biomarkers in multiple sclerosis

... for t-PA-induced intracranial bleeding in mouse models of focal stroke [37] In this model, co-treatment with the broad-spectrum MMP inhibitor GM6001 effectively reduced intracranial bleeding More ... be reinterpreted in the context of angiogenesis in the brain Is it possible that some of the acute neurovascular events in the brain after stroke represent an endogenous attempt by the brain to ... angiogenesis and recovery? In this minireview, we survey a few key events in the neurovascular unit, including blood–brain barrier (BBB) perturbations, matrix proteases, coupling between neurogenesis...

Ngày tải lên: 18/02/2014, 11:20

... bradycardia [,] The chronic increase in parasympathetic tone occurs within a few weeks after beginning regular training and this occurs independently of a lower intrinsic heart rate In crosssectional studies, ... decreased resting heart rate and increased vagal activity at rest after aerobic training [,] During exercise in the trained, a given increase in cardiac output requires less increase in heart rate ... USA King H Yang Bioengineering Center, Wayne State University, Detroit, Michigan, MI , USA Hannele Yki-Jọrvinen Department of Medicine, University of Helsinki, FIN-, Helsinki, Finland Liying Zhang...

Ngày tải lên: 15/03/2014, 09:20

... poor urine output, weak urine stream, abdominal distention, palpable abdominal or flank mass, pain, incontinence, urinary tract infection, hematuria, altered serum chemistries, or as an incidental ... of high quality data In conclusion, maintaining haemoglobin within a target range continues to pose a challenge to clinicians Further research is urgently needed in this insufficiently researched ... patients treated with ESAs Maintaining haemoglobin levels within narrow target range remains a major challenge in clinical practice The aim of this chapter is to review the definition, prevalence, risk...

Ngày tải lên: 23/03/2014, 17:20

... transformed in the sporting world, which at the elite level has become increasingly commercialised Pain and injury in the past meant missing competitions or taking a break from the rigour of training In ... Summary 11 The beginnings of sports medicine Investigating sports medicine: medical anthropology in context 52 Sporting bodies: mortal engines 53 The body and social theory 53 Pain and the body ... those making the transition: INVESTIGATING SPORTS MEDICINE 15 During the nineteenth century particularly American physicians, worried by the increasing sedentariness of a nation rapidly changing from...

Ngày tải lên: 30/03/2014, 02:20

... and can be administrated in the waiting room or used as a mailed survey [7] The KOOS questionnaire includes the WOMAC Osteoarthritis Index LK 3.0 [2,3] in its complete and original format (with ... KOOS questionnaire contains one single factor, we retained in our analyses the original subscales of the Swedish version of the KOOS questionnaire However, based on our findings we recommend additional ... have few complaints of their knee and have no or minor clinical signs of OA, which can explain the presence of ceiling effects in this group of patients Floor effects were only found in the subscale...

Ngày tải lên: 18/06/2014, 22:20

... co-staining, localized IL1α expressing microglia mainly to the penumbral tissue surrounding the infarct (Figure 2B) IgG cannot cross an intact blood brain barrier (BBB) and its presence in the brain ... mediator of the sterile inflammatory response Findings Inflammation is recognised as a major contributor to the worsening of acute brain injury [1] In particular two pro-inflammatory members of ... isoform in mediating the early inflammatory period following ischemic brain injury This is consistent with recent discoveries highlighting the earlier appearance of IL-1α in sterile inflammatory...

Ngày tải lên: 19/06/2014, 22:20

... of patients reporting doing the functions had increased to 40%, 28%, 23%, and 46% for squatting, running, jumping, and twisting/pivoting The percentage reporting kneeling had decreased to 26% ... deciding to have their knee operated on, Table 51% reported that improvement in functions included in the subscale Sport and Recreation Function such as squatting, kneeling, jumping, turning/twisting ... squatting, 17% with running, 12% with jumping, 42% with twisting/pivoting, and 34% with kneeling The others reported not performing the function At six months the percentages of patients reporting...

Ngày tải lên: 20/06/2014, 15:20

... pain or discomfort was more likely to be associated with spine and back injuries and injuries to multiple regions In terms of the nature of injury, notable findings were that those with sprains ... were actively involved interpreting the results, contributing to various drafts and approving the final manuscript Competing interests The authors declare that they have no competing interests Received: ... determine to what degree injuries resulting in relatively minor anatomical injury result in adverse outcome Holtslag and others addressed this issue by producing estimates for each specific injury...

Ngày tải lên: 20/06/2014, 15:20

... 350 joint7 joint23 Y 450 Y joint9 joint24 joint22 R 280 joint8 P joint2 P R joint1 320 R P joint6 joint3 Y P joint21 joint4 joint12 Y 95 Y P R R P joint16 joint11 225 250 joint10 P P 393 joint17 ... joint17 joint18 P P joint5 230 joint13 Z Yaw X Y Pitch Roll [mm] P R joint19 joint20 P R joint14 joint15 180 100 Figure Gorilla robot III evaluation parameters that have multiple uncertainties Since ... the injury of related tissues and organs The main recognized causes include injuries such as problematic vaginal birth, chronic increase of the intra-abdominal pressure (obesity, coughs), aging...

