biological approaches to investigating nutrition and cancer
Báo cáo khoa học: Characterization of surface n -alkanes and fatty acids of the epiphytic lichen Xanthoria parietina, its photobiont a green alga Trebouxia sp., and its mycobiont, from the Jerusalem hills pot
... library (7th edition) Results and discussion The complex hydrocarbons and fatty acids produced by the cultured photobiont green alga Trebouxia sp and the mycobiont, and also by X parietina, were ... medicines, and is used in many Asian countries [40] It has also been found as a major effluent component in the paper and pulp industry [41] and is one of the toxic compounds accumulated in fish and other ... According to BychekGuschina [43], photobionts of Trebouxia erici and Trebouxia impressa (cultures from the Botanical Institute, St Petersburg, Russia) not contain the 18 : and 18 : fatty acids, and...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... preparation, and how long they are exposed to this cytokine Consequently, IL-1b has been considered to be a mitogen and effective co-mitogen acting in conjunction with other growth factors [2] The ... synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAs Induction of cyclin D1 is one of the earliest effects of mitogenic factors leading to cell cycle re-entry, G1-phase progression, and transition ... p38 mitogen-activated protein kinase (MAPK) expression vector or preincubated with the MAPK kinase (MEK) inhibitor (50 lM U0126; U) and the phosphatidylinositol 3-kinase (PI3-K) inhibitor (50...
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Báo cáo khoa học: Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence pptx
... metabolism [33] We studied the conversion of 14C-formate to 14CO2 in rat and found it to be localized mainly in the cytosolic fraction, and to be stimulated by NAD+ [19] No further work on the fate ... peroxisomal targeting signal between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it J Biol Chem 273, 33635–33643 Baes, M., Gressens, ... excessive amounts of phytol can lead to similar severe neurological symptoms as in ARD, indicating that at least some of the symptoms in ARD might be directly related to an accumulation of phytanic...
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Báo cáo khoa học: Activation of Stat5 and induction of a pregnancy-like mammary gland differentiation by eicosapentaenoic and docosapentaenoic omega-3 fatty acids docx
... inverse association between the ratio of n-3 to n-6 PUFA and breast cancer risk [17], breast cancer metastasis [18], and sensitivity of mammary tumors to cytotoxic drugs [19] The preventative effect ... killed at 6, 8, 10, 12 and 14 weeks and subjected to whole mount morphological analysis The right inguinal gland was removed and subjected to whole mount gland fix, defat, and staining Representative ... acids are ligands for nuclear receptors and therefore could act as agonists and induce receptor transactivation [46] In an extensive effort to search for endogenous ligands for RXR, a factor in brain...
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Báo cáo khoa học: Cytochrome P450 metabolizing fatty acids in plants: characterization and physiological roles pptx
... FEBS 201 Cytochrome P450 metabolizing fatty acids in plants F Pinot and F Beisson established for yeast belonging to the genus Candida Members of the CYP52 family enable Candida maltosa to grow ... invited to refer to the specific review by Stumpe and Feussner [51] Briefly, contrary to the majority of P450s, members of this family catalyse oxidative reactions without O2 and NADPH-cytochrome ... of a peroxisome proliferator-activated receptor This peroxisome proliferator-activated receptor can be activated by clofibrate [47] and by FA derivatives such as prostaglandins Clofibrate produces...
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Effects of dietary n-3 and n-6 fatty acids levels on egg and larval quality of Eurasian perch pdf
... (Dicentrarchus labrax) Aquaculture, 149: 107-119 LANDS, W.E.M., 1989 - Differences in n-3 and n-6 eicosanoid precursor In: Advances in prostaglandin, thromboxane and leukotriene research (Samuelsson B., ... Eurasian perch egg and larval quality Henrotte et al References BELL J.G., FARNDALE B.M., BRUCE M.P., NAVAS J.M & M CARILLO, 1997 - Effects of broodstock dietary lipid on fatty acid...
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báo cáo khoa học: " Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity" pot
... for the presence of GTAs The total ion chromatogram (top), extracted mass spectra (middle), and extracted ion chromatograms for three GTAs (GTA446, 448 and 450; bottom) of the GTA-ve fraction ... anti-inflammatory and proresolving mediators J Periodontol 2008, 79:1520-1526 21 Seki H, Tani Y, Arita M: Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1 Prostaglandins Other ... levels, and numerous downregulated inflammatory markers including nitric oxide, NOS2, IL-1b, TNFa and COX2 Given the critical role of NFB in regulating both apoptosis and inflammation and its...
