brain imaging studies in bipolar disorder

... significantly increased activation compared to controls in a working memory task in several different brain regions [9] Thus, studies to date support suggestions of underlying functional changes in bipolar ... alteration in activation in specific brain regions during a word generation task in euthymic, but not depressed, bipolar patients However, there appears to be no effect in either group in a working ... Quetiapine, venlafaxine, lamotrigine Venlafaxine Risperidone Table 2: Working Memory Task change in the BOLD signal for each region of interest pre-post lithium The change in each region of interest...

Ngày tải lên: 08/08/2014, 21:20

... Leibniz being the first, to assert that events in a nonphysical mind are simply separate phenomena running in parallel to events in the brain The mind causes nothing in the brain, and the brain causes ... fact certain brain patterns interacting with and interpreted by other brain patterns Moreover, one’s self, as apprehended introspectively and Introduction represented incessantly, is a brain- dependent ... reveal anything about brain function and organization The main point is that the imaging techniques are indeed marvelous and are indeed useful, but not all imaging studies yield meaningful results...

Ngày tải lên: 11/06/2014, 15:18

... cerns, including improving inter-episode functioning and perceived quality of life Our review found that there is growing interest in characterizing QoL in bipolar disorder populations, and determining ... group in Canada, and will be dealt with in unison Following this, six other studies (one comparing QoL in patients with during different phases of the disorder, a recent study assessing QoL in bipolar ... changes in well-being, functioning and QoL Although there appears to be increasing use of QoL measures in pharmacological research in bipolar populations, we identified surprisingly few studies...

Ngày tải lên: 20/06/2014, 15:20

... deficit in inhibiting selffocus These hypotheses provide interesting lines of investigation that might be pursued in future neuroimaging studies Conclusions and future directions The mind in bipolar ... present in patients with bipolar disorder in euthymic states is exacerbated in mania and depression In fact, in studies using tests of executive functioning, including attentional setshifting [65, ... rumination in bipolar disorder reveal that not only individuals with bipolar disorder ruminate in response to negative affect in depressed states, they ruminate in response to positive affect as well In...

Ngày tải lên: 21/06/2014, 19:20

... evidence in bipolar disorder Expert Opin Pharmacother 2007, 8(7):1001-1009 McIntyre RS, Woldeyohannes HO, Yasgur BS, Soczynska JK, Miranda A, Konarski JZ: Maintenance treatment in bipolar disorder: ... against the psychotic symptoms during the acute manic/mixed and maintenance phases of bipolar illness, however there are specific issues the clinician should have in mind, such as that the maintenance ... mania, quetiapine and the olanzapine-fluoxetine combination are approved for the treatment of acute bipolar depression, and olanzapine, quetiapine and aripiprazole are approved for maintenance phase...

Ngày tải lên: 08/08/2014, 23:21

... olanzapinefluoxetine combination (OFC) [56,61-64] Quetiapine has proven efficacy against acute mania [45,65,66], including an unpublished study (NCT00309699) The data are solid also against acute bipolar ... SGAs against acute mania and SGAs in maintenance protecting from mania) Four effect cases are not adequately studied (FGAs against acute bipolar depression and in maintenance protecting from ... Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies Biol Psychiatry 2006, 59:1061-1064 39 Calabrese JR, Vieta E, Shelton MD: Latest maintenance...

Ngày tải lên: 09/08/2014, 01:21

... studies [20,83], but is contrary to those finding higher SUD rates in bipolar I disorder compared to bipolar II disorder [1,6] Our findings of no differences in BD illness severity between patients ... study, covering both in- and outpatient units including substance abuse clinics Conclusions The current findings show that there is a significant increase in illicit substance use in BD compared ... mechanisms involved in the increased substance use in BD are not known Several studies have found increased impulsivity and novelty seeking in BD patients [76,77], which have also been linked to...

Ngày tải lên: 11/08/2014, 16:22

... recruiting centres 132 patients fulfilling the criteria below will be included into this study by nine centres in Norway All the patients will first be included in the Bipolar Research And Innovation ... published guidelines defining objective clinical criteria for indications of treatment with ECT in bipolar depressions In the present protocol “indication for ECT” is one of the inclusion criteria ... participants in the study have taken part in mutual training-sessions in the different assessments and rating scales All participants have taken part in interrater-scorings The scorings for the...

Ngày tải lên: 11/08/2014, 16:22

... associated treatment costs in commercially insured patients with bipolar disorder newly treated with aripiprazole, ziprasidone, olanzapine, quetiapine or risperidone, alone or in combination with mood ... Observational studies can provide important insights into the outcomes of clinical practice in real-world settings, where dosing, titration and concomitant medications are not constrained by trial ... treating bipolar disorder in the California Medicaid (Medi-Cal) program J Affect Disord 2002, 71(1-3):131-139 Blanco C, Laje G, Olfson M, Marcus SC, Pincus HA: Trends in the treatment of bipolar disorder...

Ngày tải lên: 11/08/2014, 16:22

... BM: Neuroimaging in bipolar disorder: what have we learned? Biol Psychiatry 2000, 48:505-517 Strakowski SM, DelBello MP, Adler C, Cecil KM, Saz KW: Neuroimaging in bipolar disorder Bipolar Disord ... PF, De Micheli E, Wurtman R, Pillay SS, Cohen BM: Choline ingestion increases the resonance of choline-containing compounds in human brain: an in vivo proton magnetic resonance study Biol Psychiat ... measured, and most of the studies measured choline/creatine ratios [14-18], the other one measuring metabolite intensity/tissue volume [13] The first study to examine brain choline in basal ganglia studied...

