bracketing and matrixing designs for stability testing of new drug substances and products
direct methods for stability analysis of electric power systems theoretical foundation, bcu methodologies, and applications
Ngày tải lên :
30/05/2014, 23:38
... terms for stability concepts used in the literature Stability is a very broad subject, and the concept of stability can be formulated in a variety of ways depending on the intended use of stability ... form of error and warning messages and various options to tabulate operating conditions and dynamic data 2.6 APPROACHES FOR STABILITY ANALYSIS The complete model for the stability analysis of a ... Perspectives and Future Directions Continued Theory of Stability Regions Chapter 3: Lyapunov Stability and Stability Regions of Nonlinear Dynamical Systems Chapter 4: Quasi -Stability Regions: Analysis and...
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Báo cáo sinh học: " The efficiency of designs for fine-mapping of quantitative trait loci using combined linkage disequilibrium and linkage" doc
Ngày tải lên :
14/08/2014, 13:22
... component, and AI is the average information matrix which consists of the average of the Hessian matrix and the Fisher information matrix RESULTS 3.1 Efficient designs for fine-mapping of QTL The effect of ... the trait of interest, β is a vector of fixed effects, u is a vector of n random polygenic effects for each animal, q is a vector of n random effects due to QTL and e are residuals The random effects ... column vector of variance components (σ2 , σ2 and σ2 ), k is kth u q e ∂L iteration, ∂Θ is a column vector of the first derivatives of the log likelihood Efficiency of designs for fine-mapping of QTL 151...
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Tài liệu Developing Culturally and Linguistically Competent Health Education Materials: A Guide for the State of New Jersey ppt
Ngày tải lên :
14/02/2014, 13:20
... Understand and respond to informed consent forms, 4) Understand medication instructions for themselves and their children, and 5) Be knowledgeable about the health effects of risks, behaviors, and ... Coalition of New Jersey Sandra Fusco-Walker, Allergy & Asthma Network Mothers of Asthmatics Teresa Lampmann, Pediatric Asthma Coalition of New Jersey Guide for Developing Culturally and Linguistically ... implications for material development 23.9% of the foreign-born population of New Jersey lives in linguistic isolation (About 19.5% of the population of New Jersey is foreign-born) A linguistically isolated...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
Ngày tải lên :
07/03/2014, 00:20
... al., 2005) and New product development New product development (NPD) is a business process for developing new products for a company, whether it is an upgrade of an existing product or a new concept ... management is “the manner of implementation, of expertise, paraphernalia, knowledge and modus operandi to an extensive range of activities for the fulfillment of prerequisite of the specific project” ... manager, the information for production of a new product will be integrated, and the project will be finished in real time Furthermore, the cost for production will likely decrease The focus of this...
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Advantages and challenges of the spray drying technology for the production of pure drug particles and drug loaded polymeric carriers
Ngày tải lên :
02/09/2015, 13:31
... Advantages and challenges of the spray-drying technology for the PT production of pure drug particles and drug- loaded polymeric carriers SC RI Alejandro Sosnik1* and Katia P Seremeta2,3,4 Laboratory of ... outstanding advantages and challenges of the spray-drying method for the production of pure drug particles and drug- loaded polymeric particles and discusses the potential of this technique and the more ... advances of Nano Spray Dryer B-90 for the production of NPs suited for several drug delivery applications and presented a SC schematic diagram of this device and the functional principle of mesh...
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CHALLENGES OF HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ASSAY OF COMBINED DRUG PRODUCTS
Ngày tải lên :
10/12/2016, 13:40
... control of APIs and drug products and also develop and validate appropriate methods These methods are routinely used by manufacturing companies in process testing and by authorities for the quality ... and 0.04 mg/ml in the case of paracetamol, between 0.03 and 0.065 mg/ml for ASA and between 0.006 and 0.013 mg/ml for papaverine, these data corresponding to 70-130% of the nominal contents of ... important tasks of a chromatographic analyst in pharmaceutical R&D is the development of analytical methods for the assay of pharmaceutical products and validation of the methods before submission...
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báo cáo hóa học:" A promising method for identifying cross-cultural differences in patient perspective: the use of Internet-based focus groups for content validation of new Patient Reported Outcome assessments" potx
Ngày tải lên :
20/06/2014, 15:20
... wording of new questions and instructions are based in the natural language and phraseology of respondents; and 3) The instructions, item pool, and response options are understandable and acceptable ... specialists use this deeper understanding of patient themes and issues to design pools of questions that measure the relevant content [57] and the performance of new assessment scales are evaluated ... interpretive demands placed on the moderators tute for qualitative inquiry itself, and the process of understanding the thoughts, experiences and values of the customer IFGs and thematic analysis...
