angiogenesis signaling axis and hif 1 in hepatocellular carcinoma

... Cancer (2 015 ) 15 :18 2 DOI 10 .11 86/s12885- 015 -12 14-0 RESEARCH ARTICLE Open Access Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma Gang Wu1*, Yawei ... tumor and normal tissues (? ?14 .89 ± 2.83 vs ? ?12 .38 ± 2.96, **P < 0. 01) ; b: CpG islands located approximately 1, 200 bp upstream of the promoter Wu et al BMC Cancer (2 015 ) 15 :18 2 Page of 12 Figure In ... Wang1, Xiaojun Lu2, Hui He3, Haiyang Liu4, Xiangyu Meng1, Shuguan Xia1, Kunming Zheng1 and Boqian Liu1 Abstract Background: Recent studies have shown that miR-372 plays important roles in hepatocellular

Ngày tải lên: 30/09/2020, 11:22

... Recommendations:   01   page   It   includes   46  tables, 23 figures,? ?and? ?12 5 references  (14  Vietnamese references? ?and? ? 11 1 English references) CHAPTER? ?1:  OVERVIEW 1. 1 Overview of hepatocelular? ?carcinoma? ? ... 2,286  (1, 0 31? ?– 5,070) 18 4 ,14 8  (1, 5 71? ??? ?10 ,956) p 0,038 0,003 ­ The moderate, bad combination increases HCC risk compared  to good combination, with OR = 2,286; 95% CI  (1, 0 31? ?– 5,070); p =  0,038? ?and? ?OR = 4 ,14 8; 95% CI  (1, 5 71? ?–? ?10 ,956); p = 0,003 ... n=? ?10 2 ? ?14 Healthy  n =10 2 Genotype (n)  23 OR (95%CI) Ref p 14 CT TT CC  TT + CT CT + CC TT Alen C  Alen T  47   41 14 88 61 41 75        ? ?12 9  50  29 23 79 73 29 Allele (2n) 96 10 8 1, 544 (0, 712  – 3,3 51)

Ngày tải lên: 17/07/2020, 23:31

... cirrhosis and liver cancer Nat Rev Gastroenterol Hepatol 2 019 ;16 (9):544 Min L, He B, Hui L Mitogen-activated protein kinases in hepatocellular carcinoma development Semin Cancer Biol 2 011 ; 21( 1) :10 –20 ... confidence intervals] Low SOCS1 + High CDK1 Cell cycle 0. 015 2 0. 015 3 Poor 17 2.56 [1. 28–5 .11 ] Low SOCS1 + High CXCL8 RTK signalling, angiogenesis < 0.00 01 < 0.00 01 Poor 7.97 [2.85–22.25] Low SOCS1 + ... Targeting receptor tyrosine kinase pathways in hepatocellular carcinoma Anti Cancer Agents Med Chem 2 011 ;11 (6):560–75 Zhu AX, Duda DG, Sahani DV, Jain RK HCC and angiogenesis: possible targets and

Ngày tải lên: 20/09/2020, 00:57

... receptor signaling Nat Rev Immunol 2004;4:499– 511 Yuan et al BMC Cancer (2 015 ) 15 :245 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 O’Neill LA, Bowie AG The family of five: TIR-domain-containing ... predicts prognosis Ming-Ming Yuan1,2, Yu-Yin Xu3, Li Chen1*, Xing-Yu Li1, Jing Qin1 and Ying Shen1 Abstract Background: Toll-like receptor (TLR3) plays a key role in innate immunity In the present ... activation inhibits angiogenesis and triggers apoptosis of human hepatocellular carcinoma cells Oncol Rep 2 012 ;27:396–402 41 El-Serag HB Hepatocellular carcinoma N Engl J Med 2 011 ;365 :11 18–27 42

Ngày tải lên: 30/09/2020, 12:45

... et al BMC Cancer (2 015 ) 15 :11 6 DOI 10 .11 86/s12885- 015 -11 27-y RESEARCH ARTICLE Open Access The prognostic value of combined TGF-? ?1 and ELF in hepatocellular carcinoma Fei Ji1†, Shun-Jun Fu2†, Shun-Li ... in early G1 phase However, misregulation of TGF-β signaling promotes tumor growth and invasion, evasion of immune surveillance, and cancer cell dissemination and metastasis [11 -14 ] In HCC tissues, ... tissues (Para-T) and HCC tissue (Tumor) Ji et al BMC Cancer (2 015 ) 15 :11 6 Page of 11 Table Correlation between the clinicopathological characteristics and expression of ELF and TGF-? ?1 in the 84 HCC

