528—drugs for rare diseases or conditions

... individualized innovative concepts for patients with rare diseases Our results will provide healthcare institutions and HCPs with essential information for elaborating and implementing individual ... basis for evaluating and incorporating new experiences and information to create new healthcare concepts and treatments fitting patients’ needs [8] Different HCPs carry different expertise Therefore, ... need for knowledge sharing for explorative outcomes, operational performance also depends on the intensity of knowledge sharing between HCPs, particularly specific knowledge related to more routine...

Ngày tải lên: 10/08/2014, 10:23

... ureas for HIV protease, the discovery of inhibitors for thymidylate synthase and inhibitors for acetylcholinesterase (AChE) [46, 47, 48] Factors influencing the growth of SBDD The major factors ... energies Different force field functions are based on different force field parameter sets For example, AutoDock relies on the Amber force field and G-Score relies on the Tripos force field [98] ... applied: Force field-based, empirical scoring functions and knowledge based scoring functions [98] A short description on each scoring function is given below Detailed information about the scoring...

Ngày tải lên: 02/07/2014, 13:13

... inactive form of BRCA-1 which together account for up to 85% of BRCA-1 pathogenic mutations in humans, were not any more sensitive to PARP-1 inhibitors than wild type or heterozygous mammary tumor ... also urged caution as to whether prior findings were fully generalizable for the specific treatment of human cancers harboring naturally occurring, inactivating forms of BRCA2 mutations Int J Med ... three mammary tumor cell lines that are either hypomorphic (BRCA1Δ11/Δ11) or null (BRCA1-/-) for BRCA1 In the colonogenic assay, we found that all BRCA1-/- cell lines were much more sensitive to...

Ngày tải lên: 31/10/2012, 16:57

... salicylate, the rapidly formed metabolite of ASA, is notable for its dose dependence Salicylate is effectively reabsorbed in the kidney, except at high urinary pH A prerequisite for rapid renal elimination ... but is of little use in inflammatory and visceral pain Its mechanism of action remains unclear It can be administered orally or in the form of rectal suppositories (single dose, 0.5–1.0 g) The ... function Vasodilation Labor Impulse frequency in sensory fiber Capillary permeability Nociceptor sensibility Pain stimulus A Origin and effects of prostaglandins Lüllmann, Color Atlas of Pharmacology...

Ngày tải lên: 24/10/2013, 19:15

... Requirements for special installations or locations Section 707 - Earthing `,`,,``,``,,`,``,``,``,``-`-`,,`,,`,`,,` - requirements for the installation of data processing equipment FOREWORD I) The formal ... l'information Electrical installations of buildings `,`,,``,``,,`,``,``,``,``-`-`,,`,,`,`,,` - Part 7: Requirements for special installations or locations Section 707 - Earthing requirements for ... Publication 614-2-1 : Specification for Conduits for Electrical Installations Part 2: Particular Specifications for Conduits Section One - Metal Conduits, a conductor of not less than 2.5 mm2 shall...

Ngày tải lên: 25/12/2013, 11:05

... pedestrians) was 54 % for private cars, 27 % for buses and 11 % for cyclists By 2000, the modal split was 39 % for cars, 44 % for buses and 11 % for cyclists BACKGROUND Oxford is an historic university ... pedestrians) was 39 % for cars, 44 % for buses and 11 % for cyclists This compares with 54 % for private cars and 27 % for buses in 1991 before the implementation of the OTS (cycling as a proportion had ... into groups in order to illustrate the following themes: • Opportunities for regeneration; • From urban smog to urban life; • Creating space for sustainable transport Opportunities for regeneration...