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Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
Ngày tải lên :
09/08/2014, 01:23
... amounts of data about the drug, and has eliminated the least promising agents before the design process for randomized controlled trials occurs Design bias Design bias, on the other hand, occurs before ... and risks of the trial after pooling all arms, and that the decision point always comes before randomization and hence is independent of the relative expectations for the different arms of the trial ... effects from the placebo and new drug must exceed the expected negative effect from the loss of usual care The equipoise principle is replaced here by a new ethical standard of reasonable ‘positive...
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Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
Ngày tải lên :
12/08/2014, 23:22
... appear to be of clinical relevance because of its labile nature in T cells (unintegrated forms persist in the cytoplasm of these cells for only one day and cannot account for the formation of long-term ... elongation of both viral DNA strands The subsequent formation of double-stranded RNAs might lead to RNA interference, RNA-directed DNA methylation or generation of Page of 29 (page number not for citation ... RNAPII and from PCAF, and the recycling of Tat initiates a new cycle of transcriptional activation Page 16 of 29 (page number not for citation purposes) Retrovirology 2009, 6:111 the Sp1 and NF-κB...
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A comparison of real and simulated designs for vibratory parts feeding
Ngày tải lên :
03/01/2014, 19:15
... 0:5] in step sizes of 0.1, and we examined vibration amplitudes of 0.06 and 0.1 cm Each experiment consisted of a suite of 500 trials for a fixed set of parameter values for each of the three initial ... the mid- and tall-sized cylinders have diameters of 3.0 cm, heights of 2.5 and 3.7 cm, and masses of and 12.5 grams, respectively (see Figure 2) We measured the dimensions and masses of the parts ... vibrations of a plate In International Conference on Robotics and Automation IEEE, May 1995 [3] Geoffrey Boothroyd, Corrado R Poli, and Laurence E Murch Handbook of Feeding and Orienting Techniques for...
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Báo cáo khoa học: and protein bilinear indices – novel bio-macromolecular descriptors for protein research: I. Predicting protein stability effects of a complete set of alanine substitutions in the Arc repressor ppt
Ngày tải lên :
29/03/2014, 09:20
... [22] The construction of novel representation forms for biomolecules and the design of new descriptors that provide new information and better characterization is therefore necessary [22] Marrero-Ponce ... applied in the modelling of the interaction between RNA and drugs [26,27] and for predicting the stability of proteins [6,28] Bilinear forms have also been used in the denition of molecular descriptors ... robustness and stability of these models On the other hand, the Y-scrambling parameters for both models [a(R2) = 0.127 and a(q2) = )0.37 for Eqn (27); a(R2) = 0.119 and a(q2) = )0.38 for Eqn (28)]...
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báo cáo hóa học:" A practical approach for the validation of sterility, endotoxin and potency testing of bone marrow mononucleated cells used in cardiac regeneration in compliance with good manufacturing practice" docx
Ngày tải lên :
18/06/2014, 15:20
... 108(18):2212-2218 Food and Drug Administration: Guidance for Industry: Potency tests for cellular and Gene Therapy Products Center for Biologics Evaluation and Research US Department of Health and Human Services; ... of medicinal products and investigational medicinal products for human use When any new preparation or method of preparation is adopted, steps should be taken to demonstrate its suitability for ... ml of 5% v/v human albumin One ml was collected for migration and invasion assay and endotoxin testing For the sterility testing, peripheral blood mononucleated cells were obtained from 50 ml of...
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báo cáo hóa học: "Initial development and testing of a novel foam-based pressure sensor for wearable sensing" doc
Ngày tải lên :
19/06/2014, 10:20
... the Instron™ tensile testing instrument, courtesy of the University of Bath, England, showed that the stress-strain profile of the unadulterated PU foam sample and that of the PPy-coated PU foams ... resistance and range of the measured resistance of the sensors as determined through a series of standard repeatable exercises by the Page of (page number not for citation purposes) Journal of NeuroEngineering ... variety of body shapes and sizes would be hard to predict Similar issues would arise with sizing, fit, and sensor locations on the foot Because of the increased number of sensors and precision of...