Ngày tải lên: 30/09/2020, 13:01

... 51. 4 13 .5 73 16 21. 9 38 52 .1 19 26.0 −0.245/0. 013 * NET -1 −0.226 /0.0 21* Bcl-2 + 19 36.8 10 52.6 10 .5 ++ 11 45.5 45.5 9 .1 51 21 41. 2 21 41. 2 17 .6 Bax - 0.242/0. 014 * + 27 18 .5 14 51. 9 29.6 ++ 15 ... P>0.05 o Beclin -1+ /Bax++ 10 70.0 n vs p P>0.05 p Beclin -1+ /Bax+ 71 15 21. 1 o vs p P=0. 010 q Beclin -1+ +/MVD++ 1 100.0 r Beclin -1+ +/MVD+ 21 12 57 .1 r vs s P=0.000 s Beclin -1+ / MVD++ 33 21. 2 r vs t ... j Beclin -1+ +/Bcl-2+ 21 13 61. 9 J vs k P=0.000 k Beclin -1+ /Bcl-2++ 10 10 .0 J vs l P=0.029 l Beclin -1+ /Bcl-2+ 71 21 29.6 l vs k P=0. 015 m Beclin -1+ +/Bax++ 5 10 0.0 n Beclin -1+ +/Bax+ 17 47 .1 n vs

Ngày tải lên: 05/11/2020, 00:22

... Tiến Thịnh (2 019 ), “Results of portal vein thrombus biopsy in patients with advanced hepatocellular carcinoma? ??, Journal of 10 8 – Clinical medicine and pharmacy, volume 14 (N 5/2 019 ), 1- 7 Trịnh Xuân ... MINISTRY OF EDUCATION MINSITRY OF NATIONAL AND TRAINING DEFENCE 10 8 INSTITUTE OF CLINICAL MEDICAL AND PHARMACEUTICAL SCIENCES TRINH XUAN HUNG STUDY OF CLINICAL AND ... time and this is indeed a hude challenge for medicine in my country 1. 2 Diagnosis of hepatocellular carcinoma 1. 2 .1. Clinical symptoms The clinical symptoms of HCC are often present in late stage

Ngày tải lên: 08/01/2020, 16:26

... 27.7% 72.3% 13 17 43.3% 56.7% 11 16 40.7% 59.3% 10 16 38.5% 61. 5% 34 49 41. 0% 59.0% 0.690 708 0.795 672 0 .13 8 934 4 .13 0 12 7 19 11 63.3% 36.7% 22 81. 5% 18 .5% 22 84.6% 15 .4% 63 20 75.9% 24 .1% Spearman's ... Cytokeratin and Sal-Like Protein Expression in Hepatocellular Carcinoma and Intra-Hepatic Cholangiocarcinoma in Taiwan Yih-Shyong Lai 1, Chiung-Chi Cheng 1, 2, Ming-Tsung Lee 3, Wei-Ting Chao ... p 1. 289 525 21 70.0% 30.0% 16 11 59.3% 40.7% 19 73 .1% 26.9% 56 27 67.5% 32.5% 22 73.3% 26.7% 22 81. 5% 18 .5% 21 80.8% 19 .2% 65 18 78.3% 21. 7% 10 20 33.3% 66.7% 20 25.9% 74 .1% 20 23 .1% 76.9% 23

Ngày tải lên: 15/01/2020, 02:18

... the clinicopathological features of HCC and PTTG3P levels Characteristics High Low P Male 14 13 > 0.05 Female 12 11 Gender Age > 55 11 15 < =55 12 12 < =5 13 >5 25 I-II 17 III-IV 21 Negative 15 ... (2 019 ) 19 :7 31 https://doi.org /10 .11 86/s12885- 019 -5936-2 RESEARCH ARTICLE Open Access Long non-coding RNA PTTG3P functions as an oncogene by sponging miR-383 and up-regulating CCND1 and PARP2 in ... levels, while miR-383 inhibition can abrogate the inhibitory effect of PTTG3P on CCND1 and PARP2 (Fig 6c and d) The protein levels of CCND1 and PARP2 were in line with that of CCND1 and PARP2 mRNA (Fig