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Báo cáo y học: " Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33 000 women from the general population" ppt
... Eicosapentaenoic acid and arachidonic acid: collaboration and not antagonism is the key to biological understanding Prostaglandins Leukot Essent Fatty Acids 2002, 66(1):83-90 Simopoulos A, Cleland L: Omega-6/Omega-3 ... initiated, and women who had responded to the 1991/1992 questionnaire and who were alive and living in Sweden in October 2002 were contacted Since 1991/1992, 688 women were deceased, and 491 women ... translated from English into Swedish and back-translated to increase fidelity to the original scale Two independent professional translators did the back-translation, and the consensus version...
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Báo cáo y học: "Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial" docx
... regulatory processes that occur to control inflammatory cytokine release A strong inflammatory stimulus in vivo will lead to inflammatory cytokine production with an elevation in plasma cytokine ... between circulating pro- and antiinflammatory cytokine concentrations which are elevated early in sepsis and the ability of leukocytes to produce pro- and anti-inflammatory cytokines which is impaired ... atmosphere and at 37°C After this, the supernatant medium was collected and stored at -70°C until analysis (within nine months) Cytokine and eicosanoid analyses Cytokines, prostaglandin (PG) E2 and...
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THE EFFECT OF OMEGA-3 FATTY ACIDS ON AIRWAY INFLAMMATION, HYPERPNEA-INDUCED BRONCHOCONSTRICTION, AND AIRWAY SMOOTH MUSCLE CONTRACTILITY IN ASTHMA
... epithelial cells, fibroblasts, and bronchial smooth muscle cells in the airways (18) The eosinophils in particular secrete proinflammatory mediators, cytotoxic mediators, and cytokines which cause many ... inflammation (48) Nitric oxide, growth factors involved in respiratory tissue repair, and proinflammatory cytokines that recruit inflammatory cells to the airways are also released by the epithelium ... early and a late phase In the early phase, mast cells and macrophages in the airways are activated and release proinflammatory mediators such as histamine, leukotrienes, prostaglandins, and reactive...
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Enhanced transdermal delivery with fatty acids and electroporation
... fungi Tolypocladium inflatum CsA is an established immunosuppressant that is widely used to prevent organ transplant rejection and to treat various autoimmune diseases such as psoriasis and atopic ... to design a suitable sustained delivery system for CsA and for diseases such as psoriasis and atopic dermatitis, topical CsA has displayed superior efficacy and reduced side effects (Hewitt and ... νa(CH2) and νs(CH2) did correspond to enhanced skin permeation of both polar and nonpolar solutes (Bhatia and Singh, 1998; Barry, 1987; Takeuchi et al., 1992) Thus, FTIR has proved to be a useful tool...
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Effects of central nervous system free fatty acids, prostaglandins and lysophospholipids on allodynia in a mouse model of orofacial pain
... are provided to the face and oral cavity and the motor innervations to the muscles of mastication The three main trigeminal nerve divisions: ophthalmic, maxillary and mandibular, together constitute ... fields and can show modality convergence, for example from both cutaneous and tooth receptors (Jacquin and Rhoades, 1990) In the rat Sp5O has extensive projections to the facial motor nuclei and ... overwhelming and disrupts ongoing behavior and thought The measurement of pain is therefore essential to determine pain intensity, quality and duration, to aid in diagnosis and to help decide...
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FATTY ACID COMPOSITION INCLUDING TRANS FATTY ACIDS CONTENT OF SELECTED VIETNAMESE INSTANT NOODLES
... The amount of total TFA in the samples ranged from 0.16% to 0.83% of total fatty acid with the mean of 0.38% Total trans content was significant higher in brands IN1 and IN5, 0.7% and 0.83%, respectively ... from April to July 2011 Each brand was coded with letter from IN1 to IN16 The small oil bag taken from thirteen brands was coded with letter from SB1 to SB13 Lot numbers were checked to ensure ... AgNO3 solution in acetonitrile for 20 The plate was then left for to dry at 110oC in an oven Total fatty acid methyl esters were applied onto the plate in the narrow band, and developed in hexane/diethyl...
