a novel therapeutic target in human atherosclerosis
Regulation of the TRIP BR1 proto oncoprotein a potential therapeutic target for human cutaneous and intracavitory proliferative lesions
... transformation carcinoma, lung adenocarcinoma, in vitro and tumor ovarian cystadenocarcinoma, formation in mice colorectal carcinoma, renal cell (J.K Cheong et al, carcinoma, osteosarcoma and ... to include cutaneous and intracavitary superficial mucosal lesions such as vulvar intraepithelial neoplasia, cervical dysplasia or carcinoma in situ, oral cancer and nasopharyngeal bladder cavity ... include an N-terminal basic cyclin A- binding motif (containing a putative nuclear localization signal), a novel uncharacterized motif termed SERTA (SEI-1, RBT1 and TARA), a PHD zinc finger- and/or...
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Characterization of TROM, a novel transcription repressor in human cancers identified by modified suppression subtractive hybidization (MSSH)
... presented and discuss in Chapter Section Introduction Figure 1.3 a T7 promoter TAATACGACTCACTATAGGGAGA SP6 promoter ATTTAGGTGACACTATAGAAGNG T3 promoter AATTAACCCTCACTAAAGGGAGA b Figure 1.3 Paradigm ... fifth cause of death among all cancers The annual incidence is increasing at a rate of 0.5% globally, and at 4% in Asia, making the estimated new cases at 1.5 million in year 2010 (1) At present, ... 2000;165(2):1153-9 52 Ohminami H, Yasukawa M, Kaneko S, Yakushijin Y, Abe Y, Kasahara Y, et al Fas-independent and nonapoptotic cytotoxicity mediated by a human CD4(+) Tcell clone directed against an acute myelogenous...
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Báo cáo y học: " A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged highthroughput biophysical screening" pps
... (Grand Island, NY) The synthetic arginine-glycine-aspartic acid (RGD) containing peptide was purchased from American Peptide Company (Sunnyvale, CA) Primary antibodies against HSP20, cofilin, ... diluted appropriately in serum-free media on the day of use Statement on animal welfare Fischer 344 rat strains (male, 7-9 wk-old) were purchased from Harlan Sprague-Dawley, Inc (Indianapolis, IN) and ... concentration-dependent decreases in cell A B C D Pa Figure Spatiotemporal changes in cell traction forces Phase contrast (A) and traction field images (B, min; C, min; D, 10 min) of a single human ASM...
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Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc
... the US National Institutes of Health is in the planning stage 132 Although autoantibodies in autoimmune cytopenias and some other diseases, such as pemphigus and myasthenia gravis, have a direct ... non-Hodgkin’s lymphoma as a single agent as well as in combination therapy, emphasizing its high B-cell-depleting potency [8] In patients with lymphoma, rituximab infusion is frequently associated ... immunoglobulin levels are usually maintained, possibly as a consequence of plasma cells being spared B-cell depletion in antibody-mediated diseases It is understandable that rituximab has been most...
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Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx
... foregoing offer likely therapeutic advantage However, whether the IL-18R signalling pathway is sufficiently distinct from that of IL-1, which in turn has proven disappointing as a target in clinical ... Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colonystimulating factor and not via interferon-gamma to inhibit osteoclast formation J ... that pathogenetically useful information at least is obtained Indeed one might usefully consider this as we progress with a range of novel therapeutic targets in RA Competing interests The author(s)...
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Báo cáo y học: "High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis." ppsx
... Taniguchi N, Kawahara K, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S, Maruyama I: High mobility group box chromosomal protein plays ... improvement of disease after HMGB1 inhibition implicate HMGB1 as a key mediator and potential therapeutic target in RA HMGB1 as a novel therapeutic The recent article from Sundberg and colleagues [1] ... AR, GallowitschPuerta M, Patel NB, Huston BJ, Chavan S, Rosas-Ballina M, Gregersen PK, Czura CJ, Sloan RP, Sama AE, Tracey KJ: Cholinergic anti-inflammatory pathway activity and high mobility group...
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Báo cáo y học: "Differential cellular FGF-2 upregulation in the rat facial nucleus following axotomy, functional electrical stimulation and corticosterone: a possible therapeutic target to Bell’s pals" doc
... Chadi G: Glial bFGF and S100 immunoreactivities increase in ascending dopamine pathways following striatal 6-OHDA-induced partial lesion of the nigrostriatal system: a sterological analysis Int ... immunoreactivity mainly in astrocytes of rat facial nucleus The present findings are in line with our previous observations that adrenocortical steroid administration can increase FGF-2 mainly in ... Chadi G: Astroglial and microglial activation in the wistar rat ventral tegmental area after a single striatal injection of 6hydroxydopamine Int J Neurosci 2004, 114:197-216 25 Paxinos G, Watson...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... little data on haematological cancers Notable findings include that of single-agent activity for RHSP4 in a metastatic melanoma model, as well as in a melanoma line resistant to the platinum drug ... telomestatin, induce rapid replicative senescence in cancer cells and activate the same DNA damage response that follows DNA double-strand breaks This involves in particular ATM, p16INK 4a kinase and ... available data Studies in combination with established anticancer drugs G4 ligand Xenograft model BRACO-19 AS1410 RHPS4 A4 31 epidermal carcinoma A5 49 lung carcinoma UXF1138L human uterine carcinoma HCT116,...