Ngày tải lên: 08/08/2014, 20:23

... influencing obesity in bipolar patients include nutrient intake and physical activity In assessing the nutrient intake of persons with bipolar disorder, Elmslie and colleagues found that they had increased ... studied primarily in patients with seizure disorders Carbamazepine-induced increase in total cholesterol is primarily due to an increase in HDL [34] This occurs during the initial weeks of therapy, ... guidelines are being formulated to aid clinicians in identifying patients at risk Screening for diabetes should include questioning patients about symptoms such as excessive thirst and urination,...

Ngày tải lên: 25/10/2012, 10:51

... developments in Advances in Brain Imaging, and the shift toward xii ADVANCES IN BRAIN IMAGING greater clinical utility is clear in their descriptions of these methods Perhaps most intriguing is the ... functional imaging studies may help to 26 ADVANCES IN BRAIN IMAGING clarify some ambiguities arising out of the initial wave of functional imaging studies of mental disorders I will begin with a ... sustained firing when information is held in mind (Goldman-Rakic 1987), which in turn suggests that some information is being maintained or stored through this activity 32 ADVANCES IN BRAIN IMAGING...

Ngày tải lên: 11/04/2014, 01:01

... underlying cognitive domains in bipolar disorder The SCIP seems to work properly when it is administered by psychiatrists who have participated in a relatively brief training exercise In future investigations ... may be in order This would be facilitated by a more wide spread incorporation of cognitive assessments into the routine clinical examinations of bipolar patients A relative paucity of routine cognitive ... cognitive domains Also, sensitivity to change remains unexplored Conclusion: With minimal training, physicians obtained a reliable and valid estimate of cognitive impairment in approximately 15 minutes...

Ngày tải lên: 18/06/2014, 19:20

... non-specific NBS intervention in stroke is unlikely to be successful Other acute disorders include traumatic brain and spinal cord injury and inflammatory diseases such as multiple sclerosis In each of ... during Braille reading in the blind [5] or activation of auditory cortex during visual stimulation in the deaf [6] The most apparent clinical manifestation is the increased activation reported in ... protocols Compounding this is the diversity of disorders themselves Even with stroke, arguably the most suited to NBS therapy, brain damage can occur anywhere within the brain including subcortical...

Ngày tải lên: 19/06/2014, 08:20

... Chapter Intraoperative Human Functional Brain Mapping Using Optical Intrinsic Signal Imaging Sameer A Sheth, Vijay Yanamadala and Emad N Eskandar Chapter Functional Holography and Cliques in Brain ... conditions typically occur in the absence of significant brain damage as detected by conventional structural brain imaging techniques When some brain Neuroimaging and Dissociative Disorders 17 damage ... summarize the recent neuroimaging findings which supported the dual-process account of deductive reasoning, focusing on studies of the belief-bias effect 36 Advances in Brain Imaging Fig Material design...

Ngày tải lên: 27/06/2014, 13:20

... by housing and by strain [67] Aripiprazole in bipolar disorder RCTs Acute mania Aripiprazole was studied against acute mania in five RCT studies involving a placebo arm In the first (CN138-009), ... the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, quetiapine and aripiprazole for the maintenance phase This ... Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet 2008, 47:475-485 Findling RL, Kauffman...

Ngày tải lên: 08/08/2014, 23:21

... schizophrenia or bipolar disorder as established by the Structured Clinical Interview for DSM-IV, being clinically stable (defined as having had no changes in severity or new treatments initiated in the ... afford greater insight in describing and grading the impact of side effects associated to antipsychotic drugs [15,16] A brief instrument is preferred for use in clinical practice and in investigations ... experts translated the original version in Swedish into Spanish Experts examined and compared these three different versions in order to reach a single one by consensus (intermediate version 1.0)...

Ngày tải lên: 09/08/2014, 01:21

... bovine serum (GIBCO) and a mixture of penicillin-streptomycinglutamine (PSG from GIBCO) Puromycin-resistant MEF lines were grown, maintained, serum shocked, and serum starved in medium containing ... of β-catenin protein, which should increase as total GSK3 levels decrease [39-41] A clear reduction in GSK3α protein levels with a concomitant increase in β-catenin levels was detected in several ... imipramine, and the selective serotonin reuptake inhibitor (SSRI) fluoxetine, have been attributed chronobiotic properties in studies of their chronic administration in rodents [6,68] Considering...

Ngày tải lên: 10/08/2014, 09:20

... measure brain tissue lithium concentrations in vivo Studies using 7Li MRS have investigated the pharmacokinetics of lithium in the human brain and evaluated brain lithium concentrations in relation ... Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder Bipolar Disorders, 6(1), 43–52 Dickstein, D P., Rich, B A., Binstock, A B., ... that occur in children and adolescents with bipolar disorder, including conduct disorder, oppositional defiant disorder, anxiety disorders, and pervasive developmen- Introduction tal disorders...

Ngày tải lên: 11/08/2014, 04:20

... spectroscopic studies and structural imaging studies may be conducted in patients with pediatric bipolar disorder, studies of intracellular genetic changes, including those pertaining to neuroprotective ... exercised in translating the in vitro and animal findings to humans Lithium and Neurotransmission Preclinical studies and information from adult human studies have provided information regarding the ... terior cingulate These findings preliminarily indicate variations in neuronal activation of bipolar patients when comorbid ADHD is present Most youths with bipolar disorder in these fMRI studies, ...

Ngày tải lên: 11/08/2014, 04:20