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Characterization of the Carbon Stable Isotope Ratio and Fatty Acid Structure of Zostera japonica in Coastal Areas
... microalgae, periphyton and phytoplankton because Z japonica may have difficult system of photosynthesis compared to these plants and algae In addition, the leaves and stems as well as the roots and rhizomes ... of 18:2n6c, 18:3n3 and LCFAs in the leaves and stems was compared with that in the roots and rhizomes The roots and rhizomes contain more 18:2n6 and LCFAs than the leaves and stems (n = 15, p ... the carbon stable isotope and fatty acid structure of Z japonica because stable isotope and fatty acids are useful methods to clarify the carbon cycle in the ecosystem, and Z japonica may have...
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Tài liệu VAI TRÒ CUẢ OMEGA-3 FATTY ACIDS TRONG VIỆC ĐIỀU TRỊ VÀ PHÒNG NGỪA BỆNH doc
... tính: thromboxane A 2, prostaglandins, leukotrienes Những tế bào chứa đựng nhiều DHA EPA, trái lại với AA, sản xuất eicosanoid có viêm tính, làm giảm viêm chỗ to n diện Ngoài ra, resolvins xuất ... lớn Carlson cộng viên bàn tới tác dụng tốt cung cấp sớm DHA có liên quan tới số Bayley Psychomotor Developmental Index (PDI) ( khuôn vàng thước ngọc cuả phát triển thần kinh hệ, đo lường kiểm ... đổi LNA EPA DHA không cho đủ lượng LC n-3 PUFA Đối với đàn ông, 3% tớI 8% cuả 1.3g LNA biến EPA and 0% tới 4% EPA biến đổi DHA Đối với đàn bà, 21% EPA biến 9% kéo dài thành DHA Sự biến đổi bị...
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Tài liệu Báo cáo khoa học: Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulation ppt
... and standard deviation values of four measurements are presented external, therapeutic fibrinolysis [1], when plasmin is generated by plasminogen activators on preformed fibrin and is exposed to ... substrates Materials and methods Materials Sodium salt and free acid forms of oleic, stearic and arachidonic acids were purchased from Sigma-Aldrich Kft (Budapest, Hungary) and stock solutions (10 ... The values of kp and Km were determined from the amidolytic assay of plasmin activity, according to Model I, in the presence of oleate (OA) and arachidonate (AA), or, according to Model III, in...
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Báo cáo khoa học: Arabidopsis thaliana CYP77A4 is the first cytochrome P450 able to catalyze the epoxidation of free fatty acids in plants potx
... °C), the purified PCR product was cloned into PCRII TOPO vector (Invitrogen, Carlsbad, CA, USA), and transferred to the pYeDP60 vector using the BamHI and KpnI restriction sites The sequence was ... substrate, ranging from 10 to 200 lm for C12:0, to 120 lm for C18:1, to 80 lm for C18:2, and to 120 lm for C18:3 TLC methods Incubation media were directly spotted onto TLC plates For the separation ... performed at 27 °C and contained 20 pmol of CYP77A4 They were stopped after 30 by the addition of 20 lL of acetonitrile (containing 0.2% acetic acid) and directly spotted onto TLC Peak S, lauric...
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Báo cáo khoa học: Mutants of Saccharomyces cerevisiae deficient in acyl-CoA synthetases secrete fatty acids due to interrupted fatty acid recycling docx
... FAA1 in Candida lipolytica and in S cerevisiae to a fatty acid secretion phenotype In the mutant strains described, the control over certain fatty acid pools appeared to be restricted and, in ... The cells were grown in YPR medium and harvested at different time points during the exponential and stationary phases Medium and cells were extracted and the total fatty acid concentrations of ... the other hand, the activity of Fat1p alone was not strong enough to prevent the secretion of fatty acids upon combined deletion of FAA1 and FAA4 To allow for speculation about the biological...
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Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx
... apoptosis, insulin receptor substrate 1, mammalian target of rapamycin kinase (mTOR), mitogen-activated protein kinase kinase 3, c-Jun N-terminal kinase, translation elongation factor eEF2 and ... from 0.13 ± 0.03 to Fig Effects of palmitate, insulin and epinephrine on a-2 AMPK activity and malonyl-CoA content Hearts were perfused for 60 with mM glucose and BSA (20 mgÆmL)1) and other additions ... by 2.2-fold and increased a-2 AMPK activity to a similar extent The a-2 AMPK activities in Fig were appreciably lower than in Table and in Figs 2, and In part this difference was due to the presence...
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