Ngày tải lên: 28/06/2014, 10:20

... activity was inhibited by MSX (Fig 3b), glutamine concentration failed to increase as in the control samples An initial small increase in glutamine concentration was probably due to a lag in GS inhibition ... medium containing: a) no inhibitors (control), or b) methionine sulphoximine (MSX) (1 mM), an irreversible inhibitor of GS, or c) azaserine (1 mM), a glutamate synthase inhibitor, or d) aminooxyacetate ... glutamine pools after h in the fresh medium (Fig 3a) Glutamate levels remained constant after h but the glutamine concentration continued to increase up to h indicating glutamine as the primary product...

Ngày tải lên: 09/08/2014, 04:20

... proteins Alterations in α1 expression may also affect the function of the GABAAR Increases in α1 mRNA and protein expression during development correspond to increases in BZ binding and altered zinc ... Therefore, the initial increase in γ2 expression hours post-TBI, followed by a decrease at 24 hours may indicate greater γ2-containing GABAAR clustering and greater BZ binding potential during the first ... in an incomplete understanding of their contribution to injury-induced pathology, but have indicated that the receptor is affected by injury Sihver et al [12] found a decrease in GABAAR binding...

Ngày tải lên: 10/08/2014, 05:21

... presented with a devastating injury involving her dominant limb She was referred because of neck pain and brachial plexus palsy The brachial plexus injury dominated the clinical picture There was ... Clay Cothren et al [8] in a large series concluded that the following cervical spine injury patterns mandate screening for blunt cerebro-vascular injury; fractures extending into the transverse ... vulnerable to injury during blunt neck trauma are, V2 (inside the transverse foramina) and the V3 (between the C1 and the base of the skull) [7] The latter is usually injured in minor trauma Clay...

Ngày tải lên: 10/08/2014, 10:20

... which was in keeping with medical renal disease Within a couple of days of admission, our patient began to experience worsening nausea, vomiting and abdominal pain His serum lipase level declined ... been reported to cause cholestasis of the intra-hepatic bile ducts resulting in elevated aminotransferases, hyperbilirubinemia and clinical jaundice [7] In this paper, we present a case of pancreatitis, ... wanting to “remain in shape” as the main reason for taking these pills Anabolic steroids are readily available to the general public over the internet and at public gyms, they are easily obtained...

Ngày tải lên: 11/08/2014, 00:23

... further grouped into "developed" "low-mortality developing" including China and much of Latin America, and "high mortality developing" including Sub-Saharan Africa, and many countries in Western and ... Study [10]) for integrating, validating, analysing and disseminating fragmentary information on the health of populations so that it is truly useful for health policy and planning Features of ... cost of establishing and maintaining such a system, and often the mortality data collected are incomplete and of poor quality [5] 'Verbal autopsy' procedures, using structured interviews with...

Ngày tải lên: 11/08/2014, 18:20

... (EPO), albumin and diuretics were also administered A 24-hour urine collection detected 6.38 g of proteins Erythrocyte sedimentation rate was 111 mm/hour Urine eosinophils were negative Abdominal computed ... evidence of tumor, bleeding or renal obstruction Serum protein electrophoresis revealed a decrease in total protein, albumin and gammaglobulins, but no monoclonal protein peak was detected There ... entirely, following months of treatment At 8-month follow-up, the patient's creatinine was 0.8 mg/dl and there was no proteinuria Discussion Oliguric acute kidney injury occurs infrequently in adult...

Ngày tải lên: 11/08/2014, 19:21

... family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin H-type (TRX-H-3) (GIF1) Thioredoxin family protein No classification ... important interactions of sucrose and xenobiotic signalling or of sucrose and ROS signalling, thus resulting in induction of specific transcription factors and in an integrated response to changing ... to atrazine treatment (MA) (Table 1) Thioredoxins have been shown to be involved in supplying reducing power to reductases detoxifying lipid hydroperoxides or repairing oxidized proteins [37]...

Ngày tải lên: 12/08/2014, 03:20

... the inflammatory response to acute epithelial injury and in maintaining and repairing the epithelial barrier [16] Chen et al have found that a deficiency of γδ T cells rendered the intestinal ... protein induced changes in airway stability and closure contributed to AHR in the current study We speculate that the increases in BAL protein levels in γδ T cell deficient mice under baseline ... principally epithelial cells These values returned towards baseline at days in wild type and at days in knockout mice The increase in total cell counts was mostly attributable to increases in...

Ngày tải lên: 12/08/2014, 15:20

... Traumatic joint injury in young adults greatly increases the risk of developing OA [1,2] and post-traumatic OA remains a major clinical and societal problem Treatments following joint trauma initially ... accumulate in the synovial fluid [5] Moreover, joint injury results in an immediate surge in synovial fluid concentrations of pro-inflammatory cytokines, including tumor necrosis factor-a (TNFa), interleukin-1b ... highlighted the interplay between mechanical and cytokine-mediated pathways regulating cartilage degradation relevant to traumatic joint injury [11] We used an in vitro model involving injurious compression...

Ngày tải lên: 12/08/2014, 18:20