beyond the apoptosis and necrosis dichotomy

... tumor necrosis factor-related apoptosis inducing ligand receptor 1, tumor necrosis factor-related apoptosis inducing ligand receptor [35], and tumor necrosis factor receptor [36] are enriched in the ... control to monitor the cleavage of proteins during apoptosis and necrosis because its cleavage products in Jurkat cells undergoing apoptosis (89 kDa) and undergoing necrosis (60 and 50 kDa) are ... Since the fate of the Golgi complex during cell death has not been extensively explored, we investigated whether the Golgi complex and associated autoantigens are altered during apoptosis and necrosis...

Ngày tải lên: 09/08/2014, 03:24

... Arthritis Research & Therapy Vol No Wei et al Figure Chondrocyte death consists of apoptosis and necrosis (a) Morphonecrosis logic analysis of chondrocyte apoptosis and necrosis The nuclei of apoptotic ... interests The authors declare that they have no competing interests Authors' contributions LW carried out the study, analyzed the results, and drafted the manuscript X-jS participated in the design and ... (Figure 3a) To quantify the rates of apoptosis and necrosis, we simultaneously labeled chondrocytes with anti-annexin V (a marker of apoptosis) and propidium iodide (a marker of necrosis) FACS analysis...

Ngày tải lên: 09/08/2014, 07:20

... Leiden, The Netherlands) on an offline workstation, the magnetization transfer ratio (MTR) was calculated per voxel using the equation MTR = ([M0 - Ms])/M0) × 100%, with M0 and Ms representing the ... in the brain Competing interests The authors declare that they have no competing interests Authors' contributions SCAS,GPTB,TWJH and MAvB participated in the design of the study SCAS, GPTB and ... unit) and peak location (percent unit) were read from the normalized histogram without any function fitting [23] The mean MTR indicates the average MTR value, the peak height is a measure of the...

Ngày tải lên: 09/08/2014, 07:20

... those standards to the community is well illustrated in the on-going ‘hormone dispute’ between the EU, on the one hand, and US, Canada and Argentina, on the other hand This dispute concerns the EU’s ... kind Here the problem lies not with the indeterminacy of the standards, but with the need for the ensuing rules to be accepted and supported by citizens who experience the force of the rule’s ... concealed within the norms themselves In the EU the unique legal and institutional context that establishes and mandates a structured dialogue between the European Court of Justice and member state...

Ngày tải lên: 01/11/2013, 07:20

... locations as closets, basements, CEVs, and other tight spaces The rack-mount chassis includes cable support bars on the rear for coax cables and radius limiters on the front for protection of fibers ... modularity, and ease of service turn-up — carried over to the Extend O/E Line Extender The ADC solution was the preferred product for building reliability and operational efficiency into the growing ... guides on the front of the rack, guides that use no rack space, optical fibers can be safely routed to splice decks and storage trays The second factor that helped gain approval of the Extend...

Ngày tải lên: 24/01/2014, 12:20

... reserved 23 The Sun to the Earth and Beyond: A Decadal Research Strategy in Solar and Space Physics http://www.nap.edu/catalog/10477.html 24 THE SUN TO THE EARTH AND BEYOND THE SUN AND CLIMATE The ... (AFOSR) The Sun to the Earth and Beyond is the report of the Solar and Space Physics Survey Committee It draws on the findings and recommendations of the five study panels, as well as on the committee’s ... 13 The Sun to the Earth and Beyond: A Decadal Research Strategy in Solar and Space Physics http://www.nap.edu/catalog/10477.html 14 THE SUN TO THE EARTH AND BEYOND and private space weather...

Ngày tải lên: 05/03/2014, 11:21

Ngày tải lên: 11/03/2014, 17:08

... reserved 23 The Sun to the Earth and Beyond: A Decadal Research Strategy in Solar and Space Physics http://www.nap.edu/catalog/10477.html 24 THE SUN TO THE EARTH AND BEYOND THE SUN AND CLIMATE The ... (AFOSR) The Sun to the Earth and Beyond is the report of the Solar and Space Physics Survey Committee It draws on the findings and recommendations of the five study panels, as well as on the committee’s ... 13 The Sun to the Earth and Beyond: A Decadal Research Strategy in Solar and Space Physics http://www.nap.edu/catalog/10477.html 14 THE SUN TO THE EARTH AND BEYOND and private space weather...

Ngày tải lên: 15/03/2014, 15:20

... apoptosis and transcription Hippi Also, expression of the mitochondrial-coded genes ND1 and ND4, the nuclear genome-coded mitochondrial genes SDHA and SDHB and the antiapoptotic genes BCL-2 and ... (422–503), AP2 (262–266 and 358–360), CLH1, CLH2 (332–336), CLTA, CLTB (484–489) and other domains are taken from the published literature and mentioned in the text The positions of the amino acids are ... (45 kDa) and the activated caspase-1 (20 kDa) are shown by the arrows on the left The bar diagram (right panel) shows the average (n = 3) of integrated optical density (IOD) of the bands obtained...

Ngày tải lên: 23/03/2014, 07:20

... the longer term trend growth rates projected by the model for the period beyond 2017 We have added Malaysia and Poland to the analysis and include commentaries by senior PwC economists from these ... which shows the growth paths of the E7 and the G7 in MER terms, paints a similar picture, with the exception that the year in which the E7 overtakes the G7 is pushed back to around 2030, rather than ... should not abandon their home markets in the US and EU, even if these are growing much more slowly on average than the emerging economies For higher valued products and services, the US and EU markets...

