... staining protocol, Jin Ben and Gare Hoon Yeo for technical assistance and motivation, and lab members of A/P Chong’s lab for their constant encouragement and motivation. Last but ... TGFβ and Activin. Both TGFβ and Activin exhibit a high affinity for type II receptors and they do not interact with the isolated type I receptors (Shi and Massague, 2003). These ligands ... (Massague, 1998; Shi and Massague, 2003). Smad 1, 2, 3, 5 and 8 form the RSmads class. Smad 1, 5 and 8 are known to respond to signalling by the BMP subfamily, and Smad 2 and 3 are the mediators of the ...
Ngày tải lên: 14/09/2015, 18:03
... for 10 weeks prior to mating and throughout gestation and lactation (35) Hepatic hypertrophy and eosinophilia were observed in F1 and F2 male and female pups in the midand high-dose groups Postnatal ... (females on pnd 14 and males on pnd 35) and 0.4% dose group (females on pnd 14 and 21, and males on pnd 14, 28, and 35) Hormonally-mediated endpoints such as anogenital distance and nipple retention ... malforDams and pups evalumations.) ated on pnd for litter size and survival and body weight changes only (30) * Combined doses for F0 and F1 dams during gestation and lactation ** Only maternal and...
Ngày tải lên: 13/02/2014, 10:20
NTP-CERHR MONOGRAPH ON THE POTENTIAL HUMAN REPRODUCTIVE AND DEVELOPMENTAl EFFECTS OF BISPHENOL A pot
... based on individual body weight and measured concentrations of bisphenol in indoor and outdoor air, dust, soil, and liquid and solid food from day care and home and the assumption of 100% absorption ... bw/day) (51) and mammary glands (0.0025 – 1 mg/kg bw/day) (52, 53); altered prostate gland and urinary tract development (10 µg/kg bw/day) (54), and early onset of puberty (2.4 and 200 µg/kg ... developmental effects observed at “high” doses on survival and growth and the “low” dose effects on brain and behavior, mammary gland, prostate gland, and onset of puberty in females described above Species...
Ngày tải lên: 05/03/2014, 16:20
Báo cáo khoa học: In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities pdf
... mobility controls: labelled Comp-CT alone and a completely annealed reaction Samples were taken at 0, 1, 3, 10, and 30 Single-stranded (ss) and double-stranded (ds) species are indicated (B) Bar ... 1· Gels were dried and autoradiography visualized by using GP-Storage Phosphor Screen and storm scanner and software (Amersham Biosciences) Radioactive bands were quantified and annealing percentage ... test) protein that binds single-stranded nucleic acids and is able to promote interstrand reannealing of DNA as well as RNA [35,36] hnRNP Al is phosphorylated by CK2 and PKA PKA phosphorylation suppresses...
Ngày tải lên: 16/03/2014, 12:20
Báo cáo y học: "Primary congenital anomalies of the coronary arteries and relation to atherosclerosis: an angiographic study in Lebanon" doc
... Hopsital ZI, SS and AS analyzed the angiograms and the patients' medical files AHE and AS discussed the results and prepared the manuscript AHE answered the reviewers' questions and modified the ... artery was defined according to the guidelines of Yamanaka and Hobbs [11] http://www.cardiothoracicsurgery.org/content/4/1/58 and the "eye -and- dot method" [12] Most of the selective coronary angiographies ... characteristics including age and gender, admission diagnosis was categorized as acute coronary syndrome, arrhythmia or congestive heart failure Co-morbidities such as diabetes mellitus, hypertension and...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo khoa hoc:" Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study" ppt
... polymorphism at these loci and the presence of DDH and PPA We also explored the effect of genotype on acetabular morphology and severity of the conditions Patients and methods Hypothetically, ... and spans more than 140 kilobases The most widely studied polymorphic regions are the Pvu II and Xba I restriction fragment length polymorphisms in intron and the (TA) n variable number of tandem ... the vitamin D and oestrogen endocrine system have been described 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) and 17β-estradiol (E2) have a mutual effect on their biosynthesis [19,20] and receptor...
Ngày tải lên: 11/08/2014, 08:21
Comparing the cultural and linguistic analysis of the English word “meal” and words relating to it in contrast with Vietnamese equivalents.
