antioxidant activity of lipoic acid

... proteolytic hydrolysis of haemoglobin as a source of amino acids constitutes one of the essential processes which take place along the intra-erythrocytic stage of the parasite Degradation of haemoglobin ... Discussion Inhibition of proteases by MA It has been previously proposed that MA may inhibit the activity of proteases of T gondii [14] and HIV [12,31] To ascertain the inhibition range of MA on the different ... structure of the available inhibitors of cathepsin D [19], a lysosomal protease of mammalian cells, and chalcones and phenothiazines have been assayed as inhibitors of falcipain-2 [20,21] Inhibition of...

Ngày tải lên: 14/02/2014, 14:20

... conditions Conversely, acid phosphatase activity was measured in Synthesis of ¯uorogenic substrates the presence of NaF and of those of inhibitors that alter amidolytic activity Incubation with ... FEBS 2002 Amidolytic activity of prostatic acid phosphatase (Eur J Biochem 269) 393 Fig Puri®cation of prostatic acid phosphatase from human seminal plasma (A) SDS/PAGE of the 200 mM NaCl elution ... gradient of 0±60% acetonitrile in 0.075% CF3COOH Fig pH activity pro®le of PAP activity (full line) and PAP amidolytic activity (dashed line) Results are normalized rates and are the means of two...

Ngày tải lên: 24/03/2014, 00:21

... (Millennium32 software) The polysaccharide TMP-A (5.0 mg) was hydrolyzed with M trifluoroacetic acid (TFA) at 110 ◦ C for h on the mechanism of acid- catalyzed hydrolysis [9] Excess acid was removed ... hydroxyl radicals The ability of the TMP-A to scavenge hydrogen peroxide was determined according to the method of Smirnoff and Cumbes [17] The percentage of scavenging of hydrogen radicals was calculated ... predicted structure of the novel polysaccharide TMP-A was shown in Fig 3.3 Determination of DPPH radical scavenging activity of TMP-A Fig Superoxide radical scavenging effect of TMP-A from Tricholoma...

Ngày tải lên: 28/06/2014, 11:20

... Evaluation of In Vitro Antioxidant Activity 80 depends on a common initiating step, the peroxidation of polyunsaturated fatty acid components of LDLs.8 Such modification of LDLs can be inhibited by antioxidants.9,10 ... SD (n = 3) Evaluation of In Vitro Antioxidant Activity 90 antioxidant activity of 5H-dibenz[b,f]azepine and its derivatives on human LDL oxidation and lipid peroxidation activity in the liposome ... (1996) Structure -antioxidant activity relationships of flavonoids and phenolic acids Free Radical Biol Med., 20(7), 933–956 Yen, G C & Chen, H Y (1995) Antioxidant activity of various tea extracts...

Ngày tải lên: 07/08/2014, 14:20

... 3) to test its antioxidant activity Figure The Ugo-Basile activity cage (type 7401) The Ugo-Basile activity cage (type 7401) Materials and Methods Synthesis of TPBIA Key step of the synthesis ... dissolved in mM citric acid solution The motor activity of the rats was measured between 12-6 pm in an Ugo-Basile activity cage (type 7401) (Figure 2) in vitro The antioxidant potential of TPBIA was investigated ... (Number of experimental animals: 4) b) modifies the motor behavior of the experimental animals, c) shows antioxidant activity a) The Polar Surface Area (PSA) of a molecule is defined as the area of...

Ngày tải lên: 08/08/2014, 20:23

... 3,4,7,3’,4’ pentamethoxy flavone (Tuberosin) Assay of antioxidant property a ABTS* radical scavenging activity ABTS* radical scavenging activity of tuberosin was determined according to Re et al ... The powder of PT root-tubers are already in clinical use by Ayurvedic physicians of Indian system of medicine [6], but neither its mechanism of action nor the active principle for its antioxidant ... steps of the signaling cascade of LPS induced NO production, but it is still not clear, whether it is directly inhibiting the activity of iNOS enzyme or it is suppressing the synthesis of this...

