iOS 5 Programming Cookbook phần 8 ppt
... file of our app delegate: #import "Saving_ and_ Loading_ the_ State_ of_ Multitasking_ iOS_ AppsAppDelegate.h" @implementation Saving_ and_ Loading_ the_ State_ of_ Multitasking_ iOS_ AppsAppDelegate 12.6 Saving ... 12.5 Handling Location Changes in the Background | 635 12.6 Saving and Loading the State of Multitasking iOS Apps Problem You want the state of your iOS app to be saved when it is sent to the background, ... whenever the state of the battery of the iOS device is changed For instance, if the device is plugged into a computer when the applica642 | Chapter 12: Multitasking tion is in the foreground and then...
Ngày tải lên: 13/08/2014, 18:20
iOS 5 Programming Cookbook phần 9 pdf
... 0) is the topmost and the leftmost point on the screen, and that positive values of the x axis extend towards the right, while positive values of the y axis extend towards the bottom In other ... of the events in the event store and kept the copy somewhere, you must call the refresh instance method of that event of type EKEvent If the return value of this method is YES, you can keep the ... Presenting_Event_View_ControllersViewController @synthesize eventStore; Now let's go ahead and in the viewDidLoad method of our view controller, and display the instance of EKEventViewController on the first event we find in any of the calendars...
Ngày tải lên: 13/08/2014, 18:20
... The sequences obtained, GVHAMGGMAAQIPIK and ATPTDLSK, corresponded to the respective deduced residues 334±348 and 546±553 of Mls1p, con®rming the identity of the puri®ed recombinant protein The ... that was absent from the lane corresponding to the mls1D mutant (arrow; Fig 1A), thereby con®rming the speci®city of the antibody Application of the antibody to thin sections of wild-type cells ... Targeting of Mls1p to peroxisomes is advantageous for growth on oleic acid Two steps of the glyoxylate cycle take place in the cytosol: the splitting of isocitrate into succinate and glyoxylate, and the...
Ngày tải lên: 22/02/2014, 04:20
... from the other branches, which was indeed predicted The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences clustered with the PHF and the CGBP ... among the sequences and always follows the PHD domain Using PSI-BLAST, the dPHD of DIDO1 hits CGBP_ MOUSE at the second iteration, with an e-value of 2e-06 (inclusion threshold of 0.03) In SPP1, the ... a result of recombination processes; this signature is missing in DIDO1 and SPP1 The absence of the CXXC signature distinguishes SPP1 from the CGBP family (Figs 1, and S1); otherwise, the fungal...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair docx
... include identification of these lesions as a strand break, verification of the nature of the 3¢ end, and identification of a satisfactory pathway for repair The XRCC1 component of the XRCC1–DNA ligase ... require specific proteins for ‘cleaning’ the ends and preparing them for DNA repair, the time and mechanism of entry of these proteins and other BER partners into the repair process is unknown This ... to the DNA and to each other by the addition of formaldehyde The beads are subsequently washed before reversal of the cross-links, and released proteins are analysed by gel electrophoresis and...
Ngày tải lên: 23/03/2014, 11:20
Báo cáo khoa học: Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy pot
... structure is not observed in other long neurotoxins On the other hand, the absence of any NOE between residues 69–73 and other regions of the peptide indicates that there is no structural involvement ... this region and lower the entropy difference between the free and bound forms of the molecule [44] Furthermore poor experimental restraints and possibly bulkiness of the tip portion of loop II ... conformation for the solution and crystal state in this region The secondary elements of the X-ray structure can be observed in the NMR structures but the length of the b-strand in loop I in solution...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
... treatment of diseases such as HIV, other microbes and cancer [11,22-37] In addition, such protocols offer a more Page of 11 practical alternative for active immunotherapy of cancer and other diseases ... could very well be at the heart of both the mechanism and advantage of heterologous primeboost regimens Therefore, the remainder of this review will focus on this key feature and its underlying ... requires a deeper understanding of the mechanism of action of DNA vaccination A key observation from many studies to date is that interchanging the order of vectors utilized in these regimens has a...
Ngày tải lên: 18/06/2014, 16:20
Chapter 1: Define the Art of Communication potx
... Introduction to the topic • Why negotiation skills are integral to success • The importance of negotiations in developing partnerships Overview of the text chapters Ride the Ride Negotiations ... friends and influence people at a personal level, the ability to structure partnerships, and the ability to negotiate and to find compromises Business will be much more about finding the right ... throughout one’s life Focus of Text How successful negotiation alliances are formed Emphasizes language and the talk of negotiation Engagement connotes the active nature of negotiation begun with...