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Báo cáo khoa học: 7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target Characterization and inhibition studies pptx
... inactivation of c-aminobutyric acid transaminase by gabaculine and more recently by others for the inactivation of c-aminobutyric acid transaminase [32], d-amino acid aminotransferase [33], and ... bioA gene, the primers were the following: 5ÂCGCGCGAATTCAGGAGGAATTTAAAATGCACCAC CACCACCACCACGCTGCGGCGACTGGCG-3Â containing an EcoRI restriction site, a ribosome-binding site and a His6 tag coding ... recombinant gene: 5Â-CGCGCGAATTCAG GAGGAATTTAAAATGGCTGCGGCGACTGGCGGG-3Â containing an EcoRI restriction site and a ribosome-binding Expression and purication of wild-type and His6-tagged recombinant...
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Báo cáo khoa học: Structural characterization of a novel branching pattern in the lipopolysaccharide from nontypeable Haemophilus influenzae pot
... Methylation analysis was performed as described previously [16] The relative proportions of the various alditol acetates and partially methylated alditol acetates obtained in sugar- and methylation analyses ... adds Neu5Ac in an a- 2,3linkage to lactose in other H in uenzae strains, is present in strain 981 (data not shown) Sialyllactose is known to contribute to the resistance of H in uenzae strains to ... A (62 mg) was separated by centrifugation and the water-soluble part was repeatedly chromatographed on a P-4 column, giving a major (OS-1, 8.5 mg) and a minor (OS-2, 3.7 mg) OS-containing fraction...
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Báo cáo khoa học: The identification of a phospholipase B precursor in human neutrophils doc
... and bacterial, protease contamination Protein concentration was determined with a Bio-Rad protein assay kit using BSA as a standard according to the manufacturer’s protocol Any bacterial and protease ... staining as described in Materials and methods Marker proteins and their corresponding molecular masss are indicated in lane Lane 2, material from the acid extracts of granules; lane 3, material ... database and search engine Mass determination of proteins was done with the same instrument operated in linear mode and externally calibrated with a mixture of proteins Protein determination and...
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Báo cáo khoa học: Identification and characterization of novel PKA holoenzymes in human T lymphocytes pdf
... As shown in Fig 1B, three commercially available polyclonal antibodies (anti-PKAacat, antiPKAbcat and anti-PKAccat) and one monoclonal A T-cell Jurkat NT2 antibody (anti-Cmono) were immunoreactive ... RIa and RIIa to form PKAI and PKAII in T cells (A) Confocal laser immunofluorescence of human T cells using anti-Cb2(SNO103) in combination with anti-RIa and anti-RIIa Human T cells were incubated ... specificity (anti-PKAacat, anti-PKAbcat and anti-PKAccat; catalogue numbers sc903, sc904, sc905; Santa Cruz Biotechnology, Santa Cruz, CA, USA); a monoclonal anti-C antibody (anti-Cmono; catalogue...
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Novel Therapeutic Concepts in Targeting Glioma Edited by Faris Farassati potx
... Contents Part Chapter Part Blood-Brain Barrier in Glioma Therapy 109 Blood-Brain Barrier and Effectiveness of Therapy Against Brain Tumors 111 Yadollah Omidi and Jaleh Barar Gene Therapy of Glioma 141 ... Gabellini Antioxidant Adaptive Response in Glioma 245 Antioxidant Adaptive Response of Malignant Glioma Related to Resistance to Antitumor Treatment Tomohiro Sawa and Takaaki Akaike 247 TRP Channels ... three imaginary intersecting spatial planes based on a Cartesian coordinate system Any point within the brain can be specified by measuring its distance along these three planes This provides a precise...
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Báo cáo khoa học: Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major doc
... The C-terminal amino acid was amidated in all three chrysophsins, similarly to those in marine animals, such as solitary ascidians (styelin D) [31] and hybrid striped bass (Morone saxatilis x ... equal against B subtilis and E coli (Table 2), bactericidal activity against fish and crustacean pathogens was investigated with the synthetic chrysophsins (Table 3) All three were active against ... KCl, and 43–48 0.4–1 M KCl CA, USA) by analyzing the data calibrated with 10 pmol phenylthiohydantoin amino-acid standards Tricine/SDS/PAGE The molecular mass of the sample was estimated by Tricine/...
