amyotrophic lateral sclerosis als
Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
... involvement in amyotrophic lateral sclerosis Neurochem Int 2002; 40(6): 543-551 29 Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH Jr Amyotrophic lateral sclerosis- associated ... with amyotrophic lateral sclerosis Am J Clin Nutr 2001; Int J Med Sci 2008, 74(3): 328-334 26 Kong J, Xu Z Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral ... Swash M, Munsat TL El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1(5): 293-299 Salton SR, Volonte...
Ngày tải lên: 03/11/2012, 10:52
Structure function studies of vesicle associated membrane protein associated protein b (VAPB) associated with amyotrophic lateral sclerosis (ALS
... mechanism underlying the mutation-causing disease 1.2 What is Amyotrophic lateral sclerosis? Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease, motor neuron disease (MND) ... 1.2.1 Disease forms – Sporadic and Familiar ALS ALS is divided into two forms, sporadic ALS (SALS) and familiar ALS (FALS) SALS constitute the majority of ALS cases and the disease occurs apparently ... motor neuron survival or muscle functions 1.4 ALS8 -causing mutations in VAPB 18 A form of FALS classified as amyotrophic lateral sclerosis type (ALS8 ) is caused by a mis-sense point mutation...
Ngày tải lên: 12/10/2015, 17:34
Báo cáo khoa học: Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord pot
... the motor neurons in amyotrophic lateral sclerosis (ALS) : immunohistochemical studies on sporadic ALS, superoxide dismutase (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models Acta ... dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362, 59–62 Pasinelli P & Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics Nat ... of amyotrophic lateral sclerosis Adv Neurol 36, 61–74 Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, Getzoff ED, Hu P, Herzfeldt B, Roos RP et al (1993) Amyotrophic lateral sclerosis...
Ngày tải lên: 23/03/2014, 04:21
Báo cáo khoa học: Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis The role of glutathione doc
... a model of familial amyotrophic lateral sclerosis (FALS) Brain Res 676, 25–40 19 Rizzardini M, Mangolini A, Lupi M, Ubezio P, Bendotti C & Cantoni L (2005) Low levels of ALS- linked Cu ⁄ Zn superoxide ... (2005) Amyotrophic lateral sclerosis: recent advances and future therapies Curr Opin Neurol 18, 712–719 26 Benatar M (2007) Lost in translation: treatment trials in the SOD1 mouse and in human ALS ... information in the field of antioxidant status in ALS, which might be useful in designing effective therapies Materials and methods Materials The following materials and reagents were used: flasks and plates...
Ngày tải lên: 29/03/2014, 23:20
báo cáo hóa học: " Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients" pot
... there were 25 definite ALS patients, 15 individuals were probable ALS and remaining 10 were possible ALS at the time of sample collection ALS- functional rating score-revised (ALSFRS-R) revealed that ... factor-A; OR, odds ratio; CI, confidence interval; Adj, adjusted Abbreviations ALS: amyotrophic lateral sclerosis; ALSFRS-R: ALS functional rating scorerevised; ANOVA: analysis of variance; CCL2: chemokine ... Amyotrophic Lateral Sclerosis (ALS) patients Journal of Neuroinflammation 2011, 8:47 10 Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A: The ALSFRS-R: a revised ALS...
Ngày tải lên: 19/06/2014, 22:20
Amyotrophic Lateral Sclerosis Part 2 potx
... patients with amyotrophic lateral sclerosis Neurology, Vol 47, No 5, pp 1329-1331 34 Amyotrophic Lateral Sclerosis Miller, R.G., Gelinas, D & O’Connor, P (2005) Amyotrophic lateral sclerosis Demos ... amyotrophic lateral sclerosis Neuroreport, Vol 4, No 6, pp 819-822 40 Amyotrophic Lateral Sclerosis Weydt, P & Moller, T (2005) Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis ... results into successful clinical treatment Abbreviations ALS, amyotrophic lateral sclerosis ALSFRS, ALS functional rating scale ALSSS, ALS severity scale CNS, central nervous system FTD, Fronto-Temporal...
Ngày tải lên: 22/06/2014, 03:20
Amyotrophic Lateral Sclerosis Part 6 potx
... Henderson, C E & Haase, G (2006) Chronic activation in presymptomatic amyotrophic lateral 220 Amyotrophic Lateral Sclerosis sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL Proceedings ... transporter GLT-1 in amyotrophic lateral sclerosis Annals of neurology, Vol.38, No.1, (July 1995), pp 73-84, ISSN 0364-5134 Rowland, L P & Shneider, N A (2001) Amyotrophic lateral sclerosis The New ... inherited amyotrophic lateral sclerosis Nat Neurosci 11:251-253 Yang Z, Klionsky DJ (2010) Eaten alive: a history of macroautophagy Nat Cell Biol 12:814822 194 Amyotrophic Lateral Sclerosis...
