and doesn t in estimating
Cannibals or knights – sexual honor in the propaganda of Arthur Conan Doyle and W. T. Stead
Ngày tải lên :
01/11/2013, 08:20
... important construct for both soldiers and officers, but it remained important to maintain in public the distinctions between those two categories, distinctions of class that reveal the difficulty of ... public attention to the very high rate of mortality in some of these camps; but examination showed that this was not due to anything insanitary in their situation or arrangement, but to a severe ... brought out the worst in the British troops and the British public Stead asserts that public opinion in Britain should be a strong enough force to rein in the excesses of the military in South Africa,...
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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
Ngày tải lên :
28/03/2014, 22:21
... associated with increased in ammation and Th1 cytokine production [4] These results suggest that Tec kinases contribute to human diseases involving distinct types of T- cell activation and cytokine ... -3 protein interaction domains that are important for kinase regulation, and a Tec homology domain containing one or two proline-rich regions that interact intra- or intermolecularly with Src ... cytokine and TCR signaling may affect regulatory T- cell differentiation, it will be of interest to see the role of the TFKs in regulating the differentiation of this subset Together, these studies...
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history and trends in bioprocessing and biotransformation - t. scheper, n. n. dutta, f. hammar
Ngày tải lên :
08/04/2014, 12:48
... new institutes was F Hammar only possible through the renaming or shutting down of entire institutes in other locations The restructuring and thematic shift of emphasis affecting whole institutes ... fell at first solely to the individual German states, with respect to their sovereignty in cultural matters Since the MPS spoke with one voice for the entirety of its institutes, the states were ... years and thus alleviated the integration in institutes of higher learning through additional project promotion In addition, it set up two temporary branches of Max Planck Institutes and took...
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nuclear import and export in plants and animals - t. tzfira, vitaly citovsky
Ngày tải lên :
08/04/2014, 12:52
... matrix attachment regions, or the proteins binding to MARs Instead, it investigates the information presently available about signals involved in the intranuclear targeting of proteins, either ... liberate the cargo-transport receptor complex from the final, tightest binding site The recognition of the FG repeats and of the importance of their interactions with the transport receptors led to ... egg extracts implicate the protein in immobilizing NPCs within the NE, and specifically in importin-mediated transport.165 Like Nup153, Tpr has binding sites to importin β, and binds importin α/β...
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báo cáo hóa học:" In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells" docx
Ngày tải lên :
18/06/2014, 15:20
... still not clear in this experimental setting A recent study has demonstrated that vaccination with DCs/tumor fusion cells producing TGF-β resulted in the induction of Treg in vivo and in vitro in ... autologous vaccination were investigated We first assessed the ability of autologous FCs vaccination to stimulate T cells After the ninth vaccination, unirradiated DCs/auto-HCC stimulated T- cell ... 7A) These results suggest that vaccination with autologous FCs has the potential to increase CTL precursors against autologous HCC cells in the patient To assess the antigen specificity and HLA...
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Báo cáo hóa học: " Decreased level of recent thymic emigrants in CD4+ and CD8+T cells from CML patients" pdf
Ngày tải lên :
18/06/2014, 16:20
... site and subsequently the sjTREC was cloned in to the EcoRV restriction site of the TOPO TA Vector (Invitrogen, Groning, The Netherlands) Based on the DNA concentration, measured by spectrophotometry ... Competing interests The authors declare that they have no competing interests Authors' contributions YQL, CAS and GKP were responsible for study design and data management SXG and SHC performed the ... thymic output in CML patients The results further support and explain the significant reduction of recent thymic emigrant numbers in peripheral blood of CML patients, as measured by quantitative...
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Báo cáo sinh học: " Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages" docx
Ngày tải lên :
18/06/2014, 18:20
... .Y .T. E Q YAT.D Q YAT.D Q YAT.D QT.YAT.D QT.YAT.D QT.YAT.D QT.YAT.E QT.YAT.E S.QT.Y .T. E S.QT.Y .T. E QT.YAT.D QT.YAT.D Q YAT.E Q YAT.E QT.YAT.D QT.YAT.E QT.YAT.E CRIKQFINMW .I I T .K.R.I.R K.R.I.R .I ... and A3.01 and MT-2 not This data further supports the predominance of R5 phenotype in subtype C infected patients [37,38] and its maintenance during symptomatic AIDS Several of the patients that ... collaborative grant to NA and SJ by Fogarty International Center, National Institutes of Health (TW 01345) and grants to NA by National Institute of Allergy and Infectious Diseases (AI 40378) and Arizona...