Ngày tải lên: 19/02/2014, 04:20

... giúp hồi phục vitamin E từ gốc - tocopheryl vitamin C trở thành gốc ascorlyl bền Dạng ester vitamin C nh salmitat ascorlic ascorbat rutin dễ tan lipit qua đợc pha lipid thành mạch, vitamin E chống ... tham khảo Tài liệu khoa học công ty dợc phẩm pfizer, MSD, Fourmier (1998 - 2004) Opie H.L: Drugs for the Heart; Edition (2001); W.B Samders Company, trang 323 350 Medline (2000 - 2004) ... gan" thải 124 Ezetimibe đặc biệt cho tác dụng hiệp đồng rõ rệt phối hợp với statin (simvastatin, atorvastatin, fluvastatin, pravastatin, lovastatin), nhờ sức mạnh tổng hợp chế: ức chế hấp thụ cholesterol...

Ngày tải lên: 26/02/2014, 03:20

... Pasture management for parasite control There are very few de-worming products available for use with organic or natural poultry Pasture rotation to break the life cycle of worms is the best management ... University, Frankfort Copyright 2011 for materials developed by University of Kentucky Cooperative Extension This publication may be reproduced in portions or its entirety for educational and ... vaccine is available for use in organic poultry production but it must be While there are a number of products approved for use in Europe, there are only a few approved for use in the United...

Ngày tải lên: 08/03/2014, 09:20

... both for PMTCT and as the first-line national ART regimen for non-pregnant individuals The ability to use the same regimen for PMTCT and for first-line ART considerably simplifies drug forecasting, ... prioritize starting all women with CD4 counts ≤350 cells/ mm3 or WHO Stage or disease (approximately 40–50% of all HIV-infected pregnant women) on ART for life for their own health as well as for ... Short-term priorities for antiretroviral drug optimization Meeting report (18–19 April 2011, London, UK) Geneva, World Health Organization, 2011 http:// www.who.int/hiv/pub/arv/short_term_priorities/en/index.html...

Ngày tải lên: 08/03/2014, 15:20

Ngày tải lên: 14/03/2014, 17:20

... as a text-formatted file For a structure with the accession code 9xyz, the corresponding file would be 9xyz.pdb (For easier handling by computer programs, the same information is also stored in a ... collected for phasing For refinement, it is most important to collect a complete data set to the resolution limit of Protein crystallography for non-crystallographers diffraction, whereas for phasing ... B-factors were refined, or whether only an overall B (for the whole structure) or group B-factors (for each residue) were refined Any structure at res˚ olution lower than  A in which B-factors were...

Ngày tải lên: 16/03/2014, 06:20

... made for monitoring personnel and their equipment in a warm-up tent before the individuals occupy work or rest areas All personnel in the monitoring tent must wear protective masks during monitoring ... fails to conduct monitoring of personnel and equipment before entering sleep or work areas, the potential exists for intoxication by multiple routes of exposure Soldiers could absorb agent through ... Ct of 100 mg-min/m3 by staying in a concentration of 10 mg/m3 for 10 minutes (10x10=100), 20 mg/m3 for minutes (20x5=100), or mg/m3 for 20 minutes (5x20=100) The Ct that will cause a biological...

Ngày tải lên: 17/03/2014, 15:20

... cold, or a flu, or sinusitis, or a first bout of pneumonia, or a spring allergy attack The intense symptoms knock them flat and force them to bed for a few days or a week If they are sick more ... life-threatening conditions such as obesity with incipient heart failure, or who came to me with cancer, that were unable to stop work for financial reasons, or who could not afford a residential ... reserved © Copyright 2004 Treatments-4-Incurable -Diseases. us Alternative Treatments for Incurable Diseases page 14 for a short period, like one or two weeks, with a plan to repeat the process...

Ngày tải lên: 17/03/2014, 16:20

... trial is forthcoming Antiangiogenic Gene Therapy Antiangiogenic gene transfer inhibits formation of neovasculature required for tumor growth and may also act by collapsing immature tumor-associated ... gynecological diseases are less severe and more treatable than gynecological cancers Therefore, clinical translation of gene therapy strategies probably requires even more stringent safety information Moreover, ... cause of mortality worldwide [1] Unfortunately, neither improvements in surgery nor radiotherapy has significantly decreased mortality [65], and patients with advanced, recurrent, or metastatic...