Ngày tải lên: 22/06/2014, 03:20
Amyotrophic Lateral Sclerosis Part 8 potx
... amyotrophic lateral sclerosis patient survival." PLoS Biol 6(7): e170 Wijesekera, L C and Leigh, P N (2009) "Amyotrophic lateral sclerosis. " Orphanet J Rare Dis 4: 300 Amyotrophic Lateral Sclerosis Williamson, ... A., Horvitz, H R and Brown, R H (1997) 292 Amyotrophic Lateral Sclerosis "Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. " Ann Neurol 41(2): 210-21 Deng, H ... aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis. " J Biol Chem 283(35): 24167-76 Furukawa, Y and O'Halloran, T V (2005) "Amyotrophic lateral sclerosis mutations have the greatest...
Ngày tải lên: 22/06/2014, 03:20
Amyotrophic Lateral Sclerosis Part 9 ppt
... Zn-Superoxide Dismutase (SOD1) – The Relevance to Amyotrophic Lateral Sclerosis (ALS) 309 transgenic mouse model of familial amyotrophic lateral sclerosis European Journal of Neuroscence, Vol.9, ... Pathological Inclusions of Amyotrophic Lateral Sclerosis Yoshiaki Furukawa Department of Chemistry, Keio University Japan Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative ... Simple and defined method to detect the SOD-1 mutants from 310 Amyotrophic Lateral Sclerosis patients with familial amyotrophic lateral sclerosis by mass spectrometry Journal of Neuroscience Methods,...
Ngày tải lên: 22/06/2014, 03:20
Amyotrophic Lateral Sclerosis Part 10 docx
... sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations Ann Neurol, Vol.61, No.5, pp 427-434, ISSN 0364-5134 Protein Aggregates in Pathological Inclusions of Amyotrophic ... Protein Aggregates in Pathological Inclusions of Amyotrophic Lateral Sclerosis 351 superoxide dismutases associated with familial amyotrophic lateral sclerosis J Biol Chem, Vol.277, No.18, pp 15923-15931, ... ISSN 1460-2083 352 Amyotrophic Lateral Sclerosis Kerman, A.; Liu, H.N.; Croul, S.; Bilbao, J.; Rogaeva, E.; Zinman, L.; Robertson, J & Chakrabartty, A (2010) Amyotrophic lateral sclerosis is a non-amyloid...
Ngày tải lên: 22/06/2014, 03:20
Amyotrophic Lateral Sclerosis Part 13 ppt
... authors * 480 Amyotrophic Lateral Sclerosis Name of Disease Locus Gene Protein Inheritance Clinical features ALS1 21q22 SOD1 Cu/Zn superoxide dismutase AD/AR Typical ALS ALS2 2q33 ALSin ALSin AR Juvenile ... slowly progressive ALS6 16p11.2 FUS Fused in sarcoma AD/AR Typical ALS ALS7 20p13 N.K - AD Typical ALS ALS8 20q13 VAPB VAMP-associated protein B AD Typical ALS, SMA and atypical ALS ALS9 14q11 ANG ... patients with amyotrophic lateral sclerosis Neurology Vol 56, No 7, pp 843-8 Miller, R.G., Mitchell, J.D., Lyon, M & Moore, D.H., (2007) Riluzole for amyotrophic lateral sclerosis (ALS) /motor neuron...
Ngày tải lên: 22/06/2014, 03:20
Amyotrophic Lateral Sclerosis Part 14 pot
... patient with sporadic amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Vol 10, No 2, (April 2009), pp 118-122, ISSN 1748-2968 22 Genetics of Familial Amyotrophic Lateral Sclerosis Emily ... sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations Ann Neurol 61:427-34 Mackenzie IR, Rademakers R, Neumann M 2010 TDP-43 and FUS in amyotrophic lateral sclerosis ... Al-Chalabi A 2011 Keeping up with genetic discoveries in amyotrophic lateral sclerosis: The ALSoD and ALSGene databases Amyotrophic lateral sclerosis : official publication of the World Federation...
Ngày tải lên: 22/06/2014, 03:20
Amyotrophic Lateral Sclerosis Part 15 potx
... degeneration and amyotrophic lateral sclerosis Biochem Biophys Res Commun, 351, 3, 602-611 A Major Genetic Factor at Chromosome 9p Implicated in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal ... TDP-43 mutation in familial amyotrophic lateral sclerosis Ann Neurol, 63, 4, 538-542 Part Clinical Research in ALS 24 Multidisciplinary Rehabilitation in Amyotrophic Lateral Sclerosis Louisa Ng and ... located in the complete set of ALS, ALS- FTLD and FTLD patients `Functional unit' in this A Major Genetic Factor at Chromosome 9p Implicated in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal...