Ngày tải lên: 11/08/2014, 03:20

... determination of ferric reducing antioxidant power (FRAP), determination of antioxidant activity with thiobarbituric acid reactive species (TBARS) and automatic determination of the oxidative stability of ... Determination of Antioxidant Activity with the 2,2'-Diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging Method The antioxidant activity of volatile compounds was measured in terms of hydrogen donating ... absorbance of the control at t = and AA(t) is the absorbance of the antioxidant at t = h Determination of Ferric Reducing Antioxidant Power (FRAP Assay) The total antioxidant potential of a sample...

Ngày tải lên: 16/08/2014, 22:31

... nhiều alpha- lipoic acid acid thioctic, có số tên khác acid lipoic; l,2-dithiolane-3-pentanoic acid; l,2-ditholane-3-valeric acid; 6,8-thiotic acid; 5-[3-(l,2-dithiolaryl)]-pentanoic acid; delta-[3-(l,2dithiacyclopentyl)] ... khuyên nên sử dụng R-Alpha Lipoic Acid với chất lượng tốt R-ALA có nhiều hiệu lực (~ lần) so với dạng lipoic acid tổng hợp bán thông thường mà chứa hai 18 dạng R s lipoic acid Dạng s ích lợi nhiều ... hoá khử quan trọng chuỗi hô hấp tế bào Dihydrolipoic acid (acid lipoic dạng khử: DHLA) có công thức CgHịéSịOỊ tên khoa học: 6,8- disulfanyloctanoic acid Sau ALA thực công việc mình, chuyển thành...

Ngày tải lên: 28/08/2015, 10:01

... gratitude to Professor Bay Boon Huat of the Department of Anatomy, Yong Loo Lin School of Medicine and Associate Professor Heng Chew Kiat of the Department of Pediatrics, Yong Loo Lin School of Medicine ... University of Singapore, st nd Singapore – of August, 2008 Waisundara, V.Y., et al The antioxidant activity of Scutellaria baicalensis (poster) Waisundara, V.Y., et al Antioxidant effects of Rehmanniae ... Evaluation of the antioxidant activity of Scutellaria baicalensis in streptozotocin-induced diabetic Wistar rats Waisundara, V.Y., et al The antioxidant and anti-hyperglycemic effects of Rehmanniae...

Ngày tải lên: 12/09/2015, 10:58

... determined that the antioxidant activity of U dioica at an acidic pH was 0.013 μg/mL resorcinol equivalents (Re eq.); the DPPH method in methanolic solution determined that the antioxidant activity was ... mg/l gallic acid equivalent (GAE) [64] Concentrations of U dioica L extract of 50, 100, and 250 μg/mL showed 39%, 66%, and 98% inhibition, respectively, of the peroxidation of a linoleic acid emulsion ... showed antioxidant activity Thin-layer chromatographic analyses of the extracts showed the presence of phenolic compounds in the crude extracts, two of which were flavonoids The anti-inflammatory activity...

Ngày tải lên: 12/01/2016, 18:24

... spectrophotometric method [20] A mixture of 200 μL of 8% sodium dodecyl sulfate, 200 μL of 0.9% thiobarbituric acid and 1.5 ml 20% acetic acid was prepared 200 μL of RBCs lysate and 1.9 ml distilled ... oxidative modification of erythrocytes [10] Antioxidants can help in preservation of an adequate antioxidant status; therefore, they preserve the normal physiological function of living cells by ... ability to inhibit the production of ROS as well as maintains the antioxidants activity in the cell [24] Moreover it has been reported that supplementation of antioxidants preserve the NPSH from...

Ngày tải lên: 25/10/2012, 11:40

... to  30% of the initial rate of UBHY-R, whereas the rates of synthesis of DNA and RNA were 70% and 60% of the initial values, respectively These data suggest that the primary effect of eIF5A ... Analysis of the position of both amino acids in the human eIF5A-1 model, Leu91 and Leu101, shows that they are localized at the hydrophobic core of the b-barrel (Fig 1) Substitution of either of the ... stopped by addition of 0.5 mL of ice-cold stopping solutions (0.3 mgÆmL)1 of thymidine for DNA, 0.3 mgÆmL)1 of uracil for RNA, and 0.3 mgÆmL)1 of cycloheximide plus mgÆmL)1 of leucine for protein),...