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báo cáo hóa học:" Biomechanical testing of a polymer-based biomaterial for the restoration of spinal stability after nucleotomy" pptx
Ngày tải lên :
20/06/2014, 04:20
... (L1/L2 and L4/L5) were prepared from the spines without destruction of the ligaments, capsules and soft tissue Soft tissue was only removed from the upper half of the cranial vertebral body and ... preparation and testing, the samples were covered with PBS-soaked tissue and wrapped in plastic film Preparation and Implantation of the Spinal Units Preparation was performed according to the same standard ... annulus sealing system and developed adequate surgical techniques for the application of the nucleus and annulus implants SK participated in the design of the study and conceived of the biomechanical...
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Báo cáo hóa học: " Research Article Existence and Stability of Antiperiodic Solution for a Class of Generalized Neural Networks with Impulses and Arbitrary Delays on Time Scales" ppt
Ngày tải lên :
21/06/2014, 07:20
... of periodic solution of CNNs with impulses,” Chaos, Solitons and Fractals, vol 33, no 5, pp 1686–1693, 2007 Y K Li and L Lu, “Global exponential stability and existence of periodic solution of ... and stability of periodic solutions of high-order Hopfield neural networks with impulses and delays,” Journal of Computational and Applied Mathematics, vol 224, no 2, pp 602–613, 2009 K Li, Stability ... completely new even if the time scale T R or Z and are of great significance in designs and applications of globally stable anti-periodic Cohen-Grossberg neural networks with delays and impulses...
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Báo cáo hóa học: " Research Article Reducibility and Stability Results for Linear System of Difference Equations" potx
Ngày tải lên :
22/06/2014, 11:20
... reduced form 1.5 under some additional conditions In this study, we first give a theorem on the reducibility of 1.1 into the form of 1.5 and then obtain asymptotic stability of the zero solution of ... zero i stable if and only if ρ A ≤ and the eigenvalues of unit modulus are semisimple; ii asymptotically stable if and only if ρ A < 1, where ρ A of A} is the spectral radius of A max{|λ| : λ ... defined for n ≥ n0 Consider the system zn S n zn , n ≥ n0 1.7 Let H n be a fundamental matrix of 1.7 satisfying H n0 I This H n can be used to transform 1.1 into 1.5 Stability properties of 1.1...
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Báo cáo hóa học: " Research Article Eigenstructures of MIMO Fading Channel Correlation Matrices and Optimum Linear Precoding Designs for Maximum Ergodic Capacity" pdf
Ngày tải lên :
22/06/2014, 19:20
... Institute of Electrical and Electronics Engineers (IEEE), a Fellow of the Engineering Institute of Canada (EIC), and a Fellow of the Canadian Academy of Engineering (CAE) He is the recipient of the ... versions of E defined in (23) Therefore, the upper bound on ergodic capacity of a frequency-selective channel is a function of the sum of eigenvalue matrices of spatial correlation matrices of different ... entries and y[k] and n[k] denote the N × received and noise vectors, respectively We assume that the elements of H and n are complex Gaussian random variables with 1/2 variance per dimension, and...
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Báo cáo y học: "Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/ NMPRTase for glioma therap" doc
Ngày tải lên :
10/08/2014, 09:22
... list for further analysis The result of the virtual screening of the dataset is summarized in Table For selection of potential ligands, analysis of ligand protein contacts for top ranking poses of ... poses of the identified compounds Crystallographically observed binding modes of the known and new ligands in NMPRTase; (a) NMN, (b) FK866, and docked binding modes of compounds and (c) and (e) ... modes of compounds and respectively while panels (d) and (f) indicate the second binding modes of compounds and respectively The ligands are in ball and stick representation and colored by standard...
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Báo cáo sinh học: "The power of two experimental designs for detecting linkage between a marker locus and a locus affecting a quantitative character in a segregating population" pptx
Ngày tải lên :
14/08/2014, 19:22
... power of the kinds of designs for detecting linkage between a marker gene and a QTL can be expressed as function of design parameters and parameters describing genetic properties of the marker and ... for the mapping and analysis of quantitative trait loci with the aid of genetic markers Biometrics 42, 627-640 Weller JI, Kasi Y, Soller M (1990) Power of daughter and granddaughter designs for ... use of analysis of variance for detecting linkage between a marker gene and a QTL by means of a nested backcrossing or intercrossing experiment and attempted to work out the power of these designs...
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