accuracy type i and ii errors
Báo cáo khoa hoc:" Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison''''s disease in girls and women with Turner syndrome" docx
... disease, insulin dependent diabetes mellitus (IDDM), Addison's disease, rheumatoid arthritis, myasthenia gravis, vitiligo, alopecia, pernicious anaemia and hypoparathyroidism, but the association to ... syndrome is not definite [10] Normally Addison's disease is often associated with other autoimmune diseases, such as thyroiditis, IDDM, premature ovarian failure (POF), vitiligo and hypoparathyroidism ... in the adrenal cortex and steroid producing cells in the gonads, reflecting the risk of developing ovarian failure In addition patients with Addison's disease and POF, also show antibodies directed...
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Báo cáo khoa học: A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major pot
... TryX indicating that formation of an intramolecular disulde is important for interaction with TryX In contrast, this mutant displayed signicant activity with dithiothreitol (65% of wild -type) suggesting ... peroxiredoxin [8] TryPs were originally identied and characterized in Crithidia fasciculata [812] and these have been subsequently identied and studied in a variety of trypanosomatids [1318] Additional ... genomic DNA of L major Friedlin strain using forward primer containing an NdeI site and reverse primer containing a BamHI site (Table 3) The 525 bp PCR-product was digested with NdeI and BamHI and...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... TNF on interferon-inducible gene expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced ... downregulated in vivo but was upregulated upon TNF stimulation in vitro Meanwhile, IFI genes such as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA ... erythematosus II: IL-12 production in vitro is correlated negatively with serum IL-10, positively with serum IFN-gamma and negatively with disease activity in SLE Cytokine 1998, 10:148-153 Calvano SE, Xiao...
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Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading" ppt
... Lippiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips II Correlation of morphology with biochemical and metabolic data J Bone Joint ... expression levels of sensitive genes and be the explanation for this effect This is in line with reports of upregulation of col II and col I synthesis in chondrocytes in response to cyclic loading in ... very likely to increase inappropriate mechanical loading in many parts of the joint and, in keeping with this, col II and YKL40 expression rose in all locations after ACLT in our study Surprisingly,...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
... TNF on interferon-inducible gene expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced ... downregulated in vivo but was upregulated upon TNF stimulation in vitro Meanwhile, IFI genes such as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA ... erythematosus II: IL-12 production in vitro is correlated negatively with serum IL-10, positively with serum IFN-gamma and negatively with disease activity in SLE Cytokine 1998, 10:148-153 Calvano SE, Xiao...
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Dynamic studies of type i and type II cadherins EC domains
... Type II cadherins result in their distinct behaviour in vivo Type I cadherins, including E-cadherin, N-cadherin and C-cadherin etc., show stronger and more rapid adhesion than Type II cadherins ... observed in the Type II cadherins artificial junction under the similar condition (40) The different clustering mechanism of Type I and Type II cadherins may partly account for their distinct adhesion ... subfamily (12, 13) However, Type I and II cadherins show no heterophilic adhesion between each other (14) The distinct adhesive strength and binding specificity between Type I and Type II cadherins...
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Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot
... GAKGDRGET, at position 853–861 of the triple helical domain of the a1 (I) chain, within peptide CB7 [26] A similar sequence is present in the homologous region of type II and III collagens Without GAK, ... in 0.5 M acetic acid and the precipitate of type II collagen removed by centrifugation, dialyzed against 0.1 M acetic acid and freeze-dried Type II collagen CNBr peptides were purified essentially ... conclusively identified the collagen domains responsible for the specific association with decorin In this study, we have analyzed the binding between decorin and CNBr peptides from type I and type II collagens,...