Ngày tải lên: 17/06/2020, 16:56

... male 240 98 14 2 female 31 16 15 ≤ 50 13 1 56 75 > 50 14 0 58 82 HCC family history Yes 18 10 No 253 10 6 14 7 HBsAg negative 32 14 18 positive 239 10 0 13 9 A 269 11 3 15 6 B 1 45 Low (n = 11 4) Age (years) ... 18 .0% 11 .6% Single 18 5 51. 9% 38.4% 34.0% Multiple 86 24.4% 12 .7% 11 .1% Yes 56 12 .5% 7 .1% 5.4% No 215 51. 2% 36.3% 32.4% Low 11 4 61. 4% 49 .1% 45.3% High 15 7 29.9% 16 .6% 13 .4% I-II 15 2 59.9% 44.7% ... Calcium 2 014 ;56:68–80 21 Wang G, Rudland PS, White MR, Barraclough R Interaction in vivo and in vitro of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1 J Biol Chem 2000;275 :11 1 41? ??6

Ngày tải lên: 03/07/2020, 01:38

... processing (NLP) analysis of hepatocellular carcinoma Fourteen eligible datasets were involved in this study, which included datasets containing HCC tissues and 11 datasets containing both HCC and ... metastasis in hepatocellular carcinoma Int J Oncol 2 014 ;45(5) :18 83–90 50 Wang M, Xue L, Cao Q, Lin Y, Ding Y, Yang P, et al Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological ... controls GSE10694 Gu et al 78 88 China GPL6542 GSE12 717 Su et al 10 China GPL7274 GSE22058 Burchard 73 73 USA GPL10457 GSE 213 62 Sato et al 96 96 Japan GPL10 312 GSE 313 83 Hoshida et al 10 USA GPL1 012 2

Ngày tải lên: 24/07/2020, 00:03

... STEDB1, indicating the these fragments have binding sties with SETDB1 C Cross-linking assay confirmed Tiam1could interacted with SETDB1 Zhang et al BMC Cancer (2 018 ) 18 :539 Page of 10 Fig SETDB1 ... SETDB1 could be detected when incubated with following proteins: GST-Tiam1-C685, GST-Tiam1-C7 51, and GSTTiam1-C 119 9; however, the protein GST-Tiam1-PCER was not useful for detection of SETDB1 This ... indicating the Tiam1-PCER fragment has no binding sties with SETDB1 (b,c,d) purified Tiam1-C685 protein was obtained as indicated, as shown in above figures, Tiam1-C685, C7 51 and C 119 9 could be detected

Ngày tải lên: 24/07/2020, 00:58

... (86.9%) Stage N N0: 11 4 (82.6%) N1: 24 (17 .4%) Stage M M0: 11 6 (84 .1% ) M1: 22 (15 .9%) AJCC Stage I: (5 .1% ) II: (6.5%) III: 83 (60 .1% ) IV: 39 (28.3%) Okuda Stage I: 31 (22.4%) II: 10 9 (77.6%) BCLC ... et al BMC Cancer (2 017 ) 17 :829 DOI 10 .11 86/s12885- 017 -3847-7 RESEARCH ARTICLE Open Access Radiomics based analysis to predict local control and survival in hepatocellular carcinoma patients treated ... A: (6.5%) B: 29 ( 21. 0%) C: 10 0 (72.5%) Child-Pugh Stage A: 96 (69.6%) B: 42 (30.4%) Hepatitis (B/C) No: 19 (13 .8%) Yes: 11 9 (86.2%) Initial Alpha-feto protein (ng/mL) Mean: 11 4 81 Range: 2.4, >58300

Ngày tải lên: 06/08/2020, 03:39

... Vascular invasion Edmondson-Steiner grade Total p 0.598 60 19 30 =5 1 10 45 57 20 13 51 73 =1 10 20 60 97 >1 18 22 No 11 21 75 11 4 Yes 0 No 13 35 58 Yes 10 43 61 No 11 18 52 88 Yes 0 26 31 ES = ~ 19 ... (2 017 ) 17 :605 DOI 10 .11 86/s12885- 017 -3570-4 RESEARCH ARTICLE Open Access NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity Qijiong Li1†, Xiaofeng Liu2†, Kemin Jin3, ... (95% CI) p 0.828 (0.456? ?1. 506) 0.537 0.800 (0.424? ?1. 510 ) 0.492 1. 976 (1. 183–3.3 01) 0.009 1. 153 (0.628–2 .11 6) 0.646 1. 876 (1. 080–3.258) 0.026 1. 853 (1. 002–3.427) 0.049 2.840 (1. 605–5.025)

