aiib beta3 receptor antagonists potential clinical utilities
Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot
Ngày tải lên :
08/08/2014, 20:23
... and for a shorter duration when compared with the use of receptor antagonists. 19 Leukotriene Receptor Antagonists Leukotriene receptor antagonists (LTRAs) have been shown to decrease airway responsiveness ... leukotriene receptor antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma J Allergy Clin Immunol 2000;106: 500–6 20 Pearlman DS, Ostrom NK, Bronsky EA, et al The leukotriene D4 -receptor ... Thromboxane Inhibitors Thromboxane A2 synthesis inhibitors, especially if combined with leukotriene receptor antagonists, have been shown to protect against EIB.17 Leukotriene Modifiers Leukotriene Synthesis...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
Ngày tải lên :
12/08/2014, 18:20
... http://respiratory-research.com/content/2/2/066 lymphocytes is a unique biological activity of IL-4 because IL-4 receptors and not IL-13 receptors are expressed on T cells [10] IgE production and the induction of VCAM-1 are ... (reviewed in [23]) involves its interaction with receptors consisting of a heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in ... [32] C→T Interleukin-4 receptor, α chain Location C→T Interleukin-4 promoter Polymorphism –590 [33] Ile→Val +50 [34] Arg→Gln +551 [35] Ser→Pro +503 [36] Interleukin-13 receptor, α chain A→G +1398...
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Báo cáo y học: "Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials" pot
Ngày tải lên :
13/08/2014, 21:21
... conclusions to be drawn about clinical benefit and risks, particularly clinically important GI bleeding Key messages • The literature shows that histamine-2 -receptor antagonists (H2RA) result in ... of clinically important GI bleeding Second, the participants who developed clinically important GI bleeding were not homogeneous in the included trails of study, which did not fulfill the ‘clinically ... http://ccforum.com/content/14/5/R194 Page of 10 Clinically important gastrointestinal bleeding The events of clinically important GI bleeding were explored in three studies [16,23,30] The pooled analysis of the clinically important...
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Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt
Ngày tải lên :
19/02/2014, 05:20
... ropilins [2,3], and enzymes involved in phosphotyrosine signaling, such as the receptor protein tyrosine kinases (RTKs) [4] and receptor protein tyrosine phosphatases (RPTPs) [5–7] Evidence for the role ... vertebrate spinal and cranial motor neurons Nucleolin is a potential ligand for PTPr [35,36], and there is evidence from affinity probe assays of a potential PTPr ligand in developing muscle [37] Recent ... affinity chromatography is potentially a muscle ligand for PTPr, we compared the expression pattern of nucleolin with the distribution of the muscle binding sites for PTPr receptor affinity probes...
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Tài liệu Báo cáo khoa học: Endovanilloids Putative endogenous ligands of transient receptor potential vanilloid 1 channels docx
Ngày tải lên :
19/02/2014, 12:20
... cannabinoid receptors Therefore, its biosynthetic and metabolic pathways have been studied in great detail (Fig 4) [36,37] In 1999, it was reported that anandamide could also activate rat TRPV1 receptors ... anandamide is a partial agonist in tissues with a low receptor reserve (e.g bronchi), but it appears to be a full agonist in tissues with a high receptor reserve such as the mesentery artery [53,57] ... significantly masked by its concomitant activity on cannabinoid CB1 receptors, particularly in those tissues and cells where the two receptors are coexpressed and are coupled to opposing biological...
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Báo cáo khoa học: Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma ppt
Ngày tải lên :
07/03/2014, 05:20
... (Avastin) [5] or its receptor (sunitinib, sorafenib) [6] The latter also target VEGFproducing tumor stroma by inactivating another tyrosine kinase, platelet-derived growth factor receptor- b (PDGFRb) ... of the low expression levels of the two calcium exchange proteins, calbindin and transient receptor potential canonical ion channel (TRPC4) Calcium deficiency is critical for the correct folding ... high levels, expand tumor vasculature [35] Most strategies target angiogenic stimuli, their receptors or receptor tyrosine kinase activity [36] However, an expanding pool of natural molecules act...
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Báo cáo khoa học: The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases pdf
Ngày tải lên :
07/03/2014, 05:20
... pathogens and opsonizing them for phagocytosis 516 Several receptors are involved in opsonization and phagocytosis (e.g the C3b receptor) Receptors for MBL and C1q are also assumed to play a role ... surface receptors such as the general scavenger receptor CD91 The calreticulin/CD91 complex was shown to be present on the surface of phagocytic cells and to function as a scavenger receptor ... WJ & Malhotra R (1998) Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin Immunobiology 199, 208–224 Tarr J & Eggleton P (2005)...
