activation regulation and functions of immune responses
Báo cáo khoa học: Activation, regulation, and inhibition of DYRK1A Walter Becker1 and Wolfgang Sippl2 pptx
Ngày tải lên :
22/03/2014, 16:21
... compilation ª 2010 FEBS 251 Activation, regulation, and inhibition of DYRK1A W Becker and W Sippl Fig Structure of the ATP-binding pocket in DYRK1A and DYRK2 (A) Close-up of DYRK1A ATP binding pocket ... consequences, as Activation, regulation, and inhibition of DYRK1A exemplified by patients with homozygous deficiency of DYRK1A [27] and transgenic animal models [28] Thus, the function of DYRK1A may ... for its physiological and pathological effects, this review focuses on the molecular mechanisms of activation and regulation of DYRK1A In addition, we provide an overview of the small molecule...
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ACUTE PHASE PROTEINS – REGULATION AND FUNCTIONS OF ACUTE PHASE PROTEINS doc
Ngày tải lên :
27/06/2014, 19:20
... transcriptional activation of APP genes (Rousseau et al., 2008) Indeed, GATA4 represses 16 Acute Phase Proteins – Regulation and Functions of Acute Phase Proteins C/EBP isoform activation of the KNG1 and ... β and δ (C) Fig Regulation of APP gene expression by C/EBP isoforms involves chromatin remodeling Cell lineage-specific transcription factors and APP gene regulation 9.1 HNF-1α and APP gene regulation ... diminishing the proinflammatory responses of circulating leukocytes, and by forestalling endothelial activation 26 Acute Phase Proteins – Regulation and Functions of Acute Phase Proteins A particularly...
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báo cáo hóa học: " The impact of shift work induced chronic circadian disruption on IL-6 and TNF-a immune responses" pot
Ngày tải lên :
20/06/2014, 00:20
... proinflammatory immune responses As possible markers of these changes in the immune system we investigated the proinflammatory cytokines IL-6 and TNF-a and measured the lymphocyte cell count Materials and ... disruption on IL-6 and TNF-a immune responses Journal of Occupational Medicine and Toxicology 2010 5:18 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online ... Mark et al Journal of Occupational Medicine and Toxicology 2010, 5:18 http://www.occup-med.com/content/5/1/18 deprivation and thereby an induction of proinflammatory immune responses [7-9] Cytokine...
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Báo cáo y học: " Chitosan Interferon-c Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune Responses" pps
Ngày tải lên :
08/08/2014, 21:20
... Regulation of antigenspecific CD8+ T cell homeostasis by perforin and interferongamma Science 2000;290:1354–58 49 Lohman BL, Welsh RM Apoptotic regulation of T cells and absence of immune deficiency ... (cDNA) under the regulation of a constitutive promoter as a means of boosting in vivo production of specific cytokines IFN-c and IL-12 have proven effective as prophylactics and adjuncts in therapy ... University of South Florida College of Medicine vivarium All procedures were reviewed and approved by the Committee on Animal Research at the University of South Florida College of Medicine and VA...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
Ngày tải lên :
09/08/2014, 01:23
... with genetic defects of Foxp3 and the experimental depletion of CD25+CD4+ TR cells led several groups to investigate the potential role of Foxp3 in the development and function of TR cells Three ... cell activation state will have to await the assessment of Foxp3 expression A summary of TR cell developmental steps is shown in Fig Mechanisms of suppression The suppression mechanism of activation- induced ... processes of positive and negative selection Precursor T cells of relatively high avidity trigger a TR cell developmental programme involving the activation of Foxp3, whereas T cell receptors of intermediate...
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Báo cáo y học: " Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" doc
Ngày tải lên :
11/08/2014, 10:23
... authors thank Professors William Brett and Jim Hughes of the Department of Life sciences and Tista Page of 11 (page number not for citation purposes) Journal of Immune Based Therapies and Vaccines ... Further, only small amounts of phytol and PHIS-01 are required to stimulate immune responses None of these two compounds stimulates reaginic immune responses, nor induces autoimmune lupus-like syndromes ... Vaccine Formulation: Assessment of Safety and Efficacy in the Induction and Protective Immune Responses to Lethal Bacterial infections in Mice J Immune Based Therapies and Vaccines 2006, 4:5 Bendavid...
