female population ... the commonest cancer in females follow by colo-rectum and lung cancer (Teo and Soo, 2013) The age-standardized rate of breast cancer in Singapore is 60/100,000 at recent years (Teo and Soo, 2013),...

Ngày tải lên: 10/09/2015, 09:09

... the etiology and progression of human breast and gynaecologic cancers Some breast cancers are responsive to estrogens for growth Estrogens directly increased the growth of breast cancer cells ... Phytoestrogens and risk of breast cancer Estrogens have been implicated in the initiation and promotion stages of breast cancer, with lifetime exposure to estrogen being a major risk factor for breast cancer ... leading to hormone resistance and tamoxifen-activated mutant cancers   14 1.4 Selective estrogen receptor modulators (SERMs) and treatment of breast cancer 1.4.1 Breast cancer treatments One of the...

Ngày tải lên: 04/10/2015, 17:05

... progesterone-positive, and approximately one in five breast cancers is human epidermal growth factor receptor 2/erb-B2 (HER2)positive breast cancers Hormone receptor-positive and HER2-positive breast cancers ... 2010) Breast cancer is a heterogeneous entity with distinct subsets characterised by differences in tumor biology and response to therapy The majority of breast cancers are estrogen receptor -and/ or ... Fcy/5FC and CodA/5-FC in co-culture experiments 83 11 Figure 14 HSVtk/GCV and CD/5-FC for breast cancer therapy mediated by iPSC-NSC 86 Figure 15 Survival analysis of breast cancer...

Ngày tải lên: 09/09/2015, 18:56

... and breast cancer does not mean the end of life” (2, 2) Comfort in acquiring breast health knowledge and skills In all the FGDs, women talked about seeing or hearing about breast cancer and breast ... Survival rates for breast cancer Atlanta: 2012 http://www .cancer. org /Cancer/ BreastCancer/OverviewGuide /breast- cancer- overviewsurvival-rates Jordan Ministry of Health: Annual incidence of cancer in Jordan ... Feeling fear of breast cancer, and c) Feeling safe from breast cancer The first theme was seen in women’s prioritizing children and family needs and in their experiencing family and social support...

Ngày tải lên: 13/02/2014, 06:20

... mammographic and pathologic examination Therefore, she was not at risk for development Fig Example of a breast cancer risk profile NSABP ‫ ס‬National Surgical Adjuvant Breast and of breast cancer and ... chemotherapy, and tamoxifen used to treat the unprevented breast cancer Tools that can be used for determining a woman’s breast cancer risk and the net effect from tamoxifen when used to prevent breast cancer ... placebo group and 2.73 per 1000 women in the tamoxifen group Fractures Table Distribution of invasive cancers other than breast and uterine (endometrial) cancer No of cancers Primary cancer site*...

Ngày tải lên: 15/02/2014, 04:20

... Pro1-Asp2-Thr3-Arg4-Pro5 [13] and using nona- and 20mer peptides the resulting epitope was identified as Ala20¢-Pro1-Asp2-Thr3-Arg4-Pro5 and Pro1Asp2-Thr3, respectively [14,15] For SM3 reacting with pentamers and dimers ... is most likely due to slow exchange between the bound and the free state For dimers and pentamers of the MUC-1 tandem repeat [16], i.e 40mer and 60mer peptides, the dissociation constant was determined ... intensity in the STD spectrum Obviously, Pro1 and Asp2 get more saturation from the protein than the remaining residues of the ligand and therefore have more and tighter contacts to the antibody’s surface...

Ngày tải lên: 21/02/2014, 15:20

... Biofield Breast Examination Blue Cross/Blue Shield Association Breast Cancer Progress Review Group Breast Cancer Research Program Breast Cancer Surveillance Consortium Breast Imaging Reporting and ... Workshop speakers and other contributors Index 269 273 xix Mammography and Beyond: Executive Summary Breast cancer takes a tremendous toll in the United States After lung cancer, breast cancer is the ... of new breast cancer detection technologies should continue to emphasize research on the basic biology and etiology of breast cancer and on the creation of classification schemes for breast lesions...

Ngày tải lên: 05/03/2014, 12:20

... Fig Relation between parity and risk of (a) early breast cancer and (b) late breast cancer Table Summary of the results on the relationship between breast cancer and reproductive factors according ... for breast cancer Breast cancer risk increased with increasing age at FFTP by 5% (95% CI: 5-6%) per year for breast cancer diagnosed early or before menopause and by 3% (95% CI: 2-4%) for cancers ... at diagnosis Risk factor Age at menarche early breast cancers late breast cancers Age at first full-term pregnancy early breast cancers late breast cancers (n) studies 19 18 (n) cases Regression...

Ngày tải lên: 05/03/2014, 17:20

... budget, and priorities See Patterson (1987), especially chapters and Breast Cancer and Time, 1900–1970 383 References Adair, F.E 1943 The Doctor Looks at Women and Their Problem of Cancer of the Breast ... shaped the nature and magnitude of breast cancer risk, and our response to that risk Yet, in so many ways, our individual and collective experience of the dangers posed by breast cancer are a direct ... ideas and practices surrounding the causes and prevention of cancer, especially breast cancer. 1 Most striking are the continuities in how we have understood the relationship between time and cancer...

Ngày tải lên: 06/03/2014, 00:22

... Factors in Breast Cancer: Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 ... exposure, and other behavioral risk factors in breast cancer Curr Cancer Ther Rev 2006, 2:3–21 Brody JG, Moysich KB, Humblet O, Attfield KR, Beehler GP, Rudel RA: Environmental pollutants and breast cancer: ... in high-exposed jobs and year in prior high-exposed farm work Table Breast cancer odds ratios (matched analysis) and menopausal status with BMI and selected risk factors and major sectors, by...

Ngày tải lên: 06/03/2014, 02:21

... OCCUPATIONS AND BREAST CANCER RISK A few reports have addressed women autoworkers and risk of breast cancer A cohort study published in 1994 found no association between female breast cancer and automotive ... history of breast cancer, particularly with respect to having two or more relatives with breast cancer and mutation of the BRCA1 and BRCA2 gene, can explain less than 10% of breast cancer cases.1 ... Siwinski, Ann Sovan, and Peter Infante Funding was provided for the current Lifetime Histories Breast Cancer Research (LHBCR) by the Canadian Breast Cancer Foundation and the Breast Cancer Society...

Ngày tải lên: 06/03/2014, 02:21

... with cancer registries and clinicians, This includes cancers diagnosed outside screening (interval cancers, cancers in non attenders, cancers in women not invited) All women with breast cancer ... of screen-detected breast cancers and breast cancer diagnosed outside screening (interval cancer as well as other ‘control’ cancers - optional) can be registered in tables 19 and 20 Table 17: Primary ... ASSURANCE IN BREAST CANCER SCREENING 1.1 Introduction That a breast cancer screening programme can reduce breast cancer mortality in the age group 40-74 years has been shown in several randomised...

Ngày tải lên: 15/03/2014, 00:20

... protective role of pregnancy in breast cancer Breast Cancer Res., 7(3), pp131-42 20 Collaborative Group on Hormonal Factors in Breast Cancer (2002b) Breast cancer and breastfeeding: collaborative ... Factors in Breast Cancer (1996) Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from ... of breast cancer in relation to lifetime alcohol consumption J Natl Cancer Inst., 87, pp923-929 35 Cancer Research UK (2007) About breast cancer: Breast cancer risks and causes http://www.cancerhelp.org.uk/help/default.asp?page=3285...

Ngày tải lên: 15/03/2014, 01:20