are you in danger of being trapped
6 Secrets to Startup Success
Ngày tải lên :
15/02/2017, 08:10
... leaning into the market and adjusting your business model as you go If you want to mitigate and reduce risk to your career, your finances, your relationships, and your health before starting your ... You re not sleeping, of course You re working around the clock You re incredibly intense about meeting deadlines that are externally imposed You re running this race against all kinds of unknowns.” ... azine, or surf the Web You ll find a thousand smiling entrepreneurs, posing in front of swimming pools and Maseratis, eager to tell you how they did it and bring you into their startup fold You...
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AUTOPHAGY - A DOUBLE-EDGED SWORD CELL SURVIVAL OR DEATH? pptx
Ngày tải lên :
17/03/2014, 12:20
... X-ray structure of calnexin, our data indicate that in calreticulin, at least after binding of GABARAP, this portion protrudes from the base of the P domain, assuming a well-defined conformation ... was investigated by NMR spectroscopy Indeed, addition of CHC(510-522) lead to line broadening and reduction of peak intensities in 1H15N-HSQC spectra of native GABARAP, indicating a direct interaction ... compartment for final cargo degradation Members of the human WIPI family function as essential PtdIns(3)P-binding proteins during the initiation of macroautophagy downstream of PtdIns3KC3, and become...
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Báo cáo y học: "omparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study"
Ngày tải lên :
25/10/2012, 11:40
... induced expression of ICAM-1 in endothelial cells Overall, the foregoing data together demonstrates the better ability of Aflapin compared with 5-Loxin® in terms of reducing the pain, improving ... evaluate efficacy of Aflapin in comparison with 5-Loxin® against osteoarthritis in human subjects In the present 90-day clinical study, we assessed the efficacy and tolerability of Aflapin in comparison ... foci of inflammatory cells occur in up to 50% of OA patients [48] In this study to find out possible mechanism of actions of Aflapin we carried out in vitro studies to evaluate whether Aflapin...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
Ngày tải lên :
19/02/2014, 02:20
... amine group of the leaving peptide bringing to the breakdown of the intermediate Dashed lines indicate stabilizing interactions and ⁄ or hydrogen bonds in the catalytic pathway; Pep, the incoming ... N-terminal amine is in contact with one of the zinc ions [26,27] This mode of binding in SGAP still allows the oxygen atoms of the gem-diolate intermediate to be stabilized by interacting with ... differ in several aspects, including the exact role of the two active site zinc ions in catalysis, the detailed sequence of zinccoordination changes during catalysis and the mode of inhibition of...
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Báo cáo Y học: Ribosome-associated factor Y adopts a fold resembling a double-stranded RNA binding domain scaffold potx
Ngày tải lên :
17/03/2014, 10:20
... Half of them are nucleic acid- or nucleotide-binding proteins, with a predominance of RNA-binding proteins amongst them The best score of 12.2 was found for the recently determined structure of ... double-stranded RNA-binding domain and (b) proteins with similarity to the C-terminal domain of glycyl-tRNA synthetase The first group includes exclusively RNA-binding proteins These include the dsRBD of Xenopus ... affinity in the double-stranded RNA-binding domain (dsRBD1) of human interferon-induced kinase PKR when compared to dsRBD2 [33] Slow motions are also found at residues in loop b1-a1, in the turn...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
Ngày tải lên :
18/06/2014, 16:20
... bladder carcinoma cell line HT-1376 was kindly provided by Prof W Schulz, Heinrich-Heine University of Dusseldorf, Germany Cells were grown to confluency in a humidified incubator with 5% CO2 in polystyrene ... activity in the surrounding normal tissue [40,41] This is in addition to the known autocrine/paracrine mode of IGF2 mitogen action in the development of a wide range of human malignancies Accordingly, ... paracrine mechanism of insulin-like growth factor-2 in the development of liver metastases from colorectal carcinoma Cancer 1999, 85:18-25 Pavelic K, Bukovic D, Pavelic J: The role of insulin-like...
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báo cáo hóa học:" Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study" pdf
Ngày tải lên :
20/06/2014, 04:20
... analysis and was involved in the interpretation of the results All authors have read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received: ... introduction of confounding variables Patients where the administration of Nandrolone could result in severe side effects or in significant interaction with other drugs and possibly cause worsening of ... musculoskeletal system, including an increase in lean body mass, a dose-related hypertrophy of muscle fibers, and an increase in muscle strength and mass [13] The use of anabolic steroids in elderly patients...
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báo cáo hóa học:" Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study" pptx
Ngày tải lên :
20/06/2014, 07:20
... analysis and was involved in the interpretation of the results All authors have read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received: ... introduction of confounding variables Patients where the administration of Nandrolone could result in severe side effects or in significant interaction with other drugs and possibly cause worsening of ... musculoskeletal system, including an increase in lean body mass, a dose-related hypertrophy of muscle fibers, and an increase in muscle strength and mass [13] The use of anabolic steroids in elderly patients...