Ngày tải lên: 16/03/2014, 06:20

... showed Ó FEBS 2002 Haloperoxidase activity of phosphatases (Eur J Biochem 269) 2165 relevant levels of acid phosphatase activity On induction, the specific activity of acid phosphatase in both strains ... Enzymatic assay of bromoperoxidase activity Assay of PhoN-Sf brominating activity The brominating activity of the recombinant phosphatases was measured qualitatively by the bromination of 40 lM phenol ... means of triplicate measurements of 120–180 UÆmg)1 observed for vanadium haloperoxidases [26,27] However, the turnover for the brominating activity of the acid phosphatases is of the same order of...

Ngày tải lên: 24/03/2014, 03:21

... polymerase activity (63% of the reference activity) After h following mitosis and during the remainder of the cell cycle, the polymerase activity approached a basal level of 10–20% of the reference activity ... The activity was measured in the presence of added mM spermidineÆ3HCl (?) to neutralize the inhibitory activity of PMLA In the absence of spermidineÆ3HCl, activities of DNA polymerase, except of ... During continued addition of the polymerase, the enzyme activity increased in parallel with the activity of the control experiment in the absence of extract An amount of 0.4 U of the reporter DNA polymerase,...

Ngày tải lên: 31/03/2014, 21:21

... antioxidant activity of guest fullerenes To the best of our knowledge, this is the first result of the higher antioxidant activity of C60O in comparison with pristine C60, despite the decreasing of p-conjugation ... introduction of pin-up oxygen on C60 increases its antioxidant activity In order to clarify the reason for the significant effect of the pin-up oxygen on the antioxidant activity of C60, we calculated ... constants, kobs, for the discoloration of b-carotene on the antioxidant concentration of PVP and CD complexes of C60 and oxidized C60O Here, the rate (Rf) of discoloration of b-carotene by the LOO• radical...

Ngày tải lên: 22/06/2014, 01:20

Ngày tải lên: 28/06/2014, 11:20

... composition of fatty acids in test compounds used in this study Amounts of fatty acids (%) PA DG CLA DG-CLA SA OA LA CLA 3 31 12 24 56 43 󰠏 74 22 LLA Others 4 The composition of fatty acids was ... chromatography DG: diglyceride, PA: palmitic acid, SA: stearic acid, OA: oleic acid, LA: linoleic acid, CLA: conjugated linoleic acid, LLA: linolenic acid Experimental Animals Five week-old C57BL/6J ... (A), the expression of PPAR-γ increased with the treatment of diglyceride (B), conjugated linoleic acid (C), and diglyceride containing 22% conjugated linoleic acid as fatty acid (D) Fig Lipid...

Ngày tải lên: 07/08/2014, 23:22

... metabolic antioxidant alpha -lipoic acid Free Radic Biol Med 1997, 22:359-378 doi:10.1186/1749-7221-5-15 Cite this article as: Ranieri et al.: Possible role of alpha -lipoic acid in the treatment of peripheral ... Stasi M, Megna M: The use of alpha -lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life Int J Immunopathol ... the importance of a-LA in the treatment of peripheral nerve injuries, but further studies are needed to explain the mechanisms of its neuroprotective effects and before the use of a-LA in low...

Ngày tải lên: 10/08/2014, 10:20

... recycling, and antioxidant actions of alpha -lipoic acid in endothelial cells Free Radic Biol Med 2002, 33:83-93 Packer L, Kraemer K, Rimbach G: Molecular aspects of lipoic acid in the prevention of diabetes ... Neuroprotection by the metabolic antioxidant alpha -lipoic acid Free Radic Biol Med 1997, 22:359-378 Bast A, Haenen GR: Lipoic acid: a multifunctional antioxidant Biofactors 2003, 17:207-213 Jones ... utility of LA as an anticancer agent and the importance of the elucidation of the detailed mechanism of its antitumor activity Because of its widespread use and therapeutic potential of LA, however,...

Ngày tải lên: 10/08/2014, 22:20

... protection Involvement of antioxidant genes with varying kinetic profiles of activity could provide both immediate and more prolonged antioxidant capacity The activity of such a mechanism would ... potential pathways of their antioxidant activity In the case of coconut oil, its phenolic acid constituents have been proposed as the primary sources of its oxidant species scavenging activity [28] ... Han J, Agarwal A, Kong AN: Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated...

Ngày tải lên: 12/08/2014, 13:22