an important variable in the neuropsychological evaluation
Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... and containing the galA gene and approximately 700 bp 3¢-flanking region, in pIM4700 (containing the pkiA promoter) A niger The sugar composition of the arabinogalactans from potato, onion and soy ... proteins in A niger [33] The fusion construct (pIM3982) was made by introducing an NsiI site at the translation start point of galA and by then cloning a fragment, starting at this NsiI site and ... detected in the preparation (data not shown) This paper demonstrates the important role of GALA in the degradation of both linear and L-arabinose-substituted galactan side chains of pectin This is in...
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Báo cáo y học: "Pro/con debate: Octreotide has an important role in the treatment of gastrointestinal bleeding of unknown origin" pptx
... flowmetry in rabbits and man Am J Gastroenterol 1999, 94:1077-1082 19 Collins R, Langman M: Treatment with histamine H2 antagonists in acute upper gastrointestinal hemorrhage Implications of randomized ... omeprazole and a combination of somatostatin and ranitidine in severe GI bleeding [27] It is thus unlikely that somatostatin or octreotide can improve on results of high dose PPIs in patients ... high and low risk of rebleeding [11] Pro’s response: Defining the indication Yaseen Arabi and Bandar Al Knawy Octreotide use as an adjunct to endoscopic therapy [21,24,32] should be distinguished...
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Tài liệu Báo cáo khoa học: The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments pptx
... the N-terminal region on the molecular surface In the wildtype enzyme, the side chain of Asp266 interacted with the amino group of the main chain at Glu268 The oxygen of the main chain at Asp266 ... temperature indicates the stability of the structure of the protein The difference of the increments between the inactive temperature and the Tm should indicate that the mutations improved the stability ... enclosed in dark boxes and in open boxes are common sequences among ALP I and the neutral subtilisins, and among ALP I and the alkaline subtilisins, respectively s, Unique amino acid sequence in the...
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Báo cáo khoa học: Piecing together the structure of retroviral integrase, an important target in AIDS therapy pptx
... remove the overhanging viral 5¢-dinucleotides and seal the gaps on both sides of the integrated viral DNA In the final product, the viral insert is flanked by the repeated stagger sequence, and begins ... the protein, it provided the first chain tracing, and was important in revealing the plasticity of the IN active site and its ability to adopt different conformations Perhaps the most significant ... from the cellular IN- binding protein LEDGF, to inhibit the DNA-binding of IN by shifting the enzyme’s oligomerization equilibrium from the active dimer towards the tetramer, which, according to their...
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Hydrophytes may play an important role in sewage disinfection in constructed wetlands
... Hydrophyte is an indispensable component in CWs Researches show that the plants can produce allelochemicals and affect on the growth of other living beings The allelochemicals of the hydrophytes inhibited ... altissma and Brucea javanica, and indicated that their extracts not only inhibited the infection of TMV, but also had the inhibition for the replication of TMV Tan Q W (2007) indicated 2-dihydroailanthone ... respectively In conclusion, P hydropiper may play an important role in sewage disinfection in CWs, but its living inhibiting pathogenic micro-organisms in the ecosystem need to be further studied...
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Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... isomerohydrolase in the retina Y Takahashi et al comprises the recycling of 11cRAL through a process involving multiple enzymes and retinoid-binding proteins between photoreceptors and retinal pigment epithelium ... cell type in the vertebrate retina, comprising a specialized radial cell that spans the entire thickness of the inner retina The Muller cell constitutes an ana¨ tomical link between the retinal neurones ... neurones and supports their activities by exchanging molecules between the other retinal layers [28] In addition, it has been shown that several retinoid-binding proteins and enzymes involved in vitamin...
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Tài liệu Báo cáo khoa học: An intermediate step in the evolution of ATPases – a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase pdf
... covalently linked hairpins in the membrane [10] Importantly, the ion-binding site is not conserved in hairpin one If one assumes the same number of transmembrane helices in V0 and F0, the rotor of eukaryal ... handedness, and two of the rings face in the opposite direction in the membrane to the other two, forming the same pattern as in the AFM surface representation of Fig 2A By comparison with the ... Whereas the inner ring of densities is tightly packed, the outer one is more loosely arranged, and the densities correspond to the N- and C-terminal helices of the c ring, respectively The C-terminal...
