acid base properties of amino acids
Microbial Production of Amino Acids in Japan
... soybea1ns contain lower amounts of lysine, which is one of Microbial Production of Amino Acids in Japan 77 the essential amino acids for those livestocks The estimated amount of l-lysine produced in ... successful introduction of the technology, various methods were searched for and developed for microbial production of other amino acids Today a whole array of amino acids are produced by microbial ... the genus Corynebacterium 73 Microbial Production of Amino Acids in Japan Table Amino acid production in Japan and the world in 1996 Amino acid Method Japan Glycine l-Alanine dl-Alanine l-Aspertate...
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Properties of carboxylic acids
... Mechanism of Acid- Catalyzed Ester Hydrolysis Is the reverse of the mechanism for acidcatalyzed esterification Like the mechanism of esterification, it involves two stages: 1) formation of tetrahedral ... stage is analogous to the acidcatalyzed addition of water to a ketone Second stage: cleavage of tetrahedral intermediate O + R'OH RCOH H+ OH RC OH OR' Mechanism of formation of tetrahedral intermediate ... Key Features of Mechanism Activation of carbonyl group by protonation of carbonyl oxygen Nucleophilic addition of water to carbonyl group forms tetrahedral intermediate Elimination of alcohol from...
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Báo cáo khóa học: Vertical-scanning mutagenesis of amino acids in a model N-myristoylation motif reveals the major amino-terminal sequence requirements for protein N-myristoylation ppt
... study, to examine the effect of the combination of amino acids at positions and on protein N-myristoylation, sequential vertical-scanning mutagenesis of the amino acids at positions and in a model ... the amino acid requirements at this position were significantly affected by the amino acid at position [25] Therefore, we next determined the effect of the amino acid at position on the amino acid ... the combination of amino acids at positions and might be a critical determinant for protein Nmyristoylation In the present study, to examine the effect of the combination of amino acids at positions...
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Báo cáo khoa học: Identification of amino acids in antiplasmin involved in its noncovalent ‘lysine-binding-site’-dependent interaction with plasmin pptx
... half-lives of plasmin in these experiments (also before 50% of the plasmin activity was inhibited) Computer model of the C-terminal 40 amino acids in antiplasmin A computer model of the C-terminal 40 amino ... absence of 6-aminohexanoic acid) The reactions between ‘native’ human antiplasmin and plasmin in the presence or absence of 6-aminohexanoic acid were also studied for comparison All variants of antiplasmin ... in detail by constructing seven single-site mutants of antiplasmin Fig Computer model of the C-terminal 40 amino acids in antiplasmin Some of the residues are labelled to facilitate viewing Ó...
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Báo cáo y học: "Acid–base status of critically ill patients with acute renal failure: analysis based on Stewart–Figge methodology" ppt
... conclusion, the typical acid base picture of ARF of critical illness is one of mild acidemia due to moderate metabolic acidosis Such acidosis is the result of the net balance of acidifying forces due ... achieve a better understanding of the nature of the acid base disorders of ARF in critically ill patients To achieve this goal, we sought to define and quantify acid base disorders in these patients ... Other factors affecting acid base balance To define the unique acid base characteristics of ARF patients, we used two control groups The matched control group consisted of 40 ICU patients without...
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Guanidine catalyzed enantioselective mannich reaction towards the synthesis of amino acids
... TOWARDS THE SYNTHESIS OF -AMINO ACIDS PAN YUANHANG (BSc., Zhejiang University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY NATIONAL UNIVERSITY OF SINGAPORE To ... provided the synthetic route towards both -amino acid derivatives and -amino acid derivatives Mechanistically, based on the experimental characterization of intermediates and theoretical calculations, ... Proposed mechanism of deacylation of Mannich product 129g Scheme 4.10 Proposed mechanism of decarboxylation of Mannich product 129g Scheme 4.11 Cleavage of N-Eoc imine under acidic condition Scheme...
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Báo cáo Y học: Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes potx
... of a more buried N-terminal amino group [9] A majority of the present FVIIa variants exhibits an intermediate level of protection from carbamylation (Table 2) E296V-FVIIa retains about half of ... [9] The characterization of FVIIa variants containing one or two of the mutations at positions 158{21}, 296{154} and 298{156} has enabled the identication of the amino acid changes mainly responsible ... rate of hydrolysis of peptides of various lengths (from ể FEBS 2002 5954 E Persson and O H Olsen (Eur J Biochem 269) P4-P1Â to P4-P7Â of FX) by V158D/E296V/M298Q-FVIIa as compared with that of...