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báo cáo hóa học: " Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" ppt
Ngày tải lên :
20/06/2014, 15:20
... symptoms of acute or active chronic disease, including those of the gastrointestinal tract; (4) any change in pharmacological treatment for cardiovascular disease within one month of the start of the ... patient fulfilling the inclusion and exclusion criteria was first informed of the purpose and principles of the study, as well as given an indication of the prescribed additional drug as being specific ... shown in the analysis of the full data obtained from the two crossedover phases of the investigation The results obtained could be explained only in part by a decrease in the frequency of acid-related...
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Báo cáo hóa học: " Fano-Rashba effect in thermoelectricity of a double quantum dot molecular junction" pptx
Ngày tải lên :
20/06/2014, 23:20
... /2) S ↑ and L ↑ are enhanced strongly in the vicinity of energy tc/cos(j↑/2), and S↓ and L↓ are enhanced strongly in the vicinity of energy tc/cos(j↓/2) Some interesting features in table and Figure ... field threading the AB interferometer and S is the corresponding area of the quantum ring consisting of the double quantum dots and metallic electrodes The value S may be obtained in the previous ... electrode, which will induce an infinitesimal spin-dependent thermoelectric voltage ΔV s since the two tunneling channels related to spin are opened We divide the tunneling current into two parts:...
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Báo cáo hóa học: " Research Article Hierarchical Convergence of a Double-Net Algorithm for Equilibrium Problems and Variational Inequality Problems" ppt
Ngày tải lên :
21/06/2014, 07:20
... variational inequality 0∈ I −P x NFix T x 1.6 At this point, we wish to point out the link with some monotone variational inequalities and convex programming problems as follows Example 1.2 Setting P ... : ψ x 1.9 x∈arg ϕ Let B : C → H be a nonlinear mapping, and let F be a bifunction of C × C into R Consider the following equilibrium problem of finding z ∈ C such that F z, y If B Bz, y − z ≥ ... semicontinuous On the equilibrium problems, we have the following important lemma You can find it in 31 Lemma 2.1 Let H be a real Hilbert space, and let F be a bifunction of H × H into R satisfying...
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báo cáo hóa học:" Research Article ´ ¨ Sharp Constants of Brezis-Gallouet-Wainger Type Inequalities with a Double Logarithmic Term on Bounded Domains in Besov and Triebel-Lizorkin Spaces" pdf
Ngày tải lên :
21/06/2014, 11:20
... Theorem 5.1 In order to obtain our results, we examine a problem of minimizing ∇u nn Ω with a L unilateral constraint Let < τ ≤ We consider the following minimizing problem: m Ω, hτ inf ∇u n Ln ... 2.6 can be obtained directly from a theory of interpolation However, the proof being simple, we include it for the sake of reader’s convenience ∞ Proof of Proposition 2.6 Let us take ζ ∈ Cc Rn ... 3.11 l ii It holds ∞ ϕ0 t dt t log 3.12 Proof i In view of the size of the support of ϕ0 , we easily obtain 3.11 ii If we integrate both the sides of inequality 3.11 , then we have j 1/4 1/2j...
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Báo cáo sinh học: " Research Article A Double S-Shaped Bifurcation Curve for a Reaction-Diffusion Model with Nonlinear Boundary Conditions" doc
Ngày tải lên :
21/06/2014, 16:20
... ∞ is continuous function For details about this transformation, see 19 We prove the existence of a positive solution of 2.7 by using the fixed point index in a cone This fixed point index is equivalent ... and J Shi, “Instability and exact multiplicity of solutions of semilinear equations,” in Proceedings of the Conference on Nonlinear Differential Equations (Coral Gables, FL, 1999), vol of Electronic ... point at which the branch of solutions of 1.10 bifurcates into the separate cases To conclude the section, we present the computational results for 1.10 by combining the solutions of 1.11 in...
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Báo cáo hóa học: " Research Article A Double Inequality for Gamma Function" pot
Ngày tải lên :
22/06/2014, 02:20
... is the aim of this paper to present the new upper and lower bounds of inequality 1.8 in terms of I and L Journal of Inequalities and Applications Lemmas In order to establish our main result ... Journal of Inequalities and Applications 13 S S Dragomir, R P Agarwal, and N S Barnett, “Inequalities for beta and gamma functions via some classical and new integral inequalities,” Journal of Inequalities ... get ψ G a, b > A ψ a ,ψ b 3.7 Since ψ is strictly increasing and G a, b < L a, b , so we have ψ L a, b > ψ G a, b 3.8 Journal of Inequalities and Applications Inequalities 3.7 and 3.8 show that...