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Báo cáo khoa học: The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAAT-DisplacementProtein (CUX1) repressor ppt
... protein isolation as described previously [48] Cell culture and shRNA knockdown The HepG2 human liver carcinoma cell line, MIA PaCa-2 human pancreatic carcinoma cell line and the human adenocarcinoma ... PCR amplification with Chip1up primer (5¢-aagctccagagggtctgcac-3¢) and Chip1dw primer (5¢-gaaaggcatcccgaacgcat-3¢); Chip2up primer (5¢-aaatgtcttgaccagccgtc-3¢) and Chip2dw primer (5¢-gaaacaaaggcctctcccag-3¢); ... Tata-box binding protein (TBP) reference gene (C) Total RNA was isolated from stable Caco-2 ⁄ 15 cell populations that contained an integrated shRNA against the CUX1 mRNA or a mutated shRNA as a control...
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Báo cáo khoa học: A novel phosphorylated glycoprotein in the shell matrix of the oyster Crassostrea nippona pptx
... nippona The same amount of sample was applied to each lane Lane M, molecular mass standards; lane A, CBB staining; lane B, Stains-all staining; lane C, negative staining; lane D, Methyl green staining ... buffer containing 2-mercaptoethanol after boiling, and subsequent staining procedures with negative staining, Stains-all and Methyl green visualized an exclusive band of approximately 52 kDa, which ... preferably over Glu, and a single Cys residue was located at its center A search of the nonredundant GenBank CDS database using blast (protein–protein blast and Search for short, nearly exact matches)...
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Báo cáo hóa học: " A pilot clinical trial testing mutant von HippelLindau peptide as a novel immune therapy in metastatic Renal Cell Carcinoma" doc
... this article as: Rahma et al.: A pilot clinical trial testing mutant von Hippel-Lindau peptide as a novel immune therapy in metastatic Renal Cell Carcinoma Journal of Translational Medicine 2010 ... by helping in the manuscript drafting Drs Samara and Abdalla are postdoctoral fellows at the National Cancer Institute Author details Vaccine Branch, NCI, NIH, Bethesda, MD, USA 2Medical Oncology ... RRIHSYRGDLWLFRDA MEAGRPRPCCAR RLALQRCRDTRWA Rahma et al Journal of Translational Medicine 2010, 8:8 http://www.translational-medicine.com/content/8/1/8 Page of Table VHL mutations and HLA types in vaccinated...
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NOVEL THERAPEUTIC CONCEPTS IN TARGETING GLIOMA pot
... Contents Part Chapter Part Blood-Brain Barrier in Glioma Therapy 109 Blood-Brain Barrier and Effectiveness of Therapy Against Brain Tumors 111 Yadollah Omidi and Jaleh Barar Gene Therapy of Glioma 141 ... Gabellini Antioxidant Adaptive Response in Glioma 245 Antioxidant Adaptive Response of Malignant Glioma Related to Resistance to Antitumor Treatment Tomohiro Sawa and Takaaki Akaike 247 TRP Channels ... three imaginary intersecting spatial planes based on a Cartesian coordinate system Any point within the brain can be specified by measuring its distance along these three planes This provides a precise...
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Báo cáo khoa học: " Sequence analysis of the S1 glycoprotein gene of infectious bronchitis viruses: identification of a novel phylogenetic group in Korea" docx
... (5'TG AAAACTGAACAAAAGAC3') together with one of the reverse primers S1OLIGO3' (CTAAACTAACATAAGGG C3') or degenerate3'-2 (5'CCATAAGTAACATAAGGG CAA3') [14,16] The RT reaction for synthesis of cDNA ... (Promega, USA) and transformed into JM 109 competent cells (Promega, USA) The cells carrying recombinant plasmids were selected on Luria-Bertani agar plates containing ampicillin, X-gal and IPTG, and ... - Arkansas KM91‡ KM91 KM91 KM91 KM91 Variant KM91 Variant Variant Variant Variant GenBank accession numbers AY790368 AY790359 AY790360 AY790358 AY790362 AY790361 AY790366 AY790365 AY790363 AY790364...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
... perinuclear localisation of the channel leading to activation of Mitogen activated protein kinase (MARP) pathway resulting in increased cell proliferation The Eag channels also act through the Ca calmodulin ... independent of K+ influx through the channel Eag channels also act as a scaffold for and activate Calcium -Calmodulin activated kinase II (CaMKII), forming a complex which remains active even in the presence ... Warmke JW, Ganetzky B: A family of potassium channel genes related to eag in Drosophila and mammals Proc Natl Acad Sci USA 1994, 91(8):3438-42 16 Harmar AJ, et al: IUPHAR-DB: the IUPHAR database...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25