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Metal complexes of n (7 hydroxyl 4 methyl 8 coumarinyl) amino acid, n (2 pyridylmethyl) amino acid and related ligands synthesis, structural, photophysical and gelation properties
... interactions 1-3 Schiff base and reduced Schiff base from amino acids 1-3-1 N-(2-hydroxybenzyl) -amino acids 1-3-2 N-(2-pyridylmethyl) -amino acid ligands 14 1-4 Complexes of coumarin derivatives ... 4-methylumbelliferone-8-methyleneiminodiacetic acid (H3muia), N-(7-hydroxy-4-methyl-8-coumarinyl) -amino acid (amino acid = glycine (H2mugly), alanine (H2muala), serine (H3muser)) and N-(2-pyridylmethyl) -amino acid (amino acid = b-alanine ... complexes of salicyaldehyde -amino acid Schiff bases as they have been shown to behave analogously to those of pyridoxal -amino acid Schiff bases.9-11 The preparation and structural characterization of...
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FATTY ACID COMPOSITION INCLUDING TRANS FATTY ACIDS CONTENT OF SELECTED VIETNAMESE INSTANT NOODLES
... polyunsaturated fatty acids * TFA: trans fatty acids * MUFA: monounsaturated fatty acids The amount of total TFA in the samples ranged from 0.16% to 0.83% of total fatty acid with the mean of 0.38% Total ... polyunsaturated fatty acids * TFA: trans fatty acid* MUFA: monounsaturated fatty acids negligible proportions of trans fatty acids, bothwith monounsaturated and polyunsaturated fatty acids These results ... PUFA: polyunsaturated fatty acids * MUFA: monounsaturated fatty acids * TFA: trans fatty acids * tc: traceal 818 Fatty acid composition including trans fatty acids content of selected Vietnamese instant...
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Effects of time of heatsetting on the tensile properties of ingeo™ poly (lactic acid) (PLA) fabric
... Poly (lactic acid) fabric Figure Effect of time of heatsetting on the linearity of load extension in weft direction of knitted Ingeo™ Poly (lactic acid) Figure Mean effect of time of heatsetting ... [PLA] Figure Mean [Ā] of effect of time of heatsetting on the tensile extension EM [%] of Ingeo™ Poly (lactic acid) 3.2 Linearity of load extension curve LT [-] The linearity of load extension curve ... Poly (lactic acid) (PLA) fabric Conclusion The effect of time of heatsetting on tensile properties of knitted Ingeo™ Poly (lactic acid) (PLA) was determined using the KES-FB system of fabric testing...
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Biodegradable Polymers Composed of Naturally Occurring α-Amino Acids
... Won, C.Y (1999) Amino acid- based bioanalogous polymers Synthesis, and study of regular poly(ester amides) based on bis(α -amino acid) α,ω-alkylene diesters, and aliphatic dicarboxylic acids J Polym ... Katsarava, R., and Kricheldorf, H.R (2000) Amino acid based bioanalogous polymers Synthesis and study of new poly(ester amide)s composed of hydrophobic α -amino acids and dianhydrohexitoles J Macromol ... M (1961) Chemistry of the Amino Acids, John Wiley & Sons, Inc., New York, London Zavradashvili, N (2008) New functional biodegradable poly(ester amide)s composed of α -amino acids and their potential...
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Tài liệu THE ROLES OF AMINO ACID CHELATES IN ANIMAL NUTRITION pdf
... Association of Feed Control Officials, a metal amino acid chelate is lithe product resulting from the reaction of a metal ion from a soluble salt with amino acids with a mole ratio of one mole of metal ... (preferably two) moles of amino acids to form coordinate covalent bonds The average weight of the hydrolyzed amino acids must be approximately 150 and the resulting molecular weight of the chelate must ... of a specific mineral in the feed; (b) The Roles of Amino Acid Chelates in Animal Nutrition an imbalance of another mineral or nutrient including certain vitamins, amino acids and fats, any of...
