and or pharmacodynamic assessment of pulmonary drug delivery systems

... opportunity for “old” drugs whose patents have expired and present them with improved forms Therefore, it can give benefits to drug companies by creating new forms of established drugs and offering ... modified and investigated as controlled drug delivery matrices for both small molecule model drug of ibuprofen (IBU) and large protein drug of bovine serum albumin (BSA) In the preparation of controlled ... temperature (Dong and Hoffman, 1990), pH (Peppas and Peppas, 1989), or glucose concentration (Ishihara and Matsui, 1986), and the delivery or cease -delivery of the particular drug can be triggered...

Ngày tải lên: 13/09/2015, 19:46

... placed on ice and subsequently centrifuged at 60 × g and for 10 For analysis of the cellular content, cytospots were performed with 200 μl of native BAL at 55 × g for 10 minutes and stained with ... booster group for both isotypes (Figure 1E, and 1F) Sequential analysis of BALF and IS Analysis of the single fractions of BALF showed an increase of IgG levels and concomitantly a decrease of IgA levels, ... immunogenicity and a high responder rate of this anti pseudomonal vaccination strategy Assessment of pulmonary antibodies showed a comparable sensitivity of BAL and IS However, the different proportions of...

Ngày tải lên: 12/08/2014, 15:21

... development of alternative drug delivery systems, which attempt to address the requirements of rate and extent of drug release, and thereby absorption Delivery systems include oral sustained release formulations’ ... Chemical Aspects of Drug Delivery Systems Table 5B Formulation systems for controlled drug release and drug targeting PARENTERAL AND PULMONARY ROUTES ADMINISTRATION ROUTE FORMULATION SYSTEMS INTRAVENOUS ... regulatory approval and clearance, and the constraints imposed by the nature of the various routes of administration available for drug delivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OF DRUG DELIVERY...

Ngày tải lên: 28/03/2014, 10:20

... command logistics guidance and COA analysis Arbitrates supply of and demand for transportation Arbitrates supply of and demand for petroleum, oil, and lubricants Arbitrates supply of and demand ... provide and sustain forces more effectively and efficiently Combat and supporting force commanders need an integrated command and control (C2) system to extend authority over all forces building for ... in the forward area and the major command staff supporting and shaping the combat forces For example, the necessary CSC2 systems and processes should be incorporated into the Falconer AOC and listed...

Ngày tải lên: 29/03/2014, 14:20

... Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug delivery system is a formulation or a device ... A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug?  Prodrug is an inactive precursor of a drug  Prodrug reconversion ... MAIN TYPES OF PRODRUGS FOR TARGETED DRUG DELIVERY (a): Classic prodrugs: prodrugs are transformed into one or more active substances inside the cell (b): Two or more substances react to form the...

Ngày tải lên: 18/04/2014, 15:37

... provincial and district staff of the National Program for FP & PHC, especially the LHWs and supervisors, for their help and participation, and to PAIMAN-USAID for supporting this study Page of (page ... to serve the husband, kids and the family" or "the life or death of the mother or newborn is the will of God, in which the mortals cannot intervene" would be really helpful The workers also suggested ... included two rural districts of Attock and Charsaddah from the provinces of Punjab and NWFP, and two urban districts of Karachi and Quetta from the provinces of Sind and Baluchistan Muzaffarabad...

Ngày tải lên: 18/06/2014, 17:20

... EPO and absorption enhancer to the absorptive cells of the rat small Page of 22 intestine and the aggregation of CNTs is not the critical factor for the oral delivery of EPO Our recent works ... spectroscopic properties of CNTs, such as Raman and photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study ... Tumor lysate proteins (TLP) are composed of various tumor proteins that develop in a large number of tumors and patients, irrespective of the genetic origins of tumors However, defined tumor...

Ngày tải lên: 20/06/2014, 22:20

... In order to overcome this issue, the delivery of DCU via intravenous (IV) infusion route was explored Similar to oral delivery, IV delivery of DCU was limited by the poor aqueous solubility of ... the SC route of dosing is not free of problems Drug exposure via SC route of delivery can be still limited by absorption, stability, dissolution rate, and solubility of the drug In order to overcome ... the base case and predictions were performed for higher doses (10 and 30 mg/kg) with nanosuspension formation Results for 3, 10, and 30 mg/kg are listed in Table According to theory, this model...

Ngày tải lên: 21/06/2014, 03:20

... Evaluation of dosimetric and technical data For each group of patients, technical parameters of delivery were scored in terms of number of arcs, total number of monitor units (MU), monitor units per Gy ... abdominal and liver patients with display of an axial, sagittal and coronal plane Figure present average cumulative dose volume histograms for PTV and all organs at risk for the entire cohort of patients ... performed at first and second follow up visits and will be reported in terms of degree of response Results Dosimetric and technical data Figure illustrates examples of dose distributions of lung,...

Ngày tải lên: 09/08/2014, 09:21

... for the range of competencies under test Thus for communication skills, test time only needs to be hours to achieve a coefficient of 0.7, but hours is required for reliable assessment of history ... observed and unstandardized long cases With an assessment of 3.5 hours for history taking, long cases were equally reliable as OSCEs A review of the available evidence suggests that from 1-4 hours of ... According to Van der Vleuten [7], assessment drives learning though its format” In the case of OSCEs and more specifically the CASC, this may have a range of consequences, some desirable and...