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Báo cáo khoa học: " Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs" pot
Ngày tải lên :
12/08/2014, 04:21
... structural proteins of RVFV The elicited immune responses towards the N, GN, GC and GN/GC proteins after gene-gun immunisation were analysed and the protective abilities of the N and the GN/ GC construct ... protein and truncated variants thereof Western blot reactivity towards the N protein and truncated variants thereof (A) Schematic presentation of the full length and deleted variants of the RVFV ... Ethics Committee of Umeå University, Sweden Evaluation of immune response To evaluate and compare the immune responses after vaccination and infection, eight animals were vaccinated with cDNA...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 2
Ngày tải lên :
09/09/2015, 18:48
... population in WT and µMT mice following immunization (C) Immunofluorescence analysis of WT and µMT LN sections (D and E) Expansion of the BEC (D) and FRC (E) populations in inflamed µMT LNs mice following ... later days of immunization was probably triggered by upregulation of these ELR+ chemokines As T cells made up the largest population of cells in the µMT LNs, we next asked if upregulation of ELR+ ... governed distribution of VEGF-A into the paracortex and medulla To further support this, disruption of interstitial flow was noted to obliterate association of VEGF-A with cortical and medullary sinuses...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 1
Ngày tải lên :
09/09/2015, 18:48
... the normal cornea is devoid of blood and lymphatic vessels In normal circumstances, this prevents access of APCs to corneal antigens and the traffic of immune cells and inflammatory mediators ... modulation and curtailing of immune responses to prevent undesirable immunological reactions 15 1.4 The biology of VEGFs and their receptors 1.4.1 Introduction The VEGF family of growth factors ... receptor-binding properties and signalling complexes 19 Figure 1.3 DNA, RNA and protein products of human VEGF-A families 20 Figure 1.4 Organization of the lymph nodes 23 Figure 1.5 Regulation of neutrophil...
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Regulation of subcellular localization and functions of RGK proteins by 14 3 3 and calmodulin
Ngày tải lên :
14/09/2015, 18:28
... relocalization of RGK proteins by 14-3-3 3-3A Regulation of localization of Kir/Gem by 14-3-3 3-3B Regulation of localization of Rad by 14-3-3 3-3C Regulation of localization of Rem1 by 14-3-3 3-3D Regulation ... of work Kir/Gem, Rad, Rem and Rem2 (RGK) are members of a distinct family of Ras GTPases Two important functions of RGK proteins are the regulation of voltage gated calcium channels (VDCCs) and ... localization of Kir/Gem W269G and mutants by 14-3-3 3-5B Binding of 14-3-3 to Kir/Gem mutants lacking CaM binding 3-5C Regulation of localization of Rad L281G and mutants by 14-3-3 3-5D Regulation of localization...
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THE ROLE OF DMSO IN THE REGULATION OF IMMUNE RESPONSES BY DENDRITIC CELLS
Ngày tải lên :
16/10/2015, 11:59
... just critical APCs for the induction of primary immune responses and the regulation of T cell-mediated immune response (Liu, 2001; Shortman and Liu, 2002; and Banchereau et al., 2001) DCs also ... et al., 2003; Lutz and Schuler, 2002) The diverse functions of DCs in immune regulation reflect the heterogeneity of DC subsets and functional plasticity 1.2.2.5 Heterogeneity of dendritic cell ... of the antigenic marker CD68 in humans Figure 1.3 The ontogeny of Monocyte and Macrophage The development and differentiation of monocyte and macrophages from hemapoietic stem cells (Mosser and...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Ngày tải lên :
25/10/2013, 21:20
... direct down regulation of cyclin protein levels or by inducing members of the INK4A and/ or CIP/KIP family of cyclin dependent kinase inhibitors (CKI), resulting in the down -regulation of cyclin/Cdk ... activity and inhibition of pRb phosphorylation (Ruas and Peters 1998; Sherr and Roberts 1999; Sherr 2001) Sequestration of active E2Fs subsequently results in repression of E2F target genes and ultimately ... regulation of E2F4 activity it is likely that phosphorylation of these sites are involved in the regulation of p130 specific functions and interactions The difference in phosphorylation sites and kinases...
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Tài liệu Báo cáo khoa học: Quantitative analysis of the experimental O–J–I–P chlorophyll fluorescence induction kinetics Apparent activation energy and origin of each kinetic step Steve Boisvert, David Joly and Robert Carpentier doc
Ngày tải lên :
19/02/2014, 05:20
... thorough use of FI in the study of PSII electron transport and to obtain a more complete analysis of the OJ, JI and IP rises This method was also used to nd the apparent activation energy of each ... excellent approximation of FI traces and to quantitatively estimate the contribution of each phase The average values of amplitudes and half-times (t1 2) found for each phase of the FI measured at ... contributions and kinetics of the three main components of the FI traces Deconvolution of the traces with the sum of three exponential rises provided an excellent t between simulated and experimental...