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Báo cáo sinh học: " Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneratio" potx
Ngày tải lên :
18/06/2014, 22:20
... unknown factors may also contribute to this T cell activation seen in AMD patients Interestingly, the findings that C5a specifically promoted the Th17 family cytokine production, but not IFN nor ... death We found that monoctytes are necessary for C5a induced Th17 cytokine production through two mechanisms: 1) promoting the direct interaction between monocytes and T cells; 2) indirectly stimulating ... whether systemic observations reflects pathological events in the eye and how systemic activation may ultimately be manifest in the eye remain to be defined To date there is no effective treatments...
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Báo cáo sinh học: " HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers" potx
Ngày tải lên :
19/06/2014, 08:20
... 6604m_969CAGGTTAATGATCTTTGtatTAGGAGGctgTAGGCa 6516m_90-0 CAGGTTAAA TATTAGGAGGCTGTAGGCA 6541m_27-0 CAGGTtAAA TATTAGGAGGCTGTAGGCA 6290m_1232 CAGGTTAAA TATTAGGAGGCTGTAGGCA 467h_969-0 CAGGttAAA TATTAGGAGGCTGTAGGCA ... probability that this carrier could have been directly infected with HBV containing the T- A mutations In the 23 acute phase samples, T- A mutations were not detected and therefore the possibility to ... results in amplified samples of the initial PCR products with an deletion than in the reanalyzed two samples where the deletion was not detected An interesting fact is that these deletions alter the...
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báo cáo hóa học:" HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers" pdf
Ngày tải lên :
20/06/2014, 04:20
... 6604m_969CAGGTTAATGATCTTTGtatTAGGAGGctgTAGGCa 6516m_90-0 CAGGTTAAA TATTAGGAGGCTGTAGGCA 6541m_27-0 CAGGTtAAA TATTAGGAGGCTGTAGGCA 6290m_1232 CAGGTTAAA TATTAGGAGGCTGTAGGCA 467h_969-0 CAGGttAAA TATTAGGAGGCTGTAGGCA ... probability that this carrier could have been directly infected with HBV containing the T- A mutations In the 23 acute phase samples, T- A mutations were not detected and therefore the possibility to ... results in amplified samples of the initial PCR products with an deletion than in the reanalyzed two samples where the deletion was not detected An interesting fact is that these deletions alter the...
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Báo cáo toán học: "Superization and (q, t)-specialization in combinatorial Hopf algebras" pps
Ngày tải lên :
08/08/2014, 01:20
... that, if a factor has four terms, those terms simplify with the factors associated to the preceding letter in the permutation We recover in this way the partial factors of [24] and obtain a third ... Let T be a binary tree and T1 (resp T2 ) be its left (resp right) subtree ′ Let T2 be the left subtree of T2 We then have ′ (q #T2 − q #T2 t) (1 − q #T1 t) PT (X) = PT1 (X)PT2 (X), ′ (1 − q #T2 ... functions As already mentioned in the introduction, in the λ-ring notation, the definition of super¯ symmetric functions is transparent If X and X are two independent in nite alphabets, # the...
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Báo cáo khoa học: "Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer" ppt
Ngày tải lên :
09/08/2014, 09:20
... search, there are no report to evaluate the correlation between TIL and radiosensitivity, and this is the first one to show the direct link between the density of T cells infiltrating in solid tumor ... with tumor response to CRT [13] This finding is in line with the data in this study, and suggested that the maintenance of circulating lymphocytes number can recruit many anti-tumor lymphocytes ... into the irradiated tumor during CRT, which may lead to improvement of the clinical efficacy of RT in rectal cancer Taken together, our results indicate that the quantitative measurement of TIL...
