biodiversity conservation economic development and drug discovery in suriname

... rapid increase in population puts a considerable strain on the economic and political system of a county and may be accompanied by a rise in all criminal activity, including terrorism.46 Finally, ... studying political violence, including Samuel Huntington,14 who borrows from the relative deprivation framework to explain the increase in political violence witnessed in the United States and in ... a declining measure indicates a process of liberalization or declining repression The expectations about the relationship between ‘‘Repression’’ and ‘‘DRepression’’ and the incidence and intensity...

Ngày tải lên: 23/03/2014, 20:20

... molecular work and sequence analysis and prepared the manuscript SL and CV assisted in designing the study and drafting the manuscript KD and JR performed viral loads and genotyping KM supervised ... Prevalence and risk factors for developing K65R mutations among HIV-1 infected patients who fail an initial regimen of fixed-dose combination of stavudine, lamivudine, and nevirapine J Clin Virol ... genotyping of HIV RNA was performed by nested RT-PCR and an in- house sequencing assay as described elsewhere [4] The interpretations of genotyping data and subtyping were performed using Smartgene™...

Ngày tải lên: 10/08/2014, 05:21

... ligand-protein binding Power-law behaviors of ligand-protein binding The number of ligands (N) decays with an increase in the number (L) of (a) domains and (b) folds that bind the ligand and ... during protein folding [74,75] Thus, the free energy release during ligand binding may meet the free energy demand during protein folding It is tempting to examine the conjecture of ligand-induced ... protein-ligand binding ture-function relationships of proteins First, binding sites and ligands are quite flexible and plastic [39-41], and therefore, binding-site selection is, to certain extent,...

Ngày tải lên: 14/08/2014, 08:20

... Bioinformatics and cheminformatics in drug discovery The combination of random screening and rational drug design have played an important role in drug discovery [44] The traditional drug discovery ... 1.2 Bioinformatics and cheminformatics in drug discovery 1.3 Introduction of bioinformatics and cheminformatics database development 11 1.4 Overview of virtual screening in drug discovery ... Description Web link BindingDB Binding affinities of proteins and http://www.bindingdb.org/bind/index.jsp protein ligand MDDR http://accelrys.com/products/databases/bioa molecules PubChem Information...

Ngày tải lên: 10/09/2015, 09:04

... These included substituted purines, pyrimidines, indoles, quinazolines, pyrazines, pyrrolopyrimidines, pyrazolopyrimidines, phthalazines, pyridazines and quinoxalines[55] High-throughput screens ... They repeatedly introduce certain proteins channeled into the cells via poly-arginine anchors and sufficiently induced pluripotency[45] This new technique brings in new hope in stem cell research ... mounting (containing Dapi, Invitrogen) was performed to stain the nucleus Staining was examined under fluorescent microscope (Olympus IX70, Tokyo, Japan) 2.1.6 Teratoma formation and staining...

Ngày tải lên: 16/10/2015, 15:38

Ngày tải lên: 18/02/2014, 11:20

... housing in England, or (b) tenants of social housing and other residential property in England The function in this subsection is that of conducting or commissioning research into issues affecting— ... appointing authority, any person who is a partner authority in relation to the appointing authority (7) (9) 32 Any local authority and any joint overview and scrutiny committee must, in exercising ... can take part in those democratic arrangements and what is involved in taking part 54/4 10 Local Democracy, Economic Development and Construction Bill [HL] Part — Democracy and involvement Chapter...

Ngày tải lên: 21/02/2014, 00:20

... labelling intensity observed with the single-cysteine-containing isoforms Obtaining full labelling and its accurate quantitation are difficult to achieve in practice, resulting in occasional instances ... were examined by introducing cysteines at distinct positions in TM12 and assessing their accessibility to covalent modification with thiol-reactive probes In order to determine how changes in the ... substrate-induced fit mechanism for drug binding J Biol Chem 278, 13603–13606 Loo TW, Bartlett MC & Clarke DM (2003) Simultaneous binding of two different drugs in the binding pocket of the human multidrug...

Ngày tải lên: 06/03/2014, 22:21

... crosstalk between auxin and other plant hormones [21–24] Our study also shows that genes involved in cytokinin (e.g cytokinin-Oglucosyltransferase, cytokinin dehydrogenase, and response regulators), ... Transcript profiling of auxin-responsive genes M Jain and J P Khurana responses, which indicates crosstalk between stress and auxin signaling In the recent past, the identification of F-box proteins (TIR1 ... results reported in this study will be helpful in understanding the transcriptional network regulated by auxin and functional validation of selected auxin-responsive genes involved in developmental...

Ngày tải lên: 07/03/2014, 01:20

... and environment in each individual case In fact, there is growing interest in longitudinal analysis, as in the aforementioned study of CO2 emissions in several countries (Unruh and Moomaw, 1998), ... (1992), Panayotou (1993), Selden and Song (1994), and Holtz-Eakin and Selden (1995) Special issues of Ecological Economics (1995, 1998) and Environment and Development Economics (1996) have discussed ... support the EKC generally find inversion points in the relationship between economy and environment that are a very long way from current income in the developing countries This indicates that much...