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THIẾT KẾ HỆ THỐNG SẤY DẦU FO DÙNG CHO LÒ HƠI BẰNG THIẾT BỊ TRAO ĐỔI NHIỆT ỐNG LỒNG ỐNG SỬ DỤNG NĂNG LƯỢNG MẶT TRỜI DESIGNING A SYSTEM FOR DRYING BOILER FUEL OIL WITH A DOUBLE TUBE HEAT EXCHANGER DEVICE USING SOLAR ENGERGY pptx
Ngày tải lên :
29/06/2014, 16:20
... Lưu Nhựa đơng Độ sáp Keo Nitơ nhiệt riêng riêng học hùynh đường đặc N kg/m3 J/kg.K W/m.K Parafin Gelatin m2/s Bitum S C Nước 927,5 16,8 19 17,44.106 2,683 0,1964 14,3 10,3 0,13 0,29 H2O Để gia nhiệt ... 122, 45 [W/m2.K] ∆t − ∆t , [ C] Nhiệt độ trung bình logarit: ∆t ↓↑ = max ∆t max ln ∆t ∆tmax, ∆tmin : hiệu nhiệt độ hai mơi chất vào khỏi thiết bị trao đổi nhiệt ' '' '' ' ∆t ↓↑ = (t1 − t ) − (t ... học Đà Nẵng, 2004 [2] Nguyễn Bốn, Tính tóan thiết bị trao đổi nhiệt, Nhà xuất Đà Nẵng, 2005 [3] Đinh Văn Thuận, Võ Chí Chính, Hệ thống máy thiết bị lạnh, Nhà xuất khoa học kỹ thuật, 2005 [4] Bùi...
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Báo cáo y học: "Reproducibility and sensitivity to change of various methods to measure joint space width in osteoarthritis of the hip: a double reading of three different radiographic views taken with a three-year interval" pot
Ngày tải lên :
09/08/2014, 07:20
... of manual or digitalized measurement of joint space at the narrowest point on plain radiographic views of the pelvis in trials of structure-modifying treatment However, there remains uncertainty ... resulted in identification of an additional 30% of patients with JSN Our findings support the hypothesis that the combination of views could be superior to the use of a single view in identifying ... employed in clinical trial; instead, all radiographs are kept in such trial for use in an intent-to-treat analysis Our findings did not reveal significant differences between the ability of the...
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Báo cáo y học: "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee" potx
Ngày tải lên :
09/08/2014, 10:23
... efficacy of 5-Loxin® in OA This study also provides important information regarding the possible molecular mechanisms of action of an anti-inflammatory compound of herbal origin in the treatment of ... improvement in paw inflammation in albino Wister rats [14] Cell based in vitro studies and in vivo experiments conducted in Sprague-Dawley rats suggest that 5Loxin® can inhibit proinflammatory cytokines ... be symptomatic [3] Clinical manifestations of OA of the knee include pain in and around the joint, stiffness of the joint after rest, crepitating on motion and limited joint motion, among others...
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Báo cáo y học: " Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind" potx
Ngày tải lên :
10/08/2014, 10:20
... in the number of patients requiring additive infusion of epinephrine While in the group of vasopressin only pts (20%) required additional infusion of epinephrine, in the group of placebo it was ... infused in a minimal dose of 0.03-0.05 μg/Kg/min in patients (24%) of group A and in 18 patients (72%) of group B (p = 0.002) Epinephrine infusion was additionally necessary in patients (20%) of group ... low dose of 0.03 IU/min, in combination with its gradual starting of infusion as a factor of its effectiveness In addition, another study has shown that the combined infusion of vasopressin with...
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Báo cáo y học: " A double shunt technique for the prevention of ischaemia of a congenital, solitary, pelvic kidn" pps
Ngày tải lên :
11/08/2014, 00:22
... proposed to maintain blood flow to solitary, ectopic or transplanted pelvic kidneys during aortic cross-clamping Axillofemoral [2,3] or temporary abdominal in- line (Gott) [2,4] shunts are considered ... http://www.jmedicalcasereports.com/content/5/1/92 Page of individually, based on anatomic considerations and the surgeon’s opinion A variety of protective techniques, including shunting, cooling and passive use of collaterals have ... allowing the whole renal parenchyma to be adequately perfused responded well to intravenous administration of antibiotics, allowing discharge on the ninth postoperative day There was no rise in...
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Báo cáo y học: "Appearance of a double bubble in achalasia cardia: a case report" docx
Ngày tải lên :
11/08/2014, 19:21
... this finding has not been reported in the literature thus far The appearance of a double bubble in patients with achalasia cardia is an interesting finding following a successful dilatation of the ... delayed In our patient, there was an atypical finding in the form of the presence of an air bubble below the left hemi-diaphragm in the gastric region in the chest X-ray film Based on the clinical ... atypical findings There are case reports of achalasia presenting as acute airway obstruction and recurrent pneumonitis [5,6] In patients with atypical presentation and findings, the diagnosis is often...
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