anatomy and physiology of glutamate in the cns

... (certainly not all) of the highly intertwined processes that determine the fate of CNS neurons in the face of acute or chronic insults. The book is written mostly from the viewpoint of the basic ... receptors. These caspases (8 and 10) contain death effector domains (DED) in the N-terminal region of the pro-enzyme. The DED confers homomeric binding ability to adaptor proteins in the death inducing ... alter the fate of a neuron resulting in cell death or continued survival. The nature of the stresses affecting neurons, the duration of the stresses, the developmental stage of the neuron and a variety...

Ngày tải lên: 08/04/2014, 12:51

... ). The renewed interest in examining the indications for BCG vaccination in the United States included consideration of the wide range of vaccine efficacies deter- mined by clinical trials and ... to explore the sources of the heterogeneity in the efficacy of the BCG vaccine reported in the individual studies. Using a model that included the geographic latitude of the study site and the data ... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...

Ngày tải lên: 15/02/2014, 13:20

... 3459 terminus that is required for binding to the plasma membrane, thereby being involved in the formation of the corneum [47]. Additional amino-terminal residues of TGase 1 include the sequences ... of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger. These results indicate that the cDNA obtained covered the entire coding region. Involvement of GTP in the ... study, suggesting that the purified PpTGase is responsible for the major cross-linking reaction in P. polycephalum.Further- more, the result of the Northern blotting indicates that a single species of transcript...

Ngày tải lên: 17/03/2014, 23:20

... oligosaccharide against host glycosidases during infection or could be involved in modifying the net charge of the LPS molecule [15]. However, the rationale behind the incorporation of glycine into the core ... for the -CH 2 - protons of the glycine moiety in meningococcal LPS points to an exocyclic location for the glycine residue in N. meningitidis LPS. The genetic control of the elaboration of glycine ... location in the inner core oligosaccharide as appears to be the case for N. meningitidis. Depending on the strain of H. in uenzae glycine could be found at each of the heptose residues of the inner...

Ngày tải lên: 23/03/2014, 21:21

... and PsbJ is critical in providing proper docking sites, either directly or indirectly, by modifying the conformation of PSII on the lumenal side, making efficient binding of PsbQ and PsbP of the ... accumulating all three proteins of the OEC and traces of the D2 and CP43 core proteins as well (Fig. 1B). The presence of minor amounts of D2 in both DpsbE and DpsbF supports the suggestion that the ... hold true. In rapidly expanding young leaves in particular, some of the PSII core proteins and all of the OEC proteins can accumulate in thylakoids in the absence of any assembly of PSII, as...

Ngày tải lên: 30/03/2014, 13:20

Ngày tải lên: 12/05/2014, 15:38

Ngày tải lên: 20/06/2014, 15:20

Ngày tải lên: 22/06/2014, 13:20

... neurotrans- mitter in the insect CNS [1], and octopaminergic neurons [31] and several octopamine receptors [2,32] have been identified in the fly and other insects. At the cellular level, TrnDAT and TrnOAT ... does the moth OAT substitute for DAT in dopami- nergic signaling pathways in the moth CNS, and what is the nature of the mechanism that substitutes for OAT in the octopaminergic pathways in the ... Northern analysis and in situ hybridiza- tion. The pattern of DAT RNA expression in the caterpillar CNS was shown to differ from that of OAT and thus, unlike the fly and worm CNS, neurons in the...

Ngày tải lên: 23/03/2014, 20:22

... great principles of the system of the universe, and extirpated upon this subject the dreams of romance and the dogmas of superstition. Literature has unfolded the nature of the human mind, and Locke and others ... . In such circumstances, they certainly do honour to the liberality and taste of those who are at the expence of preserving them: but they are of little service in adorning and fertilizing the ... rank, of every age, and of both sexes. They are intimately acquainted with every language, the dead as well as the living. To the culti- vation of letters they join that of the arts; and the mechanics are...

Ngày tải lên: 21/09/2012, 11:00

... in any joint including the ankle, knee, hand, wrist, elbow, sacroiliac joint and other joints of the spine, however most commonly occurs in the lower extremity. In this case, although the patient ... deposits in the wrist due to gout [6,8,9]. The prevalence of gout in the USA ranges between 0.5–2.8% in men and 0.1–0.6% in women [2]. The prevalence rises to 4.4% of men and 1.8% of women over the ... One week after the initiation of colchicine, no swelling was present and only mild pain was noted with flexion/extension of his wrist and fingers. The patient was taken off colchicine due to diarrhea....

Ngày tải lên: 25/10/2012, 10:06

... against Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the ... dose discontinuation in 3/20 (15%). Forns and colleagues used relatively high-dose interferon/ribavirin therapy in their cohort of 30 patients awaiting transplantation in Spain in an effort ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy in this high-risk group...

Ngày tải lên: 31/10/2012, 17:11

Ngày tải lên: 05/09/2013, 09:08

Ngày tải lên: 05/09/2013, 09:38

Ngày tải lên: 06/09/2013, 05:48