... They often have cereal or porridge, egg and bacon followed by toast and marmalade and coffee and tea or they may just have a toast and marmalade and coffee and tea *Elevenses - brunch Elevenses ... of making tea and using service by rinsing teapot with boiling water and putting tea and hot water into the teapot and waiting for a short time and pouring it into cups (with handle or not) Regardless ... understand cultural meaning of speech, words to communicate well Lexical and semantic field of words Many linguists have given out their own definition about lexical and semantic field of words, and...
Ngày tải lên: 15/04/2013, 15:11
A study of semantic and pragmatic features of the adjective warm and its vietnamese equivalents
... nation, and the administration and control of its internal and external affairs 3.1 RESEARCH DESIGN AND METHODOLOGY This study is intended to follow quantitative and qualitative approach and develops ... works and their Vietnamese equivalents, examines how they are used and then describes them Warm-hearted AP 3.3.3 RELIABILITY AND VALIDITY Adverb +Warm Warm and + As +Warm+ as + Noun Reliability and ... study, which describes and compares some semantic and and make a sharp noisy by rubbing its legs against its body” pragmatic features of the adjective Warm in English and Vietnamese 2.2.1.3 Meaning...
Ngày tải lên: 26/11/2013, 13:21
A contrastive analysis of semantic and pragmatic features of the words denoting birds in english and vietnamese
... the WDBs both English and Vietnamese Clarifying the semantic features will help learners of English and Vietnamese to understand and use them effectively in order to achieve their communication ... DESIGN AND METHODOLOGY The study is conducted with both qualitative and quantitative approaches We use descriptive and contrastive methods to described, analyse and find out the similarities and ... understand their cases of Secondly, English considers the WDB “owl” as the symbol meaning, it is important to consider them in their collocations From of “wisdom” on the basis of their experience and...
Ngày tải lên: 26/11/2013, 13:30
Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
... Environment, Agricultural Sciences and Spatial Planning (to L.W and S.E.), the 4928 Swedish Research Council (to H.E and P.N.) and the Swedish Cancer Foundation (to H.E and P.N.) The Structural Genomics ... domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig 1A) The two subunits ... PRTFDC1 (A) monomer and (B) tetramer generated using symmetry-related molecules Interactions with GMP (C) GMP, phosphate and calcium ions are shown as sticks and spheres colored pink and black, respectively...
Ngày tải lên: 15/02/2014, 01:20
Tài liệu NEW AND ORIGINAL THEORIES OF THE GREAT PHYSICAL FORCES doc
... tabulated—Unbiassed estimate of their character and location CHAPTER XI SOUNDS, AND THEIR TRANSMISSION 77 Essential character and mode of progression—Waves have no act or part in their conveyance CHAPTER ... notwithstanding the satisfactory progress which has been made in solving the grand problem of their correlation, little has been learned of their intimate nature, and the method of their operation ... transmission of light and sound; of the production of winds, and sun-spots, and of the method of development and dissemination of heat, are in point of fact, unphilosophical and incomprehensible...
Ngày tải lên: 17/02/2014, 01:20
Tài liệu STRATIGRAPHY AND AMMONITE FAUNA OF THE VOLGIAN AND BERRIASIAN ROCKS OF EAST GREENLAND ppt
... conglomerates, sands and sandstones, and ::::-z; , Sond &sandstone oooo Doggerr Bonded rhole rand , ~ - - @ 50m Fossil locality Altitude 500m Fig Rkebcll map of the country north and easl, ... division into Lower and Upper IIartzfjalrl Sandstone, see page 15 1V Stratigraphy and Ammonite Fauna of East Greenland South-western Jameson Land A suc~cession here was observed by MAYNCand puhlished ... Jurassic and Berriasian age arp krtown from five places in East Greenland, namely 1) Milne Land: 2) soutll-western Jamcson Land; 3) northern Wollaston Forland; 4) I\-?;tern ICnhn B and 5) eastern...
Ngày tải lên: 17/02/2014, 20:20
Tài liệu A Dissertation on the Medical Properties and Injurious Effects of the Habitual Use of Tobacco pptx
... clubs, and grog-shops, and taverns, and thus helps to make idlers and spendthrifts; and finally, that it is a very serious and needless expense; are things which cannot be denied by any observing and ... ale, and brandy must be taken, to satisfy this unnatural demand Hence, smoking has, in many instances, been the sad precursor to the whiskey-jug and brandy-bottle, which together have plunged their ... them sufficiently fluid, and afterwards, by their peculiar properties, to promote digestion and assimilation The great increase of these just before and after eating, and the large quantities...