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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... to these interfaces is located in the PYR and middle domains The interface contains 10 hydrogen bonds in IPDC The dimer–dimer interface in IPDC is smaller than the corresponding interface in ... side chain Furthermore, there are significant structural differences between ZmPDC and IPDC on the one hand, and ScPDC on the other hand involving the C-terminal part of the polypeptide chain (Fig ... of the corresponding intermediate in transketolase [37] and the model derived for ScPDC [38] (Fig 6) In the immediate vicinity of the modelled a-carbanion/enamine, there are a number of invariant...
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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
... by desA and its possible involvement in desferrioxamine biosynthesis, two apramycin-resistant and kanamycin-sensitive transformants were isolated among S coelicolor transformants with the desA ... procedures), and the DdesA mutation was verified in one of the mutants by PCR and Southern blot analysis A 1462-bp PCR band corresponding to the extended resistance cassette was found only in the mutant ... [12] Therefore, binding of the iron regulator DmdR1 will interfere with RNA polymerase interaction and expression of the desferrioxamine cluster Indeed, binding of the pure DmdR1 protein to the...
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Báo cáo khoa học: Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain pdf
... according to TALOS, had amide resonances in the random coil region of the 15N-HSQC spectrum and showed significantly narrower line-widths than any other residues in the protein This indicates that the ... phosphotyrosine binding but may have an important functional role Results hydrophilic in PtdIns 3-kinase but not in SOCS3 were identified and mutated to match the PtdIns 3-kinase residue The six mutants ... acid, serine and threonine residues, and not contain lysine, arginine or histidine The X-ray structures of several proteins containing PEST sequences have been determined, but in each case the electron...
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Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region pot
... (Fig 1A) We then analysed, by Northern blot, the induction and decay of IFN-b transcript in the same conditions As shown in Fig 1B, IFN-b mRNA was detectable h after the beginning of the infection, ... Discussion In the present study, we analysed the expression and the poly(A) status of human IFN-b mRNA in human endothelial Hec-1B cells in response to infection by the Sendaı¨ virus As observed in other ... investigated the in uence of the ARE and the CRID on the poly(A) status of the human IFN-b mRNA in natural conditions of IFN-b synthesis Materials and methods Reagents All the reagents and enzymes used in...
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx
... release The increased mechanistic understanding gained from this study should allow incremental advances in the design and production of inhibitors and mimetics of CNS and other enzymes in the pathways ... mutation, shortened the chain while maintaining H-bonding capacity in a Q104N mutation and provided a hydrophobic residue larger than alanine in a Q104L mutant All of these proteins were over-expressed ... Mg2+-binding ligand in a product complex, in addition to its initial role in direct ligation of the sugar OH group in an analogous manner to that found in the DNA ⁄ RNA polymerase reaction mechanism...
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Báo cáo khoa học: NtKTI1, a Kunitz trypsin inhibitor with antifungal activity from Nicotiana tabacum, plays an important role in tobacco’s defense response pot
... indicated by an arrow in the right lane (B) In vitro bovine trypsin inhibition by the recombinant NtKTI1 protein (open circles) Soybean trypsin inhibitor (triangles) was assayed in parallel as a positive ... Tobacco plants overexpressing NtKTI1 show enhanced resistance to R solani infection To evaluate the in planta role of NtKTI1 in defense, sense and antisense lines under the control of the cauliflower ... resulting in visible necrosis days after infection in all three lines However, the detectable necrosis was substantially smaller in sense plants than in antisense and control plants: days after infection,...
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Báo cáo khoa học: A unique tetrameric structure of deer plasma haptoglobin – an evolutionary advantage in the Hp 2-2 phenotype with homogeneous structure pot
... the a-chain in whales and dolphins as well as other ruminants (cattle and goat) to determine the possible time of the tandem repeat evolution in deer Hp Interestingly, the inserted panel of Fig ... leading to ruminants and pig, as pig possesses only the Hp 1-1 phenotype [24] As dolphins and whales are the closest divergences before the ruminants, we further examined the size of the a-chain ... level, the deer a-chain belongs to the a2 group, and is identical to the human a2-chain in possessing a tandem repeat Interestingly, the sequence homology between the two repeat units (B1 and B)...