Ngày tải lên: 24/03/2014, 21:21

... all of the brand and its values Therefore, a financial service brand is based entirely on the way the company does things’ and on the company’s values and culture This means that a brand personality ... commitment to and their understanding of the brand benefits A booklet explaining the brand values was distributed to staff and customers and the entire LVFS literature was rewritten to reflect the newly ... performance of the service They are also contributors to the quality and value of the service thereby influencing their assessments about the service brand Consumers who believe they have played their...

Ngày tải lên: 30/03/2014, 09:20

... is therefore possible to discuss tastes and argue about them because people genuinely differ in their tastes, in their aesthetic preferences, and, hence, in what they regard as beautiful Nevertheless, ... Calculating the loadings separately for the first 84 paired comparisons and their immediate repetition as the second 84 paired comparisons, there were correlations of 888 and 920 for the loadings on the ... collection of response times, and they in turn can be used to assess the details of the process by which aesthetic preferences are made Finally, and it was the primary purpose of the study, we wanted...

Ngày tải lên: 30/03/2014, 16:20

... inhibiting the degradation of the Scc1/Mcd1 cohesin subunit (reviewed in [28–30]) Below we review in further detail the nature of centromeric chromatin and SCC and the relationship between them THE ... integrity of the cohesion proteins (and perhaps the underlying CAR, as in the case of centromere-proximal cohesion), there is little information about the mechanism of 2308 P B Meluh and A V Strunnikov ... Schizosaccharomyces pombe (Swi6 and Clr4), Drosophila and mammalian cells [HP1 and Su (var)3–9] Recently, these chromo domain proteins have been implicated in the recruitment and/ or stabilization of...

Ngày tải lên: 31/03/2014, 21:21

... Brazil, all of whom confront the interventions of geneticists They also involve the genomes of the dog, the cloned sheep, and the chimpanzee, and the many ways that other species are implicated ... and identity, race and culture, history and the human future What stories genes tell? And what stories we tell about genes and, in so doing, about others and ourselves, science and society, and ... The two events the one from the 1960s and the other from the 1990s— involved different groups of scientists and, to a large extent, distinct methodological approaches and research goals Yet they...

Ngày tải lên: 08/04/2014, 12:36

... healthfulness, etc.), and (5) menu label preference On the back of the survey, participants were presented a menu and asked which item (s) and beverage they ordered and if they ordered dessert ... All of the authors were involved in designing the research BE and JLL conducted the research and DD oversaw management of the restaurant BE had primary responsibility for analyzing the data and ... labels significantly reduced intake while others concluded the labels had no effect These inconclusive results led us to ask: are there factors beyond the label’s presence which influence caloric...

Ngày tải lên: 08/04/2014, 18:33

... presents the Thomas precession of relativity physics as the motivational approach that led the author to the discovery of the theory of gyrogroups and gyrovector spaces The theory of gyrogroups and ... counterparts, the theory of groups and the theory of vector spaces Readers who wish to start familiarizing themselves with the theory may, therefore, start reading this book from its second chapter and ... deals with the symmetry and with the mathematical regularity which the Thomas precession encodes, presenting these as the very bedrock of relativity physics At first sight the study of the Thomas...

Ngày tải lên: 24/04/2014, 17:08

... methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility To the fullest extent of the law, neither the Publisher ... became part of Wells Fargo The video department would gather the news stories and then upload them via the Internet to the main office When there was a need for live coverage, they would hire a satellite ... editing of the video, you could phone them and ask them how they want their names to appear on the screen Do they have a particular title or company name they want to include? Would they like...

Ngày tải lên: 30/05/2014, 23:13

... light; in other words, black The 255 at the other end of the spectrum represents 100% light in the channel—so, 255 in the red channel and in the green and blue channels would appear as the color ... Menus and click the arrow to the left of the word “Object” in the Applications Menu Command section of the dialog 15 Scroll down until you see the words “Display Performance” and then click the ... methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility To the fullest extent of the law, neither the Publisher...

Ngày tải lên: 31/05/2014, 00:57

... opportunities, the value of their money, whether they feel that their values are safe or under attack, and perhaps whether they will be safe from attack by weapons of mass destruction or terrorism These ... bases its evaluation of them on their mathematical elegance, the complexity of their notation, the journals in which they appear, or simply the reputations of those who design them.”39 A more extreme ... to these questions is affirmative, it has implications for the kinds of problems SIR scholars examine, the publication outlets they choose, and the style in which they package the arguments and...

Ngày tải lên: 01/06/2014, 00:53

... from the mystical intercourse of music and prayer have captured the attention of prophets and poets, scientists and physicians, the lay and the learned alike throughout the ages and across the ... meditation, and healing in and beyond the roof of the world, for all that we have shared, and all the journeys yet to come; and to our children Naseem and Solya, who are a constant example of the miracles ... and consultation regarding the medical and neurological aspects and implications of my research; and to my parents Thelma and Leon Koen for their unfailing and unconditional love, strength, and...

Ngày tải lên: 11/06/2014, 01:41