Ngày tải lên: 22/03/2014, 11:20

... is the performance of significant duties over a reasonable period of time while working for pay or profit, or in work generally done for pay or profit Full-time work (or part-time work done at ... Publication 519, U.S Tax Guide for Aliens You may want to see: Publication 554 Tax Guide for Seniors Form (and instruction) Schedule R (Form 1040A or 1040) Credit for the Elderly or the Disabled See How ... file Form 1040 or Form 1040A You cannot take the credit if you file Form 1040EZ or Form 1040NR Qualified Individual You are a qualified individual for this credit if you are a U.S citizen or resident...

Ngày tải lên: 22/03/2014, 18:20

... worms, mites) range from 77 KHz to 900 KHz Fortunately for us we can work on zapping pathogens in the lower ranges without affecting humans in the upper range 17 THE CURE FOR ALL DISEASES BIORADIATION ... Century Press: The Cure For All Cancers Heilverfahren Aller Krebsarten (Cure For Cancers, German) The Cure for All Cancers (Japanese Translation) The Cure For All Cancers (Korean Translation) Heilung ... something without flavor and identify it electronically The system worked fine for detecting things in the skin and tongue Would it be reliable for internal organs, too? A whole world of discovery...

Ngày tải lên: 22/03/2014, 20:21

... by a law enforcement agency or an insurance, transportation, or similar business organization, provide a copy of the report COMPLETION OF FORM – Print clearly in ink or type all information requested ... date, as required on the form, and impress the seal of your organization INSTRUCTIONS PURPOSE OF FORM – Use this form to apply for relief on account of the loss, theft, or destruction of United ... information may be disclosed to a law enforcement agency for investigation purposes; courts and counsel for litigation purposes; others entitled to distribution or payment; agents and contractors...

Ngày tải lên: 22/03/2014, 21:20

... 4.0 for line C2 (n ¼ 6) and 6.2 ± 2.8 lM, h ¼ 1.43 ± 0.33 and a ¼ 33.0 ± 4.2 for line E (n ¼ 8) (for Ki P ¼ 0.09 after log transformation for all comparisons, one way ANOVA with Bonferronni correction) ... 1.5–3 MW for whole-cell recording and 6–9 MW for single-channel recordings The capacitance of pipettes was reduced by coating pipettes with a parafilm/mineral oil suspension and compensated for by ... current, with 1.2 mM ATP in the patch pipette for lines A and E, 600 lM ATP for line C2 and 100 lM ATP for lines B and D (C) Concentration–response curves for the effect of tolbutamide (1–500 lM) on...

Ngày tải lên: 31/03/2014, 08:20

... event information and safety laboratory data should be collected Age- and sex-appropriate normal laboratory values should be included with clinical measurements when reporting laboratory data ... benefit for treatment of ABS by antimicrobial drugs Therefore, we not recommend the use of noninferiority trials to establish evidence of effectiveness for regulatory approval of a new indication for ... can be performed by a telephone contact or other interactive technology For patients with adverse events occurring at or after the early follow-up assessment, investigators should perform an assessment...

Ngày tải lên: 31/03/2014, 14:21

... essential host factors including Tsg101, required for vacuolar sorting and efficient budding of HIV-1 progeny [49], and the chemokine receptor CCR5, required as a coreceptor for HIV-1 cell entry ... adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses Cel 1989, 56:849-853 Uncapher CR, Dewitt CM, Colonno RJ: The major and minor group receptor families contain all but one human ... of (page number not for citation purposes) Virology Journal 2004, 1:12 globulin or RSV-IG) became available for use in children less than two years of age with high-risk factors [8-10] The use...

Ngày tải lên: 18/06/2014, 22:20