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Báo cáo y học: " Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus" pptx
Ngày tải lên :
09/08/2014, 10:21
... containing 0.5% Tween (TBS -T) and 5% milk for h at room temperature (RT), and then incubated with rabbit antisera diluted 1:500 in TBS -T- milk for h at RT After washing, strips were incubated with ... we investigated the potential capacity of peptide 131– 151 to generate antibodies that react with spliceosomal peptides and proteins encompassing, or not, the RNP1 motif We tested the reactivity ... protein (intramolecular spreading), then proceeds in an ordered manner to other proteins containing the RNP1 motif, and finally, to proteins that not contain any RNP1 motif but are colocalized in the...
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Báo cáo y học: "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen" pot
Ngày tải lên :
09/08/2014, 10:21
... of inflammatory cell infiltration in the two strains In contrast, in late arthritis (6 to weeks after onset), inflammatory cell infiltration Page of (page number not for citation purposes) Arthritis ... therefore, an increasing need to model the anti-arthritic effects of methotrexate in combination with other therapies in order to optimise treatment regimens and to identify possible interactions Likewise, ... as methotrexate Competing interests The authors declare that they have no competing interests uted to the preparation of the manuscript All authors read and approved the final manuscript Acknowledgements...
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Báo cáo y học: "Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis" docx
Ngày tải lên :
09/08/2014, 10:23
... production These findings suggest that TNF-α and IL-6 play important roles in acuteonset arthritis in GPI-immunized mice These results point to the potential roles played by these cytokines in the ... purposes) Arthritis Research & Therapy Vol 10 No Matsumoto et al Treatment of GPI-induced arthritis with CTLA-4Ig and anti-IL-6 mAb To investigate the effect of CTLA-4Ig in vivo, we treated arthritic ... protein (etanercept) from days to completely protected against the development of arthritis in GPI-induced arthritis In this regard, we demonstrated a clear therapeutic effect for TNF antagonist...
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Báo cáo y học: "T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis" docx
Ngày tải lên :
09/08/2014, 13:22
... combined with MTX remained almost intact The findings support the view that T6 14 can protect the joints from damage in an inflammatory environment, in concert with MTX Proinflammatory cytokines TNF-α, ... destruction and inflammation in CIA Furthermore, combination with MTX enhanced the therapeutic effect of T- 614 Competing interests The authors declare that they have no competing interests Authors' ... articular cartilage, activate the complement system and initiate tissue damage; this indicates that there is T- B cell cooperation and activation in vivo [47,48] More interestingly, T- 614 not only suppressed...
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Báo cáo y học: "Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies" ppt
Ngày tải lên :
09/08/2014, 14:21
... under treatment (a) Spondylarthropathy patient with infliximab + methotrexate (b) Rheumatoid arthritis patient with adalimumab + methotrexate Both responses to latent peptides and lytic peptides ... contributed to interpretation of the data Competing interests The authors declare that they have no competing interests Page of (page number not for citation purposes) Acknowledgements The set of EBV ... MTX and anti-TNF drug on EBV-specific T- cell effector functions in patients with RA or SpA At 3month follow-up, neither MTX treatment in RA patients nor anti-TNF therapy in RA and/ or SpA patients...
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Báo cáo y học: " Estimating the impact of expanded access to antiretroviral therapy on maternal, paternal and double orphans in sub-Saharan Africa, 2009-2020" ppt
Ngày tải lên :
10/08/2014, 05:22
... within a country [31] In order to incorporate this reduction in TFR in HIVinfected women into our projections, we used the default TFR reduction feature in AIM, which inputs age-specific ratios ... matching current population estimates with projection outputs is described elsewhere [23,28,29] Fertility estimates We obtained country- and age-specific total fertility rates (TFR) from the US ... assumed that the number of adults receiving ART remained constant following year 2008, reflecting country-specific rates of ART uptake and clinical eligibility of people living with HIV/AIDS in that...
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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc
Ngày tải lên :
10/08/2014, 22:21
... that BCL2L1 was affected by the BCL11B gene in transcriptional regulation, and both participated in the same protein-protein interactions, acting as apoptosis regulators along with a competitive ... gene in transcriptional regulation (b, d) BCL11B and BCL2L1 participate in the same protein-protein interactions, along with competitive downstream target proteins BCL2L1 (Bcl-xL) normally interferes ... competitive target proteins downstream of BCL11B (c) The SPP1 gene may be a target of the BCL11B gene in transcriptional regulation: it plays a consistent role in anti-apoptotic effects with the...
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