Ngày tải lên: 22/06/2014, 03:20
AMYOTROPHIC LATERAL SCLEROSIS ppt
... replacing apoptotic cells Amyotrophic Lateral Sclerosis: An Introduction to Treatment and Trials Clinical trials in ALS 5.1 Programmed failure in clinical trials for ALS? In the typical process ... results into successful clinical treatment Abbreviations ALS, amyotrophic lateral sclerosis ALSFRS, ALS functional rating scale ALSSS, ALS severity scale CNS, central nervous system FTD, Fronto-Temporal ... twitters Amyotroph Lateral Scler, Vol 10, No 3, pp 129-130 Amyotrophic Lateral Sclerosis: An Introduction to Treatment and Trials 25 Bedlack, R.S (2010) Amyotrophic lateral sclerosis: current...
Ngày tải lên: 28/06/2014, 11:20
báo cáo khoa học: "A patient with amyotrophic lateral sclerosis and atypical clinical and electrodiagnostic features: a case report" pptx
... of amyotrophic lateral sclerosis Case Presentation: We present the case of a 57-year-old Caucasian man with pathological findings on postmortem examination consistent with amyotrophic lateral sclerosis ... upper motor neuron signs should reinforce the possibility that amyotrophic lateral sclerosis may be present Since amyotrophic lateral sclerosis is a fatal illness, however, the possibility of this ... Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis Subcommittee on Motor Neuron Diseases /Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: " Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature" potx
... with lateral amyotrophic sclerosis with vitamin B12 Zh Nevropatol Psikhiatr Im S S Korsakova 1959, 59:1447-1450 doi:10.1186/1752-1947-4-298 Cite this article as: Rison and Beydoun: Amyotrophic lateral ... 2004, 2:2247 Bensimon G, Lacomblez L, Meininger V, the ALS/ Riluzole Study group: A controlled trial of riluzole in amyotrophic lateral sclerosis N Engl J Med 1994, 330:585-591 Alexianu ME, Ciabarra ... Treatment of ALS with vitamin B12 has been attempted without success [30] It therefore appears that the simultaneous occurrence of NMD /ALS is by chance alone Vitamin B12 therapy in ALS/ MND is unsuccessful...
Ngày tải lên: 11/08/2014, 02:21
Reducing pathological accumulations of phosphorylated neurofilament h through modulation of pin1 activity implications in amyotrophic lateral sclerosis
... Disease…………………………………………… 12 Amyotrophic Lateral Sclerosis …… 16 AMYOTROPHIC LATERAL SCLEROSIS …………… 17 1.2.1 Familial ALS ………………………………… 17 1.2.2 Molecular Pathways In ALS Pathogenesis…… ... of Pin1 in ALS has not been widely studied since and whether it promotes or inhibits disease progression had not been properly characterized 16 1.2 AMYOTROPHIC LATERAL SCLEROSIS ALS, also known ... cells, therefore ALS may be regarded as a multisystem disorder (Ota et al., 2005; Ferraiuolo et al., 2011a) 1.2.1 FAMILIAL ALS Most ALS cases are classified as sporadic ALS (sALS), with no apparent...
Ngày tải lên: 10/09/2015, 09:29
Metabonomic study of amyotrophic lateral sclerosis in SOD1G93A mouse model
... AMP; PNC, purine nucleotide cycle 32 iii Introduction 1.1 Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis (ALS) , the most common of the Motor Neuron Diseases (MND) [1], is ... conduction tests is used for diagnosis ALS is classified into familial ALS (FALS) and sporadic ALS (SALS), with FALS making up approximately 10% of all ALS cases It has been almost 150 years ... 1.1 Amyotrophic Lateral Sclerosis 1.2 ALS Drug Discovery, Disease Model and Clinical Study 1.3 Metabonomics in the study of ALS Materials and Methods...
Ngày tải lên: 30/09/2015, 10:12
Xe ô tô BMW X5 E70 SM 04b_E70 Lateral Dynamics Systems
... In the E70, there are two systems which count as lateral dynamics systems Lateral dynamics systems (effective direction mainly along the y or lateral axis): • Servotronic - Speed-dependent hydraulic ... Coding • Programming The AS control unit uses various input signals to calculate the signals for controlling the AS actuating unit 16 E70 Lateral Dynamics Systems AS Actuating Unit The AS actuating ... disc The line camera converts optical signals that penetrate the code disc into electrical signals Index Explanation Line camera Light guide and LED 27 E70 Lateral Dynamics Systems Hydraulic Pump...
Ngày tải lên: 19/10/2012, 13:48