Ngày tải lên: 06/08/2020, 05:08

... (2 017 ) 17 :16 1 DOI 10 .11 86/s12885- 017 - 313 9-2 RESEARCH ARTICLE Open Access Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/βcatenin signaling ... chromosome 16 q13 [11 ] The MT -1 protein comprises many subtypes encoded by a set of MT -1 genes (MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, etc.) MT -1 genes are reported to be involved in carcinogenesis in various ... BMC Cancer (2 017 ) 17 :16 1 Page of 11 Fig MT1H regulates Wnt/β-catenin signaling in HCC cells a GSEA analysis showed that MT1H might has a regulative role in Wnt/β-catenin signaling in HCC cells

Ngày tải lên: 20/09/2020, 01:32

... Carcinoma (HCC) Patients Clinicopathological Parameter n Relative Gene Expression (Mean ± SEM) 42 14 18 .35 ± 2.95 16 .15 ± 5 .11 0.570† 49 17 .24 ± 2.74 21. 72 ± 6.83 0.436† 41 13 14 .00 ± 13 .10 17 .39 ... Reticulocalbin DUSP12 Dual specificity phosphatase 12 USP1 Ubiquitin specific peptidase S100P S100 calcium binding protein P USP5 Ubiquitin specific peptidase (isopeptidase T) XBP1 X-box binding protein ... P-value 12 .74 95% (53) 0.000 5.36 93% (52) 0.000 4.22 91% ( 51) 0.000 1. 96 80% (45) 0.000 1. 51 84% (47) 0.000 1. 49 68% (38) 0. 010 1. 29 64% (36) 0.044 1. 69 62% (35) 0.0 81 1.34 62% (35) 0.0 81 1.08...

Ngày tải lên: 16/10/2015, 15:38

... against hypoxia and reoxygenation This is mainly ascribed to its ability to maintain redox status [17 ], intervening in the DNA repair system [18 –20] and restoring antioxidant capacities [ 21 26] ... 2 .11 2.0 1. 5 1. 0 0.38 0.5 0.0 Intracellular glutathione (reduced and oxidized nmol/mg of protein) Glutathione (reduced and oxidized nmol/mg of protein) 0. 31 0.20 [2- 13 C]-GSH [4- 13 C]-GSH [3- 13 C]- ... were incubated for h with DMEM base (Sigma-Aldrich) containing 5.5 mm glucose, 10 mm Hepes (Sigma-Aldrich), 10 % fetal bovine serum, antibiotics (10 0 000 UÆL )1 penicillin, 10 0 mgÆL )1 streptomycin),...

Ngày tải lên: 18/02/2014, 16:20

... development 17 1. 9 Cooperative and distinct functions of HDAC1 and 18 1. 9 .1 Redundancy of HDAC1 and HDAC2 functions 18 1. 9.2 Distinct functions of HDAC1 and HDAC2 19 1. 10 Inhibition ... 1. 11. 4 Anti -angiogenesis, anti-metastasis and invasion 24 1. 11. 5 Anti-tumor immunity 25 1. 12 HDAC inhibitors in cancer therapy 26 1. 12 .1 Clinical trials 26 1. 12.2 ... discrepancy between clinical samples and in vitro data 12 1 5.7 Genes regulated by HDAC1 and HDAC2 12 2 5.7 .1 Comparing HDAC inhibitor PXD1 01 with knocking down HDAC1 and 12 2 5.7.2 Genes differentially...

Ngày tải lên: 10/09/2015, 08:27

... Nakanishi H: Involvement of COX -1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia J Neuroimmunol 2006, 17 2 :11 2 -12 0 13 Coghlan ... rapamycin increases the production of prostaglandins It has been shown that mTOR inhibitors reduced NOS activity and iNOS expression induced by hypoxia and a mixture of cytokines in BV-2 cells and ... LPS-induced COX-2 and mPGES -1 protein synthesis Interestingly, rapamycin, a well-known mTOR inhibitor, increased both COX-2 and mPGES -1 immunoreactivity (Fig 3A-B) The production of PGE2 and...

Ngày tải lên: 19/06/2014, 22:20

... pathogenesis of OA References 10 11 12 13 Conclusion Taken together, our findings show for the first time that exposure to IL -1 and oxidative stress induce HIF- 1 expression in degenerated articular ... degeneration, and they provide new insights into pathogenesis of OA 14 15 16 17 Competing interests The authors declare that they have no competing interests 18 Authors' contributions KY carried out in ... stabilization of HIF [39] Our results of catabolic stress-induced expression of HIF- 1 in chondrocytes are consistent with these findings These findings suggest that HIF- 1 may, at least in part, have...

Ngày tải lên: 09/08/2014, 06:23