Ngày tải lên: 11/08/2014, 15:22

... domains – working memory, verbal memory, and processing speed, and discrete domains of functioning of the QLS – instrumental, intrapsychic, and interpersonal, at baseline and following 24 weeks of antipsychotic ... indicating better fit); and 3) Root Mean Square Error of Approximation [RMSEA] An RMSEA of 0.05 or less indicates a good fit and an RMSEA of 0.10 or more indicates a poor fit Analyses were conducted ... presence of a significant relationship between working memory or verbal memory and functioning However, previous work has incorporated additional constructs, such as social competence and functional...

Ngày tải lên: 11/08/2014, 17:20

... to drug policy, termed as 'Harm Reduction' or 'Harm minimisation' in which reduction of adverse consequences of drug use is valued as high priority at least as important as reducing demand and ... risk of blood-borne infections A range of interlinking factors compound this risk – the large number of IDUs, scarcity of sterile injecting equipment and correspondingly higher prevalence of needle-syringe ... vans increase accessibility for clients who not have a vehicle or money for transportation, and/ or may be too drug- impaired to drive to the fixed-site The importance of having a service close to...

Ngày tải lên: 11/08/2014, 18:20

... for age, ethnicity, marital status, educational levels, recruitment site, length of residency in the area, length of lifetime drug injecting, size of drug use network, and frequency of daily drug ... acknowledge the participants of this study and also thank J Koerner for her comments and assistance in preparing the manuscript and H Tajdar, M Borumand, and M Rafiee for their research assistance ... from the program, data of the 105 male IDUs with a complete set of variables for multivariate analysis were considered for this report and then categorized based on the rate of exposure to the program...

Ngày tải lên: 11/08/2014, 20:20

... (111) with minor modification Briefly, 0.5 g of PLGA was dissolved in 10 ml of methylene chloride and activated by the addition of 26.3 mg of p-nitrophenyl chloroformate and 18 μL of pyridine to ... Antiangiogenesis inhibitors 10 1.3 Drug delivery system for vascular targeted antiangiogenesis or antitumor therapy 15 1.3.1 Conjugation of drug with ligand for vascular targeting ... cancers (3) 1.1.2 Metastasis of cancer Metastasis, the spread of cancer from its primary site to a distant organ, is responsible for the major cause of morbidity and mortality of cancer suffering patients...

Ngày tải lên: 11/09/2015, 09:58

... the site of action Microcapsules and microspheres for chemoembolization belong to this group, as similar systems used for the controlled release of proteins and peptides or for drug delivery ... Samples of Drug Delivery Systems As far as the physical form of drug delivery systems is concerned, these can be molecular or particulate Molecular carriers include soluble polymers to which drug ... is important for drug delivery because lipophilic drugs dissolved in the triglyceride core and the release of drugs in blood is considered to depend on both lipolysis of triglycerides and removal...

Ngày tải lên: 16/09/2015, 08:30

... duration of clinical use and Table 15.1 Use of a drug delivery system for kinetic control Dissolution of drug is too slow Drug and/ or formulation is physically removed from the site of action ... 15.1 and 15.2 provide generic reasons for using drug delivery systems For drug delivery systems containing biodegradable polymers, the major motivations for clinical use have been to deliver drugs ... referred to more comprehensive review articles throughout 15.2 The Clinical Need for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from...

Ngày tải lên: 25/10/2013, 08:20

... gene delivery systems (viral vectors) The design of efficient vectors for vaccine development and cancer gene therapy is an area of intensive research Page of 20 Live vectors (attenuated or non-pathogenic ... delivery systems Live or biological gene delivery systems include viral and/ or bacterial vectors Non-live or nonbiological delivery systems mainly include cationic lipids/liposomes, polysaccharides and ... side, oral or respiratory immunization usually favors the development of mucosal antibodies and cell-mediated immune responses [113] The efficacy of M-cell delivery of DNA or any other orally...

Ngày tải lên: 06/03/2014, 02:21

... range of drug- delivery systems for the delivery (targeted or otherwise), through a variety of routes of administration, of drugs, diagnostics, and vaccines in the treatment or prevention of disease, ... physicochemical, and biological properties of chitosan The review covered various applications of chitosan -delivery systems for colon-specific delivery, as absorption enhancers, and for GI tract delivery systems ... transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or...

Ngày tải lên: 04/06/2014, 14:47

... improve the uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown ... needed for the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of ... for directing drugs to inflammatory and tumor cells The anti-inflammatory activity of MTX is due to the suppression of production of antiinflammatory cytokines such as (interleukin-6) IL-6 and...

Ngày tải lên: 20/06/2014, 00:20

... posterior segment of the eye Ocular drug therapy often involves topical or systemic administration of drugs Therefore, for effective delivery to intraocular tissues, drugs must penetrate across cornea, ... contains the channels for the exit of chloride, sodium, bicarbonate, and ascorbate into the posterior chamber and induce the movement of water for the formation of the aqueous humor (Zadunaisky, 1992) ... expanding Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal collagen shields, iontophoresis, and viral and nonviral gene delivery systems, ...

Ngày tải lên: 10/08/2014, 00:20