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Báo cáo khoa học: An intermediate step in the evolution of ATPases ) the F1F0-ATPase from Acetobacterium woodii contains F-type and V-type rotor subunits and is capable of ATP synthesis Michael Fritz and Volker Muller ¨ docx
... protein with two hairpins [20] Most important, the ion-binding site is not conserved in hairpin If one assumes the same number of hairpins in V0 and F0, the rotor of V1V0ATPases has only half the ... (1981) The mechanism and regulation of ATP synthesis by F1-ATPases Annu Rev Biochem 50, 681–714 Fillingame RH (1992) H+ transport and coupling by the F0 sector of the ATP synthase ) insights into the ... membrane-embedded motor This is the starting point for a detailed analysis of the stucture and function of the rotor of the Na+ F1F0-ATP synthase from A woodii, the first containing V0- and F0-like...
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Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf
... Mcl-1, Bcl-B and A1 The proapoptotic proteins are divided into two distinct groups: the multidomain proteins, containing three BH domains (Bax, Bak and Bok); and the BH3-only proteins (Bad, Bid, Bim, ... originally discovered in a yeast twohybrid screen as a Bcl-2-interacting protein, and was the first human protein shown to be indispensable for autophagy [44] The interaction between Beclin and ... present in two different complexes, one that stimulates autophagy and involves an interaction with hVps34, and another that inhibits autophagy and involves an interaction with Bcl-2 and Bcl-xL...
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Báo cáo sinh học: " Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition potx
... the other hand, both the G7L and A17L gene products, VV membrane proteins, are required for virus replication and are involved in the early development of IV membranes G7L, a phosphoprotein in ... construction of the p7.5:TetOA12L:NEO plasmid Transfection of the p7.5:TetOA12L:NEO plasmid in concert with VV WR infection induced the first recombination The Neomycin resistance gene (NEOR) in the p7.5:TetOA12L:NEO ... transient selective marker in the presence of Geneticin G418 sulfate (Invitrogen) The second recombination of NEOR-containing viruses occurred in the absence of Geneticin G418 sulfate, producing...
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báo cáo hóa học: " Maize pollen is an important allergen in occupationally exposed workers" doc
... concerning the lung function testing and the discussion of the allergic findings (Skin-prick-testing, IgE antibodies) AP was responsible for the immunoblot analysis and discussed its findings The manuscript ... with the approval of the Institutional Review Board and is in compliance with the Helsinki Declaration Competing interests None of the authors had competing interests Authors Contributions As the ... from windpollinated rather than from insect-pollinated plants This is true for clinically important pollens from the various geographic regions [10] Considering the weight of maize pollen grains...
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Báo cáo hóa học: " Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition" pdf
... the other hand, both the G7L and A17L gene products, VV membrane proteins, are required for virus replication and are involved in the early development of IV membranes G7L, a phosphoprotein in ... construction of the p7.5:TetOA12L:NEO plasmid Transfection of the p7.5:TetOA12L:NEO plasmid in concert with VV WR infection induced the first recombination The Neomycin resistance gene (NEOR) in the p7.5:TetOA12L:NEO ... transient selective marker in the presence of Geneticin G418 sulfate (Invitrogen) The second recombination of NEOR-containing viruses occurred in the absence of Geneticin G418 sulfate, producing...
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Online Public Relations A Practical Guide to Developing an Online Strategy in the World of Social Media PR in Practice by David Phillips and Philip Young_1 docx
... relations sources very important part in the work ethic of the organization and ignorance of it can adversely affect the consultancys relationships with the client Mixing and matching There are occasions ... Ethics and the law The second was the action where the Coca-Cola Corporation were also successful in forcing the supermarket chain, Sainsburys, to change the appearance the get-up of their ... licence is being granted Any assignment must be in writing It can be in the form of a letter and must be signed by, or on behalf of, the assignor Licences can either be in writing or granted orally...
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