6application of microwave activation in heterocyclic chemistry
Báo cáo khoa học: Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems pptx
Ngày tải lên :
06/03/2014, 22:21
... of prothrombin conformation induced by the agent Modulator of the activation of plasma hyaluronan-binding protein Plasma hyaluronan-binding protein activation Plasma hyaluronan-binding protein ... K4 of plasminogen, the AH site can bind an internal lysine residue in addition to the C-terminal lysine [30], which is a preferred ligand for the lysine-binding site in K1, K2 and K4 Thus, aminohexyl ... surfactin C action involves modulation of Glu-plasminogen activation through relaxing the conformation of the protein Surfactin C increases the intrinsic fluorescence of Glu-plasminogen, shortens...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
Ngày tải lên :
19/06/2014, 22:20
... synthesized in other organs including the brain [31] Protein fragments generated during activation of the system enzymatically cleave the next protein in the sequence, generating a variety of "activation ... regulatory proteins including CD59, clusterin, vitronectin, C1-inhibitor, C4-binding protein, decay-activating factor, and Factor H, which inhibit different steps in the complement cascade All of these ... systemic administration of the excitotoxin kainic acid [108,109], or injection of the neurotoxin colchicine into the dorsal hippocampus [109] Surgical transection of the perforant pathway increased...
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Báo cáo y học: " Construction and analysis of a modular model of caspase activation in apoptosis" pot
Ngày tải lên :
13/08/2014, 16:21
... The influence of the intrinsic pathway demonstrated by the comparison of time courses in Figure shows a significant delay of caspase activation upon disabling the pathway coupling through tBid In ... through the extrinsic pathway 2) solely through the intrinsic pathway 3) through the extrinsic triggering the intrinsic pathway and 4) through the intrinsic triggering the extrinsic pathway Whether ... mechanism that involves the intrinsic pathway triggering the extrinsic pathway Furthermore, the role of Smac* as an indirect activator of Casp3 through the sequestration of XIAP is Analysis of the Jurkat...
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Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
Ngày tải lên :
18/02/2014, 11:20
... regarding the role of the aVb3 integrin, because it is also reported to suppress collagen I-induced activation of proMMP-2 [8] Another MMP inhibitor, reversion-inducing cysteinerich protein with ... colchicine-induced rearrangements of the microtubule network in osteosarcoma cell lines increase activation of proMMP-2 along with an increased level of MT1-MMP [18] This study shows that the interaction ... direct binding of either the 72 kDa proform or the 64 kDa intermediate to the cell membrane Lafleur et al [6] have shown that TIMP-2, in addition to being involved in the first step in the MT1-MMP activation...
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Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc
Ngày tải lên :
07/03/2014, 06:20
... derived from jararhagin disintegrin) is essential for binding to the I domain of a2 integrins [24] Similarly, members of the ‘lysine–threonine–serine (KTS)–disintegrin’ family contain the consensus ... a-amino group of the tissue inhibitor of metalloproteinases-2 NH2-terminal cysteine has been used to demonstrate the key role of this amino group in the inhibitory effect of tissue inhibitor of metalloproteinases-2 ... than RGD, in their integrin- binding loop [25,26] In addition, glycation of collagen lysine side chains is responsible for an impaired interaction of type I collagen with b1 integrins [27,28]...
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Báo cáo khoa học: Human anionic trypsinogen Properties of autocatalytic activation and degradation and implications in pancreatic diseases potx
Ngày tải lên :
17/03/2014, 03:20
... identical in size (band A) Activation of double-chain trypsinogen to double-chain trypsin results in the appearance of band B, which corresponds to the N-terminal chain of double-chain trypsin For ... Trypsin activity was expressed as percentage of the initial activity measured at the beginning of the incubation SDS/PAGE analysis of trypsinogens Autoactivation and degradation of trypsinogens ... trypsin functions, i.e activation of other zymogens and digestion of ingested proteins; are unaffected by up-regulation of anionic trypsinogen In contrast, trypsinogen activation was markedly diminished...
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Báo cáo Y học: The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils doc
Ngày tải lên :
18/03/2014, 01:20
... antisera by dot blotting (bottom of the figure) In all panels, the inserts correspond to SDS/PAGE of fractions of interest followed by Coomassie blue staining, except the insert b in (C) which corresponds ... protein) in a volume of 450 lL (d) A parallel incubation was carried out in the presence of 2500 pmol of S100A8/A9 (s) Following incubation, 10 lg protein aliquots were withdrawn for measurement of ... concentration induces the transition of the heme iron of flavocytochrome b from an inactive hexacoordinated form to a pentacoordinated form capable of binding O2 [25] In a previous study on oxidase activation...