Ngày tải lên: 31/07/2014, 17:20
Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx
... manuscript, and preparation of the figures SMB was involved with the design and coordination of the study AL was involved with the design and coordination of the study, drafting and editing of the manuscript ... target of MEK/ERK signalling and that IL-1 induction of Egr-1 inhibits the activity of the human type II collagen proximal promoter [31] We therefore focused the remainder of our study on Egr-1 and ... MEK1/2-independent manner Surprisingly, the activation of NFB and the inhibition of Sox9 activity by TNF were independent of MEK1/2 The DNA binding activity of the transcription factor early growth...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... [11,12] In this disease, the body of evidence points towards these being part of a more profound change in chondrocyte biosynthesis [13] driven by local production of IL-1 and tumour necrosis factor ... Biosystems The total gene specificity of the nucleotide sequences chosen for the primers and probes were confirmed by BLAST searches (GenBank database sequences) The nucleotide sequences of the ... set of primers and probes, the efficiency of the amplification was assessed using template titrations as recommended by Applied Biosystems PCR reactions were then performed and monitored using the...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt
... was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Ministry of Health, Labour and Welfare of Japan, and the Japan Rheumatism Foundation ... alignment, and drafted the manuscript HN, K H-M, TK, and KN conceived the study, participated in its design and coordination, and helped to draft the manuscript All authors read and approved the final ... during the progression of OA Our data show here for the first time a correlation between the levels of expression of HIF-1α and degeneration of articular cartilage in patients with OA To clarify the...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... chromatography The amount of 7α-OH-DHEA is expressed as the percentage [3H]-7α-OH-DHEA of the total amount of [3H]-label measured Results are expressed as the mean ± standard error of the mean of triplicate ... (Breda, The Netherlands), dissolved in dimethylsulfoxide or methanol and used as controls The proteasome inhibitor PSI and the JNK inhibitor SP600125 were purchased at Omnilabo (Breda, The Netherlands) ... most of the studies, carried out most of the assays and wrote the manuscript AK (Allard Kaptein) helped in conceiving the study and helped to draft the manuscript AK (Annemieke Kavelaars) and...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx
... other available tests, it will not replace a standard work-up panel as of yet Nonetheless, the current study demonstrates that there is a difference in expression of HMGB1 between those with and ... Consequently, the results are not generalisable and not immediately valid nor advisable for use in the general population at large [7,8] As the authors of the current study point out [5], the high ... H: Genetic and environmental influences on the risk of acute appendicitis in twins Br J Surg 2009, 96(11):1336-1340 Andren-Sandberg A, Korner H: Quantitative and qualitative aspects of diagnosing...
Ngày tải lên: 13/08/2014, 23:20
homomorphisms of the fundamental group of a surface into psu(1,1), and the action of the mapping class group
... to be crucial for the proof of the ergodicity of the mapping class group In section 6.3 we state the main theorem of this paper To proceed the proof of the theorem we state and prove two key ... ]} The level sets of R1 are connected ±1 {U0 } R1 (Ell × Ell) = R1 (G \ Hyp) × G ∪ G × (G \ Hyp) = {ρ = 0} We present the proof of the first and the third part of this proposition The proof of ... conj denote the projection The idea of the proof is to prove first that the space of conjugacy classes of Im(Rp−1 ) ∩ gc Im(R1 ) is connected, then use the fact that each ˜ one of the conjugacy...
Ngày tải lên: 13/11/2014, 09:14
Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... kidneys and unusually low levels in the brain and other tissues The clinical manifestations arise due to the deficiencies in the activity of the essential cuproenzymes On the other hand, Wilson’s ... cause cellular necrosis and leakage of copper into the plasma and deposition of copper in extra hepatic tissues, including the limbus of the cornea and the basal ganglia of the brain (Culotta, 2001) ... form the large T-loop and the 3' G-strand binds to the doublestranded telomere repeat sequence of the 5'-end strand, forming a D-loop (Figure 1B)(Greider, 1999) The protective function of telomeres...
Ngày tải lên: 11/09/2015, 10:18
THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
... attributed to the lack of activation of the members of the MAPK family – pERK, pP38 and pJNK The absence of ANXA1, on the other hand, markedly increased basal expression of these markers, thereby relating ... based on their molecular sizes They are, the large molecular weight HSPs of 100-110 kDa, the HSP90 family of 83-90 kDa, the HSP70 family of 66-78 kDa, the HSP60 family, the HSP40 family and the small ... in the promoter region of the target genes Activation of the HSR results in the sudden and vast change in gene expression leading to an increase in transcription and synthesis of a family of...
Ngày tải lên: 01/10/2015, 17:27
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
... microglia and oligodendrocytes and was also the first to describe the two types of microglia: amoeboid and ramified Microglia, comprising 10-20% of the total glial cell population of the CNS, are the ... novo synthesis and the salvage pathway The endoplasmic reticulum is the site for the de novo synthesis of sphingolipids Palmitoyl CoA and serine get condensed to form 3-ketosphinganine in the presence ... Hormones: prolactin and estradiol; (d) Hypoxia, and (e) Histamine 1.6.3 Functions of SphK1 and S1P The cellular levels of sphingosine, ceramide and S1P and the activation/inactivation of SphK1 play...
Ngày tải lên: 16/10/2015, 15:38
Task 1 Explain the purpose of the following project document.
... provide an overview of the allocation of funds or the estimation of cost for the project (salaries, outsourcing costs, research fees, use of materials, hire of equipment and administrative support) ... arisen and need to be addressed Progress reports are useful for explaining the status of the project as it currently stands and its future direction They also put the project’s progress into the ... in the management of spending & saving money D) Progress report: Regular progress reports should be prepared and should outline: • Decisions reached and make by the project team • Activities and...
Ngày tải lên: 24/04/2016, 12:10