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Báo cáo khoa học: Comparing the substrate specificities of cytochrome c biogenesis Systems I and II docx
... Specificity of cytochrome c biogenesis System II System I Disulfide isomerization Heme handling/ligation Fig Schematic representation of cytochrome c biogenesis Systems I and II The systems illustrated ... recognition or specificity of System II A particularly notable point for examination is the ability of Systems I and II to mature single-cysteinecontaining c -type cytochromes (XXXCH or CXXXH motifs) ... towards a diheme cytochrome c [11] In E coli, natural cytochrome c biogenesis requires at least 10 proteins, contrasting with the single protein constituting System III System II is of intermediate...
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Báo cáo khoa học: Differential interactions of decorin and decorin mutants with type I and type VI collagens pptx
... chips and with 0.3 M NaCl in the case of immobilized type VI collagen To form a complex consisting of decorin, type I and type VI collagen, type VI collagen was first immobilized After binding ... Interaction with wild -type decorin core protein (obtained by chondroitin ABC lyase digestion) in HBS Decorin core protein concentrations were as indicated (B) Interaction with wild -type decorin in ... decorin significantly increases the binding affinity between the two collagens (Table 4) Discussion In this study we investigated the interaction of wild -type decorin and decorin mutants with type I...
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Báo cáo Y học: Comparison of starch branching enzyme I and II from potato ppt
... SBE II to 64% (Fig 1B) Thus, the potato isoforms differed in that SBE I was more active than SBE II on amylose and SBE II was more active than SBE I on amylopectin, which is in accordance with ... activity on amylose and amylopectin with the starch –iodine assay Amylose (type III, Sigma) and amylopectin (Sigma) from potato were typically dissolved at 10 mg:mL21 in 0.5 M NaOH The solutions ... results obtained with maize SBE I and II [3,15,16] The lmax of the amylose substrate shifted from 616 nm to 543 nm after incubation for 180 with SBE I and to 574 nm after incubation with SBE II for...
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báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
... Denileukin diftitox (Onzar) is a recombinant protein comprising IL-2 fused with the alpha chain of diphtheria toxin, (DAB389+IL-2), capable of transiently eliminating T regs Phase II/ III clinical ... stability of the phenotype following in vivo administration, the ability to migrate to sites of T cell activation and generation of CTLs Activated and mature DCs results in antigen-specific immunity, ... with minimal toxicity Conclusion: Addition of IFN-α to ex vivo monocyte-derived DCs, did not significantly enhance peptide-specific T cell responses in vivo, compared with TNF-α alone Class II...
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Báo cáo toán học: " On Systems of Quasivariational Inclusion Problems of Type I and Related Problems" potx
... Guerraggio and Tan [4] etc for quasi-equilibrium problems and quasivariational inequalities; Blum and Oettli [5], Tan [7], Minh and Tan [8], Ky Fan [9] etc for equilibrium and variational inequality ... ∩ dom F (ii) If F is upper C-continuous and lower C-continuous in x simultaneously, we ¯ say that it is C-continuous in x ¯ (iii) If F is upper, lower, , C-continuous in any point of dom ... Minh, and N X Tan, Some sufficient conditions for the existence of equilibrium points concerning multivalued mappings, Vietnam J Math 28 (2000) 295–310 K Fan, A minimax inequality and application,...
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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx
... 0 Time (s) Fig BIAcore analysis of IGF -II and IGF -II analogue binding to highanity recombinant IGF1R Binding of IGF -II (A), des-(1±6)-IGF -II (B) and Arg6-IGF -II (C) to rhIGF1R measured by BIAcore ... deprivation-induced cell death (Fig 4E) and Arg6IGF -II and des(1±6)-IGF -II were essentially equipotent to IGF -II Leu27-IGF -II and des-(1±6,10)-Leu27-IGF -II did not exhibit any survival-promoting ... relationship (Fig 5) Thus, those IGF -I mutants designed to investigate IGFBP binding [Long IGF -I, des-(1±3)-IGF -I, Arg3-IGF -I, Gly3IGF -I, Arg6-IGF -II and des(1±6)IGF -II] have basically equal abilities to...