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Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
Ngày tải lên :
23/03/2014, 21:20
... action of Zn in induction of apoptosis remains to be unclear In this study, we investigated the molecular mechanism underlying the mode of action of the induction of apoptosis by elevation of intracellular ... the Ministry of Education, Sciences, Sports and Culture of Japan REFERENCES Fig Involvement of activation of p38MAPK in the induction of apoptosis by Py/Zn (A) Time-course study of activation of ... caspase One of the most relevant aspects in the regulation of apoptosis is the involvement of mitogen-activated protein kinases (MAPKs), a family of serine/threonine kinases that mediate intracellular...
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Báo cáo khoa học: Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches pot
Ngày tải lên :
29/03/2014, 23:20
... fragments of the thiazolium ring remaining It is worth noting that hydrolysis of the thiazolium ring of ThDP generates open-chain neutral species similar to and In view of the fact that the enzymes bind ... role of diphosphate in binding For example, there is a difference in binding to ZmPDC between the diphosphate and its alcohol precursor of the order of ã 107 The general trend observed in binding ... either as terminators of transcription (e.g in Bacillus subtilis) or as inhibitors of translation (by masking the ribosome binding site, e.g in E coli) or to cause mis-splicing of the RNA (in eukaryotes)...
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Báo cáo khoa học: Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors pdf
Ngày tải lên :
29/03/2014, 23:20
... thiamin-degradation products, such as formylaminopyrimidine formed in the soil, to aminopyrimidine and hydroxypyrimidine, a building block for the biosynthesis of ThMP Hydrolysis of aminopyrimidine ... initiated with the binding of thiamin or one of its phosphate derivatives to the periplasmic protein component of the transporter [19] Interestingly, thiaminase I from B thiaminolyticus shares ... ThDP-sensing noncoding mRNA elements present in some mRNAs coding for enzymes involved in the thiamin biosynthetic pathways [17,18] When plenty of ThDP is present, binding to the riboswitch induces a...
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Báo cáo khoa học: Synergistic co-operation of signal transducer and activator of transcription 5B with activator protein 1 in angiotensin II-induced angiotensinogen gene activation in vascular smooth muscle cells potx
Ngày tải lên :
30/03/2014, 02:20
... c-Jun may be involved in Ang II-induced AGT mRNA expression (Fig 1C) DNA-binding activity of STAT5B and c-Jun increases in Ang II-induced AGT expression To find out whether the increase in STAT5B ... and c-Jun in the induction of expression of AGT mRNA by Ang II, using super-EMSA, ChIP, CoIP and western blot analysis Co-operative DNA binding of proteins usually involves regions in close proximity, ... STAT5B and c-Jun phosphorylation induced by Ang II affects the binding of STAT5B and c-Jun to their cis-elements, the activity of STAT5B binding and of c-Jun binding to DNA was detected, respectively,...
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reaction mechanisms of inorganic and organometallic systems (topics in inorganic chemistry)
Ngày tải lên :
01/04/2014, 10:37
... type of modeling is capable of providing an indication of the effects of steric interactions on reactivity, but gives no measure of the actual energetics of the reaction More recently, modeling of ... predicts that a plot of In [A] versus t should be linear with a slope of -k\ The linearity of such plots often is taken as evidence of a first-order rate law Since the assessment of linearity is somewhat ... Reaction Mechanisms of Inorganic and Organometallic Systems TOPICS IN INORGANIC CHEMISTRY A Series of Advanced Textbooks in Inorganic Chemistry Series Editor Peter C Ford, University of California,...
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new developments in the chemistry of war gasses 1950
Ngày tải lên :
09/05/2014, 17:01
... hydrochlorides of N-alkyl-2 ,2'dihydroxydiethylamines instead of the free amines The reaction is carried out in boiling benzene (50, 56) or chloroform (27, 39) and in the presence of an excess of thionyl ... period of time deposit a fluffy mass of small crystals, the rate of formation of which increases with an increase in temperature Changes in the length of the alkyl chain R and the presence of solvents ... forms of the dimer were obtained, the cis-form predominating in the case of N-methyl-2 ,2’-dichlorodiethylamine Comparative studies of the rate of dimerization show that this rate falls off very...
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the synthetic use of metals in organic chemistry
Ngày tải lên :
09/05/2014, 17:02
... h e last case di-cinnamyl-vinyl ketone results Anofcl*cn* crtse of quinoline formation is the con^ Toenzoyl acetone and aniline, resulting in OH HC /X < HC HC < Vr It ydr densing1 CH CO.CGH5 CO.CH, ... the use of aluminium chloride in the preparation of various aromatic compounds, will hear the story of the discovery of the zinc alkyls, and will possibly be attracted by those interesting bodies, ... nitrides—Hydroxides of the metals 42 CHAPTER IV ZINO AND MERCURY Metallic Zinc—Zinc chloride—Mercuric oxide—Metallic mercury ^ V1U CONTENTS CHAPTER V ALUMINIUM, TIN AND LEAD PAGE Aluminium chloride—Aluminium-mercury...