Ngày tải lên: 15/03/2014, 16:20

... movements in heights and the parallel changes in life expectancy Baten (2002) shows that colder winters beginning in the late 1750s lowered grain and protein production, leading to reductions in physical ... links mor¨ tality crises to human capital accumulation and early economic growth He correctly points out that crises receded in continental Europe and Scandinavia much after than in England and ... aggregate income gains were the dominating factor in explaining mortality decline during 1960s–70s (Preston, 1985) Similar quantitative effects were found by Pritchett and Summers (1996) and Easterly...

Ngày tải lên: 17/03/2014, 08:20

... worked in reducing maternal mortality include those relating to innovative financing measures; investment in human resources, both in terms of strengthening pre-service education and emphasizing in- service ... NGOs and other institutions Improving maternal and perinatal health working in the field on maternal and infant health Work with Doctors with Africa CUAMM, an NGO operating in Africa since 1955 in ... Hypertension in Pregnancy (ISSHP), in Geneva WHO will be leading and coordinating a number of sessions in both Congresses increasing visibility and repositioning HRP's work and priorities in the global...

Ngày tải lên: 23/03/2014, 06:20

Ngày tải lên: 03/06/2014, 02:20

... widespread dissemination of information on business, investment, and economic opportunities and conditions in the State The Hawaii Tourism Office has been inactive since July 1, 1998 and was abolished ... function, and its authority is limited to reviewing, evaluating, and reporting on its findings and recommendations to the Legislature and the Governor THE AUDITOR STATE OF HAWAII Kekuanao‘a Building ... the following types of examinations: Financial audits attest to the fairness of the financial statements of agencies They examine the adequacy of the financial records and accounting and internal...

Ngày tải lên: 18/06/2014, 20:20

... licensing and permit information and referral; business advocacy; planning and coordination of programs and projects aimed at specific business sectors or economically-distressed areas, including ... recommendations on the financial accounting and internal control practices and procedures of the Department of Business, Economic Development and Tourism (department) Summary of Findings We found several ... written guidelines over loan origination, maintenance of loan files, loan payment processing, and monitoring of delinquent borrowers Formally documenting and enforcing established policies and procedures...

Ngày tải lên: 18/06/2014, 20:20

... REPORT ON INTERNAL CONTROL OVER FINANCIAL REPORTING AND ON COMPLIANCE AND OTHER MATTERS Independent Auditors' Report on Internal Control over Financial Reporting and on Compliance and Other Matters ... financial reporting and compliance and the results of that testing, and not to provide an opinion on the internal control over financial reporting or on compliance That report is an integral part ... DBEDT's ongoing obligations for its operations relating to business and economic development This is trial version www.adultpdf.com 11 Department of Business, Economic Development and Tourism...

Ngày tải lên: 19/06/2014, 17:20

... Strategic Industries, Strategic Marketing and Support, Creative Industries, Economic Planning and Research for Economic Development, General Support for Economic Development, Aloha Tower Development ... Technology Development Corporation Office of Planning General Support for Economic Development Strategic Industries Strategic Marketing and Support Economic Planning and Research for Economic Development ... Technology Development Corporation Office of Planning Aloha Tower Development Corporation Strategic Industries General Support for Economic Development Economic Planning and Research for Economic Development...

Ngày tải lên: 19/06/2014, 17:20

... federally-insured savings and checking accounts, time certificates of deposit, and repurchase agreements with federally-insured financial institutions Information relating to the bank balance, insurance, ... Creative Industries High Technology Development Corporation General Support for Economic Development Foreign-Trade Zone Office of Planning Economic Planning and Research for Economic Development Land ... revenues and expenditures Net changes in unreserved liabilities Unbudgeted revenues and other financing sources net of expenditures and other financing uses Net change in fund balances - GAAP basis Economic...

Ngày tải lên: 19/06/2014, 17:20

... States Internal Control Over Financial Reporting In planning and performing our audit, we considered the DBEDT's internal control over financial reporting as a basis for designing our auditing procedures ... our audit in accordance with auditing standards generally accepted in the United States of America and the standards applicable to financial audits contained in Govemment Auditing Standards, issued ... State records a liability for risk financing and insurance related losses, including incurred but not reported, if it is determined that a loss has been incurred and the amount can be reasonably...

Ngày tải lên: 19/06/2014, 17:20

... program in order to determine our auditing procedures for the purpose of expressing our opinion on compliance, but not for the purpose of expressing an opinion on the effectiveness of internal ... defined above This report is intended solely for the information and use of the Office of the Auditor, the management of DBEDT, federal awarding agencies and pass-through entities and is not intended ... Department of Business, Economic Development and Tourism State of Hawaii SCHEDULE OF FINDINGS AND QUESTIONED COSTS Fiscal Year Ended June 30, 2009 SECTION I - SUMMARY OF AUDITORS' RESULTS Financial Statements...

Ngày tải lên: 19/06/2014, 17:20