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Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples pptx
Ngày tải lên :
22/03/2014, 21:20
... MicroRNA-22 and estrogen receptor a J Xiong et al Frequent downregulation of miR-22 expression in ERa-positive breast cancer cell lines and clinical samples To evaluate the therapeutic potential and to ... regulator of ESR1 encoding estrogen receptor a (ERa) and demonstrated that miR-22 is frequently downregulated in ERa-positive human breast cancer cell lines and clinical samples In addition, further ... protein levels in pancreatic cancer cells [33] Estrogen receptors (mainly ERa and ERb) constitute a group of ligand-activated nuclear receptors that are activated by estrogen Human ERa is a transcription...
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Báo cáo y học: " Adding 5-hydroxytryptamine receptor type 3 antagonists may reduce drug-induced nausea in poor insight obsessive-compulsive patients taking off-label doses of selective serotonin reuptake inhibitors: a 52-week follow-up case report" potx
Ngày tải lên :
09/08/2014, 01:21
... Page of Y-BOCS score ranges are considered as follows: 0-7 subclinical, 8-15 mild, 16-23 moderate, 24-32 severe and 32-40 extreme A clinical follow-up was obtained after months The patient was ... management of PI-OCD and potential iatrogenic effects exists This is essentially due to a relatively low prevalence [2] of the disorder and difficulty in detection of related clinical features Fluoxetine ... between 20-80 mg/day) is an SSRI antidepressant stimulating 5-HT2A postsynaptic receptors and desensitising 1A receptors; it also acts as a 5-HT2C antagonist, increasing norepinephrine and dopamine...
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Báo cáo khoa học: "Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications" doc
Ngày tải lên :
09/08/2014, 07:21
... and adenovirus receptor (CAR) is a 46kDa transmembrane protein, which functions as a primary receptor for both coxsackie B virus (CVB) and adenovirus (Ad) [1] This cell surface receptor plays ... coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer Int J Cancer 2007, 120:2568-2575 Qin M, Chen S, Yu T, Escuadro B, Sharma S, Batra RK: Coxsackievirus adenovirus receptor ... adenovirus receptor expression in clinical bladder cancer Urology 2002, 60:531-536 Fuxe J, Liu L, Malin S, Philipson L, Collins VP, Pettersson RF: Expression of the coxsackie and adenovirus receptor...
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Báo cáo y học: "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis" pdf
Ngày tải lên :
09/08/2014, 10:23
... the extracellular domain of TNF receptor type II, is an example of a clinically effective soluble receptor- based therapeutic, with potent activity in RA [8] Soluble receptors are known to occur ... molecular cloning of 60 novel soluble receptors as splice variants of 21 RTKs and other cell surface receptor genes, including VEGF and TNF receptors These cell surface receptor- derived ASV differ from ... segment Soluble receptors may retain their ability to bind ligands and function as ligand antagonists [9]; for example, soluble TNF receptors [8] and soluble VEGFR1 [56] Soluble receptors are often...
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báo cáo khoa học: "The clinical potential of microRNAs" docx
Ngày tải lên :
10/08/2014, 22:21
... cancer diagnosis [10,40] Prognostic MicroRNAs The potential clinical utility of microRNA extends beyond the realm of diagnosis to other important clinical measures such as prognosis and treatment ... The translation of these findings to in-vivo models and clinical studies will unquestionably lead to greater insight into their utility in clinical settings The notion of microRNAs as therapeutic ... Mol Biol 2009, 487:435-449 doi:10.1186/1756-8722-3-37 Cite this article as: Budhu et al.: The clinical potential of microRNAs Journal of Hematology & Oncology 2010 3:37 Submit your next manuscript...
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Báo cáo y học: "Proteinase-activated receptor-2: two potential inflammatory mediators of the gastrointestinal tract in Atlantic salmon" ppt
Ngày tải lên :
11/08/2014, 08:22
... resensitize the cells from the irreversible receptor cleavage new receptors are mobilized by large Golgi stores as well as synthesis of new receptors [30] The PAR-2 receptor has been detected in various ... proteinaseactivated receptors have been cloned and studied in man [24-27], but to our knowledge no proteinase-activated receptors have been studied in teleost fish Activation of PAR-2 (proteinase-activated receptor ... N-terminal tethered ligand domain that binds to and activates the receptor [28,29] Upon activation of the PAR-2 receptor in mammals, the receptor is internalized and targeted to lysosomes for degradation...