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Báo cáo sinh học: " Kaposi''''s sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial ce" pptx
Ngày tải lên :
18/06/2014, 18:20
... c-Jun N-terminal kinase/stressactivated protein kinase (JNK/SAPK), and protein kinase C/activator protein-1 (PKC/AP-1), all of which regulate COX-2 expression [8,10-15] The KSHV vGPCR also induces ... role of COX-2 in vGPCR-induced PGE2 secretion, SC-560 (COX-1 selective inhibitor), NS-398 (COX-2 selective inhibitor), or Indomethacin (Non-selective COX inhibitor) was added to vGPCR-expressing ... time-dependent increase in COX-2 expression in vGPCRexpressing HUVEC and represents the mean of independent infections each measured in triplicate (*= p < 0.001) Valencia, CA) and ligated into either...
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Báo cáo hóa học: " Kaposi''''s sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells" ppt
Ngày tải lên :
20/06/2014, 01:20
... c-Jun N-terminal kinase/stressactivated protein kinase (JNK/SAPK), and protein kinase C/activator protein-1 (PKC/AP-1), all of which regulate COX-2 expression [8,10-15] The KSHV vGPCR also induces ... role of COX-2 in vGPCR-induced PGE2 secretion, SC-560 (COX-1 selective inhibitor), NS-398 (COX-2 selective inhibitor), or Indomethacin (Non-selective COX inhibitor) was added to vGPCR-expressing ... time-dependent increase in COX-2 expression in vGPCRexpressing HUVEC and represents the mean of independent infections each measured in triplicate (*= p < 0.001) Valencia, CA) and ligated into either...
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Báo cáo hóa học: " Assessment of Microwave/UV/O3 in the Photo-Catalytic Degradation of Bromothymol Blue in Aqueous Nano TiO2 Particles Dispersion" pptx
Ngày tải lên :
21/06/2014, 17:20
... UV-B intensities increased with the microwave intensity, whereas the UV-C intensity showed little change at microwave intensity larger than 0.4 kW Figure shows the MDEL emitting UV light upon microwave ... that the degradation rate increases with amount of TiO2 nano particle dosages Effect of Microwave Intensity The results are shown in Fig as a function of microwave intensity The experiments were ... intensity for decomposition of BTB in aqueous solutions contributed to degradation of BTB indirectly by increasing UV intensity The thermal and non-thermal effects of microwave are also presumed...
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Metal Complexes of 4′-Substituted-2,2′:6′,2″-Terpyridines in Supramolecular Chemistry
Ngày tải lên :
02/07/2014, 13:33
... substituents at the 4′-position of the 2,2′:6′,2″-terpyridine which differ from one another in the length of the chains, in the linkages of the chains or in the terminal domains Chapter describes the ... of appropriate molecular components containing metal-binding domains."20 The principle of the formation of metallosupramolecules depends mainly on (1) the number and orientation of the coordination ... importance of designing ligands with correct number and orientation of the coordination sites (molecular components containing metal-binding domains) and of choosing metal ions with the correct coordination...
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Báo cáo lâm nghiệp: "Element analysis of tree rings in pedunculate oak heartwood: an indicator of historical trends in the soil chemistry, related to atmospheric deposition" ppsx
Ngày tải lên :
08/08/2014, 18:21
... consequence of an increase in the number of protons, which results in a gradual decline of the soil acid neutralizing capacity (Van Breemen et al, 1984) and in most cases leads to a decrease in available ... elemental concentrations in radial increments of old growth eastern redcedar to examine the chemical history of the environment In: Proc of the Int Symp on Ecological Aspects of Tree-Ring Analysis, Tarrytown, ... depending on the location in the forest, probably in relation to the collapse of the steel industry (Thimonier, 1994) Over 60% was in the form of NH ; + however, these nitrogen inputs in 1991...
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Báo cáo y học: "Importance of basophil activation testing in insect venom allergy" pdf
Ngày tải lên :
08/08/2014, 21:20
... eliciting only a partial activation of basophils in majority of tested subjects, and the second concentration (1 μg/ml) was maximal and elicited a complete activation of basophils in all responding ... Safety of VIT In different immunotherapy protocols a cumulative dose of 100 μg of venom (corresponding to honeybee or 10 wasp stings) is reached in few hours or days with no allergic reactions in ... accuracy of the test Competing interests The authors declare that they have no competing interests Authors' contributions • Severe pre-treatment reaction MK has been involved in drafting the manuscript,...
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