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
... the second-half reaction and are part of the active-site of CoaB; these residues may be directly involved in binding of one of the substrates, the amino acid cysteine (Fig 3) However, it cannot ... conditional lethality of the dfp-707 mutant is that one amino acid residue of the N-terminal PPC decarboxylase (CoaC) domain of Dfp is exchanged [4] For further characterization of the dfp-1 mutation, ... 4¢-phosphopantothenic acid, CTP and cysteine The synthesis of PPC occurs in two half reactions starting with the formation of 4¢-phosphopantothenoyl-CMP (activation of the carboxyl group of 4¢-phosphopantothenate)...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... automatically the positions of the a-proton and the side chain of any bound amino acid The lability of the a-proton observed for a large number of amino acids [5] under the action of TPL gives evidence ... orientation of the a-proton with respect to the cofactor plane [17], and shows that the pattern of binding is the same for a variety of amino acids It has been established [5] that for a number of amino ... References Konnikova, A.S., Dobbert, N.N & Braunstein, A.E (1947) Labilization of a-hydrogen of amino acids under the action of aminoferase Biokhimia 12, 556–568 (in Russian) Ó FEBS 2004 Esaki, N., Nakayuma,...
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Báo cáo khoa học: The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids doc
... activities of NBD2A and NBD2B could result from an inhibitory effect of the C-terminal 42 amino acids of NBD2B or a stimulatory effect of the equivalent amino acids of NBD2A To determine which of these ... last 42 amino acids Figure 2A and Table show that the ATPase activity of NBD2-DC was greater than that of SUR2B but similar to that of NBD2A, favoring the idea that the last 42 amino acids of NBD2B ... that of NBD2A This suggests that the final 42 amino acids of SUR2B may reduce its hydrolytic activity, and that the catalytic activity of SUR2A is not measurably affected by its final 42 amino acids...
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Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx
... involved in the action of amino acids on gene expression Amino acid( s) manipulations Factor(s) implied Inhibiting effect resulting from the presence of amino acids Pooled amino acids deprivation Increased ... presence of amino acid( s) resulted in inhibition of the DNA binding of the involved transcription factors By contrast, the presence of amino acid may also result in stimulation of the DNA binding of ... effects of different amino acids (except glutamine), together with the identified transcription factors and the responsive elements involved Most of the data concern the inhibitory effect of amino acids...
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Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding pptx
... to consist of six domains: the N-terminal cytoplasmic tail (amino acids 1–18), the helical transmembrane region (amino acids 19–43), and four extracellular domains spanning amino acids 44–150 ... recovered, apparently as a result of the blocking of the N-terminal amino acid Subsequent Western blot analysis, exploiting the 7E11 mAb recognizing the first six amino acids of the full-length GCPII [31], ... contribution of the N- and C-terminal regions of GCPII to its enzymatic properties and structure/folding The results clearly show that the amino acids at the extreme C-terminus of GCPII are crucial...
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Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx
... of the water molecule Its deprotonation by the a -amino group of SerB1 is favored by stronger interaction of the general base with the side chain oxygens of AsnB241 and Scheme Modified scheme of ... The specific orientation and interaction of several amino acids at the active site of PGA, combined with the effect of the substituent on the geometry of the second TS, leads to a change in the ... release of 5 -amino- 2-nitrobenzoic acid allows the progress of the reaction to be followed spectrophotometrically (k = 380 nm) The decrease of PGA activity as a function of the amount of the inhibitor...
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Báo cáo khoa học: Mutational analyses of human eIF5A-1 – identification of amino acid residues critical for eIF5A activity and hypusine modification doc
... or C-terminal domains of eIF5A are required for eIF5A activity, we generated truncated eIF5A eIF5A with deletions of six or 13 amino acids from the N-terminus, or five amino acids from the C-terminus, ... Analysis of the position of both amino acids in the human eIF5A-1 model, Leu91 and Leu101, shows that they are localized at the hydrophobic core of the b-barrel (Fig 1) Substitution of either of the ... Lys47 acetylation Therefore, we substituted Lys47 with three different amino acids, i.e acidic, neutral and basic amino acids The fact that eIF5A activity is impaired partially by Ala substitution...
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Báo cáo khoa học: Properties of two multifunctional plant fatty acid acetylenase/desaturase enzymes pptx
... added fatty acids into their lipids In absence of exogenous fatty acids, the yeast expressing the C alpina acetylenase gene converted up to 0.65% of their fatty acids into 18:2 in a ratio of D12(E) ... shown that epoxy fatty acid production in A thaliana severely inhibits formation of linoleate and that the degree of inhibition is correlated with the levels of the epoxy fatty acids accumulated [11] ... products of the desaturation reactions, i.e 18:3D6Z,9Z,12Z and 18:2D6a,9Z,12Z accounted for about 1.3% of all fatty acids in the cell and of which 40% was found as the acetylenic fatty acid and...
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