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Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... activator inhibitor type (HAI-1), a Kunitz -type serine protease inhibitor, is implicated in the inhibition of two members of the TTSP family, matriptase and hepsin HAI-1 was originally identified as ... enzymatic activity without inhibitors was used as an uninhibited control The IC50 was defined as the concentration of inhibitor that inhibited the enzymatic activity by 50% compared with the uninhibited ... two-chain form exclusively in the injured tissue This conversion is mediated by serine protease activity, which is induced in the injured tissue [28] The two-chain form is required for the biological...
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Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx
... immunoprecipitated with an anti-FGFR3 serum then immunoblotted with anti-ubiquitin and anti-FGFR3 sera (D) Disabling the c-Cbl ubiquitylating activity does not affect the ubiquitylation of the wild -type, ... with chloroquine as indicated Lysates were immunoprecipitated and processed for immunoblotting with anti-ubiquitin and anti-FGFR3 sera (C) Ubiquitylation of the wild -type receptor is increased by ... pBSII to pcDNA3.1 at the HindIII ⁄ EcoRI restriction sites Single-point mutations in the intracellular domain, namely K650M and X807R were generated by site-directed mutagenesis (Quick ChangeÒ site-directed...
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Tài liệu Báo cáo khoa học: Identi®cation and properties of type I-signal peptidases of Bacillus amyloliquefaciens doc
... Cloning of sipU Cloning of sipU Cloning of sipU Cloning of sipU Cloning of sipU Cloning of sipU Cloning of sipU Cloning of sipU Cloning of sipV Cloning of sipV Cloning of sipV Cloning of sipV ... or HindIII (lane a) or EcoRI-SacI (lane b) digested genomic DNA in case of sipW Hybridization indicated DNA fragments of about 2.5 and 1.6 kb or 0.8 and 1.2 kb, respectively Each digest indicated ... cut with either PstI and EcoRI in case of sipV or EcoRI-SacI in case of sipW and ligated into corresponding sites of pUC18 DNA The ligation mixes were used for PCR with oligo nucleotides Uni1 or...
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Tài liệu Báo cáo Y học: Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II ppt
... syntaxin-1A, and munc18 by CKI, CKII and PKA Casein kinase I a (CKIa, upper panel), casein kinase II (CKII, middle panel) or protein kinase A (PKA, bottom panel) were tested for their ability to phosphorylate ... phosphorylation of synaptic vesicle-associated protein SV2 by CKI modulates its ability to interact with synaptotagmin Phosphorylation of syntaxin-1A by CKII increases its ability to interact with synaptotagmin ... that CKII phosphorylates in vitro syntaxin-1A on Ser14, and that this residue is phosphorylated in vivo, it remains to be determined whether CKII is the kinase Fig Summary of phosphorylation sites...
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Báo cáo khoa học: Apolipoproteins A-I and A-II are potentially important effectors of innate immunity in the teleost fish Cyprinus carpio pot
... mammalian HDL and its principal apolipoproteins A -I and A -II in antimicrobial or antiviral activities in vitro [13,14,30], these proteins have not been yet recognized as important effectors in innate ... apoA -II, both major apolipoproteins contribute significantly to the antimicrobial activity displayed by carp plasma HDL Results Purification of HDL and apolipoproteins A -I and A -II As shown in Fig ... apolipoproteins A -I and A -II in the in vitro antimicrobial activity of carp HDL Both proteins inhibit the Ó FEBS 2004 growth of Gram-positive and -negative bacteria, including fish pathogens, at micromolar...
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Báo cáo khoa học: Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry doc
... protein, providing evidence that domains of type I PKS retain their intrinsic activity after cleavage of their linkers It is significant that KS1 was still observed fully acylated after acylation ... pretreated with NPDS, and after digestion incubated with propionyl-CoA The identity of domains present in each peak is indicated, together with their inferred acylation status Separation conditions ... Propionyl-CoA/n-butyryl-CoA incubation with intact and digested DKS Purified DKS was subjected to limited tryptic proteolysis under various conditions as described in Experimental procedures Domain and multidomain FEBS...
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