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Báo cáo y học: "Potential role and mechanism of IFN-gamma inducible protein-10 on receptor activator of nuclear factor kappa-B ligand (RANKL) expression in rheumatoid arthritis" pptx
Ngày tải lên :
12/08/2014, 17:22
... mediated by Gai subunits of CXCR3, which is a well-known receptor for CXCL9, CXCL10, and CXCL11 CXCR3 is a G protein-coupled, seven-transmembrane receptor and has heterotrimeric G proteins consisting ... of proinflammatory cells, CXCL10 may have a potential role in Figure Effect of Gai2 siRNA (small interfering RNA) on CXCL10-induced expression of receptor activator of nuclear factor kappa-B ... osteoprotegerin; PTX: pertussis toxin; RA: rheumatoid arthritis; RANK: receptor activator of nuclear factor-kappa B; RANKL: receptor activator of nuclear factor-kappa B ligand; RT-PCR: reverse...
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Báo cáo y học: " Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?" ppsx
Ngày tải lên :
12/08/2014, 18:20
... that specifically activate either TNFR1 or TNFR2 receptor led us to conclude that TNF-α mediates most of its cellular effects by activating the TNFR1 receptor [17•] The effect of TNF-α on calcium ... agonist-induced calcium homeostasis and/or force generation TNF receptor signaling pathways that are activated in airway smooth muscle cells TNF receptor- associated factor-2–nuclear factor κB pathway ... TNF-α activates at least two cell-surface receptors – TNFR1 (55 kDa) and TNFR2 (75 kDa) – that are expressed in most cell types (for review [22]) Both receptors are expressed on cultivated human...
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Báo cáo y học: "Clinical review: Emergency department overcrowding and the potential impact on the critically il" pot
Ngày tải lên :
12/08/2014, 20:20
... and delivery in the ED setting could potentially represent a threat to patient safety Adding to the current landscape of ED critical care capacity is the potential threat of terrorism and other ... patient care The use of protocols to complement clinical decision making for the critically ill has been shown to decrease unnecessary variations in clinical practice [43] Protocol-directed care ... http://ccforum.com/content/9/3/291 observational studies, survey studies in the literature have linked ED overcrowding to clinically significant delays in diagnosis and treatment, as well as to poor patient outcomes [10,15]...
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Báo cáo khoa học: "Clinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsis" pptx
Ngày tải lên :
12/08/2014, 22:22
... PKC, protein kinase C; PLC, phospholipase C; SOS, son of sevenless; TLR, Toll-like receptor; TREM, triggering receptor expressed on myeloid cells; TREM-1L, TREM-1 ligand 488 Available online http://ccforum.com/content/9/5/485 ... immunity Science 1999, 284:1313-1318 Medzhitov R: Toll-like receptors and innate immunity Nat Rev Immunol 2001, 1:135-145 Lanier LL: NK cell receptors Annu Rev Immunol 1998, 16:359393 Bouchon A, Dietrich ... et al.: Cutting edge: TREM-like transcript, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather inhibits, calcium signaling via...
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Báo cáo sinh học: "Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer" pot
Ngày tải lên :
14/08/2014, 19:22
... the previous approaches This would represent a clinical significance if translated into clinical setting because cisplatin resistance could be potentially overcome by this approach [34] The chemo- ... called cetuximab has been developed It has shown excellent clinical effects for the treatment of lung and head and neck cancer in a clinical trial in humans [11,12] Other small chemical inhibitors, ... vivo for NSCLC Hopefully in the near future, strategies based on RNAi will be ready for preclinical or clinical trials Acknowledgements We are grateful for the grant support from the Science and...
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Characterization of zebrafish vitellogenin gene family for potential development of receptor mediated gene transfer method 5
Ngày tải lên :
16/09/2015, 17:13
... alternative approach, recombinant Vtg fragments were expressed and shown to have a potential as DNA carriers To localize the receptor- binding domain in these fragments, seven 6xHis-tagged recombinant ... uptake by oocytes The reason may be due to degradation or denaturation of Vtgs, destruction of receptor- binding capacity by SPDP modification or improper charge ratio of DNA to Vtg-polylysine ... tissues in the control female fish 6) Red tilapia (Oreochromis mossambica) was used to explore the potential of using Vtgs as DNA carriers for development of a novel method for producing transgenic...
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Characterization of zebrafish vitellogenin gene family for potential development of receptor mediated gene transfer method 4
Ngày tải lên :
16/09/2015, 17:13
... Chapter Receptor- mediated gene transfer Abstract The potential of receptor- mediated gene transfer using vitellogenin protein as DNA carrier ... Vtgs with their receptors 170 Chapter Receptor- mediated gene transfer 3) Improper charge ratio of DNA to poly-L-lysine Zauner et al (1998) pointed out that in order to allow receptor- mediated ... A reported N-terminal receptor- binding region (158-242 amino acid residues), including eight critical residues (site A), is in italic letters (Li et al., 2003) Potential receptorbinding sites...
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