Ngày tải lên: 17/02/2014, 22:20
Tài liệu The Dynamic Retention Model for Air Force Officers- New Estimates and Policy Simulations of the Aviator Continuation Pay Program doc
... readiness, and support of current and future aerospace forces Research is conducted in four programs: Aerospace Force Development; Manpower, Personnel, and Training; Resource Management; and Strategy and ... caveat: In their original work, Gotz and McCall did not present standard errors or confidence intervals for their estimates; therefore, we cannot ascertain whether or not the differences noted in their ... 15213-2665 RAND URL: http://www.rand.org To order RAND documents or to obtain additional information, contact Distribution Services: Telephone: (310) 451-7002; Fax: (310) 451-6915; Email: order@rand.org...
Ngày tải lên: 17/02/2014, 23:20
Tài liệu Static and Dynamic Analysis of the Internet’s Susceptibility to Faults and Attacks docx
... nodes), 11/08/1999 (6127 nodes), and 01/02/2000 (6474 nodes), and measured their diameters For comparison, we also generated the BA and GE models and measured their average diameters We generated ... characteristics of the Internet; , Ko and DIKo are defined as the average diameter, K, and DIK of the original networks and df , Kf and DIKf denote the diameter, K, and DIK after 10% of the nodes are ... characteristics of the Internet—average degree, creation of nodes and links, and death of nodes and links; (a): mn and me denotes the number of nodes and links added since November, 1997 In general, 1.36...
Ngày tải lên: 18/02/2014, 01:20
Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... supplied with the enzyme, and contained Aba, Abb and Abc at 40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of dATP, dCTP, dGTP and dTTP The product was ... Ab(1–40) and Ab(M1–40) are at least 97% pure In the lanes containing Ab(1–42) and Ab(M1– 42), there were prominent bands at approximately kDa and faint bands at approximately 14 kDa The band at ... by side with Ab(1–40) and Ab(1–42) synthesized using standard Fmoc chemistry and isolated by SEC as described above Thioflavin T binds to Ab fibrils and protofibrils [30], and has been extensively...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... the zero, xN and 0.87xH frequencies, versus the sequence of the TTF-1 HD Measurements were done at 11.7 T and 286 K Blank slots are for residues 29 and 42 (prolines) and Glu17, Leu34 and Lys46, ... of J(0) and J(xN) and a significant maximum of J(0.87xH), and that emerges not only within helix III, but also over a large portion of the protein, from Phe8 to Met56, including the loop and the ... (9.84 ± 0.20 ns) and two for sgi (0.26 ± 0.03 ns and 0.55 ± 0.06 ns) (supplementary Doc S1 and Fig S2) Comparison of results from MF and RSDM The results for sm obtained by the MF and RSDM approaches...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Molecular modeling and functional characterization of the monomeric primase–polymerase domain from the Sulfolobus solfataricus plasmid pIT3 doc
... 60, 70 and 80 °C between 190 and 260 nm with a step increase of 0.2 nm, and a bandwidth of nm Thermal stability of Rep245 was measured by incubating the protein at 60, 70 and 80 °C for 30 and then ... activities of Rep245 and Rep516 proteins were assayed between and 90 °C for 30 on M13 single-stranded DNA, with dNTPs including [32P]dATP[aP] as substrates The approximate size of the bands (in nucleotides) ... prim–pol domain S Prato et al Zn-binding motif and the two disulfide bonds respectively connecting the a4-helix to the b4 strand and the b9 strand to the b10 strand at the bottom of the Zn-stem loop in...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf
... contribution of Met1, and Met23 substituted for Leu, Fig Comparison of the cyclization reaction as a function of temperature and pH (A), (B) and (C): (d), (s) and (.) correspond to pH 2.5, 8.0 and 11.5, ... hydrolysis reaction as a function of denaturing agent and pH (A), (B) and (C): (d), (s) and (.) correspond to guanidinium chloride concentrations of , and M, respectively Hydrolysis was calculated as ... The pH was adjusted to 2.5, 8.0 and 11.5 and the samples were incubated at 37 °C, 50 °C and 70 °C Aliquots were taken at different time-points from each sample and analyzed by MALDI-TOF MS The...
Ngày tải lên: 19/02/2014, 12:20