... malonyl-CoA and CPT1c in the treatment
of obesity
Michael J. Wolfgang and M. Daniel Lane
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Introduction
All ... malonyl-CoA;
neurometabolism; nutrient sensing; obesity
Correspondence
M. J. Wolfgang, Department of Biological
Chemistry, Johns Hopkins University School
of Medicine, Center for Metabolism and
Obesity Research, 475 Rangos ... major user of long-chain fatty
acids making a brain-specific isoform intriguing.
CPT1c was identified and cloned from in silico
sequences as a highly homologous member of the
CPT1 class of enzymes...
... emerging targets for treatment
of obesity and related metabolic diseases
Tsuyoshi Kadomatsu, Mitsuhisa Tabata and Yuichi Oike
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto ... metabolism;
insulin resistance; metabolic syndrome;
obesity; obesity- related metabolic disease
Correspondence
Y. Oike, Department of Molecular Genetics,
Graduate School of Medical Sciences,
Kumamoto University, ... roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and
related metabolic diseases, and discuss the possibility that both could func-
tion as molecular targets for the prevention and treatment of obesity...
... most prevalent form of MetS is
associated with abdominal (visceral) obesity and that
this type ofobesity contributes to insulin resistance
(IR) and the increased release of cytokines, as well ... risk of T2DM, hypertension and CVD;
however, the exact underlying pathophysiological
mechanisms by which obesity increases the risk of
VD remains the subject of intensive investigation [20].
Obesity ... deficiency
and hypogonadism-induced obesity remain the subject
of intense investigation.
Several hypotheses have discussed the relationship of
androgen deficiency and obesity. That obesity is
commonly associated...
... use of drugs to counteract
obesity risk factors or simply to the latency of the effect.
This analysis does not take account of the impact of childhood obesity. The health consequences of overweight ... prevalence of obesity
THE DETERMINANTS
•
13
2. The determinants of obesity
Main messages
• The simultaneous presence of physical inactivity and poor diet to a large extent explains the obesity ... sense of fatalism about their
health.
Lower socioeconomic status not only increases the risk ofobesity but may result from obesity. Several stud-
ies have noted that obesity increases time off...
...
Department of Ichthyology and Aquatic Environment, University of Thessaly, 38446, Nea Ionia, Volos, Greece
Received 19 February 2007; Accepted 29 May 2009
Abstract. The reproductive biologyof the ... basis at the mouth of the river
using a bag seine net and overall a total of 4 563 individuals were collected. The total length of
males ranged between 2.5 and 6.0 cm and that of females between ...
throughout most of the year may be a specific character of the marbled goby (F o u d a et al.
1993), as well as of some other goby species (M i l l e r 1984).
The marbled goby, one of the few species...
... Birds
Mercury Cadmium Lead
Range of
Means
Median of
Means
No. of
Data Sets
Range of
Means
Median of
Means
No. of
Data Sets
Range of
Means
Median of
Means
No. of
Data Sets
Loons and Grebes 9.7–10.9 ... LLC
490 Biologyof Marine Birds
for mercury (20 of 21 studies), lead (4 of 7), cadmium (3 of 5), manganese (5 of 5), and selenium
(3 of 3), with chromium showing less of a difference (only 1 of 4 ... concentration in
eggs of about 1 ppb. Many of the congeners of PCB, PCDF, and PCDD are capable of inducing
this condition, although their potency varies.
Increased incidence rates of craniofacial defects...
... CCAMLR applied to the U.S. Because of the
complex nature of international treaties and the lack of traditional police and courts, enforcement
of international law is often extremely difficult to secure.
Early ... publish lists of birds, including seabirds, that are
endangered, threatened, or are of special concern. For example, the U.S. Fish and Wildlife Act of
1980 created a list of species of concern that ... component of the major
threats to seabirds, few of which are listed under CITES (see Table 17.2).
The Convention on the Conservation of Antarctic Marine Living Resources (CCAMLR) was
enacted because of...
... possible
effects of a loss of feeding grounds on wading birds (Charadrii). Journal of Applied Ecology 14:
721–739.
GOSS-CUSTARD, J. D., AND M. E. MOSER. 1988. Rates of change in the numbers of Dunlin, ... MARINE
ENVIRONMENT
One of the most spectacular yet poorly understood aspects of shorebirds is their biology during
passage over large bodies of water. With the exception of phalaropes, shorebirds ... detection in birds: the use of principles of seabed dynamics? Proceedings
of the Royal Society of London B 265: 1377–1383.
PRATER, A. J. 1981. Estuary Birds of Britain and Ireland. T. & A. D....
... lumbar ROM appears
to be a feature ofobesity and it appears plausible that it
might play a role in the onset of cLBP in obese patients.
A rehabilitative spin-off of our study is that targeted
exercises ... here:
http://www.biomedcentral.com/info/publishing_adv.asp
BioMedcentral
Vismara et al. Journal of NeuroEngineering and Rehabilitation 2010, 7:3
http://www.jneuroengrehab.com/content/7/1/3
Page 8 of 8
➢ absence of a not-obe se cLBP cohort of patients:
including such ... kinematics of the spine: under static
conditions, obesity per se seems c orrelated to an
increased anterior pelvic tilt; under dynamic conditions,
to impaired mobility of the thoracic spine. Obesity...
... adversely affects health [1]. The rates ofobesity rates have doubled since 1980 [2] and as of 2007,
33% of men and 35% of women in the US are obese [3]. Obesity is positively associated to many ... Open Access
Effects ofobesity on bone metabolism
Jay J Cao
Abstract
Obesity is traditionally viewed to be beneficial to bone health because of well-established positive effect of
mechanical loading ... positive effec ts of body we ight could
not completely offset the detrimental effects of obesity
on bone, at least in obese animal models.
Conclusions
Accumula ting data suggest that obesity is detrimental...