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Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx
Ngày tải lên :
07/03/2014, 00:20
... full details) (B) Sites of cleavage of APP by b- and c-secretases to form Ab peptides The sites of the juxtamembrane and intramembrane cleavages of transmembrane APP by b- and c-secretases, respectively, ... Modulation of oligomeric state and hence activity of the enzyme Modulation of protein–protein interactions affecting localization and ⁄ or activity Modulation of lipid environment of the enzyme ... FEBS 1849 Biology and chemistry of b-secretase (BACE-1) C E Hunt and A J Turner BACE-1 promoter, and several studies have reported the upregulation of BACE-1 mRNA both in vitro and in vivo following...
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Báo cáo khoa học: Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species pptx
Ngày tải lên :
16/03/2014, 06:20
... compilation ª 2008 FEBS 3257 Structure, regulation and evolution of Nox H Sumimoto Fig Activation of gp91phox ⁄ Nox2 and Nox1 (A) Interactions required for activation of gp91phox ⁄ Nox2 Interactions ... chain of this residue forming hydrogen bonds with oxygens of the 3-phosphate; NH1 and NH2 of Arg105 form hydrogen bonds with the 4-OH and 5-OH of the inositol moiety; and the aromatic ring of Tyr59 ... of p67phox, and oxidase activation [181] The crystal structures of the p67phox– PB1 and p40phox–PB1 complexes [187] demonstrate that Lys355 of p67phox forms direct bonds with Asp289, Glu291 and...
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The Practices and Functions of Customer Reference Marketing − Leveraging Customer References as Marketing Assets pptx
Ngày tải lên :
23/03/2014, 03:20
... Wernerfelt, 1984; Grant, 1991), and particularly to the customer-based view of strategy and firm growth (Zander and Zander, 2005), in terms of addressing the multifaceted nature of customer references ... pay more attention to the role and importance of customer relationships, and to examine them as a source of competitive advantage and firm growth (Zander and Zander, 2005) Moreover, further empirical ... for customer-need and market sensing supports the customer-based view of strategy and firm growth (Zander and Zander, 2005) and could be compared with Penrose’s (1959) notion of an ‘inside track’,...
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Báo cáo y học: "Regulation and localization of endogenous human tristetraprolin" doc
Ngày tải lên :
09/08/2014, 01:23
... µl of Lipofectamine 2000 reagent (Life Technologies, Rockville, MD, USA) in a total volume of 50 µl of serum-free RPMI per cm2 of cells, incubated for hours, and followed by the addition of an ... in the regulation of TTP Materials and methods A deficiency of TTP is associated with a profound proinflammatory phenotype TTP-deficient mice exhibit cachexia, with dermatitis, medullary and extramedullary ... neutrophils, and lymphocytes The upregulation of human TTP occurs rapidly, within the first hour of stimulation This is consistent with murine data demonstrating that upregulation occurs within 30 of LPS...
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Báo cáo y học: "Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV" pps
Ngày tải lên :
11/08/2014, 08:21
... pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV Journal of Immune Based Therapies and Vaccines 2011 9:2 Page of Submit your next manuscript ... delivery of attenuated Lmdd-HIV-gag is immunogenic and can induce Gagspecific cellular immune responses, even in the presence of multiple prior Lmdd exposures Anti-vector and anti-HIV Gag antibody responses ... Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708 USA Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104 USA 8The Immune Disease Institute and...
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báo cáo khoa học: " Different subcellular localizations and functions of Arabidopsis myosin VIII" ppsx
Ngày tải lên :
12/08/2014, 05:20
... (Figure 1B) Because of the lack of good anti ATM1 antibodies in our hands, no comparison to endogenous protein's level of expression was done Confocal-microscope images of roots of the transgenic ... GFP-ATM1(IQ-tail) (dots of 980 ± 145 nm in diameter) B FM4-64 C Overlay of A and B (1 optic section) D GFP-ATM1(IQ-tail) (dots of 630 ± 60 nm) E FYVE-DsRED F Overlay of D and E (1 optic section) ... RFP-ATM1(IQ-tail) (dots of 300 ± 100, colored green for ease of demonstration) H GFP-ARA7 (colored magenta for ease of demonstration) I Overlay of G and H (1 optic section) J RFPATM1(IQ-tail) (dots of 570 ±...
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